{"id":"https://openalex.org/W3137965592","doi":"https://doi.org/10.1016/j.jlr.2021.100071","title":"ANGPTL4 sensitizes lipoprotein lipase to PCSK3 cleavage by catalyzing its unfolding","display_name":"ANGPTL4 sensitizes lipoprotein lipase to PCSK3 cleavage by catalyzing its unfolding","publication_year":2021,"publication_date":"2021-01-01","ids":{"openalex":"https://openalex.org/W3137965592","doi":"https://doi.org/10.1016/j.jlr.2021.100071","mag":"3137965592","pmid":"https://pubmed.ncbi.nlm.nih.gov/33771536","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8175412"},"language":"en","primary_location":{"id":"doi:10.1016/j.jlr.2021.100071","doi":"https://doi.org/10.1016/j.jlr.2021.100071","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jlr.2021.100071","pdf_url":"http://www.jlr.org/article/S0022227521000535/pdf","source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"http://www.jlr.org/article/S0022227521000535/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5062435076","display_name":"Anne-Marie Lund Winther","orcid":"https://orcid.org/0000-0002-5776-0989","observed_orcids":["https://orcid.org/0000-0002-5776-0989"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Anne-Marie Lund Winther","raw_affiliation_strings":["Finsen Laboratory, Rigshospitalet, Copenhagen, Denmark; Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark","Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark","Finsen Laboratory, Rigshospitalet, Copenhagen, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-5776-0989","affiliations":[{"raw_affiliation_string":"Finsen Laboratory, Rigshospitalet, Copenhagen, Denmark; Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2802709434"]},{"raw_affiliation_string":"Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"Finsen Laboratory, Rigshospitalet, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2802709434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073655202","display_name":"Anni Kumari","orcid":"https://orcid.org/0000-0001-8245-269X","observed_orcids":["https://orcid.org/0000-0001-8245-269X"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Anni Kumari","raw_affiliation_strings":["Finsen Laboratory, Rigshospitalet, Copenhagen, Denmark; Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark","Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark","Finsen Laboratory, Rigshospitalet, Copenhagen, Denmark"],"raw_orcid":"https://orcid.org/0000-0001-8245-269X","affiliations":[{"raw_affiliation_string":"Finsen Laboratory, Rigshospitalet, Copenhagen, Denmark; Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2802709434"]},{"raw_affiliation_string":"Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"Finsen Laboratory, Rigshospitalet, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2802709434"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085755071","display_name":"Stephen G. Young","orcid":"https://orcid.org/0000-0001-7270-3176","observed_orcids":["https://orcid.org/0000-0001-7270-3176"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen G. Young","raw_affiliation_strings":["Department of Medicine, University of California, Los Angeles, CA, USA; Department of Human Genetics, University of California, Los Angeles, CA, USA","Department of Human Genetics, University of California, Los Angeles, CA, USA","Department of Medicine, University of California, Los Angeles, CA, USA"],"raw_orcid":"https://orcid.org/0000-0001-7270-3176","affiliations":[{"raw_affiliation_string":"Department of Medicine, University of California, Los Angeles, CA, USA; Department of Human Genetics, University of California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Human Genetics, University of California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Medicine, University of California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5071117617","display_name":"Michael Ploug","orcid":"https://orcid.org/0000-0003-2215-4265","observed_orcids":["https://orcid.org/0000-0003-2215-4265"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I2802709434","display_name":"Rigshospitalet","ror":"https://ror.org/03mchdq19","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2802567020","https://openalex.org/I2802709434","https://openalex.org/I4210145385"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Michael Ploug","raw_affiliation_strings":["Finsen Laboratory, Rigshospitalet, Copenhagen, Denmark; Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark. Electronic address: m-ploug@finsenlab.dk","Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark","Finsen Laboratory, Rigshospitalet, Copenhagen, Denmark"],"raw_orcid":"https://orcid.org/0000-0003-2215-4265","affiliations":[{"raw_affiliation_string":"Finsen Laboratory, Rigshospitalet, Copenhagen, Denmark; Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark. Electronic address: m-ploug@finsenlab.dk","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2802709434"]},{"raw_affiliation_string":"Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"Finsen Laboratory, Rigshospitalet, Copenhagen, Denmark","institution_ids":["https://openalex.org/I2802709434"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5071117617"],"corresponding_institution_ids":["https://openalex.org/I124055696","https://openalex.org/I2802709434"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":{"value":2500,"currency":"USD","value_usd":2500},"fwci":1.8422,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.86636094,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"62","issue":null,"first_page":"100071","last_page":"100071"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13430","display_name":"Lipid metabolism and disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/angptl4","display_name":"ANGPTL4","score":0.9980000257492065},{"id":"https://openalex.org/keywords/lipoprotein-lipase","display_name":"lipoprotein lipase","score":0.9660000205039978},{"id":"https://openalex.org/keywords/protein-unfolding","display_name":"protein unfolding","score":0.828000009059906},{"id":"https://openalex.org/keywords/catalytic-domain","display_name":"catalytic domain","score":0.7250000238418579},{"id":"https://openalex.org/keywords/triglyceride-rich-lipoproteins","display_name":"triglyceride-rich lipoproteins","score":0.8550000190734863},{"id":"https://openalex.org/keywords/lipolysis","display_name":"lipolysis","score":0.8349999785423279},{"id":"https://openalex.org/keywords/gpihbp1","display_name":"GPIHBP1","score":0.7960000038146973},{"id":"https://openalex.org/keywords/hydrogen-deuterium-exchange","display_name":"hydrogen-deuterium exchange","score":0.8849999904632568},{"id":"https://openalex.org/keywords/protein-protein-binding","display_name":"protein-protein binding","score":0.5699999928474426},{"id":"https://openalex.org/keywords/capillary-endothelium","display_name":"capillary endothelium","score":0.6520000100135803},{"id":"https://openalex.org/keywords/adipose-tissue","display_name":"adipose tissue","score":0.8629999756813049}],"concepts":[{"id":"https://openalex.org/C77305985","wikidata":"https://www.wikidata.org/wiki/Q18040028","display_name":"ANGPTL4","level":3,"score":0.8538824319839478},{"id":"https://openalex.org/C94879076","wikidata":"https://www.wikidata.org/wiki/Q420014","display_name":"Lipoprotein lipase","level":3,"score":0.7313017249107361},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6440873742103577},{"id":"https://openalex.org/C2777062983","wikidata":"https://www.wikidata.org/wiki/Q21126841","display_name":"Adipose triglyceride lipase","level":4,"score":0.6354787349700928},{"id":"https://openalex.org/C2778913445","wikidata":"https://www.wikidata.org/wiki/Q186319","display_name":"Triglyceride","level":3,"score":0.4307456612586975},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3772052526473999},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.3572048246860504},{"id":"https://openalex.org/C2779697368","wikidata":"https://www.wikidata.org/wiki/Q380967","display_name":"Lipase","level":3,"score":0.35195791721343994},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3201552629470825},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.1832556426525116},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1300903856754303}],"mesh":[{"descriptor_ui":"D000075803","descriptor_name":"Angiopoietin-Like Protein 4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000075803","descriptor_name":"Angiopoietin-Like Protein 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008071","descriptor_name":"Lipoprotein Lipase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D058767","descriptor_name":"Protein Unfolding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1016/j.jlr.2021.100071","doi":"https://doi.org/10.1016/j.jlr.2021.100071","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jlr.2021.100071","pdf_url":"http://www.jlr.org/article/S0022227521000535/pdf","source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8175412","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8175412","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Lipid Res","raw_type":"Text"},{"id":"pmid:33771536","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33771536","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of lipid research","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:a9e0f04d5e584cf18a6de908d5ece740","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a9e0f04d5e584cf18a6de908d5ece740","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Lipid Research, Vol 62, Iss , Pp 100071- (2021)","raw_type":"article"},{"id":"pmh:oai:pure.atira.dk:openaire/fd8a9dd6-d7be-4b62-a7dc-8e2f2359fa23","doi":null,"is_oa":true,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/fd8a9dd6-d7be-4b62-a7dc-8e2f2359fa23","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Lund Winther, A-M, Kumari, A, Young, S G & Ploug, M 2021, 'ANGPTL4 sensitizes lipoprotein lipase to PCSK3 cleavage by catalyzing its unfolding', Journal of Lipid Research, vol. 62, 100071. https://doi.org/10.1016/j.jlr.2021.100071","raw_type":"info:eu-repo/semantics/annotation"}],"best_oa_location":{"id":"doi:10.1016/j.jlr.2021.100071","doi":"https://doi.org/10.1016/j.jlr.2021.100071","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jlr.2021.100071","pdf_url":"http://www.jlr.org/article/S0022227521000535/pdf","source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.766700029373169,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1909123573","display_name":"Refining Physiologic Mechanisms for Intravascular Triglyceride Metabolism","funder_award_id":"R01HL087228","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2195428415","display_name":"New approaches for understanding lipid movement in health and disease","funder_award_id":"P01HL146358","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2772487540","display_name":null,"funder_award_id":"R230\u20132016\u20132930","funder_id":"https://openalex.org/F4320321999","funder_display_name":"Lundbeckfonden"},{"id":"https://openalex.org/G2991559264","display_name":null,"funder_award_id":"NNF17OC0026868","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"},{"id":"https://openalex.org/G331281257","display_name":null,"funder_award_id":"HL-087228","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3752646566","display_name":null,"funder_award_id":"HL139725","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4193003059","display_name":null,"funder_award_id":"HL146358","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G434337789","display_name":null,"funder_award_id":"HORIZON2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5216767855","display_name":null,"funder_award_id":"NNF20OC0063444","funder_id":"https://openalex.org/F4320322436","funder_display_name":"Novo Nordisk"},{"id":"https://openalex.org/G5841387489","display_name":"Investigating Mechanisms for Lipid Transport in Health and Disease","funder_award_id":"R35HL139725","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7068895712","display_name":null,"funder_award_id":"801481","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"},{"id":"https://openalex.org/G822537046","display_name":null,"funder_award_id":"NNF18OC0033864","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"},{"id":"https://openalex.org/G8315213195","display_name":null,"funder_award_id":"NNF17OC0026868","funder_id":"https://openalex.org/F4320322436","funder_display_name":"Novo Nordisk"},{"id":"https://openalex.org/G8556136195","display_name":null,"funder_award_id":"NNF18OC0033864","funder_id":"https://openalex.org/F4320322436","funder_display_name":"Novo Nordisk"},{"id":"https://openalex.org/G8981266112","display_name":null,"funder_award_id":"NNF20OC0063444","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"},{"id":"https://openalex.org/G906120448","display_name":"International Doctoral Programme in Molecular Mechanisms of Disease","funder_award_id":"801481","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321999","display_name":"Lundbeckfonden","ror":"https://ror.org/03hz8wd80"},{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"},{"id":"https://openalex.org/F4320325957","display_name":"Novo Nordisk Fonden","ror":"https://ror.org/04txyc737"},{"id":"https://openalex.org/F4320327918","display_name":"H. Lundbeck A/S","ror":"https://ror.org/0564cd633"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3137965592.pdf","grobid_xml":"https://content.openalex.org/works/W3137965592.grobid-xml"},"referenced_works_count":5,"referenced_works":["https://openalex.org/W2559898767","https://openalex.org/W2884453662","https://openalex.org/W2956054395","https://openalex.org/W3138693900","https://openalex.org/W6730935714"],"related_works":["https://openalex.org/W3019949522","https://openalex.org/W4408668015","https://openalex.org/W1987813755","https://openalex.org/W2559898767","https://openalex.org/W3138693900","https://openalex.org/W24826586","https://openalex.org/W2094177365","https://openalex.org/W4301651702","https://openalex.org/W4366816414","https://openalex.org/W3004683289"],"abstract_inverted_index":{"The":[0],"lipolytic":[1],"processing":[2],"of":[3,17,52,61],"triglyceride-rich":[4],"lipoproteins":[5],"within":[6],"capillaries":[7],"is":[8],"mediated":[9],"by":[10],"LPL":[11,32],"complexed":[12],"to":[13,45,48],"GPIHBP1,":[14],"a":[15],"protein":[16,23],"capillary":[18],"endothelial":[19],"cells":[20],"(1).":[21],"Angiopoietin-like":[22],"4":[24],"(ANGPTL4)":[25],"plays":[26],"an":[27],"important":[28],"role":[29],"in":[30,35],"regulating":[31],"activity,":[33],"particularly":[34],"adipose":[36],"tissue.":[37],"Hydrogen-deuterium":[38],"exchange":[39],"experiments":[40],"show":[41],"that":[42],"ANGPTL4":[43,68],"binds":[44],"sequences":[46],"adjacent":[47],"the":[49],"catalytic":[50,63],"pocket":[51],"LPLs.":[53],"This":[54],"binding":[55],"triggers":[56],"progressive":[57],"and":[58],"irreversible":[59],"unfolding":[60],"LPLs":[62],"domain":[64],"(2,":[65],"3).":[66],"Importantly,":[67],"catalyzes":[69],"this":[70],"unfolding.":[71]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-03-29T00:00:00"}