{"id":"https://openalex.org/W3138319201","doi":"https://doi.org/10.1186/s13287-021-02272-2","title":"Process development and safety evaluation of ABCB5+ limbal stem cells as advanced-therapy medicinal product to treat limbal stem cell deficiency","display_name":"Process development and safety evaluation of ABCB5+ limbal stem cells as advanced-therapy medicinal product to treat limbal stem cell deficiency","publication_year":2021,"publication_date":"2021-03-19","ids":{"openalex":"https://openalex.org/W3138319201","doi":"https://doi.org/10.1186/s13287-021-02272-2","mag":"3138319201","pmid":"https://pubmed.ncbi.nlm.nih.gov/33741066","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7980611"},"language":"en","primary_location":{"id":"doi:10.1186/s13287-021-02272-2","doi":"https://doi.org/10.1186/s13287-021-02272-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13287-021-02272-2","pdf_url":"https://stemcellres.biomedcentral.com/counter/pdf/10.1186/s13287-021-02272-2","source":{"id":"https://openalex.org/S2061155","display_name":"Stem Cell Research & Therapy","issn_l":"1757-6512","issn":["1757-6512"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research &amp; Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://stemcellres.biomedcentral.com/counter/pdf/10.1186/s13287-021-02272-2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026623835","display_name":"Alexandra Norrick","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexandra Norrick","raw_affiliation_strings":["TICEBA GmbH, Im Neuenheimer Feld 517, 69120, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TICEBA GmbH, Im Neuenheimer Feld 517, 69120, Heidelberg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033917552","display_name":"Jasmina Esterlechner","orcid":"https://orcid.org/0000-0002-9840-9431","observed_orcids":["https://orcid.org/0000-0002-9840-9431"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jasmina Esterlechner","raw_affiliation_strings":["TICEBA GmbH, Im Neuenheimer Feld 517, 69120, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TICEBA GmbH, Im Neuenheimer Feld 517, 69120, Heidelberg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031962714","display_name":"Elke Niebergall\u2010Roth","orcid":"https://orcid.org/0000-0001-7846-3388","observed_orcids":["https://orcid.org/0000-0001-7846-3388"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Elke Niebergall-Roth","raw_affiliation_strings":["TICEBA GmbH, Im Neuenheimer Feld 517, 69120, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TICEBA GmbH, Im Neuenheimer Feld 517, 69120, Heidelberg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075557482","display_name":"Ulf Dehio","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210121985","display_name":"Rheacell (Germany)","ror":"https://ror.org/0363m9h89","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210121985"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ulf Dehio","raw_affiliation_strings":["RHEACELL GmbH & Co. KG, Im Neuenheimer Feld 517, Heidelberg, 69120, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RHEACELL GmbH & Co. KG, Im Neuenheimer Feld 517, Heidelberg, 69120, Germany","institution_ids":["https://openalex.org/I4210121985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091773013","display_name":"Samar Sadeghi","orcid":"https://orcid.org/0000-0001-6846-4264","observed_orcids":["https://orcid.org/0000-0001-6846-4264"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Samar Sadeghi","raw_affiliation_strings":["TICEBA GmbH, Im Neuenheimer Feld 517, 69120, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TICEBA GmbH, Im Neuenheimer Feld 517, 69120, Heidelberg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021896307","display_name":"Hannes M. Schr\u00f6der","orcid":"https://orcid.org/0000-0002-0427-5867","observed_orcids":["https://orcid.org/0000-0002-0427-5867"]},"institutions":[{"id":"https://openalex.org/I4210121985","display_name":"Rheacell (Germany)","ror":"https://ror.org/0363m9h89","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210121985"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hannes M. Schr\u00f6der","raw_affiliation_strings":["RHEACELL GmbH & Co. KG, Im Neuenheimer Feld 517, Heidelberg, 69120, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RHEACELL GmbH & Co. KG, Im Neuenheimer Feld 517, Heidelberg, 69120, Germany","institution_ids":["https://openalex.org/I4210121985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021078117","display_name":"Seda Ballikaya","orcid":"https://orcid.org/0000-0001-9746-0422","observed_orcids":["https://orcid.org/0000-0001-9746-0422"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seda Ballikaya","raw_affiliation_strings":["TICEBA GmbH, Im Neuenheimer Feld 517, 69120, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TICEBA GmbH, Im Neuenheimer Feld 517, 69120, Heidelberg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009423664","display_name":"Nicole Stemler","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicole Stemler","raw_affiliation_strings":["TICEBA GmbH, Im Neuenheimer Feld 517, 69120, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TICEBA GmbH, Im Neuenheimer Feld 517, 69120, Heidelberg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008099067","display_name":"Christoph Ganss","orcid":"https://orcid.org/0000-0003-0396-6591","observed_orcids":["https://orcid.org/0000-0003-0396-6591"]},"institutions":[{"id":"https://openalex.org/I4210121985","display_name":"Rheacell (Germany)","ror":"https://ror.org/0363m9h89","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210121985"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christoph Ganss","raw_affiliation_strings":["RHEACELL GmbH & Co. KG, Im Neuenheimer Feld 517, Heidelberg, 69120, Germany","TICEBA GmbH, Im Neuenheimer Feld 517, 69120, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RHEACELL GmbH & Co. KG, Im Neuenheimer Feld 517, Heidelberg, 69120, Germany","institution_ids":["https://openalex.org/I4210121985"]},{"raw_affiliation_string":"TICEBA GmbH, Im Neuenheimer Feld 517, 69120, Heidelberg, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028054804","display_name":"Kathrin Dieter","orcid":"https://orcid.org/0000-0001-6341-4161","observed_orcids":["https://orcid.org/0000-0001-6341-4161"]},"institutions":[{"id":"https://openalex.org/I4210121985","display_name":"Rheacell (Germany)","ror":"https://ror.org/0363m9h89","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210121985"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Kathrin Dieter","raw_affiliation_strings":["RHEACELL GmbH & Co. KG, Im Neuenheimer Feld 517, Heidelberg, 69120, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RHEACELL GmbH & Co. KG, Im Neuenheimer Feld 517, Heidelberg, 69120, Germany","institution_ids":["https://openalex.org/I4210121985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077765847","display_name":"Ann-Kathrin Dachtler","orcid":"https://orcid.org/0000-0003-3744-1937","observed_orcids":["https://orcid.org/0000-0003-3744-1937"]},"institutions":[{"id":"https://openalex.org/I4210121985","display_name":"Rheacell (Germany)","ror":"https://ror.org/0363m9h89","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210121985"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ann-Kathrin Dachtler","raw_affiliation_strings":["RHEACELL GmbH & Co. KG, Im Neuenheimer Feld 517, Heidelberg, 69120, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RHEACELL GmbH & Co. KG, Im Neuenheimer Feld 517, Heidelberg, 69120, Germany","institution_ids":["https://openalex.org/I4210121985"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002674451","display_name":"P. Merz","orcid":"https://orcid.org/0000-0003-2971-0308","observed_orcids":["https://orcid.org/0000-0003-2971-0308"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Patrick Merz","raw_affiliation_strings":["Department of Ophthalmology, Lions Eye Bank, University of Heidelberg, Heidelberg, Germany","Department of Ophthalmology, University Hospital Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Lions Eye Bank, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"Department of Ophthalmology, University Hospital Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089338770","display_name":"Saadettin Sel","orcid":"https://orcid.org/0000-0003-3307-3305","observed_orcids":["https://orcid.org/0000-0003-3307-3305"]},"institutions":[{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Saadettin Sel","raw_affiliation_strings":["Department of Ophthalmology, University Hospital Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, University Hospital Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030299442","display_name":"James Chodosh","orcid":"https://orcid.org/0000-0002-7463-1599","observed_orcids":["https://orcid.org/0000-0002-7463-1599"]},"institutions":[{"id":"https://openalex.org/I1287163989","display_name":"Massachusetts Eye and Ear Infirmary","ror":"https://ror.org/04g3dn724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1287163989"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James Chodosh","raw_affiliation_strings":["Department of Ophthalmology, Massachusetts Eye & Ear, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Massachusetts Eye & Ear, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1287163989","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085296140","display_name":"Claus Cursiefen","orcid":"https://orcid.org/0000-0002-1958-411X","observed_orcids":["https://orcid.org/0000-0002-1958-411X"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]},{"id":"https://openalex.org/I4210153755","display_name":"University Hospital Cologne","ror":"https://ror.org/05mxhda18","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210153755"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Claus Cursiefen","raw_affiliation_strings":["Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany","Department of Ophthalmology, University Hospital Cologne, Cologne, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular Medicine Cologne (CMMC), University of Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I180923762"]},{"raw_affiliation_string":"Department of Ophthalmology, University Hospital Cologne, Cologne, Germany","institution_ids":["https://openalex.org/I4210153755"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022291678","display_name":"Natasha Y. Frank","orcid":"https://orcid.org/0000-0001-8196-0449","observed_orcids":["https://orcid.org/0000-0001-8196-0449"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801671727","display_name":"VA Boston Healthcare System","ror":"https://ror.org/04v00sg98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I2801671727","https://openalex.org/I4210095851"]},{"id":"https://openalex.org/I4210157861","display_name":"Harvard Stem Cell Institute","ror":"https://ror.org/04kj1hn59","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Natasha Y. Frank","raw_affiliation_strings":["Department of Medicine, VA Boston Healthcare System, Boston, MA, USA","Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA","Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA","Transplant Research Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, VA Boston Healthcare System, Boston, MA, USA","institution_ids":["https://openalex.org/I2801671727"]},{"raw_affiliation_string":"Division of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]},{"raw_affiliation_string":"Transplant Research Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038756249","display_name":"Gerd Uwe Auffarth","orcid":"https://orcid.org/0000-0002-6927-5251","observed_orcids":["https://orcid.org/0000-0002-6927-5251"]},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gerd U. Auffarth","raw_affiliation_strings":["Department of Ophthalmology, Lions Eye Bank, University of Heidelberg, Heidelberg, Germany","Department of Ophthalmology, University Hospital Heidelberg, Heidelberg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Lions Eye Bank, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"Department of Ophthalmology, University Hospital Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086226110","display_name":"Bruce R. Ksander","orcid":"https://orcid.org/0000-0001-5546-0360","observed_orcids":["https://orcid.org/0000-0001-5546-0360"]},"institutions":[{"id":"https://openalex.org/I1287163989","display_name":"Massachusetts Eye and Ear Infirmary","ror":"https://ror.org/04g3dn724","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1287163989"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bruce Ksander","raw_affiliation_strings":["The Schepens Eye Research Institute, Massachusetts Eye & Ear, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Schepens Eye Research Institute, Massachusetts Eye & Ear, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1287163989","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089843842","display_name":"Markus H. Frank","orcid":"https://orcid.org/0000-0002-1312-0488","observed_orcids":["https://orcid.org/0000-0002-1312-0488","https://orcid.org/0000-0001-8196-0449"]},"institutions":[{"id":"https://openalex.org/I12079687","display_name":"Edith Cowan University","ror":"https://ror.org/05jhnwe22","country_code":"AU","type":"education","lineage":["https://openalex.org/I12079687"]},{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210157861","display_name":"Harvard Stem Cell Institute","ror":"https://ror.org/04kj1hn59","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]}],"countries":["AU","US"],"is_corresponding":false,"raw_author_name":"Markus H. Frank","raw_affiliation_strings":["Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA","Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA","School of Medical and Health Sciences, Edith Cowan University, Perth, Western Australia, Australia","Transplant Research Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Stem Cell Institute, Harvard University, Cambridge, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210157861"]},{"raw_affiliation_string":"School of Medical and Health Sciences, Edith Cowan University, Perth, Western Australia, Australia","institution_ids":["https://openalex.org/I12079687"]},{"raw_affiliation_string":"Transplant Research Program, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5054721822","display_name":"Mark A. Kluth","orcid":"https://orcid.org/0000-0003-0764-4645","observed_orcids":["https://orcid.org/0000-0003-0764-4645"]},"institutions":[{"id":"https://openalex.org/I4210121985","display_name":"Rheacell (Germany)","ror":"https://ror.org/0363m9h89","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210121985"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Mark A. Kluth","raw_affiliation_strings":["RHEACELL GmbH & Co. KG, Im Neuenheimer Feld 517, Heidelberg, 69120, Germany. andreas.kluth@ticeba.com","TICEBA GmbH, Im Neuenheimer Feld 517, 69120, Heidelberg, Germany. andreas.kluth@ticeba.com","RHEACELL GmbH & Co. KG, Im Neuenheimer Feld 517, Heidelberg, 69120, Germany"],"raw_orcid":"https://orcid.org/0000-0003-0764-4645","affiliations":[{"raw_affiliation_string":"RHEACELL GmbH & Co. KG, Im Neuenheimer Feld 517, Heidelberg, 69120, Germany. andreas.kluth@ticeba.com","institution_ids":["https://openalex.org/I4210121985"]},{"raw_affiliation_string":"TICEBA GmbH, Im Neuenheimer Feld 517, 69120, Heidelberg, Germany. andreas.kluth@ticeba.com","institution_ids":[]},{"raw_affiliation_string":"RHEACELL GmbH & Co. KG, Im Neuenheimer Feld 517, Heidelberg, 69120, Germany","institution_ids":["https://openalex.org/I4210121985"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5054721822"],"corresponding_institution_ids":["https://openalex.org/I4210121985"],"apc_list":{"value":2590,"currency":"USD","value_usd":2590},"apc_paid":{"value":2590,"currency":"USD","value_usd":2590},"fwci":5.3178,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.96885493,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"12","issue":"1","first_page":"194","last_page":"194"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11828","display_name":"Corneal Surgery and Treatments","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/limbal-stem-cell-deficiency","display_name":"limbal stem cell deficiency","score":0.871999979019165},{"id":"https://openalex.org/keywords/abcb5","display_name":"ABCB5","score":0.8820000290870667},{"id":"https://openalex.org/keywords/limbal-stem-cells","display_name":"limbal stem cells","score":0.9649999737739563},{"id":"https://openalex.org/keywords/advanced-therapy-medicinal-products","display_name":"advanced therapy medicinal products","score":0.8939999938011169},{"id":"https://openalex.org/keywords/ex-vivo-cell-expansion","display_name":"ex vivo cell expansion","score":0.8330000042915344},{"id":"https://openalex.org/keywords/allogeneic-cell-transplantation","display_name":"allogeneic cell transplantation","score":0.796999990940094},{"id":"https://openalex.org/keywords/corneal-regeneration","display_name":"corneal regeneration","score":0.6610000133514404},{"id":"https://openalex.org/keywords/p63","display_name":"p63","score":0.8420000076293945},{"id":"https://openalex.org/keywords/pax6","display_name":"Pax6","score":0.9760000109672546},{"id":"https://openalex.org/keywords/engraftment","display_name":"engraftment","score":0.6940000057220459},{"id":"https://openalex.org/keywords/good-manufacturing-practices","display_name":"good manufacturing practices","score":0.5120000243186951}],"concepts":[{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.7337429523468018},{"id":"https://openalex.org/C2778155685","wikidata":"https://www.wikidata.org/wiki/Q5918496","display_name":"Limbal stem cell","level":4,"score":0.5830967426300049},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.4945673644542694},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.47663602232933044},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4503065049648285},{"id":"https://openalex.org/C190672674","wikidata":"https://www.wikidata.org/wiki/Q3866591","display_name":"Decellularization","level":3,"score":0.4465055465698242},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.43766483664512634},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.41272085905075073},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3848660886287689},{"id":"https://openalex.org/C2776882836","wikidata":"https://www.wikidata.org/wiki/Q168291","display_name":"Cornea","level":2,"score":0.3627322018146515},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3456803560256958},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3421820402145386},{"id":"https://openalex.org/C2779257441","wikidata":"https://www.wikidata.org/wiki/Q2040445","display_name":"Corneal epithelium","level":3,"score":0.3410615026950836},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3389744758605957},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.27509722113609314},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.2319331169128418},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.23034033179283142},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.1717914342880249},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.13423258066177368},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.12663564085960388},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003316","descriptor_name":"Corneal Diseases","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013234","descriptor_name":"Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016850","descriptor_name":"Limbus Corneae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018435","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018435","descriptor_name":"ATP Binding Cassette Transporter, Subfamily B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019573","descriptor_name":"Epithelium, Corneal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1186/s13287-021-02272-2","doi":"https://doi.org/10.1186/s13287-021-02272-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13287-021-02272-2","pdf_url":"https://stemcellres.biomedcentral.com/counter/pdf/10.1186/s13287-021-02272-2","source":{"id":"https://openalex.org/S2061155","display_name":"Stem Cell Research & Therapy","issn_l":"1757-6512","issn":["1757-6512"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research &amp; Therapy","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-89981/v1","doi":"https://doi.org/10.21203/rs.3.rs-89981/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-89981/v1","pdf_url":"https://www.researchsquare.com/article/rs-89981/v1.pdf?c=1637261652000","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmid:33741066","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33741066","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cell research & therapy","raw_type":"Journal Article"},{"id":"pmh:oai:USBKOELN.ub.uni-koeln.de:60102","doi":null,"is_oa":false,"landing_page_url":"https://kups.ub.uni-koeln.de/60102/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400371","display_name":"K\u00f6lner Universit\u00e4ts PublikationsServer (Universit\u00e4t zu K\u00f6ln)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115942","host_organization_name":"Rhenish Institute for Environmental Research","host_organization_lineage":["https://openalex.org/I4210115942"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"doc-type:article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7980611","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7980611/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Res Ther","raw_type":"Text"},{"id":"pmh:oai:ro.ecu.edu.au:ecuworkspost2013-11080","doi":null,"is_oa":true,"landing_page_url":"https://ro.ecu.edu.au/ecuworkspost2013/10073","pdf_url":null,"source":{"id":"https://openalex.org/S2765015692","display_name":"Australasian Journal of Paramedicine","issn_l":"2202-7270","issn":["2202-7270"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20"],"host_organization":"https://openalex.org/I4405272673","host_organization_name":"Australasian College of Paramedicine","host_organization_lineage":["https://openalex.org/I4405272673"],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research outputs 2014 to 2021","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:05442d04f1184b4784987718c697fe9b","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/05442d04f1184b4784987718c697fe9b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Stem Cell Research & Therapy, Vol 12, Iss 1, Pp 1-21 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13287-021-02272-2","doi":"https://doi.org/10.1186/s13287-021-02272-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13287-021-02272-2","pdf_url":"https://stemcellres.biomedcentral.com/counter/pdf/10.1186/s13287-021-02272-2","source":{"id":"https://openalex.org/S2061155","display_name":"Stem Cell Research & Therapy","issn_l":"1757-6512","issn":["1757-6512"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cell Research &amp; Therapy","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5597099177","display_name":"Multipotent ABCB5-positive cell therapeutics for corneal disease","funder_award_id":"R24EY028767","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000913620","display_name":"ABCB5-positive stem cells for LSCD therapy","funder_award_id":"R01EY025794","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320330130","display_name":"Universit\u00e4tsklinikum Heidelberg","ror":"https://ror.org/013czdx64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3138319201.pdf","grobid_xml":"https://content.openalex.org/works/W3138319201.grobid-xml"},"referenced_works_count":77,"referenced_works":["https://openalex.org/W220935706","https://openalex.org/W821593376","https://openalex.org/W1494685416","https://openalex.org/W1777597537","https://openalex.org/W1803642874","https://openalex.org/W1968432716","https://openalex.org/W1979094948","https://openalex.org/W1982220589","https://openalex.org/W1985481249","https://openalex.org/W1990757263","https://openalex.org/W1993577427","https://openalex.org/W1994650249","https://openalex.org/W2000218315","https://openalex.org/W2009203019","https://openalex.org/W2010162578","https://openalex.org/W2013176877","https://openalex.org/W2014850470","https://openalex.org/W2021204333","https://openalex.org/W2022985798","https://openalex.org/W2023468388","https://openalex.org/W2036697390","https://openalex.org/W2037451360","https://openalex.org/W2041746039","https://openalex.org/W2054351923","https://openalex.org/W2059048070","https://openalex.org/W2068563203","https://openalex.org/W2075123157","https://openalex.org/W2076050606","https://openalex.org/W2090856763","https://openalex.org/W2091302289","https://openalex.org/W2091421632","https://openalex.org/W2091483311","https://openalex.org/W2091580452","https://openalex.org/W2100465544","https://openalex.org/W2102186965","https://openalex.org/W2111251876","https://openalex.org/W2121062346","https://openalex.org/W2122104511","https://openalex.org/W2132984034","https://openalex.org/W2163535696","https://openalex.org/W2164384962","https://openalex.org/W2168211018","https://openalex.org/W2201685611","https://openalex.org/W2295369096","https://openalex.org/W2312843543","https://openalex.org/W2407784262","https://openalex.org/W2414553211","https://openalex.org/W2426244175","https://openalex.org/W2474486292","https://openalex.org/W2530665415","https://openalex.org/W2611457130","https://openalex.org/W2749944776","https://openalex.org/W2765247620","https://openalex.org/W2765601141","https://openalex.org/W2765808364","https://openalex.org/W2766297399","https://openalex.org/W2767269119","https://openalex.org/W2794087267","https://openalex.org/W2811374632","https://openalex.org/W2838747349","https://openalex.org/W2886095954","https://openalex.org/W2896975470","https://openalex.org/W2910893554","https://openalex.org/W2919500415","https://openalex.org/W2954032864","https://openalex.org/W2955504961","https://openalex.org/W2965283627","https://openalex.org/W2971954408","https://openalex.org/W2977592743","https://openalex.org/W2981488155","https://openalex.org/W2991827177","https://openalex.org/W3041069858","https://openalex.org/W3099433617","https://openalex.org/W3166618611","https://openalex.org/W4254498430","https://openalex.org/W4319431825","https://openalex.org/W7075655950"],"related_works":["https://openalex.org/W6902025809","https://openalex.org/W6976934757","https://openalex.org/W2919500415","https://openalex.org/W2075123157","https://openalex.org/W2563166259","https://openalex.org/W2593893138","https://openalex.org/W4390989398","https://openalex.org/W3182653041","https://openalex.org/W3007003902","https://openalex.org/W1972552247"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"While":[2],"therapeutic":[3,266],"success":[4],"of":[5,16,28,44,54,65,70,77,85,101,193,215,222,285,293,308,314,324],"the":[6,26,31,41,45,55,72,75,86,99,168,216,231,237,243,263,280,309],"limbal":[7,17,113],"tissue":[8],"or":[9],"cell":[10,19,148],"transplantation":[11],"to":[12,91,233,249,261],"treat":[13],"severe":[14],"cases":[15],"stem":[18],"(LSC)":[20],"deficiency":[21],"(LSCD)":[22],"strongly":[23],"depends":[24],"on":[25,98],"percentage":[27],"LSCs":[29,66,108,135,179,289],"within":[30],"transplanted":[32],"cells,":[33],"prospective":[34],"LSC":[35,48,200,311],"enrichment":[36],"has":[37],"been":[38],"hampered":[39],"by":[40,131,236],"intranuclear":[42],"localization":[43],"previously":[46,281],"reported":[47],"marker":[49,64],"p63.":[50],"The":[51],"recent":[52],"identification":[53],"ATP-binding":[56],"cassette":[57],"transporter":[58],"ABCB5":[59,87,106,133,177,287],"as":[60,146,152,185],"a":[61,93,120,163,315,325],"plasma":[62],"membrane-spanning":[63],"that":[67,188,303],"are":[68,136],"capable":[69],"restoring":[71],"cornea":[73],"and":[74,118,124,128,150,174,183,204,218,224,242,265,322],"development":[76],"an":[78,82,153,186,253,297],"antibody":[79],"directed":[80],"against":[81,318],"extracellular":[83],"loop":[84],"molecule":[88],"stimulated":[89],"us":[90],"develop":[92],"novel":[94],"treatment":[95,301],"strategy":[96,302],"based":[97],"utilization":[100],"in":[102,162,252,268,277,290],"vitro":[103],"expanded":[104,142,182],"allogeneic":[105,299],"+":[107,134,178,288],"derived":[109,137],"from":[110,138],"human":[111,139,286],"cadaveric":[112],"tissue.":[114],"Methods":[115],"We":[116],"developed":[117],"validated":[119],"Good":[121],"Manufacturing":[122],"Practice-":[123],"European":[125],"Pharmacopeia-conform":[126],"production":[127],"quality-control":[129],"process,":[130],"which":[132],"corneal":[140,205],"rims,":[141],"ex":[143],"vivo,":[144],"isolated":[145],"homogenous":[147],"population,":[149],"manufactured":[151,184],"advanced-therapy":[154],"medicinal":[155],"product":[156,159,232],"(ATMP).":[157],"This":[158],"was":[160],"tested":[161,251],"preclinical":[164],"study":[165],"program":[166],"investigating":[167],"cells\u2019":[169],"engraftment":[170,213],"potential,":[171],"biodistribution":[172],"behavior,":[173],"safety.":[175],"Results":[176],"were":[180,228],"reliably":[181],"ATMP":[187],"contains":[189],"comparably":[190],"high":[191],"percentages":[192],"cells":[194,217,321],"expressing":[195],"transcription":[196],"factors":[197],"critical":[198],"for":[199,230,306],"stemness":[201],"maintenance":[202],"(p63)":[203],"epithelial":[206],"differentiation":[207],"(PAX6).":[208],"Preclinical":[209],"studies":[210],"confirmed":[211],"local":[212],"potential":[214],"gave":[219],"no":[220],"signals":[221],"toxicity":[223],"tumorgenicity.":[225],"These":[226],"findings":[227],"sufficient":[229],"be":[234,250],"approved":[235],"German":[238],"Paul":[239],"Ehrlich":[240],"Institute":[241],"U.S.":[244],"Food":[245],"&":[246],"Drug":[247],"Administration":[248],"international":[254],"multicenter":[255],"phase":[256],"I/IIa":[257],"clinical":[258],"trial":[259],"(NCT03549299)":[260],"evaluate":[262],"safety":[264],"efficacy":[267],"patients":[269],"with":[270,279],"LSCD.":[271],"Conclusion":[272],"Building":[273],"upon":[274],"these":[275],"data":[276],"conjunction":[278],"shown":[282],"cornea-restoring":[283],"capacity":[284],"animal":[291],"models":[292],"LSCD,":[294],"we":[295],"provide":[296],"advanced":[298],"LSC-based":[300],"shows":[304],"promise":[305],"replenishment":[307],"patient\u2019s":[310],"pool,":[312],"recreation":[313],"functional":[316],"barrier":[317],"invading":[319],"conjunctival":[320],"restoration":[323],"transparent,":[326],"avascular":[327],"cornea.":[328]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-03-29T00:00:00"}
