{"id":"https://openalex.org/W3137968445","doi":"https://doi.org/10.18502/cmm.6.3.4500","title":"Generalized exfoliative skin rash as an early predictor of supratherapeutic voriconazole trough levels in a leukemic child: A case report","display_name":"Generalized exfoliative skin rash as an early predictor of supratherapeutic voriconazole trough levels in a leukemic child: A case report","publication_year":2020,"publication_date":"2020-10-28","ids":{"openalex":"https://openalex.org/W3137968445","doi":"https://doi.org/10.18502/cmm.6.3.4500","mag":"3137968445","pmid":"https://pubmed.ncbi.nlm.nih.gov/33834148","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8018824"},"language":"en","primary_location":{"id":"doi:10.18502/cmm.6.3.4500","doi":"https://doi.org/10.18502/cmm.6.3.4500","is_oa":true,"landing_page_url":"https://doi.org/10.18502/cmm.6.3.4500","pdf_url":null,"source":{"id":"https://openalex.org/S4210220295","display_name":"Current Medical Mycology","issn_l":"2423-3420","issn":["2423-3420","2423-3439"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319134","host_organization_name":"Mazandaran University of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310319134"],"host_organization_lineage_names":["Mazandaran University of Medical Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Medical Mycology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.18502/cmm.6.3.4500","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008506007","display_name":"Ali Amanati","orcid":"https://orcid.org/0000-0001-9173-2853","observed_orcids":["https://orcid.org/0000-0001-9173-2853"]},"institutions":[{"id":"https://openalex.org/I194604659","display_name":"Shiraz University of Medical Sciences","ror":"https://ror.org/01n3s4692","country_code":"IR","type":"education","lineage":["https://openalex.org/I194604659"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Ali Amanati","raw_affiliation_strings":["Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran","institution_ids":["https://openalex.org/I194604659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029361020","display_name":"Parisa Badiee","orcid":"https://orcid.org/0000-0003-4221-2995","observed_orcids":["https://orcid.org/0000-0003-4221-2995"]},"institutions":[{"id":"https://openalex.org/I194604659","display_name":"Shiraz University of Medical Sciences","ror":"https://ror.org/01n3s4692","country_code":"IR","type":"education","lineage":["https://openalex.org/I194604659"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Parisa Badiee","raw_affiliation_strings":["Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Professor Alborzi Clinical Microbiology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran","institution_ids":["https://openalex.org/I194604659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073053021","display_name":"Mehrzad Lotfi","orcid":"https://orcid.org/0000-0001-5192-4930","observed_orcids":["https://orcid.org/0000-0001-5192-4930"]},"institutions":[{"id":"https://openalex.org/I194604659","display_name":"Shiraz University of Medical Sciences","ror":"https://ror.org/01n3s4692","country_code":"IR","type":"education","lineage":["https://openalex.org/I194604659"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Mehrzad Lotfi","raw_affiliation_strings":["Medical Imaging Research Center, Department of Radiology, Shiraz University of Medical Sciences, Shiraz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Imaging Research Center, Department of Radiology, Shiraz University of Medical Sciences, Shiraz, Iran","institution_ids":["https://openalex.org/I194604659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006962453","display_name":"Ahmad Monabati","orcid":"https://orcid.org/0000-0002-3378-1937","observed_orcids":["https://orcid.org/0000-0002-3378-1937"]},"institutions":[{"id":"https://openalex.org/I194604659","display_name":"Shiraz University of Medical Sciences","ror":"https://ror.org/01n3s4692","country_code":"IR","type":"education","lineage":["https://openalex.org/I194604659"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Ahmad Monabati","raw_affiliation_strings":["Department of Hematopathology, Molecular Pathology and Cytogenetics, Shiraz University of Medical Sciences, Shiraz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematopathology, Molecular Pathology and Cytogenetics, Shiraz University of Medical Sciences, Shiraz, Iran","institution_ids":["https://openalex.org/I194604659"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088828479","display_name":"Mohammad Ali Faghihi","orcid":"https://orcid.org/0000-0002-8330-9067","observed_orcids":["https://orcid.org/0000-0002-8330-9067"]},"institutions":[{"id":"https://openalex.org/I145608581","display_name":"University of Miami","ror":"https://ror.org/02dgjyy92","country_code":"US","type":"education","lineage":["https://openalex.org/I145608581"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohammad Ali Faghihi","raw_affiliation_strings":["Center for Therapeutic Innovation, Department of Psychiatry and Behavioral Sciences, University of Miami, Miami, USA","Persian Bayan Gene Research and Training Center, Shiraz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Therapeutic Innovation, Department of Psychiatry and Behavioral Sciences, University of Miami, Miami, USA","institution_ids":["https://openalex.org/I145608581"]},{"raw_affiliation_string":"Persian Bayan Gene Research and Training Center, Shiraz, Iran","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081708128","display_name":"Majid Yavarian","orcid":"https://orcid.org/0000-0002-4708-6281","observed_orcids":["https://orcid.org/0000-0002-4708-6281"]},"institutions":[{"id":"https://openalex.org/I166459259","display_name":"Shiraz University","ror":"https://ror.org/028qtbk54","country_code":"IR","type":"education","lineage":["https://openalex.org/I166459259"]},{"id":"https://openalex.org/I194604659","display_name":"Shiraz University of Medical Sciences","ror":"https://ror.org/01n3s4692","country_code":"IR","type":"education","lineage":["https://openalex.org/I194604659"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Majid Yavarian","raw_affiliation_strings":["Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran","Persian Bayan Gene Research and Training Center, Shiraz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran","institution_ids":["https://openalex.org/I166459259","https://openalex.org/I194604659"]},{"raw_affiliation_string":"Persian Bayan Gene Research and Training Center, Shiraz, Iran","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020048116","display_name":"Nazafarin Hatami-Mazinani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I194604659","display_name":"Shiraz University of Medical Sciences","ror":"https://ror.org/01n3s4692","country_code":"IR","type":"education","lineage":["https://openalex.org/I194604659"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Nazafarin Hatami Mazinani","raw_affiliation_strings":["Department of Clinical Pharmacy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Pharmacy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran","institution_ids":["https://openalex.org/I194604659"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0329,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.49830615,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"6","issue":"3","first_page":"73","last_page":"78"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.8657000064849854,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.8657000064849854,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.08139999955892563,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12937","display_name":"Chemotherapy-related skin toxicity","score":0.024299999698996544,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/voriconazole","display_name":"voriconazole","score":0.9929999709129333},{"id":"https://openalex.org/keywords/drug-induced-rash","display_name":"drug rash","score":0.5730000138282776},{"id":"https://openalex.org/keywords/erythroderma","display_name":"erythroderma","score":0.9819999933242798},{"id":"https://openalex.org/keywords/supratherapeutic-drug-levels","display_name":"supratherapeutic drug levels","score":0.800000011920929},{"id":"https://openalex.org/keywords/t-cell-acute-lymphoblastic-leukemia","display_name":"T-cell acute lymphoblastic leukemia","score":0.8270000219345093},{"id":"https://openalex.org/keywords/pediatric-leukemia","display_name":"pediatric leukemia","score":0.7960000038146973},{"id":"https://openalex.org/keywords/caspofungin","display_name":"caspofungin","score":0.8669999837875366},{"id":"https://openalex.org/keywords/serum-drug-monitoring","display_name":"serum drug concentration monitoring","score":0.5720000267028809},{"id":"https://openalex.org/keywords/antifungal-prophylaxis","display_name":"antifungal prophylaxis","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.756239116191864},{"id":"https://openalex.org/C2780690907","wikidata":"https://www.wikidata.org/wiki/Q412236","display_name":"Voriconazole","level":3,"score":0.6380696296691895},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.5993156433105469},{"id":"https://openalex.org/C2778570526","wikidata":"https://www.wikidata.org/wiki/Q653197","display_name":"Rash","level":2,"score":0.5671625137329102},{"id":"https://openalex.org/C2780402444","wikidata":"https://www.wikidata.org/wiki/Q420875","display_name":"Caspofungin","level":4,"score":0.4999210834503174},{"id":"https://openalex.org/C2780664588","wikidata":"https://www.wikidata.org/wiki/Q1878682","display_name":"Toxic epidermal necrolysis","level":2,"score":0.44236642122268677},{"id":"https://openalex.org/C2778784858","wikidata":"https://www.wikidata.org/wiki/Q1363741","display_name":"Erythroderma","level":2,"score":0.4375268220901489},{"id":"https://openalex.org/C2779548794","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal","level":2,"score":0.0838787853717804}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.18502/cmm.6.3.4500","doi":"https://doi.org/10.18502/cmm.6.3.4500","is_oa":true,"landing_page_url":"https://doi.org/10.18502/cmm.6.3.4500","pdf_url":null,"source":{"id":"https://openalex.org/S4210220295","display_name":"Current Medical Mycology","issn_l":"2423-3420","issn":["2423-3420","2423-3439"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319134","host_organization_name":"Mazandaran University of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310319134"],"host_organization_lineage_names":["Mazandaran University of Medical Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Medical Mycology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8018824","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8018824","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Curr Med Mycol","raw_type":"Text"},{"id":"pmid:33834148","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33834148","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current medical mycology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:97adbbd76b7245cea00450e1dfb4ca62","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/97adbbd76b7245cea00450e1dfb4ca62","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Current Medical Mycology, Vol 6, Iss 3, Pp 73-78 (2020)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.18502/cmm.6.3.4500","doi":"https://doi.org/10.18502/cmm.6.3.4500","is_oa":true,"landing_page_url":"https://doi.org/10.18502/cmm.6.3.4500","pdf_url":null,"source":{"id":"https://openalex.org/S4210220295","display_name":"Current Medical Mycology","issn_l":"2423-3420","issn":["2423-3420","2423-3439"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20","russia-white-list-3"],"host_organization":"https://openalex.org/P4310319134","host_organization_name":"Mazandaran University of Medical Sciences","host_organization_lineage":["https://openalex.org/P4310319134"],"host_organization_lineage_names":["Mazandaran University of Medical Sciences"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Medical Mycology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8199999928474426,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W38637850","https://openalex.org/W1009689743","https://openalex.org/W1834911564","https://openalex.org/W1900202826","https://openalex.org/W1964720826","https://openalex.org/W1967864006","https://openalex.org/W1989617949","https://openalex.org/W1995236993","https://openalex.org/W2031250753","https://openalex.org/W2056863521","https://openalex.org/W2063280109","https://openalex.org/W2077645320","https://openalex.org/W2082695689","https://openalex.org/W2088158906","https://openalex.org/W2105376278","https://openalex.org/W2135215253","https://openalex.org/W2135256580","https://openalex.org/W2160097634","https://openalex.org/W2162857158","https://openalex.org/W2163554629","https://openalex.org/W2163659090","https://openalex.org/W2393833631","https://openalex.org/W2795983009","https://openalex.org/W2890671382","https://openalex.org/W2992250822","https://openalex.org/W3044675649"],"related_works":["https://openalex.org/W1834911564","https://openalex.org/W2113696780","https://openalex.org/W7214202841","https://openalex.org/W4244187596","https://openalex.org/W7170359069","https://openalex.org/W4385684211","https://openalex.org/W2163082049","https://openalex.org/W2096908731","https://openalex.org/W2615855170","https://openalex.org/W2274146398"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1],"PURPOSE:":[2],"Skin":[3],"rashes,":[4],"mostly":[5],"seen":[6],"in":[7,51,67,83,156,171,194],"children":[8],"and":[9,90,126,141],"adolescents,":[10],"are":[11],"considered":[12,205],"among":[13],"the":[14,112,116,127,142,160,195,217,225],"most":[15],"common":[16],"side":[17,42,63],"effects":[18,43],"of":[19,25,65,166,197,220],"azole":[20],"antifungals.":[21],"Although":[22],"therapeutic":[23,200],"concentrations":[24],"voriconazole":[26],"(VCZ)":[27],"have":[28],"been":[29],"documented":[30],"for":[31,162,168],"infected":[32],"skin,":[33],"there":[34],"is":[35,212],"no":[36],"evidence":[37],"specifying":[38],"whether":[39],"specific":[40],"dermatologic":[41,176],"could":[44,190],"predict":[45],"high":[46,164,221],"VCZ":[47,66,95,108,118,123,169,187,222],"serum":[48,109],"concentration,":[49],"especially":[50,178],"high-risk":[52],"leukemic":[53],"children.":[54],"CASE":[55],"REPORT:":[56],"Herein,":[57],"we":[58],"report":[59],"a":[60,68,121,163,208],"unique":[61,153],"skin":[62,101,106,181,226],"effect":[64,219],"5-year-old":[69],"boy":[70],"with":[71,131,149,174],"T-cell":[72],"acute":[73],"lymphoblastic":[74],"leukemia":[75],"(ALL)":[76],"referred":[77],"to":[78,98,104,206,214],"Amir":[79],"Medical":[80],"Oncology":[81],"Center":[82],"Shiraz,":[84],"Iran.":[85],"The":[86,133,152],"patient":[87,128,143,173],"experienced":[88],"erythroderma":[89],"macular":[91],"rashes":[92],"shortly":[93],"after":[94],"consumption,":[96],"leading":[97],"generalized":[99,179],"exfoliative":[100,180],"rashes.":[102,182],"Concurrent":[103],"these":[105],"manifestations,":[107,177],"concentration":[110,189,223],"reached":[111],"supratherapeutic":[113,188],"levels":[114],"despite":[115],"recommended":[117],"doses.":[119],"As":[120],"result,":[122],"was":[124,129],"withheld,":[125],"treated":[130],"caspofungin.":[132,150],"lesions":[134],"were":[135],"resolved":[136],"gradually":[137],"within":[138],"2":[139],"weeks,":[140],"successfully":[144],"completed":[145],"his":[146],"treatment":[147],"course":[148,196],"CONCLUSION:":[151],"case":[154],"presented":[155],"this":[157,185],"study":[158],"emphasizes":[159],"need":[161],"index":[165],"suspicion":[167],"toxicity":[170],"any":[172],"atypical":[175],"Based":[183],"on":[184,224],"report,":[186],"be":[191,204],"predicted":[192],"early":[193],"treatment.":[198],"Additional":[199],"dose":[201],"monitoring":[202],"should":[203],"establish":[207],"confirmatory":[209],"diagnosis.":[210],"It":[211],"required":[213],"further":[215],"investigate":[216],"toxic":[218],"epithelium.":[227]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2021-03-29T00:00:00"}
