{"id":"https://openalex.org/W3138320957","doi":null,"title":"dCas9 targeted chromatin and histone enrichment for mass spectrometry (Catchet-MS) identifies IKZF1 as a novel drug-able target for HIV-1 latency reversal","display_name":"dCas9 targeted chromatin and histone enrichment for mass spectrometry (Catchet-MS) identifies IKZF1 as a novel drug-able target for HIV-1 latency reversal","publication_year":2021,"publication_date":"2021-03-22","ids":{"openalex":"https://openalex.org/W3138320957","mag":"3138320957"},"language":"en","primary_location":{"id":"mag:3138320957","doi":null,"is_oa":false,"landing_page_url":"https://biorxiv.org/content/10.1101/2021.03.19.436149v1.full.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv (Cold Spring Harbor Laboratory)","raw_type":null},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5000585957","display_name":"Ne E","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ne E","raw_affiliation_strings":["Department of Biochemistry, Erasmus University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Erasmus University Medical Center","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048367579","display_name":"Raquel Crespo","orcid":"https://orcid.org/0000-0002-6751-6621","observed_orcids":["https://orcid.org/0000-0002-6751-6621"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Raquel Crespo","raw_affiliation_strings":["Department of Biochemistry, Erasmus University Medical Center"],"raw_orcid":"https://orcid.org/0000-0002-6751-6621","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Erasmus University Medical Center","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077075131","display_name":"Ray W. Izquierdo-Lara","orcid":"https://orcid.org/0000-0001-9912-6970","observed_orcids":["https://orcid.org/0000-0001-9912-6970"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ray Izquierdo-Lara","raw_affiliation_strings":["Department of Biochemistry, Erasmus University Medical Center"],"raw_orcid":"https://orcid.org/0000-0001-9912-6970","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Erasmus University Medical Center","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100601896","display_name":"\u015eeng\u00fcl KO\u00c7ER","orcid":"https://orcid.org/0009-0001-9838-5847","observed_orcids":["https://orcid.org/0009-0001-9838-5847"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"\u015eeng\u00fcl KO\u00c7ER","raw_affiliation_strings":["Department of Biochemistry, Erasmus University Medical Center"],"raw_orcid":"https://orcid.org/0009-0001-9838-5847","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Erasmus University Medical Center","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006680934","display_name":"Alicja Gorszka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Alicja Gorszka","raw_affiliation_strings":["Department of Biochemistry, Erasmus University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Erasmus University Medical Center","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062232018","display_name":"Thomas van Staveren","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"van Staveren T","raw_affiliation_strings":["Department of Biochemistry, Erasmus University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Erasmus University Medical Center","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014544262","display_name":"Kan Tw","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Kan Tw","raw_affiliation_strings":["Department of Biochemistry, Erasmus University Medical Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Erasmus University Medical Center","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065630525","display_name":"Dick H. W. Dekkers","orcid":"https://orcid.org/0000-0001-7057-6257","observed_orcids":["https://orcid.org/0000-0001-7057-6257"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Dekkers Dh","raw_affiliation_strings":["Proteomics Center, Erasmus University Medical Center;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Proteomics Center, Erasmus University Medical Center;","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056575262","display_name":"Casper Rokx","orcid":"https://orcid.org/0000-0002-1904-6450","observed_orcids":["https://orcid.org/0000-0002-1904-6450"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Casper Rokx","raw_affiliation_strings":["Department of Internal Medicine, Section of Infectious Diseases, Erasmus University Medical Center"],"raw_orcid":"https://orcid.org/0000-0002-1904-6450","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Section of Infectious Diseases, Erasmus University Medical Center","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079422639","display_name":"Panagiotis Moulos","orcid":"https://orcid.org/0000-0002-4199-0333","observed_orcids":["https://orcid.org/0000-0002-4199-0333"]},"institutions":[{"id":"https://openalex.org/I6820528","display_name":"Alexander Fleming Biomedical Sciences Research Center","ror":"https://ror.org/013x0ky90","country_code":"GR","type":"facility","lineage":["https://openalex.org/I6820528"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Panagiotis Moulos","raw_affiliation_strings":["Fleming Genomics Facility, Biomedical Sciences Research Center \u201cAlexander Fleming\u201d"],"raw_orcid":"https://orcid.org/0000-0002-4199-0333","affiliations":[{"raw_affiliation_string":"Fleming Genomics Facility, Biomedical Sciences Research Center \u201cAlexander Fleming\u201d","institution_ids":["https://openalex.org/I6820528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069153102","display_name":"Pantelis Hatzis","orcid":"https://orcid.org/0000-0001-5002-7728","observed_orcids":["https://orcid.org/0000-0001-5002-7728"]},"institutions":[{"id":"https://openalex.org/I6820528","display_name":"Alexander Fleming Biomedical Sciences Research Center","ror":"https://ror.org/013x0ky90","country_code":"GR","type":"facility","lineage":["https://openalex.org/I6820528"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Pantelis Hatzis","raw_affiliation_strings":["Fleming Genomics Facility, Biomedical Sciences Research Center \u201cAlexander Fleming\u201d"],"raw_orcid":"https://orcid.org/0000-0001-5002-7728","affiliations":[{"raw_affiliation_string":"Fleming Genomics Facility, Biomedical Sciences Research Center \u201cAlexander Fleming\u201d","institution_ids":["https://openalex.org/I6820528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022876579","display_name":"Robert-Jan T. S. Palstra","orcid":"https://orcid.org/0000-0003-4600-2303","observed_orcids":["https://orcid.org/0000-0003-4600-2303"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Robert\u2010Jan Palstra","raw_affiliation_strings":["Department of Biochemistry, Erasmus University Medical Center"],"raw_orcid":"https://orcid.org/0000-0003-4600-2303","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Erasmus University Medical Center","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041698326","display_name":"Demmers Ja","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Demmers Ja","raw_affiliation_strings":["Proteomics Center, Erasmus University Medical Center;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Proteomics Center, Erasmus University Medical Center;","institution_ids":["https://openalex.org/I2801952686"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077282469","display_name":"Tokameh Mahmoudi","orcid":"https://orcid.org/0000-0002-2060-9353","observed_orcids":["https://orcid.org/0000-0002-2060-9353"]},"institutions":[{"id":"https://openalex.org/I2801952686","display_name":"Erasmus MC","ror":"https://ror.org/018906e22","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I2801952686"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Tokameh Mahmoudi","raw_affiliation_strings":["Department of Biochemistry, Erasmus University Medical Center"],"raw_orcid":"https://orcid.org/0000-0002-2060-9353","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Erasmus University Medical Center","institution_ids":["https://openalex.org/I2801952686"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1-latency-reversal","display_name":"HIV-1 latency reversal","score":0.9789999723434448},{"id":"https://openalex.org/keywords/hiv-1-provirus","display_name":"HIV-1 provirus","score":0.6079999804496765},{"id":"https://openalex.org/keywords/5-ltr","display_name":"5' LTR","score":0.7730000019073486},{"id":"https://openalex.org/keywords/ikzf1","display_name":"IKZF1","score":0.9129999876022339},{"id":"https://openalex.org/keywords/iberdomide","display_name":"iberdomide","score":0.722000002861023},{"id":"https://openalex.org/keywords/polycomb-repressive-complex-2","display_name":"polycomb repressive complex 2","score":0.8849999904632568},{"id":"https://openalex.org/keywords/transcriptional-repression","display_name":"transcriptional repression","score":0.8560000061988831},{"id":"https://openalex.org/keywords/host-factors","display_name":"host factors","score":0.6800000071525574},{"id":"https://openalex.org/keywords/cd4-t-cells","display_name":"CD4+ T cells","score":0.8389999866485596},{"id":"https://openalex.org/keywords/hiv-cure","display_name":"HIV cure","score":0.7860000133514404},{"id":"https://openalex.org/keywords/drug-target-identification","display_name":"drug target identification","score":0.5809999704360962}],"concepts":[{"id":"https://openalex.org/C102906071","wikidata":"https://www.wikidata.org/wiki/Q422467","display_name":"Provirus","level":4,"score":0.8790156245231628},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.7249997854232788},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.7141125202178955},{"id":"https://openalex.org/C158448853","wikidata":"https://www.wikidata.org/wiki/Q425218","display_name":"Repressor","level":4,"score":0.5607328414916992},{"id":"https://openalex.org/C119157956","wikidata":"https://www.wikidata.org/wiki/Q796604","display_name":"Acetylation","level":3,"score":0.5466384291648865},{"id":"https://openalex.org/C186310378","wikidata":"https://www.wikidata.org/wiki/Q941796","display_name":"Psychological repression","level":4,"score":0.5396203398704529},{"id":"https://openalex.org/C82876162","wikidata":"https://www.wikidata.org/wiki/Q17096504","display_name":"Latency (audio)","level":2,"score":0.5248444080352783},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48093241453170776},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.46420344710350037},{"id":"https://openalex.org/C2778852064","wikidata":"https://www.wikidata.org/wiki/Q4115619","display_name":"Virus latency","level":4,"score":0.42585331201553345},{"id":"https://openalex.org/C2776915012","wikidata":"https://www.wikidata.org/wiki/Q17125871","display_name":"PRC2","level":5,"score":0.418750524520874},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41314437985420227},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.33455950021743774},{"id":"https://openalex.org/C2776745794","wikidata":"https://www.wikidata.org/wiki/Q24777451","display_name":"Histone H3","level":4,"score":0.24733585119247437},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.23060864210128784},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.19509413838386536},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.15335699915885925},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.15275347232818604},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.13975131511688232},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.11572569608688354},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.11170753836631775},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.11081203818321228},{"id":"https://openalex.org/C119599485","wikidata":"https://www.wikidata.org/wiki/Q43035","display_name":"Electrical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3138320957","doi":null,"is_oa":false,"landing_page_url":"https://biorxiv.org/content/10.1101/2021.03.19.436149v1.full.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv (Cold Spring Harbor Laboratory)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":95,"referenced_works":["https://openalex.org/W81453212","https://openalex.org/W115244646","https://openalex.org/W1548897126","https://openalex.org/W1893765893","https://openalex.org/W1943598347","https://openalex.org/W1963802821","https://openalex.org/W1966703230","https://openalex.org/W1971112771","https://openalex.org/W1972761742","https://openalex.org/W1973999018","https://openalex.org/W1985772010","https://openalex.org/W1986743724","https://openalex.org/W1987161628","https://openalex.org/W1987895181","https://openalex.org/W1994921092","https://openalex.org/W1996808619","https://openalex.org/W2000337153","https://openalex.org/W2001356550","https://openalex.org/W2015345028","https://openalex.org/W2016991182","https://openalex.org/W2031708680","https://openalex.org/W2033499765","https://openalex.org/W2037524921","https://openalex.org/W2039739637","https://openalex.org/W2040329520","https://openalex.org/W2041380706","https://openalex.org/W2060916625","https://openalex.org/W2061965605","https://openalex.org/W2063628696","https://openalex.org/W2065609322","https://openalex.org/W2066013688","https://openalex.org/W2068412287","https://openalex.org/W2068427957","https://openalex.org/W2079026626","https://openalex.org/W2087908618","https://openalex.org/W2092104135","https://openalex.org/W2094755232","https://openalex.org/W2098194107","https://openalex.org/W2101516953","https://openalex.org/W2103441770","https://openalex.org/W2105707485","https://openalex.org/W2109010689","https://openalex.org/W2111705463","https://openalex.org/W2114570899","https://openalex.org/W2120948855","https://openalex.org/W2122660117","https://openalex.org/W2125724353","https://openalex.org/W2125815499","https://openalex.org/W2131847113","https://openalex.org/W2135493913","https://openalex.org/W2143013829","https://openalex.org/W2158136052","https://openalex.org/W2158520397","https://openalex.org/W2163268386","https://openalex.org/W2168539009","https://openalex.org/W2171808845","https://openalex.org/W2173459981","https://openalex.org/W2191507484","https://openalex.org/W2194616187","https://openalex.org/W2416459311","https://openalex.org/W2513896518","https://openalex.org/W2513977320","https://openalex.org/W2519978149","https://openalex.org/W2526176724","https://openalex.org/W2528836681","https://openalex.org/W2570488943","https://openalex.org/W2604519322","https://openalex.org/W2730065374","https://openalex.org/W2736297680","https://openalex.org/W2736403752","https://openalex.org/W2742081920","https://openalex.org/W2761486126","https://openalex.org/W2782696110","https://openalex.org/W2789029405","https://openalex.org/W2790372871","https://openalex.org/W2793568153","https://openalex.org/W2794341976","https://openalex.org/W2799616694","https://openalex.org/W2799892461","https://openalex.org/W2802839248","https://openalex.org/W2804658899","https://openalex.org/W2805128721","https://openalex.org/W2891364583","https://openalex.org/W2896942496","https://openalex.org/W2961032267","https://openalex.org/W2967117221","https://openalex.org/W2969639913","https://openalex.org/W2988470278","https://openalex.org/W3004326605","https://openalex.org/W3010033147","https://openalex.org/W3013091596","https://openalex.org/W3018496414","https://openalex.org/W3133011268","https://openalex.org/W3158214190","https://openalex.org/W7074230359"],"related_works":["https://openalex.org/W4281744972","https://openalex.org/W4410717466","https://openalex.org/W2613225635","https://openalex.org/W4410396504","https://openalex.org/W6942609649","https://openalex.org/W7160233188","https://openalex.org/W4306816386","https://openalex.org/W2909067857","https://openalex.org/W4404486738","https://openalex.org/W3041941475"],"abstract_inverted_index":{"Summary":[0],"A":[2],"major":[3],"pharmacological":[4],"strategy":[5,72],"toward":[6],"HIV":[7],"cure":[8],"aims":[9],"to":[10,21,42,55,74,78,120,133],"reverse":[11],"latency":[12,52,143],"in":[13,144],"infected":[14,151],"cells":[15],"as":[16],"a":[17,108,135],"first":[18],"step":[19],"leading":[20],"their":[22],"elimination.":[23],"While":[24],"the":[25,34,44,80,91,121,125],"unbiased":[26],"identification":[27,89],"of":[28,47,90],"molecular":[29,45],"targets":[30,129],"physically":[31],"associated":[32],"with":[33],"latent":[35,81,100],"HIV-1":[36,48,84,110,142,150],"provirus":[37],"would":[38],"be":[39,134],"highly":[40],"valuable":[41],"unravel":[43],"correlates":[46],"transcriptional":[49,111],"repression":[50],"and":[51,69,82,98],"reversal,":[53],"due":[54],"technical":[56],"limitations,":[57],"this":[58],"has":[59],"not":[60],"been":[61],"possible.":[62],"Here":[63],"we":[64],"use":[65],"dCas9":[66],"targeted":[67],"chromatin":[68],"histone":[70],"enrichment":[71],"coupled":[73],"mass":[75],"spectrometry":[76],"(Catchet-MS)":[77],"isolate":[79],"activated":[83],"5\u2019LTR,":[85],"followed":[86],"by":[87],"MS":[88],"differentially":[92],"locus-bound":[93],"proteins.":[94],"Catchet-MS":[95],"identified":[96],"known":[97],"novel":[99,109,138],"5\u2019LTR-associated":[101],"host":[102],"factors.":[103],"Among":[104],"these,":[105],"IKZF1":[106,130],"is":[107],"repressor,":[112],"required":[113],"for":[114,131],"Polycomb":[115],"Repressive":[116],"Complex":[117],"2":[118],"recruitment":[119],"LTR.":[122],"We":[123],"find":[124],"drug":[126],"iberdomide,":[127],"which":[128],"degradation,":[132],"clinically":[136],"advanced":[137],"LRA":[139],"that":[140],"reverses":[141],"CD4+T-cells":[145],"isolated":[146],"from":[147],"virally":[148],"suppressed":[149],"participants.":[152]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-03-29T00:00:00"}
