{"id":"https://openalex.org/W3137969676","doi":"https://doi.org/10.1111/1462-2920.15470","title":"Identification of trans \u2010AT polyketide clusters in two marine bacteria reveals cryptic similarities between distinct symbiosis factors","display_name":"Identification of trans \u2010AT polyketide clusters in two marine bacteria reveals cryptic similarities between distinct symbiosis factors","publication_year":2021,"publication_date":"2021-03-18","ids":{"openalex":"https://openalex.org/W3137969676","doi":"https://doi.org/10.1111/1462-2920.15470","mag":"3137969676","pmid":"https://pubmed.ncbi.nlm.nih.gov/33734547"},"language":"en","primary_location":{"id":"doi:10.1111/1462-2920.15470","doi":"https://doi.org/10.1111/1462-2920.15470","is_oa":false,"landing_page_url":"https://doi.org/10.1111/1462-2920.15470","pdf_url":null,"source":{"id":"https://openalex.org/S6919857","display_name":"Environmental Microbiology","issn_l":"1462-2912","issn":["1462-2912","1462-2920"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Microbiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2020/09/26/2020.09.18.303172.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028293735","display_name":"Dina Ka\u010dar","orcid":"https://orcid.org/0000-0002-0141-0357","observed_orcids":["https://orcid.org/0000-0002-0141-0357"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210147680","display_name":"Centro de Investigaciones Biol\u00f3gicas Margarita Salas","ror":"https://ror.org/04advdf21","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210147680"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Dina Ka\u010dar","raw_affiliation_strings":["Department of Microbial and Plant Biotechnology, Centro de Investigaciones Biol\u00f3gicas Margarita Salas, Agencia Estatal Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbial and Plant Biotechnology, Centro de Investigaciones Biol\u00f3gicas Margarita Salas, Agencia Estatal Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Madrid, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210147680"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015876866","display_name":"Librada M. Ca\u00f1edo","orcid":"https://orcid.org/0000-0002-1273-4138","observed_orcids":["https://orcid.org/0000-0002-1273-4138"]},"institutions":[{"id":"https://openalex.org/I4210116403","display_name":"PharmaMar (Spain)","ror":"https://ror.org/02h694m69","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210116403"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Librada M Ca\u00f1edo","raw_affiliation_strings":["Research and Development Department, PharmaMar S.A., Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development Department, PharmaMar S.A., Madrid, Spain","institution_ids":["https://openalex.org/I4210116403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101410979","display_name":"Pilar Rodr\u00edguez","orcid":"https://orcid.org/0009-0000-3142-404X","observed_orcids":["https://orcid.org/0009-0000-3142-404X"]},"institutions":[{"id":"https://openalex.org/I4210116403","display_name":"PharmaMar (Spain)","ror":"https://ror.org/02h694m69","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210116403"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Pilar Rodr\u00edguez","raw_affiliation_strings":["Research and Development Department, PharmaMar S.A., Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development Department, PharmaMar S.A., Madrid, Spain","institution_ids":["https://openalex.org/I4210116403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083661528","display_name":"Elena Gonz\u00e1lez","orcid":"https://orcid.org/0000-0002-4614-3889","observed_orcids":["https://orcid.org/0000-0002-4614-3889"]},"institutions":[{"id":"https://openalex.org/I4210116403","display_name":"PharmaMar (Spain)","ror":"https://ror.org/02h694m69","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210116403"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Elena Gonzalez","raw_affiliation_strings":["Research and Development Department, PharmaMar S.A., Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development Department, PharmaMar S.A., Madrid, Spain","institution_ids":["https://openalex.org/I4210116403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068081073","display_name":"Beatriz Gal\u00e1n","orcid":"https://orcid.org/0000-0002-2596-6034","observed_orcids":["https://orcid.org/0000-0002-2596-6034"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210147680","display_name":"Centro de Investigaciones Biol\u00f3gicas Margarita Salas","ror":"https://ror.org/04advdf21","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210147680"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Beatriz Gal\u00e1n","raw_affiliation_strings":["Department of Microbial and Plant Biotechnology, Centro de Investigaciones Biol\u00f3gicas Margarita Salas, Agencia Estatal Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbial and Plant Biotechnology, Centro de Investigaciones Biol\u00f3gicas Margarita Salas, Agencia Estatal Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Madrid, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210147680"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060882764","display_name":"Carmen Schleissner","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Carmen Schleissner","raw_affiliation_strings":["UnolabManufacturing., Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UnolabManufacturing., Madrid, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000083420","display_name":"Stefan Leopold\u2010Messer","orcid":"https://orcid.org/0000-0003-3490-3550","observed_orcids":["https://orcid.org/0000-0003-3490-3550"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Stefan Leopold-Messer","raw_affiliation_strings":["ETH, Z\u00fcrich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ETH, Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016755309","display_name":"J\u00f6rn Piel","orcid":"https://orcid.org/0000-0002-2282-8154","observed_orcids":["https://orcid.org/0000-0002-2282-8154"]},"institutions":[{"id":"https://openalex.org/I35440088","display_name":"ETH Zurich","ror":"https://ror.org/05a28rw58","country_code":"CH","type":"education","lineage":["https://openalex.org/I2799323385","https://openalex.org/I35440088"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"J\u00f6rn Piel","raw_affiliation_strings":["ETH, Z\u00fcrich, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ETH, Z\u00fcrich, Switzerland","institution_ids":["https://openalex.org/I35440088"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103856099","display_name":"Carmen Cuevas","orcid":"https://orcid.org/0000-0002-9116-2405","observed_orcids":["https://orcid.org/0000-0002-9116-2405"]},"institutions":[{"id":"https://openalex.org/I4210116403","display_name":"PharmaMar (Spain)","ror":"https://ror.org/02h694m69","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210116403"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carmen Cuevas","raw_affiliation_strings":["Research and Development Department, PharmaMar S.A., Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development Department, PharmaMar S.A., Madrid, Spain","institution_ids":["https://openalex.org/I4210116403"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066835702","display_name":"Fernando de la Calle","orcid":"https://orcid.org/0000-0001-8161-8299","observed_orcids":["https://orcid.org/0000-0001-8161-8299"]},"institutions":[{"id":"https://openalex.org/I4210116403","display_name":"PharmaMar (Spain)","ror":"https://ror.org/02h694m69","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210116403"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Fernando de la Calle","raw_affiliation_strings":["Research and Development Department, PharmaMar S.A., Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development Department, PharmaMar S.A., Madrid, Spain","institution_ids":["https://openalex.org/I4210116403"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100739784","display_name":"Jos\u00e9 Luis Garc\u00eda","orcid":"https://orcid.org/0000-0002-9238-2485","observed_orcids":["https://orcid.org/0000-0002-9238-2485"]},"institutions":[{"id":"https://openalex.org/I134820265","display_name":"Consejo Superior de Investigaciones Cient\u00edficas","ror":"https://ror.org/02gfc7t72","country_code":"ES","type":"government","lineage":["https://openalex.org/I134820265"]},{"id":"https://openalex.org/I4210147680","display_name":"Centro de Investigaciones Biol\u00f3gicas Margarita Salas","ror":"https://ror.org/04advdf21","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210147680"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Jos\u00e9 L. Garc\u00eda","raw_affiliation_strings":["Department of Microbial and Plant Biotechnology, Centro de Investigaciones Biol\u00f3gicas Margarita Salas, Agencia Estatal Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbial and Plant Biotechnology, Centro de Investigaciones Biol\u00f3gicas Margarita Salas, Agencia Estatal Consejo Superior de Investigaciones Cient\u00edficas (CSIC), Madrid, Spain","institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210147680"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100739784"],"corresponding_institution_ids":["https://openalex.org/I134820265","https://openalex.org/I4210147680"],"apc_list":{"value":4200,"currency":"USD","value_usd":4200},"apc_paid":null,"fwci":1.0334,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.67753623,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"23","issue":"5","first_page":"2509","last_page":"2521"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10252","display_name":"Microbial Natural Products and Biosynthesis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11340","display_name":"Marine Sponges and Natural Products","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12673","display_name":"Microbial Metabolism and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trans-at-polyketide-synthase","display_name":"trans-AT polyketide synthase","score":0.9319999814033508},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.7229999899864197},{"id":"https://openalex.org/keywords/genome-mining","display_name":"genome mining","score":0.49799999594688416},{"id":"https://openalex.org/keywords/comparative-genomics","display_name":"comparative genomics","score":0.6579999923706055},{"id":"https://openalex.org/keywords/natural-product-biosynthesis","display_name":"natural product biosynthesis","score":0.4819999933242798}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9298017024993896},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.7495601177215576},{"id":"https://openalex.org/C2778635478","wikidata":"https://www.wikidata.org/wiki/Q516751","display_name":"Polyketide","level":4,"score":0.663867712020874},{"id":"https://openalex.org/C43144210","wikidata":"https://www.wikidata.org/wiki/Q121610","display_name":"Symbiosis","level":3,"score":0.6526256799697876},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.5933939218521118},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.48736125230789185},{"id":"https://openalex.org/C153568844","wikidata":"https://www.wikidata.org/wiki/Q96392018","display_name":"Marine bacteriophage","level":3,"score":0.4403686821460724},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.342851459980011},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3289496898651123},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2757907509803772},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.22785449028015137},{"id":"https://openalex.org/C553450214","wikidata":"https://www.wikidata.org/wiki/Q851162","display_name":"Biosynthesis","level":3,"score":0.06235554814338684}],"mesh":[{"descriptor_ui":"D005810","descriptor_name":"Multigene Family","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013559","descriptor_name":"Symbiosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041902","descriptor_name":"Rhodobacteraceae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D048630","descriptor_name":"Polyketide Synthases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D061065","descriptor_name":"Polyketides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1111/1462-2920.15470","doi":"https://doi.org/10.1111/1462-2920.15470","is_oa":false,"landing_page_url":"https://doi.org/10.1111/1462-2920.15470","pdf_url":null,"source":{"id":"https://openalex.org/S6919857","display_name":"Environmental Microbiology","issn_l":"1462-2912","issn":["1462-2912","1462-2920"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental Microbiology","raw_type":"journal-article"},{"id":"doi:10.1101/2020.09.18.303172","doi":"https://doi.org/10.1101/2020.09.18.303172","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.09.18.303172","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/09/26/2020.09.18.303172.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmid:33734547","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33734547","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Environmental microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:digital.csic.es:10261/235759","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10261/235759","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"http://purl.org/coar/resource_type/c_6501"}],"best_oa_location":{"id":"doi:10.1101/2020.09.18.303172","doi":"https://doi.org/10.1101/2020.09.18.303172","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.09.18.303172","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2020/09/26/2020.09.18.303172.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7134075281","display_name":null,"funder_award_id":"RTC\u20102016\u20104892\u20101","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"}],"funders":[{"id":"https://openalex.org/F4320321837","display_name":"Ministerio de Econom\u00eda y Competitividad","ror":"https://ror.org/034900433"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3137969676.pdf","grobid_xml":"https://content.openalex.org/works/W3137969676.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W1422521001","https://openalex.org/W1523336822","https://openalex.org/W1534406401","https://openalex.org/W1750155065","https://openalex.org/W1855537617","https://openalex.org/W1965644889","https://openalex.org/W1975407624","https://openalex.org/W1979633782","https://openalex.org/W1994755289","https://openalex.org/W1994762405","https://openalex.org/W2005684839","https://openalex.org/W2005778903","https://openalex.org/W2009000996","https://openalex.org/W2009699054","https://openalex.org/W2011757239","https://openalex.org/W2013705423","https://openalex.org/W2016233397","https://openalex.org/W2017739927","https://openalex.org/W2019724758","https://openalex.org/W2019833246","https://openalex.org/W2021231007","https://openalex.org/W2030966943","https://openalex.org/W2034383954","https://openalex.org/W2045021635","https://openalex.org/W2045467158","https://openalex.org/W2058588836","https://openalex.org/W2068926796","https://openalex.org/W2071926991","https://openalex.org/W2078044611","https://openalex.org/W2082928585","https://openalex.org/W2092452187","https://openalex.org/W2095032938","https://openalex.org/W2095548713","https://openalex.org/W2097706568","https://openalex.org/W2131887397","https://openalex.org/W2139434153","https://openalex.org/W2154952425","https://openalex.org/W2171908880","https://openalex.org/W2185261440","https://openalex.org/W2187467595","https://openalex.org/W2267146008","https://openalex.org/W2311203695","https://openalex.org/W2325918749","https://openalex.org/W2327944389","https://openalex.org/W2333496983","https://openalex.org/W2334057882","https://openalex.org/W2346792764","https://openalex.org/W2511214913","https://openalex.org/W2747950529","https://openalex.org/W2792362613","https://openalex.org/W2808345903","https://openalex.org/W2895366230","https://openalex.org/W2913875306","https://openalex.org/W2942829220","https://openalex.org/W2961626135","https://openalex.org/W2978629681","https://openalex.org/W2981516637","https://openalex.org/W3005161501","https://openalex.org/W3037382645"],"related_works":["https://openalex.org/W3162547463","https://openalex.org/W4256464496","https://openalex.org/W1988032281","https://openalex.org/W4409708438","https://openalex.org/W4387376479","https://openalex.org/W3216263735","https://openalex.org/W2017739927","https://openalex.org/W1968056001","https://openalex.org/W2081684886","https://openalex.org/W3127658848"],"abstract_inverted_index":{"Summary":[0],"Glutarimide\u2010containing":[1],"polyketides":[2],"are":[3,146],"known":[4,42],"as":[5,117,183,185],"potent":[6],"antitumoral":[7],"and":[8,24,36,45,56,70,73,77,89,98,137,180],"antimetastatic":[9],"agents.":[10],"The":[11,28,156],"associated":[12],"gene":[13,109,141,165],"clusters":[14,145,166],"have":[15],"only":[16],"been":[17],"identified":[18],"in":[19,86,135,139,162],"a":[20],"few":[21],"Streptomyces":[22],"producers":[23],"Burkholderia":[25],"gladioli":[26],"symbiont.":[27],"new":[29],"glutarimide\u2010family":[30],"polyketides,":[31],"denominated":[32],"sesbanimides":[33],"D,":[34],"E":[35],"F":[37],"along":[38],"with":[39],"the":[40,62,102,105,113,121,149,175,186],"previously":[41],"sesbanimide":[43,114],"A":[44],"C,":[46],"were":[47,65],"isolated":[48,63],"from":[49],"two":[50],"marine":[51],"alphaproteobacteria":[52],"Stappia":[53],"indica":[54],"PHM037":[55],"Labrenzia":[57],"aggregata":[58],"PHM038.":[59],"Structures":[60],"of":[61,104,124,151,159,188],"compounds":[64,81],"elucidated":[66],"based":[67],"on":[68],"1D":[69],"2D":[71],"homo":[72],"heteronuclear":[74],"NMR":[75],"analyses":[76],"ESI\u2010MS":[78],"spectrometry.":[79],"All":[80],"exhibited":[82],"strong":[83],"antitumor":[84],"activity":[85],"lung,":[87],"breast":[88],"colorectal":[90],"cancer":[91],"cell":[92],"lines.":[93],"Subsequent":[94],"whole":[95],"genome":[96,99],"sequencing":[97],"mining":[100],"revealed":[101,130],"presence":[103,158],"trans":[106],"\u2010AT":[107],"PKS":[108],"cluster":[110],"responsible":[111,147],"for":[112,148],"biosynthesis,":[115],"described":[116],"sbn":[118],"cluster.":[119],"Strikingly,":[120],"modular":[122],"architecture":[123],"downstream":[125],"mixed":[126],"type":[127],"PKS/NRPS,":[128],"SbnQ,":[129],"high":[131],"similarity":[132],"to":[133],"PedH":[134],"pederin":[136],"Lab13":[138],"labrenzin":[140],"clusters,":[142],"although":[143],"those":[144],"production":[150],"structurally":[152],"completely":[153],"different":[154],"molecules.":[155],"unexpected":[157],"SbnQ":[160],"homologues":[161],"unrelated":[163],"polyketide":[164],"across":[167],"phylogenetically":[168],"distant":[169],"bacteria,":[170],"raises":[171],"intriguing":[172],"questions":[173],"about":[174],"evolutionary":[176],"relationship":[177],"between":[178],"glutarimide\u2010like":[179],"pederin\u2010like":[181],"pathways,":[182],"well":[184],"functionality":[187],"their":[189],"synthetic":[190],"products.":[191]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2021-03-29T00:00:00"}