{"id":"https://openalex.org/W3138322352","doi":"https://doi.org/10.1371/journal.pone.0235938","title":"Functional domain studies uncover novel roles for the ZTL Kelch repeat domain in clock function","display_name":"Functional domain studies uncover novel roles for the ZTL Kelch repeat domain in clock function","publication_year":2021,"publication_date":"2021-03-17","ids":{"openalex":"https://openalex.org/W3138322352","doi":"https://doi.org/10.1371/journal.pone.0235938","mag":"3138322352","pmid":"https://pubmed.ncbi.nlm.nih.gov/33730063","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7968664"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0235938","doi":"https://doi.org/10.1371/journal.pone.0235938","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0235938","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0235938&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0235938&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049411591","display_name":"Ann Feke","orcid":"https://orcid.org/0000-0002-8246-0056","observed_orcids":["https://orcid.org/0000-0002-8246-0056"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ann Feke","raw_affiliation_strings":["Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, United States of America","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016108144","display_name":"Morgan M. Vanderwall","orcid":"https://orcid.org/0000-0001-8875-7996","observed_orcids":["https://orcid.org/0000-0001-8875-7996"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Morgan Vanderwall","raw_affiliation_strings":["Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-8875-7996","affiliations":[{"raw_affiliation_string":"Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, United States of America","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075618009","display_name":"Wei Liu","orcid":"https://orcid.org/0000-0002-5693-4086","observed_orcids":["https://orcid.org/0000-0002-5693-4086"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wei Liu","raw_affiliation_strings":["Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, United States of America","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052119800","display_name":"Joshua M. Gendron","orcid":"https://orcid.org/0000-0001-8605-3047","observed_orcids":["https://orcid.org/0000-0001-8605-3047"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joshua M. Gendron","raw_affiliation_strings":["Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-8605-3047","affiliations":[{"raw_affiliation_string":"Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, CT, United States of America","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5052119800"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":{"value":1749,"currency":"USD","value_usd":1749},"apc_paid":{"value":1749,"currency":"USD","value_usd":1749},"fwci":0.8716,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.70380157,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"16","issue":"3","first_page":"e0235938","last_page":"e0235938"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11268","display_name":"Light effects on plants","score":0.9115999937057495,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11268","display_name":"Light effects on plants","score":0.9115999937057495,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10184","display_name":"Plant Molecular Biology Research","score":0.07150000333786011,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.010200000368058681,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zeitlupe","display_name":"ZEITLUPE","score":0.8610000014305115},{"id":"https://openalex.org/keywords/plant-circadian-clock","display_name":"plant circadian clock","score":0.8569999933242798},{"id":"https://openalex.org/keywords/flowering-time","display_name":"flowering time","score":0.9480000138282776},{"id":"https://openalex.org/keywords/e3-ubiquitin-ligase","display_name":"E3 ubiquitin ligase","score":0.8679999709129333},{"id":"https://openalex.org/keywords/protein-protein-interaction","display_name":"protein-protein interaction","score":0.7870000004768372},{"id":"https://openalex.org/keywords/protein-complexes","display_name":"protein complexes","score":0.546999990940094},{"id":"https://openalex.org/keywords/fkf1","display_name":"FKF1","score":0.699999988079071},{"id":"https://openalex.org/keywords/lov-domain","display_name":"LOV domain","score":0.625},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.5130000114440918}],"concepts":[{"id":"https://openalex.org/C38606739","wikidata":"https://www.wikidata.org/wiki/Q5121352","display_name":"Circadian clock","level":3,"score":0.6012828946113586},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5063682794570923},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46648314595222473},{"id":"https://openalex.org/C10522644","wikidata":"https://www.wikidata.org/wiki/Q24775216","display_name":"HAMP domain","level":4,"score":0.456886351108551},{"id":"https://openalex.org/C144292202","wikidata":"https://www.wikidata.org/wiki/Q898273","display_name":"Protein domain","level":3,"score":0.4405839741230011},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3279198408126831},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15421757102012634}],"mesh":[{"descriptor_ui":"D000071776","descriptor_name":"Kelch Repeat","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002851","descriptor_name":"Chromatography, High Pressure Liquid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D017360","descriptor_name":"Arabidopsis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D029681","descriptor_name":"Arabidopsis Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D030821","descriptor_name":"Plants, Genetically Modified","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D035264","descriptor_name":"Flowers","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D057906","descriptor_name":"Circadian Clocks","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pone.0235938","doi":"https://doi.org/10.1371/journal.pone.0235938","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0235938","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0235938&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"doi:10.1101/2020.06.26.173096","doi":"https://doi.org/10.1101/2020.06.26.173096","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.06.26.173096","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/06/26/2020.06.26.173096.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:33730063","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33730063","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7968664","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7968664/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:61cd021d23c44aa9b8355e4ff522bf05","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/61cd021d23c44aa9b8355e4ff522bf05","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 16, Iss 3, p e0235938 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0235938","doi":"https://doi.org/10.1371/journal.pone.0235938","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0235938","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0235938&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G350472716","display_name":"Dissecting how protein degradation couples the circadian clock to downstream processes","funder_award_id":"1548538","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G3901495901","display_name":null,"funder_award_id":"T32 GM007499","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G4063813045","display_name":null,"funder_award_id":"R35 GM128670","funder_id":"https://openalex.org/F4320306080","funder_display_name":"Foundation for the National Institutes of Health"},{"id":"https://openalex.org/G5630036598","display_name":"Predoctoral Training Program in Genetics","funder_award_id":"T32GM007499","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6864024205","display_name":null,"funder_award_id":"GRFP DGE-1122492","funder_id":"https://openalex.org/F4320312392","funder_display_name":"Gruber Foundation"},{"id":"https://openalex.org/G742612136","display_name":"Graduate Research Fellowship Program","funder_award_id":"1122492","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G9000860234","display_name":"Protein degradation mechanisms that regulate daily and seasonal timing","funder_award_id":"R35GM128670","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306080","display_name":"Foundation for the National Institutes of Health","ror":"https://ror.org/00k86s890"},{"id":"https://openalex.org/F4320308380","display_name":"Yale University","ror":"https://ror.org/03v76x132"},{"id":"https://openalex.org/F4320312392","display_name":"Gruber Foundation","ror":"https://ror.org/03m5tgj44"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3138322352.pdf","grobid_xml":"https://content.openalex.org/works/W3138322352.grobid-xml"},"referenced_works_count":56,"referenced_works":["https://openalex.org/W1484075860","https://openalex.org/W1965717790","https://openalex.org/W1967008937","https://openalex.org/W1981593008","https://openalex.org/W1990834064","https://openalex.org/W2000009089","https://openalex.org/W2002821316","https://openalex.org/W2004037030","https://openalex.org/W2007343477","https://openalex.org/W2014034577","https://openalex.org/W2023124677","https://openalex.org/W2024952216","https://openalex.org/W2030847509","https://openalex.org/W2035114302","https://openalex.org/W2042900432","https://openalex.org/W2056657640","https://openalex.org/W2059981497","https://openalex.org/W2071903046","https://openalex.org/W2073231088","https://openalex.org/W2075124527","https://openalex.org/W2084441961","https://openalex.org/W2099540110","https://openalex.org/W2101089197","https://openalex.org/W2104219577","https://openalex.org/W2106807470","https://openalex.org/W2113656016","https://openalex.org/W2113878162","https://openalex.org/W2116122104","https://openalex.org/W2117408580","https://openalex.org/W2118086386","https://openalex.org/W2122866913","https://openalex.org/W2126527441","https://openalex.org/W2133438017","https://openalex.org/W2137280247","https://openalex.org/W2137504876","https://openalex.org/W2137753785","https://openalex.org/W2140539351","https://openalex.org/W2141329235","https://openalex.org/W2158706468","https://openalex.org/W2160521086","https://openalex.org/W2164567370","https://openalex.org/W2165418541","https://openalex.org/W2167844024","https://openalex.org/W2368923972","https://openalex.org/W2400767493","https://openalex.org/W2525274258","https://openalex.org/W2586762267","https://openalex.org/W2593067963","https://openalex.org/W2652618884","https://openalex.org/W2803408028","https://openalex.org/W2919677985","https://openalex.org/W2934537932","https://openalex.org/W2969832434","https://openalex.org/W2988528165","https://openalex.org/W3026550983","https://openalex.org/W3136918052"],"related_works":["https://openalex.org/W2073231088","https://openalex.org/W2122866913","https://openalex.org/W2243804170","https://openalex.org/W2400767493","https://openalex.org/W2145734945","https://openalex.org/W2593067963","https://openalex.org/W2035114302","https://openalex.org/W2258619143","https://openalex.org/W2803408028","https://openalex.org/W2113878162"],"abstract_inverted_index":{"The":[0,25],"small":[1],"LOV/F-box/Kelch":[2,205],"family":[3,26,75],"of":[4,15,28,66,72,87,101,117,123,143,159,182,194,202,214],"E3":[5],"ubiquitin":[6],"ligases":[7],"plays":[8],"an":[9,219],"essential":[10],"role":[11,221],"in":[12,140],"the":[13,82,88,106,111,141,151,164,172,179,190,203,212,215,223],"regulation":[14],"plant":[16],"circadian":[17,131],"clocks":[18],"and":[19,38,84,120,133,176,178,199,207,218],"flowering":[20,134],"time":[21],"by":[22,147],"sensing":[23],"dusk.":[24],"consists":[27],"three":[29,204],"members,":[30],"ZEITLUPE":[31],"(ZTL),":[32],"LOV":[33,108,180],"KELCH":[34,40],"PROTEIN":[35,43],"2":[36],"(LKP2),":[37],"FLAVIN-BINDING":[39],"REPEAT":[41],"F-BOX":[42],"1":[44],"(FKF1),":[45],"which":[46],"share":[47],"a":[48,157,187],"unique":[49,94],"protein":[50,74,89,216],"domain":[51,109,125,138,155,168,181,193],"architecture":[52],"allowing":[53],"them":[54],"to":[55,129],"act":[56],"as":[57],"photoreceptors":[58],"that":[59,91,189],"transduce":[60],"light":[61],"signals":[62],"via":[63],"altering":[64],"stability":[65],"target":[67],"proteins.":[68],"Despite":[69],"intensive":[70],"study":[71],"this":[73],"we":[76,97],"still":[77],"lack":[78],"important":[79],"knowledge":[80],"about":[81],"biochemical":[83],"functional":[85],"roles":[86],"domains":[90,116],"comprise":[92],"these":[93],"photoreceptors.":[95],"Here,":[96],"perform":[98],"comparative":[99],"analyses":[100],"transgenic":[102],"lines":[103],"constitutively":[104],"expressing":[105],"photoreceptor":[107],"or":[110],"Kelch":[112,153,166,191,224],"repeat":[113,154,167,192,225],"protein-protein":[114],"interaction":[115],"ZTL,":[118],"FKF1,":[119,177],"LKP2.":[121],"Expression":[122],"each":[124,137],"alone":[126],"is":[127],"sufficient":[128],"disrupt":[130],"rhythms":[132],"time,":[135],"but":[136],"differs":[139],"magnitude":[142],"effect.":[144],"Immunoprecipitation":[145],"followed":[146],"mass":[148],"spectrometry":[149],"with":[150,171],"ZTL":[152,165,173,183,195],"identified":[156],"suite":[158],"potential":[160],"interacting":[161],"partners.":[162],"Furthermore,":[163],"can":[169],"interact":[170],"homologs,":[174],"LKP2":[175],"itself.":[184],"This":[185],"suggests":[186],"hypothesis":[188],"may":[196],"mediate":[197],"inter-":[198],"intra-molecular":[200],"interactions":[201],"proteins":[206],"provides":[208],"added":[209],"insight":[210],"into":[211],"composition":[213],"complexes":[217],"additional":[220],"for":[222],"domain.":[226]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-03-29T00:00:00"}