{"id":"https://openalex.org/W3138098911","doi":"https://doi.org/10.21037/atm-20-2661","title":"RUNX2 promotes vascular injury repair by activating miR-23a and inhibiting TGFBR2","display_name":"RUNX2 promotes vascular injury repair by activating miR-23a and inhibiting TGFBR2","publication_year":2021,"publication_date":"2021-03-01","ids":{"openalex":"https://openalex.org/W3138098911","doi":"https://doi.org/10.21037/atm-20-2661","mag":"3138098911","pmid":"https://pubmed.ncbi.nlm.nih.gov/33842584","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8033336"},"language":"en","primary_location":{"id":"doi:10.21037/atm-20-2661","doi":"https://doi.org/10.21037/atm-20-2661","is_oa":true,"landing_page_url":"https://doi.org/10.21037/atm-20-2661","pdf_url":"https://atm.amegroups.com/article/viewFile/64561/pdf","source":{"id":"https://openalex.org/S2755174949","display_name":"Annals of Translational Medicine","issn_l":"2305-5839","issn":["2305-5839","2305-5847"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Translational Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://atm.amegroups.com/article/viewFile/64561/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102832372","display_name":"Kai Wu","orcid":"https://orcid.org/0000-0003-4835-8741","observed_orcids":["https://orcid.org/0000-0003-4835-8741"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai Wu","raw_affiliation_strings":["Department of Rehabilitation, Xiangya Hospital, Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rehabilitation, Xiangya Hospital, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zhou Cai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhou Cai","raw_affiliation_strings":["Department of General & Vascular Surgery, Xiangya Hospital, Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General & Vascular Surgery, Xiangya Hospital, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100461614","display_name":"Bo Liu","orcid":"https://orcid.org/0000-0002-0459-9132","observed_orcids":["https://orcid.org/0000-0002-0459-9132"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210153856","display_name":"Second Xiangya Hospital of Central South University","ror":"https://ror.org/053v2gh09","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210153856"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bo Liu","raw_affiliation_strings":["Department of General Surgery, The Second Xiangya Hospital, Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, The Second Xiangya Hospital, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210153856","https://openalex.org/I4210159865"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036111618","display_name":"Yu Hu","orcid":"https://orcid.org/0000-0002-4878-3169","observed_orcids":["https://orcid.org/0000-0002-4878-3169","https://orcid.org/0000-0002-2815-4568"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210156904","display_name":"Third Xiangya Hospital","ror":"https://ror.org/05akvb491","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156904"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Hu","raw_affiliation_strings":["Center for Experimental Medical Research, The Third Xiangya Hospital, Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Experimental Medical Research, The Third Xiangya Hospital, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210156904"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084548257","display_name":"Pu Yang","orcid":"https://orcid.org/0000-0002-8783-5136","observed_orcids":["https://orcid.org/0000-0002-8783-5136","https://orcid.org/0009-0000-5580-264X"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210159865","display_name":"Xiangya Hospital Central South University","ror":"https://ror.org/05c1yfj14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210159865"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Pu Yang","raw_affiliation_strings":["Department of General & Vascular Surgery, Xiangya Hospital, Central South University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General & Vascular Surgery, Xiangya Hospital, Central South University, Changsha, China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5084548257"],"corresponding_institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210159865"],"apc_list":null,"apc_paid":null,"fwci":0.4299,"has_fulltext":true,"cited_by_count":6,"citation_normalized_percentile":{"value":0.4721035,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"9","issue":"5","first_page":"363","last_page":"363"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9663000106811523,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.024700000882148743,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11001","display_name":"Renin-Angiotensin System Studies","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/runx2","display_name":"Runx2","score":1.0},{"id":"https://openalex.org/keywords/mir-23a","display_name":"miR-23a","score":0.9789999723434448},{"id":"https://openalex.org/keywords/tgf-beta-receptor-ii","display_name":"TGFBR2","score":1.0},{"id":"https://openalex.org/keywords/vascular-injury-repair","display_name":"vascular injury repair","score":0.9869999885559082},{"id":"https://openalex.org/keywords/arterial-injury","display_name":"arterial injury","score":0.7789999842643738},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.9800000190734863},{"id":"https://openalex.org/keywords/microrna-regulation","display_name":"microRNA regulation","score":0.621999979019165},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.8370000123977661},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.7739999890327454},{"id":"https://openalex.org/keywords/collagen-deposition","display_name":"collagen deposition","score":0.7570000290870667},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6100000143051147},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8429999947547913}],"concepts":[{"id":"https://openalex.org/C134320426","wikidata":"https://www.wikidata.org/wiki/Q901026","display_name":"Chromatin immunoprecipitation","level":5,"score":0.7240834832191467},{"id":"https://openalex.org/C97037327","wikidata":"https://www.wikidata.org/wiki/Q5334291","display_name":"Ectopic expression","level":3,"score":0.5648496747016907},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5556879043579102},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5038658976554871},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.46591782569885254},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4611400067806244},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4442179203033447},{"id":"https://openalex.org/C161733203","wikidata":"https://www.wikidata.org/wiki/Q911828","display_name":"Reporter gene","level":4,"score":0.44075509905815125},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.43110254406929016},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.4206756055355072},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3524993062019348},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.16931504011154175},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.15318673849105835},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07801097631454468},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0491885244846344}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.21037/atm-20-2661","doi":"https://doi.org/10.21037/atm-20-2661","is_oa":true,"landing_page_url":"https://doi.org/10.21037/atm-20-2661","pdf_url":"https://atm.amegroups.com/article/viewFile/64561/pdf","source":{"id":"https://openalex.org/S2755174949","display_name":"Annals of Translational Medicine","issn_l":"2305-5839","issn":["2305-5839","2305-5847"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Translational Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8033336","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8033336","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Ann Transl Med","raw_type":"Text"},{"id":"pmid:33842584","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33842584","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of translational medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.21037/atm-20-2661","doi":"https://doi.org/10.21037/atm-20-2661","is_oa":true,"landing_page_url":"https://doi.org/10.21037/atm-20-2661","pdf_url":"https://atm.amegroups.com/article/viewFile/64561/pdf","source":{"id":"https://openalex.org/S2755174949","display_name":"Annals of Translational Medicine","issn_l":"2305-5839","issn":["2305-5839","2305-5847"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310321814","host_organization_name":"AME Publishing Company","host_organization_lineage":["https://openalex.org/P4310321814"],"host_organization_lineage_names":["AME Publishing Company"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Translational Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322843","display_name":"Natural Science Foundation of\u00a0Hunan Province","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3138098911.pdf","grobid_xml":"https://content.openalex.org/works/W3138098911.grobid-xml"},"referenced_works_count":34,"referenced_works":["https://openalex.org/W1785270475","https://openalex.org/W1894240809","https://openalex.org/W2016106370","https://openalex.org/W2025324742","https://openalex.org/W2026057304","https://openalex.org/W2036640037","https://openalex.org/W2047995813","https://openalex.org/W2054271984","https://openalex.org/W2082893668","https://openalex.org/W2091312291","https://openalex.org/W2098001153","https://openalex.org/W2101018118","https://openalex.org/W2131050523","https://openalex.org/W2131998303","https://openalex.org/W2135133647","https://openalex.org/W2149852376","https://openalex.org/W2580979550","https://openalex.org/W2585223803","https://openalex.org/W2591000278","https://openalex.org/W2762515622","https://openalex.org/W2767428503","https://openalex.org/W2788909627","https://openalex.org/W2791100847","https://openalex.org/W2799467557","https://openalex.org/W2802587000","https://openalex.org/W2888247702","https://openalex.org/W2897147375","https://openalex.org/W2898033484","https://openalex.org/W2941518494","https://openalex.org/W2948117492","https://openalex.org/W2990468416","https://openalex.org/W2997852414","https://openalex.org/W3024806011","https://openalex.org/W4301044408"],"related_works":["https://openalex.org/W4395041077","https://openalex.org/W2101987836","https://openalex.org/W4253587968","https://openalex.org/W1967379035","https://openalex.org/W2177722931","https://openalex.org/W1966270726","https://openalex.org/W2283917268","https://openalex.org/W962866440","https://openalex.org/W2975254547","https://openalex.org/W2005889517"],"abstract_inverted_index":{"BACKGROUND:":[0],"Previous":[1],"evidence":[2],"has":[3,32],"suggested":[4],"that":[5],"the":[6,15,22,45,66,72,80,154,202,231,255],"transcription":[7,10],"factor,":[8],"runt-related":[9],"factor":[11],"2":[12],"(RUNX2),":[13],"promotes":[14],"repair":[16,81],"of":[17,24,68,74,82,120,180,188,204,233,252,257],"vascular":[18,53,83,241,264],"injury":[19,54,87,265],"and":[20,50,76,105,114,124,140,148,159,167,175,206,220,227,237,262],"activates":[21],"expression":[23,73,189,215,256],"microRNA-23a":[25],"(miR-23a).":[26],"TGF-\u03b2":[27],"receptor":[28],"type":[29],"II":[30],"(TGFBR2)":[31],"been":[33,57],"found":[34,198],"to":[35,64,101,199,201],"mediate":[36],"smooth":[37,242],"muscle":[38,243],"cells":[39,244],"(SMCs)":[40],"following":[41],"arterial":[42,194],"injury.":[43,84,195],"However,":[44],"interactions":[46],"among":[47],"RUNX2,":[48],"miR-23a":[49,75,141,158,176,205,210,226],"TGFBR2":[51,160,183,261],"in":[52,190,240],"have":[55],"not":[56],"investigated":[58],"thoroughly":[59],"yet.":[60],"Therefore,":[61],"we":[62],"aim":[63],"explore":[65],"mechanism":[67],"how":[69],"RUNX2":[70,139,174,196,214,234,253],"triggers":[71],"its":[77],"effects":[78],"on":[79],"METHODS:":[85],"cell":[86,103,109,218],"induction":[88],"by":[89,107,131,144,163,224,246],"100":[90],"nmol/L":[91],"tumor":[92],"necrosis":[93],"factor-\u03b1":[94],"(TNF-\u03b1).":[95],"Gain-and":[96],"loss-of-function":[97],"studies":[98],"were":[99,129],"conducted":[100],"assess":[102],"viability":[104,236],"apoptosis":[106,239],"using":[108],"counting":[110],"kit":[111],"(CCK)-8":[112],"assay":[113,134],"flow":[115],"cytometry":[116],"respectively.":[117],"The":[118,136,250],"levels":[119,179],"TNF-\u03b1,":[121],"interleukin-6":[122],"(IL-6),":[123],"monocyte":[125],"chemotactic":[126],"protein-1":[127],"(MCP-1)":[128],"examined":[130],"enzyme-linked":[132],"immunosorbent":[133],"(ELISA).":[135],"interaction":[137],"between":[138,157],"was":[142,161,197],"identified":[143],"chromatin":[145],"immunoprecipitation":[146,165],"(ChIP)":[147],"dual":[149,168],"luciferase":[150,169],"reporter":[151,170],"assays,":[152],"while":[153,182,209],"targeting":[155],"relationship":[156],"analyzed":[162],"RNA":[164],"(RIP)":[166],"assays.":[171],"RESULTS:":[172],"Both":[173],"exhibited":[177],"low":[178],"expressions,":[181],"had":[184],"a":[185],"high":[186],"level":[187],"mice":[191],"with":[192],"induced":[193],"bind":[200],"promoter":[203],"activate":[207],"miR-23a,":[208],"targeted":[211],"TGFBR2.":[212,229],"Ectopic":[213],"inhibited":[216],"inflammatory":[217],"infiltration,":[219],"promoted":[221],"collagen":[222],"content":[223],"upregulating":[225],"downregulating":[228],"Furthermore,":[230],"overexpression":[232,251],"increased":[235],"decreased":[238],"(VSMCs)":[245],"activating":[247],"miR-23a.":[248],"CONCLUSIONS:":[249],"elevated":[254],"miR-23,":[258],"thus":[259],"inhibiting":[260],"promoting":[263],"repair.":[266]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2021-03-29T00:00:00"}