{"id":"https://openalex.org/W3138043669","doi":"https://doi.org/10.21203/rs.3.rs-262577/v1","title":"The Effect of Different Concentrations of Nitrogen and Phosphorous on the Production of Lipid Metabolites in Haematococcus Pluvialis UTEX 25051","display_name":"The Effect of Different Concentrations of Nitrogen and Phosphorous on the Production of Lipid Metabolites in Haematococcus Pluvialis UTEX 25051","publication_year":2021,"publication_date":"2021-03-04","ids":{"openalex":"https://openalex.org/W3138043669","doi":"https://doi.org/10.21203/rs.3.rs-262577/v1","mag":"3138043669"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-262577/v1","doi":"https://doi.org/10.21203/rs.3.rs-262577/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-262577/v1","pdf_url":"https://www.researchsquare.com/article/rs-262577/v1.pdf?c=1631871603000","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-262577/v1.pdf?c=1631871603000","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065148358","display_name":"Brenda S. Hoyos","orcid":"https://orcid.org/0000-0001-7363-5902","observed_orcids":["https://orcid.org/0000-0001-7363-5902"]},"institutions":[{"id":"https://openalex.org/I862322245","display_name":"Universidad EAFIT","ror":"https://ror.org/03y3y9v44","country_code":"CO","type":"education","lineage":["https://openalex.org/I862322245"]}],"countries":["CO"],"is_corresponding":true,"raw_author_name":"Brenda Seleny Hoyos Gutierrez","raw_affiliation_strings":["Department of Biological Sciences, EAFIT University, Carrera 49, n\u00famero 7 sur 50, Cra. 49, Medell\u00edn, Colombia, 050001"],"raw_orcid":"https://orcid.org/0000-0001-7363-5902","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, EAFIT University, Carrera 49, n\u00famero 7 sur 50, Cra. 49, Medell\u00edn, Colombia, 050001","institution_ids":["https://openalex.org/I862322245"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Alejandra Miranda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I862322245","display_name":"Universidad EAFIT","ror":"https://ror.org/03y3y9v44","country_code":"CO","type":"education","lineage":["https://openalex.org/I862322245"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Alejandra Miranda","raw_affiliation_strings":["Department of Biological Sciences, EAFIT University, Carrera 49, n\u00famero 7 sur 50, Cra. 49, Medell\u00edn, Colombia, 050001"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, EAFIT University, Carrera 49, n\u00famero 7 sur 50, Cra. 49, Medell\u00edn, Colombia, 050001","institution_ids":["https://openalex.org/I862322245"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Diana Meneses","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I862322245","display_name":"Universidad EAFIT","ror":"https://ror.org/03y3y9v44","country_code":"CO","type":"education","lineage":["https://openalex.org/I862322245"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Diana Meneses","raw_affiliation_strings":["Department of Biological Sciences, EAFIT University, Carrera 49, n\u00famero 7 sur 50, Cra. 49, Medell\u00edn, Colombia, 050001"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, EAFIT University, Carrera 49, n\u00famero 7 sur 50, Cra. 49, Medell\u00edn, Colombia, 050001","institution_ids":["https://openalex.org/I862322245"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086063948","display_name":"Gabriel J. Vargas","orcid":"https://orcid.org/0000-0001-5408-4252","observed_orcids":["https://orcid.org/0000-0001-5408-4252"]},"institutions":[{"id":"https://openalex.org/I4210104863","display_name":"Argos Cement (Colombia)","ror":"https://ror.org/01gyh5y52","country_code":"CO","type":"company","lineage":["https://openalex.org/I4210104863"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Gabriel Vargas","raw_affiliation_strings":["I&D Cementos Argos S.A, Argos Center for Innovation (CAPI), Carrera 49, n\u00famero 7 sur 50, Cra. 49, Medell\u00edn, Colombia, 050001"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"I&D Cementos Argos S.A, Argos Center for Innovation (CAPI), Carrera 49, n\u00famero 7 sur 50, Cra. 49, Medell\u00edn, Colombia, 050001","institution_ids":["https://openalex.org/I4210104863"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011784221","display_name":"Alex A. S\u00e1ez","orcid":"https://orcid.org/0000-0001-5314-0515","observed_orcids":["https://orcid.org/0000-0001-5314-0515"]},"institutions":[{"id":"https://openalex.org/I862322245","display_name":"Universidad EAFIT","ror":"https://ror.org/03y3y9v44","country_code":"CO","type":"education","lineage":["https://openalex.org/I862322245"]}],"countries":["CO"],"is_corresponding":false,"raw_author_name":"Alex S\u00e1ez","raw_affiliation_strings":["Department of Biological Sciences, EAFIT University, Carrera 49, n\u00famero 7 sur 50, Cra. 49, Medell\u00edn, Colombia, 050001"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, EAFIT University, Carrera 49, n\u00famero 7 sur 50, Cra. 49, Medell\u00edn, Colombia, 050001","institution_ids":["https://openalex.org/I862322245"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5065148358"],"corresponding_institution_ids":["https://openalex.org/I862322245"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10476","display_name":"Algal biology and biofuel production","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2105","display_name":"Renewable Energy, Sustainability and the Environment"},"field":{"id":"https://openalex.org/fields/21","display_name":"Energy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10476","display_name":"Algal biology and biofuel production","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2105","display_name":"Renewable Energy, Sustainability and the Environment"},"field":{"id":"https://openalex.org/fields/21","display_name":"Energy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10450","display_name":"Aquaculture Nutrition and Growth","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11390","display_name":"Seaweed-derived Bioactive Compounds","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/haematococcus-pluvialis","display_name":"Haematococcus pluvialis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/astaxanthin","display_name":"astaxanthin","score":0.8410000205039978},{"id":"https://openalex.org/keywords/lipid-metabolites","display_name":"lipid metabolites","score":0.8389999866485596},{"id":"https://openalex.org/keywords/nitrogen-source","display_name":"nitrogen source","score":0.7070000171661377},{"id":"https://openalex.org/keywords/phosphate-sources","display_name":"phosphate sources","score":0.7350000143051147},{"id":"https://openalex.org/keywords/nitrate","display_name":"nitrate","score":0.6610000133514404},{"id":"https://openalex.org/keywords/bold-s-basal-medium","display_name":"Bold's Basal Medium","score":0.9509999752044678},{"id":"https://openalex.org/keywords/cell-growth","display_name":"cell growth","score":0.8119999766349792},{"id":"https://openalex.org/keywords/antioxidant-capacity","display_name":"antioxidant capacity","score":0.9620000123977661},{"id":"https://openalex.org/keywords/orac-assay","display_name":"ORAC","score":0.7699999809265137},{"id":"https://openalex.org/keywords/essential-fatty-acids","display_name":"essential fatty acids","score":0.828000009059906},{"id":"https://openalex.org/keywords/nutraceuticals","display_name":"nutraceuticals","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C2777399995","wikidata":"https://www.wikidata.org/wiki/Q469662","display_name":"Haematococcus pluvialis","level":4,"score":0.983944296836853},{"id":"https://openalex.org/C537208039","wikidata":"https://www.wikidata.org/wiki/Q627","display_name":"Nitrogen","level":2,"score":0.6177988648414612},{"id":"https://openalex.org/C2776937821","wikidata":"https://www.wikidata.org/wiki/Q2359014","display_name":"Pluvialis","level":5,"score":0.5861615538597107},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.5205398797988892},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4998018741607666},{"id":"https://openalex.org/C2780962900","wikidata":"https://www.wikidata.org/wiki/Q413740","display_name":"Astaxanthin","level":3,"score":0.4991617202758789},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.34645017981529236},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.33826881647109985},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3379928469657898},{"id":"https://openalex.org/C28781525","wikidata":"https://www.wikidata.org/wiki/Q191907","display_name":"Carotenoid","level":2,"score":0.21775925159454346},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.04523709416389465}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-262577/v1","doi":"https://doi.org/10.21203/rs.3.rs-262577/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-262577/v1","pdf_url":"https://www.researchsquare.com/article/rs-262577/v1.pdf?c=1631871603000","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-262577/v1","doi":"https://doi.org/10.21203/rs.3.rs-262577/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-262577/v1","pdf_url":"https://www.researchsquare.com/article/rs-262577/v1.pdf?c=1631871603000","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Zero hunger","score":0.5666999816894531,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320314236","display_name":"Universidad EAFIT","ror":"https://ror.org/03y3y9v44"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3138043669.pdf","grobid_xml":"https://content.openalex.org/works/W3138043669.grobid-xml"},"referenced_works_count":28,"referenced_works":["https://openalex.org/W1128363000","https://openalex.org/W1471838055","https://openalex.org/W1965931498","https://openalex.org/W1983085687","https://openalex.org/W1987539003","https://openalex.org/W1994144319","https://openalex.org/W1995250319","https://openalex.org/W1995744148","https://openalex.org/W2007079184","https://openalex.org/W2010805526","https://openalex.org/W2016520057","https://openalex.org/W2017764543","https://openalex.org/W2032367603","https://openalex.org/W2044077020","https://openalex.org/W2068761018","https://openalex.org/W2083565938","https://openalex.org/W2092686460","https://openalex.org/W2117922458","https://openalex.org/W2134079810","https://openalex.org/W2183046441","https://openalex.org/W2218224357","https://openalex.org/W2265350555","https://openalex.org/W2299723041","https://openalex.org/W2508538588","https://openalex.org/W2522339488","https://openalex.org/W2592539910","https://openalex.org/W2762273475","https://openalex.org/W2790285747"],"related_works":["https://openalex.org/W2920510921","https://openalex.org/W2968630146","https://openalex.org/W2790285747","https://openalex.org/W4317787011","https://openalex.org/W4406359215","https://openalex.org/W2040861017","https://openalex.org/W4388133844","https://openalex.org/W3217805709","https://openalex.org/W3163950274","https://openalex.org/W2007079184"],"abstract_inverted_index":{"Abstract":[0],"Microalgae":[1],"as":[2,14,193],"Haematococcus":[3,86],"pluvialis":[4,87,226],"produce":[5],"lipid":[6,45,79,217],"metabolites":[7,33,80,218],"of":[8,23,31,44,51,70,78,81,94,101,143,155,204,216,224,233],"great":[9],"interest":[10],"for":[11,27,131,146,160,190,241],"different":[12],"industries":[13],"the":[15,24,28,35,42,68,76,99,102,115,126,132,135,178,188,214,222],"nutraceutical,":[16],"pharmaceutical,":[17],"cosmetic,":[18],"among":[19],"other.":[20],"Currently,":[21],"one":[22],"main":[25],"limitations":[26],"massive":[29],"commercialization":[30],"these":[32],"are":[34],"low":[36,163,202],"yields":[37],"between":[38,60],"cell":[39],"growth":[40,122],"and":[41,104,109,138,167,196,207,219,235],"production":[43,77],"metabolites.":[46],"Thus,":[47],"a":[48,58,152,210],"better":[49],"understanding":[50],"culture":[52,117],"parameters":[53],"that":[54,201,221],"allow":[55],"to":[56,184],"get":[57],"balance":[59],"both":[61],"variables":[62],"is":[63,229],"needed.":[64],"Herein":[65],"we":[66],"evaluated":[67],"effect":[69,212],"Bold\u2019s":[71],"Basal":[72],"Medium":[73],"(BBM)":[74],"on":[75,213],"high":[82],"biotechnological":[83],"value":[84,154],"in":[85,114,187,237],"UTEX":[88,227],"2505.":[89],"A":[90],"factorial":[91],"experimental":[92],"design":[93],"32":[95],"was":[96,123,175],"used":[97],"whereby":[98],"concentrations":[100,203],"nitrogen":[103],"phosphorus":[105],"source":[106,232],"(0.2,":[107],"0.6":[108],"1.0":[110,144],"g":[111],"/":[112],"l)":[113],"BBM":[116],"medium":[118,168],"were":[119],"varied.":[120],"Cell":[121],"measured,":[124],"showed":[125,151],"highest":[127,136],"concentration":[128,142,215],"(1.148\u00b10.842":[129],"g/l)":[130],"treatment":[133,161],"with":[134,162],"nitrate":[137,164,206],"phosphate":[139,169,208],"content":[140,150],"(a":[141],"g/l":[145],"both).":[147],"The":[148,172,198],"Astaxanthin":[149],"maximum":[153],"76.22":[156],"\u00b1":[157],"3.02":[158],"\u00b5g/mL":[159],"(0.2":[165],"g/L)":[166],"(0.6":[170],"g/L).":[171],"antioxidant":[173],"capacity":[174],"determined":[176],"by":[177],"ORAC":[179],"method,":[180],"achieving":[181],"superior":[182],"values":[183],"those":[185],"found":[186],"literature":[189],"compounds":[191],"such":[192],"vitamins":[194],"E":[195],"C.":[197],"results":[199],"suggested":[200],"nutrients,":[205],"have":[209],"positive":[211],"affirm":[220],"biomass":[223],"H.":[225],"2505":[228],"an":[230],"excellent":[231],"antioxidants":[234],"rich":[236],"essential":[238],"fatty":[239],"acids":[240],"human":[242],"nutrition.":[243]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2021-03-29T00:00:00"}
