{"id":"https://openalex.org/W3138522151","doi":"https://doi.org/10.2147/cmar.s280326","title":"High Expression of MDM2 and the p53 Protein is Predictive Biomarkers for Poor Prognosis of Oesophageal Squamous Cell Carcinoma","display_name":"High Expression of MDM2 and the p53 Protein is Predictive Biomarkers for Poor Prognosis of Oesophageal Squamous Cell Carcinoma","publication_year":2021,"publication_date":"2021-03-01","ids":{"openalex":"https://openalex.org/W3138522151","doi":"https://doi.org/10.2147/cmar.s280326","mag":"3138522151","pmid":"https://pubmed.ncbi.nlm.nih.gov/33790647","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8005260"},"language":"en","primary_location":{"id":"doi:10.2147/cmar.s280326","doi":"https://doi.org/10.2147/cmar.s280326","is_oa":true,"landing_page_url":"https://doi.org/10.2147/cmar.s280326","pdf_url":"https://www.dovepress.com/getfile.php?fileID=67913","source":{"id":"https://openalex.org/S2764554612","display_name":"Cancer Management and Research","issn_l":"1179-1322","issn":["1179-1322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Management and Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.dovepress.com/getfile.php?fileID=67913","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100682479","display_name":"Juan Ye","orcid":"https://orcid.org/0000-0002-1510-1248","observed_orcids":["https://orcid.org/0000-0002-1510-1248"]},"institutions":[{"id":"https://openalex.org/I182386381","display_name":"Zunyi Medical University","ror":"https://ror.org/00g5b0g93","country_code":"CN","type":"education","lineage":["https://openalex.org/I182386381"]},{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juan Ye","raw_affiliation_strings":["Department of Experimental Research, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, People's Republic of China","Department of Head and Neck Oncology, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Research, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, People's Republic of China","institution_ids":["https://openalex.org/I4210146711","https://openalex.org/I4391768007"]},{"raw_affiliation_string":"Department of Head and Neck Oncology, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, People's Republic of China","institution_ids":["https://openalex.org/I182386381"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Lin Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lin Zhang","raw_affiliation_strings":["Department of Clinical Laboratory, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, People's Republic of China","Department of Clinical Laboratory, Yunfu People's Hospital, Yunfu, Guangdong, People's Republic of China","Department of Experimental Research, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, People's Republic of China","institution_ids":["https://openalex.org/I4210146711","https://openalex.org/I4391768007"]},{"raw_affiliation_string":"Department of Clinical Laboratory, Yunfu People's Hospital, Yunfu, Guangdong, People's Republic of China","institution_ids":[]},{"raw_affiliation_string":"Department of Experimental Research, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, People's Republic of China","institution_ids":["https://openalex.org/I4210146711","https://openalex.org/I4391768007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100767410","display_name":"Zhongwen Li","orcid":"https://orcid.org/0000-0001-7187-5566","observed_orcids":["https://orcid.org/0000-0001-7187-5566"]},"institutions":[{"id":"https://openalex.org/I182386381","display_name":"Zunyi Medical University","ror":"https://ror.org/00g5b0g93","country_code":"CN","type":"education","lineage":["https://openalex.org/I182386381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhongwen Li","raw_affiliation_strings":["Department of Head and Neck Oncology, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Head and Neck Oncology, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, People's Republic of China","institution_ids":["https://openalex.org/I182386381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016920678","display_name":"Runduan Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Runduan Lin","raw_affiliation_strings":["Department of Clinical Laboratory, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, People's Republic of China","institution_ids":["https://openalex.org/I4210146711","https://openalex.org/I4391768007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102616811","display_name":"Yiling Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiling Song","raw_affiliation_strings":["Department of Clinical Laboratory, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, People's Republic of China","institution_ids":["https://openalex.org/I4210146711","https://openalex.org/I4391768007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011167317","display_name":"Huan-he Ni","orcid":"https://orcid.org/0000-0001-9875-5943","observed_orcids":["https://orcid.org/0000-0001-9875-5943"]},"institutions":[{"id":"https://openalex.org/I4210146711","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146711"]},{"id":"https://openalex.org/I4391768007","display_name":"State Key Laboratory of Oncology in South China","ror":"https://ror.org/04dn2ax39","country_code":"CN","type":"facility","lineage":["https://openalex.org/I157773358","https://openalex.org/I4391768007"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huanhe Ni","raw_affiliation_strings":["Department of Experimental Research, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Research, Sun Yat-Sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, People's Republic of China","institution_ids":["https://openalex.org/I4210146711","https://openalex.org/I4391768007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068573415","display_name":"Xiaoxia Gou","orcid":"https://orcid.org/0000-0002-3842-4007","observed_orcids":["https://orcid.org/0000-0002-3842-4007"]},"institutions":[{"id":"https://openalex.org/I182386381","display_name":"Zunyi Medical University","ror":"https://ror.org/00g5b0g93","country_code":"CN","type":"education","lineage":["https://openalex.org/I182386381"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiaoxia Gou","raw_affiliation_strings":["Department of Head and Neck Oncology, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, People's Republic of China"],"raw_orcid":"https://orcid.org/0000-0002-3842-4007","affiliations":[{"raw_affiliation_string":"Department of Head and Neck Oncology, The Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, People's Republic of China","institution_ids":["https://openalex.org/I182386381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5113937210","display_name":"Rongzhang Xie","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rongzhang Xie","raw_affiliation_strings":["Department of Clinical Laboratory, Yunfu People's Hospital, Yunfu, Guangdong, People's Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, Yunfu People's Hospital, Yunfu, Guangdong, People's Republic of China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5068573415","https://openalex.org/A5113937210"],"corresponding_institution_ids":["https://openalex.org/I182386381"],"apc_list":{"value":2836,"currency":"USD","value_usd":2836},"apc_paid":{"value":2836,"currency":"USD","value_usd":2836},"fwci":0.1997,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.46494991,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"Volume 13","issue":null,"first_page":"2733","last_page":"2744"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.6064000129699707,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.6064000129699707,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10619","display_name":"Esophageal Cancer Research and Treatment","score":0.3734999895095825,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/esophageal-squamous-cell-carcinoma","display_name":"esophageal squamous cell carcinoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/mdm2","display_name":"MDM2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.9639999866485596},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.9739999771118164},{"id":"https://openalex.org/keywords/tumor-markers","display_name":"tumor markers","score":0.7120000123977661},{"id":"https://openalex.org/keywords/mdm2-amplification","display_name":"MDM2 amplification","score":0.8820000290870667},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.6489999890327454},{"id":"https://openalex.org/keywords/disease-free-survival","display_name":"disease-free survival","score":0.9570000171661377},{"id":"https://openalex.org/keywords/tnm-staging","display_name":"TNM staging","score":0.8999999761581421},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.7310000061988831},{"id":"https://openalex.org/keywords/lymph-node-metastasis","display_name":"lymph node metastasis","score":0.6480000019073486}],"concepts":[{"id":"https://openalex.org/C2776192174","wikidata":"https://www.wikidata.org/wiki/Q18028978","display_name":"Mdm2","level":3,"score":0.6923141479492188},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.6644507646560669},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.5971803069114685},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.5833118557929993},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5758519172668457},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5476214289665222},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.5058915019035339},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5030071139335632},{"id":"https://openalex.org/C3019992690","wikidata":"https://www.wikidata.org/wiki/Q92767510","display_name":"Basal cell","level":2,"score":0.48104503750801086},{"id":"https://openalex.org/C144301174","wikidata":"https://www.wikidata.org/wiki/Q7893852","display_name":"Univariate analysis","level":3,"score":0.4666588008403778},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.44651710987091064},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.42436468601226807},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.40165138244628906},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3992851972579956},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3974173665046692},{"id":"https://openalex.org/C38180746","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate analysis","level":2,"score":0.36440178751945496},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31093358993530273},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.16992154717445374},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.2147/cmar.s280326","doi":"https://doi.org/10.2147/cmar.s280326","is_oa":true,"landing_page_url":"https://doi.org/10.2147/cmar.s280326","pdf_url":"https://www.dovepress.com/getfile.php?fileID=67913","source":{"id":"https://openalex.org/S2764554612","display_name":"Cancer Management and Research","issn_l":"1179-1322","issn":["1179-1322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Management and Research","raw_type":"journal-article"},{"id":"pmid:33790647","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33790647","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer management and research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8005260","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8005260/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Manag Res","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:fe474471e79649c0bba758e2d1ccac7a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/fe474471e79649c0bba758e2d1ccac7a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Management and Research, Vol Volume 13, Pp 2733-2744 (2021)","raw_type":"article"},{"id":"pmh:oai:dovepress.com/63338","doi":null,"is_oa":true,"landing_page_url":"https://www.dovepress.com/high-expression-of-mdm2-and-the-p53-protein-is-predictive-biomarkers-f-peer-reviewed-article-CMAR","pdf_url":null,"source":{"id":"https://openalex.org/S4306401012","display_name":"Dove Medical Press (Taylor and Francis Group)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.2147/cmar.s280326","doi":"https://doi.org/10.2147/cmar.s280326","is_oa":true,"landing_page_url":"https://doi.org/10.2147/cmar.s280326","pdf_url":"https://www.dovepress.com/getfile.php?fileID=67913","source":{"id":"https://openalex.org/S2764554612","display_name":"Cancer Management and Research","issn_l":"1179-1322","issn":["1179-1322"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320348","host_organization_name":"Dove Medical Press","host_organization_lineage":["https://openalex.org/P4310320348","https://openalex.org/P4310320547"],"host_organization_lineage_names":["Dove Medical Press","Taylor & Francis"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Management and Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G2575128777","display_name":null,"funder_award_id":"82003268","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6644430473","display_name":"lncRNA ATB/miR-429\u8c03\u63a7\u81ea\u566c\u5728\u98df\u7ba1\u9cde\u764c\u53d1\u751f\u53d1\u5c55\u4e2d\u7684\u4f5c\u7528\u53ca\u5206\u5b50\u673a\u5236","funder_award_id":"81860441","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321160","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71"},{"id":"https://openalex.org/F4320336632","display_name":"Sun Yat-sen University Cancer Center","ror":"https://ror.org/0400g8r85"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3138522151.pdf","grobid_xml":"https://content.openalex.org/works/W3138522151.grobid-xml"},"referenced_works_count":36,"referenced_works":["https://openalex.org/W1486886967","https://openalex.org/W1894295571","https://openalex.org/W1965296739","https://openalex.org/W1971170894","https://openalex.org/W1993386409","https://openalex.org/W2003313289","https://openalex.org/W2007680140","https://openalex.org/W2018385269","https://openalex.org/W2039317789","https://openalex.org/W2113236360","https://openalex.org/W2164743855","https://openalex.org/W2175728132","https://openalex.org/W2211997014","https://openalex.org/W2268572259","https://openalex.org/W2284846659","https://openalex.org/W2402029297","https://openalex.org/W2565710145","https://openalex.org/W2590092651","https://openalex.org/W2593759473","https://openalex.org/W2594386026","https://openalex.org/W2603997054","https://openalex.org/W2747888156","https://openalex.org/W2749884966","https://openalex.org/W2755149889","https://openalex.org/W2793707558","https://openalex.org/W2808119561","https://openalex.org/W2884688463","https://openalex.org/W2889646458","https://openalex.org/W2939645462","https://openalex.org/W2963956483","https://openalex.org/W3037443017","https://openalex.org/W3041100082","https://openalex.org/W3042591596","https://openalex.org/W3042912353","https://openalex.org/W3045058545","https://openalex.org/W4210685329"],"related_works":["https://openalex.org/W3156079231","https://openalex.org/W7096986430","https://openalex.org/W2391452658","https://openalex.org/W2081265526","https://openalex.org/W2171136249","https://openalex.org/W2071638726","https://openalex.org/W2389893544","https://openalex.org/W2371469036","https://openalex.org/W2030582708","https://openalex.org/W2007680140"],"abstract_inverted_index":{"Background":[0],"and":[1,13,31,37,47,51,63,75,85,102,110,118,138,150,172,188,216,224,238,245,290],"Objective:":[2],"In":[3,131],"the":[4,9,26,33,59,64,73,80,97,133,154,183,194,203,211,254,268,277,299],"present":[5],"study,":[6],"we":[7,57],"detected":[8,58],"expression":[10,60,104,114,141,152,185,213,270],"of":[11,28,35,61,99,116,153,186,197,202,206,214,226,256,271,279,298,301],"MDM2":[12,36,62,101,117,139,187,215,246,265,272,280,289],"p53":[14,38,65,103,119,155,189,217,244,291,315],"in":[15,53,67,105,120,142,229],"oesophageal":[16,304,309],"squamous":[17,305,310],"cell":[18,306,311],"carcinoma":[19],"(OSCC)":[20],"specimens,":[21],"studied":[22],"their":[23],"relationship":[24],"with":[25,160,221,276,303],"survival":[27,179],"OSCC":[29,43,69,106,121,143,161,207,227,257],"patients,":[30],"explored":[32],"potential":[34],"to":[39,193],"serve":[40],"as":[41,250,295],"predictive":[42],"tumour":[44],"markers.":[45],"Patients":[46],"Methods:":[48],"Through":[49],"immunohistochemistry":[50],"fluorescence":[52],"situ":[54],"hybridization":[55],"(FISH),":[56],"protein":[66,140,156],"157":[68],"specimens":[70],"that":[71,96,182,210,243,267,288],"met":[72],"inclusion":[74],"exclusion":[76],"criteria.":[77],"After":[78],"scoring":[79],"results,":[81],"Pearson\u2019s":[82],"chi-square":[83],"test":[84],"Cox":[86,239],"regression":[87],"were":[88,108,122,144],"used":[89,249,294],"for":[90,253,264],"analysis.":[91],"Results:":[92],"The":[93,113],"results":[94,263],"showed":[95,181,209,242,266],"rates":[98],"high":[100,151,184,212,269],"tissues":[107],"60.5%":[109],"51.0%,":[111],"respectively.":[112],"levels":[115],"significantly":[123,145,191,219,274],"positively":[124,158],"correlated":[125,146,159,220,275],"(":[126,147,163,169,175,281],"p":[127,148,164,170,176,282],"<":[128],"0.001,":[129],"r=0.414).":[130],"addition,":[132],"pathological":[134,166],"metastasis":[135],"(M)":[136],"status":[137,168],"=0.027),":[149],"was":[157,190,218,273],"transfer":[162],"=0.005),":[165],"node":[167],"=0.008),":[171],"clinical":[173],"stage":[174,231],"=0.003).":[177],"Kaplan-Meier":[178],"analysis":[180,201],"related":[192],"poor":[195,222],"prognosis":[196,255,300],"OSCC.":[198],"Moreover,":[199],"subgroup":[200],"TNM":[204],"staging":[205],"patients":[208,228,302],"OS":[223],"DFS":[225],"either":[230],"I\u2013II":[232],"or":[233],"III\u2013IV":[234],"patients.":[235,258],"Both":[236],"univariate":[237],"multivariate":[240],"analyses":[241],"can":[247,292],"be":[248,293],"independent":[251,296],"factors":[252],"Finally,":[259],"our":[260],"FISH":[261],"detection":[262],"amplification":[278],"=0.015).":[283],"Conclusion:":[284],"This":[285],"study":[286],"shows":[287],"predictors":[297],"carcinoma.":[307],"Keywords:":[308],"carcinoma,":[312],"biomarkers,":[313],"MDM2,":[314]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-03-29T00:00:00"}
