{"id":"https://openalex.org/W3137937952","doi":"https://doi.org/10.1002/anie.202102153","title":"Antiprotozoal Structure\u2013Activity Relationships of Synthetic Leucinostatin Derivatives and Elucidation of their Mode of Action","display_name":"Antiprotozoal Structure\u2013Activity Relationships of Synthetic Leucinostatin Derivatives and Elucidation of their Mode of Action","publication_year":2021,"publication_date":"2021-03-17","ids":{"openalex":"https://openalex.org/W3137937952","doi":"https://doi.org/10.1002/anie.202102153","mag":"3137937952","pmid":"https://pubmed.ncbi.nlm.nih.gov/33730410","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8360131"},"language":"en","primary_location":{"id":"doi:10.1002/anie.202102153","doi":"https://doi.org/10.1002/anie.202102153","is_oa":true,"landing_page_url":"https://doi.org/10.1002/anie.202102153","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/anie.202102153","source":{"id":"https://openalex.org/S67393510","display_name":"Angewandte Chemie International Edition","issn_l":"1433-7851","issn":["1433-7851","1521-3773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie International Edition","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/anie.202102153","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5063891801","display_name":"Michael J. D. Brand","orcid":"https://orcid.org/0000-0002-6998-0516","observed_orcids":["https://orcid.org/0000-0002-6998-0516"]},"institutions":[{"id":"https://openalex.org/I858936495","display_name":"ZHAW Zurich University of Applied Sciences","ror":"https://ror.org/05pmsvm27","country_code":"CH","type":"education","lineage":["https://openalex.org/I858936495"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Michael Brand","raw_affiliation_strings":["Institute of Chemistry and Biotechnology Center for Organic and Medicinal Chemistry Zurich University of Applied Sciences (ZHAW)  Einsiedlerstrasse 31 8820 W\u00e4denswil Switzerland"],"raw_orcid":"https://orcid.org/0000-0002-6998-0516","affiliations":[{"raw_affiliation_string":"Institute of Chemistry and Biotechnology Center for Organic and Medicinal Chemistry Zurich University of Applied Sciences (ZHAW)  Einsiedlerstrasse 31 8820 W\u00e4denswil Switzerland","institution_ids":["https://openalex.org/I858936495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100435763","display_name":"Lei Wang","orcid":"https://orcid.org/0000-0001-7103-9402","observed_orcids":["https://orcid.org/0000-0001-7103-9402"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Lei Wang","raw_affiliation_strings":["Institute of Biochemistry and Molecular Medicine University of Bern  B\u00fchlstrasse 28 3012 Bern Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry and Molecular Medicine University of Bern  B\u00fchlstrasse 28 3012 Bern Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050581285","display_name":"Stefano Agnello","orcid":"https://orcid.org/0000-0003-4113-8674","observed_orcids":["https://orcid.org/0000-0003-4113-8674"]},"institutions":[{"id":"https://openalex.org/I858936495","display_name":"ZHAW Zurich University of Applied Sciences","ror":"https://ror.org/05pmsvm27","country_code":"CH","type":"education","lineage":["https://openalex.org/I858936495"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Stefano Agnello","raw_affiliation_strings":["Institute of Chemistry and Biotechnology Center for Organic and Medicinal Chemistry Zurich University of Applied Sciences (ZHAW)  Einsiedlerstrasse 31 8820 W\u00e4denswil Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chemistry and Biotechnology Center for Organic and Medicinal Chemistry Zurich University of Applied Sciences (ZHAW)  Einsiedlerstrasse 31 8820 W\u00e4denswil Switzerland","institution_ids":["https://openalex.org/I858936495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047174593","display_name":"Silvia Gazzola","orcid":"https://orcid.org/0000-0001-6745-3598","observed_orcids":["https://orcid.org/0000-0001-6745-3598"]},"institutions":[{"id":"https://openalex.org/I858936495","display_name":"ZHAW Zurich University of Applied Sciences","ror":"https://ror.org/05pmsvm27","country_code":"CH","type":"education","lineage":["https://openalex.org/I858936495"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Silvia Gazzola","raw_affiliation_strings":["Institute of Chemistry and Biotechnology Center for Organic and Medicinal Chemistry Zurich University of Applied Sciences (ZHAW)  Einsiedlerstrasse 31 8820 W\u00e4denswil Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chemistry and Biotechnology Center for Organic and Medicinal Chemistry Zurich University of Applied Sciences (ZHAW)  Einsiedlerstrasse 31 8820 W\u00e4denswil Switzerland","institution_ids":["https://openalex.org/I858936495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032905451","display_name":"Flavio M. Gall","orcid":"https://orcid.org/0000-0001-5243-1521","observed_orcids":["https://orcid.org/0000-0001-5243-1521"]},"institutions":[{"id":"https://openalex.org/I858936495","display_name":"ZHAW Zurich University of Applied Sciences","ror":"https://ror.org/05pmsvm27","country_code":"CH","type":"education","lineage":["https://openalex.org/I858936495"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Flavio M. Gall","raw_affiliation_strings":["Institute of Chemistry and Biotechnology Center for Organic and Medicinal Chemistry Zurich University of Applied Sciences (ZHAW)  Einsiedlerstrasse 31 8820 W\u00e4denswil Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chemistry and Biotechnology Center for Organic and Medicinal Chemistry Zurich University of Applied Sciences (ZHAW)  Einsiedlerstrasse 31 8820 W\u00e4denswil Switzerland","institution_ids":["https://openalex.org/I858936495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070640147","display_name":"Luka Ragu\u017e","orcid":"https://orcid.org/0000-0001-5383-3012","observed_orcids":["https://orcid.org/0000-0001-5383-3012"]},"institutions":[{"id":"https://openalex.org/I858936495","display_name":"ZHAW Zurich University of Applied Sciences","ror":"https://ror.org/05pmsvm27","country_code":"CH","type":"education","lineage":["https://openalex.org/I858936495"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Luka Ragu\u017e","raw_affiliation_strings":["Institute of Chemistry and Biotechnology Center for Organic and Medicinal Chemistry Zurich University of Applied Sciences (ZHAW)  Einsiedlerstrasse 31 8820 W\u00e4denswil Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Chemistry and Biotechnology Center for Organic and Medicinal Chemistry Zurich University of Applied Sciences (ZHAW)  Einsiedlerstrasse 31 8820 W\u00e4denswil Switzerland","institution_ids":["https://openalex.org/I858936495"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084123396","display_name":"Marcel Kaiser","orcid":"https://orcid.org/0000-0003-1785-7302","observed_orcids":["https://orcid.org/0000-0003-1785-7302"]},"institutions":[{"id":"https://openalex.org/I158937107","display_name":"Swiss Tropical and Public Health Institute","ror":"https://ror.org/03adhka07","country_code":"CH","type":"facility","lineage":["https://openalex.org/I158937107"]},{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Marcel Kaiser","raw_affiliation_strings":["Swiss Tropical and Public Health Institute, Socinstrasse 57, 4051 Basel, Switzerland","University of Basel, Petersplatz 1, 4001 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Swiss Tropical and Public Health Institute, Socinstrasse 57, 4051 Basel, Switzerland","institution_ids":["https://openalex.org/I158937107"]},{"raw_affiliation_string":"University of Basel, Petersplatz 1, 4001 Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051182008","display_name":"Remo S. Schmidt","orcid":"https://orcid.org/0000-0002-6599-9201","observed_orcids":["https://orcid.org/0000-0002-6599-9201"]},"institutions":[{"id":"https://openalex.org/I158937107","display_name":"Swiss Tropical and Public Health Institute","ror":"https://ror.org/03adhka07","country_code":"CH","type":"facility","lineage":["https://openalex.org/I158937107"]},{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Remo S. Schmidt","raw_affiliation_strings":["Swiss Tropical and Public Health Institute, Socinstrasse 57, 4051 Basel, Switzerland","University of Basel, Petersplatz 1, 4001 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Swiss Tropical and Public Health Institute, Socinstrasse 57, 4051 Basel, Switzerland","institution_ids":["https://openalex.org/I158937107"]},{"raw_affiliation_string":"University of Basel, Petersplatz 1, 4001 Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071241772","display_name":"Am\u00e9lie Ritschl","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I158937107","display_name":"Swiss Tropical and Public Health Institute","ror":"https://ror.org/03adhka07","country_code":"CH","type":"facility","lineage":["https://openalex.org/I158937107"]},{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Am\u00e9lie Ritschl","raw_affiliation_strings":["Swiss Tropical and Public Health Institute, Socinstrasse 57, 4051 Basel, Switzerland","University of Basel, Petersplatz 1, 4001 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Swiss Tropical and Public Health Institute, Socinstrasse 57, 4051 Basel, Switzerland","institution_ids":["https://openalex.org/I158937107"]},{"raw_affiliation_string":"University of Basel, Petersplatz 1, 4001 Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009773037","display_name":"Jennifer Jelk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Jennifer Jelk","raw_affiliation_strings":["Institute of Biochemistry and Molecular Medicine University of Bern  B\u00fchlstrasse 28 3012 Bern Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry and Molecular Medicine University of Bern  B\u00fchlstrasse 28 3012 Bern Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026773861","display_name":"Andrew Frederick Hemphill","orcid":"https://orcid.org/0000-0002-0622-2128","observed_orcids":["https://orcid.org/0000-0002-0622-2128"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Andrew Hemphill","raw_affiliation_strings":["Institute of Parasitology Vetsuisse Faculty University of Bern  L\u00e4nggass-Strasse 122 3012 Bern Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Parasitology Vetsuisse Faculty University of Bern  L\u00e4nggass-Strasse 122 3012 Bern Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010850019","display_name":"Pascal M\u00e4ser","orcid":"https://orcid.org/0000-0003-3122-1941","observed_orcids":["https://orcid.org/0000-0003-3122-1941"]},"institutions":[{"id":"https://openalex.org/I158937107","display_name":"Swiss Tropical and Public Health Institute","ror":"https://ror.org/03adhka07","country_code":"CH","type":"facility","lineage":["https://openalex.org/I158937107"]},{"id":"https://openalex.org/I1850255","display_name":"University of Basel","ror":"https://ror.org/02s6k3f65","country_code":"CH","type":"education","lineage":["https://openalex.org/I1850255"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Pascal M\u00e4ser","raw_affiliation_strings":["Swiss Tropical and Public Health Institute, Socinstrasse 57, 4051 Basel, Switzerland","University of Basel, Petersplatz 1, 4001 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Swiss Tropical and Public Health Institute, Socinstrasse 57, 4051 Basel, Switzerland","institution_ids":["https://openalex.org/I158937107"]},{"raw_affiliation_string":"University of Basel, Petersplatz 1, 4001 Basel, Switzerland","institution_ids":["https://openalex.org/I1850255"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050868687","display_name":"Peter B\u00fctikofer","orcid":"https://orcid.org/0000-0001-9360-1013","observed_orcids":["https://orcid.org/0000-0001-9360-1013"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Peter B\u00fctikofer","raw_affiliation_strings":["Institute of Biochemistry and Molecular Medicine University of Bern  B\u00fchlstrasse 28 3012 Bern Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biochemistry and Molecular Medicine University of Bern  B\u00fchlstrasse 28 3012 Bern Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Michael Adams","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Michael Adams","raw_affiliation_strings":["Bacoba AG, Elisabethenstrasse 15, 4051 Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bacoba AG, Elisabethenstrasse 15, 4051 Basel, Switzerland","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035054698","display_name":"Rainer Riedl","orcid":"https://orcid.org/0000-0003-2534-1963","observed_orcids":["https://orcid.org/0000-0003-2534-1963"]},"institutions":[{"id":"https://openalex.org/I858936495","display_name":"ZHAW Zurich University of Applied Sciences","ror":"https://ror.org/05pmsvm27","country_code":"CH","type":"education","lineage":["https://openalex.org/I858936495"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Rainer Riedl","raw_affiliation_strings":["Institute of Chemistry and Biotechnology Center for Organic and Medicinal Chemistry Zurich University of Applied Sciences (ZHAW)  Einsiedlerstrasse 31 8820 W\u00e4denswil Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-2534-1963","affiliations":[{"raw_affiliation_string":"Institute of Chemistry and Biotechnology Center for Organic and Medicinal Chemistry Zurich University of Applied Sciences (ZHAW)  Einsiedlerstrasse 31 8820 W\u00e4denswil Switzerland","institution_ids":["https://openalex.org/I858936495"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5035054698"],"corresponding_institution_ids":["https://openalex.org/I858936495"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":{"value":5000,"currency":"USD","value_usd":5000},"fwci":1.8219,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.83263047,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":97},"biblio":{"volume":"60","issue":"28","first_page":"15613","last_page":"15621"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10890","display_name":"Trypanosoma species research and implications","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13188","display_name":"Synthesis and bioactivity of alkaloids","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antiprotozoal-agents","display_name":"antiprotozoal agents","score":0.8109999895095825},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.925000011920929},{"id":"https://openalex.org/keywords/trypanosoma-brucei","display_name":"Trypanosoma brucei","score":0.9990000128746033},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.7020000219345093},{"id":"https://openalex.org/keywords/membrane-potential","display_name":"membrane potential","score":0.527999997138977},{"id":"https://openalex.org/keywords/sirna-screening","display_name":"siRNA screening","score":0.4880000054836273},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"drug resistance","score":0.7440000176429749}],"concepts":[{"id":"https://openalex.org/C2776635100","wikidata":"https://www.wikidata.org/wiki/Q582559","display_name":"Antiprotozoal","level":3,"score":0.9841430187225342},{"id":"https://openalex.org/C121587506","wikidata":"https://www.wikidata.org/wiki/Q6888113","display_name":"Mode of action","level":2,"score":0.7610343098640442},{"id":"https://openalex.org/C2779502636","wikidata":"https://www.wikidata.org/wiki/Q33244","display_name":"Trypanosoma brucei","level":3,"score":0.7353319525718689},{"id":"https://openalex.org/C168240541","wikidata":"https://www.wikidata.org/wiki/Q45948","display_name":"Organelle","level":2,"score":0.5353906750679016},{"id":"https://openalex.org/C2778918659","wikidata":"https://www.wikidata.org/wiki/Q186915","display_name":"Phospholipid","level":3,"score":0.5181226134300232},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.510316789150238},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4822271764278412},{"id":"https://openalex.org/C75385678","wikidata":"https://www.wikidata.org/wiki/Q4896390","display_name":"Inner mitochondrial membrane","level":3,"score":0.4770975708961487},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.47072044014930725},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.4561466872692108},{"id":"https://openalex.org/C185154212","wikidata":"https://www.wikidata.org/wiki/Q410454","display_name":"Liposome","level":2,"score":0.4409600794315338},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3983319401741028},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.39302802085876465},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.37099286913871765},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.11868870258331299},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000981","descriptor_name":"Antiprotozoal Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000981","descriptor_name":"Antiprotozoal Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000981","descriptor_name":"Antiprotozoal Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014346","descriptor_name":"Trypanosoma brucei brucei","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D014346","descriptor_name":"Trypanosoma brucei brucei","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D021261","descriptor_name":"Parasitic Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023181","descriptor_name":"Antimicrobial Cationic Peptides","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D023181","descriptor_name":"Antimicrobial Cationic Peptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D023181","descriptor_name":"Antimicrobial Cationic Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1002/anie.202102153","doi":"https://doi.org/10.1002/anie.202102153","is_oa":true,"landing_page_url":"https://doi.org/10.1002/anie.202102153","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/anie.202102153","source":{"id":"https://openalex.org/S67393510","display_name":"Angewandte Chemie International Edition","issn_l":"1433-7851","issn":["1433-7851","1521-3773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie International Edition","raw_type":"journal-article"},{"id":"pmid:33730410","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33730410","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie (International ed. in English)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8360131","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8360131/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angew Chem Int Ed Engl","raw_type":"Text"},{"id":"pmh:oai:edoc.unibas.ch:88978","doi":null,"is_oa":false,"landing_page_url":"https://edoc.unibas.ch/88978/1/20220719102748_62d66b04d33de.pdf","pdf_url":"https://edoc.unibas.ch/88978/1/20220719102748_62d66b04d33de.pdf","source":{"id":"https://openalex.org/S4306401836","display_name":"edoc (University of Basel)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1850255","host_organization_name":"University of Basel","host_organization_lineage":["https://openalex.org/I1850255"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:boris.unibe.ch:157902","doi":null,"is_oa":true,"landing_page_url":"https://boris.unibe.ch/157902/","pdf_url":"https://boris.unibe.ch/157902/","source":{"id":"https://openalex.org/S4306401086","display_name":"Bern Open Repository and Information System (University of Bern)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I118564535","host_organization_name":"University of Bern","host_organization_lineage":["https://openalex.org/I118564535"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:digitalcollection.zhaw.ch:11475/22883","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11475/22883","pdf_url":"https://digitalcollection.zhaw.ch/handle/11475/22883","source":{"id":"https://openalex.org/S4306401811","display_name":"Z\u00fcrcher Hochschule f\u00fcr Angewandte Wissenschaften digital collection (Zurich University of Applied Sciences)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I858936495","host_organization_name":"ZHAW Zurich University of Applied Sciences","host_organization_lineage":["https://openalex.org/I858936495"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:doi:10.48350/157902","doi":null,"is_oa":false,"landing_page_url":"https://boris-portal.unibe.ch/handle/20.500.12422/42869","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"pmh:oai:irinsubria.uninsubria.it:11383/2113265","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11383/2113265","pdf_url":null,"source":{"id":"https://openalex.org/S4377196351","display_name":"IrInSubria (University of Insubria)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I115752224","host_organization_name":"University of Insubria","host_organization_lineage":["https://openalex.org/I115752224"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1002/anie.202102153","doi":"https://doi.org/10.1002/anie.202102153","is_oa":true,"landing_page_url":"https://doi.org/10.1002/anie.202102153","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/anie.202102153","source":{"id":"https://openalex.org/S67393510","display_name":"Angewandte Chemie International Edition","issn_l":"1433-7851","issn":["1433-7851","1521-3773"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Angewandte Chemie International Edition","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1831044233","display_name":null,"funder_award_id":"16445.1 PFLS-LS and 19208.1 PFPL-LS","funder_id":"https://openalex.org/F4320320998","funder_display_name":"Kommission f\u00fcr Technologie und Innovation"},{"id":"https://openalex.org/G2078108940","display_name":null,"funder_award_id":"19208.1 PFPL-LS","funder_id":"https://openalex.org/F4320327931","funder_display_name":"Innosuisse - Schweizerische Agentur f\u00fcr Innovationsf\u00f6rderung"},{"id":"https://openalex.org/G3682716839","display_name":null,"funder_award_id":"16445.1 PFLS-LS","funder_id":"https://openalex.org/F4320327931","funder_display_name":"Innosuisse - Schweizerische Agentur f\u00fcr Innovationsf\u00f6rderung"},{"id":"https://openalex.org/G3952664734","display_name":"Effects of a double-edged sword: exploiting the interaction between immunity and chemotherapy in murine and ovine models of congenital neosporosis and toxoplasmosis","funder_award_id":"184662","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G4759445448","display_name":"Mitochondrial lipid synthesis in Trypanosoma brucei: protein complexes forming lipids and lipids forming protein complexes","funder_award_id":"169355","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G7153587834","display_name":null,"funder_award_id":"34227.1 IP-LS","funder_id":"https://openalex.org/F4320327931","funder_display_name":"Innosuisse - Schweizerische Agentur f\u00fcr Innovationsf\u00f6rderung"},{"id":"https://openalex.org/G7631565876","display_name":"Development of a new predictive solubility equation for drugs based ont the thermodynamics of mobile order","funder_award_id":"34227","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G8690818240","display_name":null,"funder_award_id":"310030","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309607","display_name":"Velux Stiftung","ror":"https://ror.org/00kgf1c95"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320320998","display_name":"Kommission f\u00fcr Technologie und Innovation","ror":"https://ror.org/012y9zp98"},{"id":"https://openalex.org/F4320327931","display_name":"Innosuisse - Schweizerische Agentur f\u00fcr Innovationsf\u00f6rderung","ror":"https://ror.org/05a2bhn71"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3137937952.pdf","grobid_xml":"https://content.openalex.org/works/W3137937952.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1964318956","https://openalex.org/W1965318658","https://openalex.org/W1967969517","https://openalex.org/W1987303464","https://openalex.org/W1987647341","https://openalex.org/W1989817448","https://openalex.org/W1995253936","https://openalex.org/W2025039420","https://openalex.org/W2032481049","https://openalex.org/W2036531953","https://openalex.org/W2045554838","https://openalex.org/W2079026251","https://openalex.org/W2092159508","https://openalex.org/W2099847350","https://openalex.org/W2099925248","https://openalex.org/W2116350092","https://openalex.org/W2136006818","https://openalex.org/W2161956414","https://openalex.org/W2472341050","https://openalex.org/W2605324091","https://openalex.org/W2735989981","https://openalex.org/W2792202407","https://openalex.org/W2800538677","https://openalex.org/W2803984019","https://openalex.org/W2895666882","https://openalex.org/W2941192242","https://openalex.org/W2946554283","https://openalex.org/W3122131477","https://openalex.org/W4299947650"],"related_works":["https://openalex.org/W3156466891","https://openalex.org/W6888516783","https://openalex.org/W3176568541","https://openalex.org/W2983109795","https://openalex.org/W1974741353","https://openalex.org/W1971965890","https://openalex.org/W7203822407","https://openalex.org/W2982789199","https://openalex.org/W2939367718","https://openalex.org/W2003398755"],"abstract_inverted_index":{"Leucinostatin":[0],"A":[1],"is":[2,82],"one":[3],"of":[4,53,80,89,111,114,123,141,149,155],"the":[5,54,121,124,159],"most":[6],"potent":[7],"antiprotozoal":[8,63,112],"compounds":[9,40],"ever":[10],"described,":[11],"but":[12,37],"little":[13],"was":[14],"known":[15],"on":[16,85],"structure-activity":[17,87],"relationships":[18],"(SAR).":[19],"We":[20],"used":[21],"Trypanosoma":[22],"brucei":[23,143],"as":[24,128],"a":[25,86],"protozoal":[26],"model":[27],"organism":[28],"to":[29,56,158],"test":[30],"synthetically":[31],"modified":[32,49],"derivatives,":[33],"resulting":[34],"in":[35,50,67,91,95,120],"simplified":[36],"equally":[38],"active":[39],"2":[41],"(ZHAWOC6025)":[42],"and":[43,74,98,105,116,135,146],"4":[44],"(ZHAWOC6027),":[45],"which":[46],"were":[47,76],"subsequently":[48],"all":[51],"regions":[52],"molecule":[55],"gain":[57],"an":[58],"in-depth":[59],"SAR":[60,64,66],"understanding.":[61],"The":[62,78,108],"matched":[65],"phospholipid":[68],"liposomes,":[69],"where":[70],"membrane":[71,100,103,106],"integrity,":[72],"leaking,":[73],"dynamics":[75],"studied.":[77],"mode":[79],"action":[81,113],"discussed":[83],"based":[84],"analysis":[88],"derivatives":[90],"efficacy,":[92],"ultrastructural":[93,131],"studies":[94],"T.":[96,142],"brucei,":[97],"artificial":[99],"models,":[101],"mimicking":[102],"stability":[104],"potential.":[107],"main":[109],"site":[110],"natural":[115],"synthetic":[117,160],"leucinostatins":[118],"lies":[119],"destabilization":[122],"inner":[125],"mitochondrial":[126,136],"membrane,":[127],"demonstrated":[129],"by":[130],"analysis,":[132],"electron":[133],"microscopy":[134],"staining.":[137],"Long-time":[138],"sublethal":[139],"exposure":[140],"(200":[144],"passages)":[145],"siRNA":[147],"screening":[148],"12'000":[150],"mutants":[151],"showed":[152],"no":[153],"signs":[154],"resistance":[156],"development":[157],"derivatives.":[161]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-03-29T00:00:00"}
