{"id":"https://openalex.org/W3137910158","doi":"https://doi.org/10.3390/cancers13071519","title":"OTX015 Epi-Drug Exerts Antitumor Effects in Ovarian Cancer Cells by Blocking GNL3-Mediated Radioresistance Mechanisms: Cellular, Molecular and Computational Evidence","display_name":"OTX015 Epi-Drug Exerts Antitumor Effects in Ovarian Cancer Cells by Blocking GNL3-Mediated Radioresistance Mechanisms: Cellular, Molecular and Computational Evidence","publication_year":2021,"publication_date":"2021-03-25","ids":{"openalex":"https://openalex.org/W3137910158","doi":"https://doi.org/10.3390/cancers13071519","mag":"3137910158","pmid":"https://pubmed.ncbi.nlm.nih.gov/33806232","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8059141"},"language":"en","primary_location":{"id":"doi:10.3390/cancers13071519","doi":"https://doi.org/10.3390/cancers13071519","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers13071519","pdf_url":"https://www.mdpi.com/2072-6694/13/7/1519/pdf?version=1616747114","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6694/13/7/1519/pdf?version=1616747114","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048517130","display_name":"Francesca Megiorni","orcid":"https://orcid.org/0000-0003-3705-3248","observed_orcids":["https://orcid.org/0000-0003-3705-3248"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Francesca Megiorni","raw_affiliation_strings":["Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039094924","display_name":"Simona Camero","orcid":"https://orcid.org/0000-0001-8286-3640","observed_orcids":["https://orcid.org/0000-0001-8286-3640"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Simona Camero","raw_affiliation_strings":["Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057342286","display_name":"Paola Pontecorvi","orcid":"https://orcid.org/0000-0003-2392-3775","observed_orcids":["https://orcid.org/0000-0003-2392-3775"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paola Pontecorvi","raw_affiliation_strings":["Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0003-2392-3775","affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079387366","display_name":"Lucrezia Camicia","orcid":"https://orcid.org/0000-0002-0154-6182","observed_orcids":["https://orcid.org/0000-0002-0154-6182"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lucrezia Camicia","raw_affiliation_strings":["Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051278445","display_name":"Francesco Marampon","orcid":"https://orcid.org/0000-0002-0588-3039","observed_orcids":["https://orcid.org/0000-0002-0588-3039"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Marampon","raw_affiliation_strings":["Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054410590","display_name":"Simona Ceccarelli","orcid":"https://orcid.org/0000-0001-8789-7719","observed_orcids":["https://orcid.org/0000-0001-8789-7719"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Simona Ceccarelli","raw_affiliation_strings":["Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0001-8789-7719","affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038581738","display_name":"Eleni Anastasiadou","orcid":"https://orcid.org/0000-0003-0212-6734","observed_orcids":["https://orcid.org/0000-0003-0212-6734"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Eleni Anastasiadou","raw_affiliation_strings":["Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0003-0212-6734","affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040520015","display_name":"Nicola Bernab\u00f2","orcid":"https://orcid.org/0000-0001-5140-9656","observed_orcids":["https://orcid.org/0000-0001-5140-9656"]},"institutions":[{"id":"https://openalex.org/I124326101","display_name":"University of Teramo","ror":"https://ror.org/01yetye73","country_code":"IT","type":"education","lineage":["https://openalex.org/I124326101"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Nicola Bernab\u00f2","raw_affiliation_strings":["Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo, Italy"],"raw_orcid":"https://orcid.org/0000-0001-5140-9656","affiliations":[{"raw_affiliation_string":"Faculty of Bioscience and Technology for Food, Agriculture and Environment, University of Teramo, 64100 Teramo, Italy","institution_ids":["https://openalex.org/I124326101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088920406","display_name":"Giorgia Perniola","orcid":"https://orcid.org/0000-0003-0321-9828","observed_orcids":["https://orcid.org/0000-0003-0321-9828"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giorgia Perniola","raw_affiliation_strings":["Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086706420","display_name":"Antonio Pizzuti","orcid":"https://orcid.org/0000-0003-3245-1925","observed_orcids":["https://orcid.org/0000-0003-3245-1925"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Antonio Pizzuti","raw_affiliation_strings":["Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070572496","display_name":"Pierluigi Benedetti Panici","orcid":"https://orcid.org/0000-0001-6752-2039","observed_orcids":["https://orcid.org/0000-0001-6752-2039"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Pierluigi Benedetti Panici","raw_affiliation_strings":["Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Maternal and Child Health and Urological Sciences, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015515380","display_name":"Vincenzo Tombolini","orcid":"https://orcid.org/0000-0001-5359-9991","observed_orcids":["https://orcid.org/0000-0001-5359-9991"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vincenzo Tombolini","raw_affiliation_strings":["Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiological, Oncological and Pathological Sciences, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075605378","display_name":"Cinzia Marchese","orcid":"https://orcid.org/0000-0002-9280-8917","observed_orcids":["https://orcid.org/0000-0002-9280-8917"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cinzia Marchese","raw_affiliation_strings":["Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0002-9280-8917","affiliations":[{"raw_affiliation_string":"Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5048517130"],"corresponding_institution_ids":["https://openalex.org/I861853513"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2376},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2376},"fwci":0.981,"has_fulltext":true,"cited_by_count":18,"citation_normalized_percentile":{"value":0.72119283,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"13","issue":"7","first_page":"1519","last_page":"1519"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.5863999724388123,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12534","display_name":"Protein Degradation and Inhibitors","score":0.5863999724388123,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10550","display_name":"Ovarian cancer diagnosis and treatment","score":0.21230000257492065,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11914","display_name":"PARP inhibition in cancer therapy","score":0.07349999994039536,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/otx015","display_name":"OTX015","score":0.9929999709129333},{"id":"https://openalex.org/keywords/bet-inhibitors","display_name":"BET inhibitors","score":0.7590000033378601},{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"ovarian cancer","score":0.875},{"id":"https://openalex.org/keywords/gnl3","display_name":"GNL3","score":0.890999972820282},{"id":"https://openalex.org/keywords/radioresistance-biology","display_name":"radioresistance (biology)","score":0.953000009059906},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.8859999775886536},{"id":"https://openalex.org/keywords/epigenetic-drugs","display_name":"epigenetic drugs","score":0.8930000066757202},{"id":"https://openalex.org/keywords/nucleolar-stress","display_name":"nucleolar stress","score":0.8259999752044678},{"id":"https://openalex.org/keywords/dna-damage","display_name":"DNA damage","score":0.9649999737739563},{"id":"https://openalex.org/keywords/cell-cycle-arrest","display_name":"cell cycle arrest","score":0.8809999823570251},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.8619999885559082},{"id":"https://openalex.org/keywords/gene-network-analysis","display_name":"gene network analysis","score":0.5720000267028809}],"concepts":[{"id":"https://openalex.org/C58962609","wikidata":"https://www.wikidata.org/wiki/Q2353022","display_name":"Radioresistance","level":3,"score":0.7229610085487366},{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.6624222993850708},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6042609214782715},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5640201568603516},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.49555695056915283},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4723590314388275},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.45978763699531555},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3982604146003723},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34810131788253784},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3405648469924927},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.2644093632698059},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23435086011886597},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.19707661867141724},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09929919242858887}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3390/cancers13071519","doi":"https://doi.org/10.3390/cancers13071519","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers13071519","pdf_url":"https://www.mdpi.com/2072-6694/13/7/1519/pdf?version=1616747114","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},{"id":"pmid:33806232","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33806232","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8059141","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8059141/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers (Basel)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:4049152ddf14469e926ad9d3da7bb5ab","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4049152ddf14469e926ad9d3da7bb5ab","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancers, Vol 13, Iss 1519, p 1519 (2021)","raw_type":"article"},{"id":"pmh:oai:iris.uniroma1.it:11573/1540377","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11573/1540377","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:research.unite.it:11575/113790","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11575/113790","pdf_url":null,"source":{"id":"https://openalex.org/S4306401171","display_name":"UniTERAMO Research Catalog (University of Teramo)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124326101","host_organization_name":"University of Teramo","host_organization_lineage":["https://openalex.org/I124326101"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3390/cancers13071519","doi":"https://doi.org/10.3390/cancers13071519","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers13071519","pdf_url":"https://www.mdpi.com/2072-6694/13/7/1519/pdf?version=1616747114","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1661615954","display_name":null,"funder_award_id":"Ateneo2019","funder_id":"https://openalex.org/F4320322510","funder_display_name":"Sapienza Universit\u00e0 di Roma"},{"id":"https://openalex.org/G3586673665","display_name":null,"funder_award_id":"RM11916B7040B1F8","funder_id":"https://openalex.org/F4320322510","funder_display_name":"Sapienza Universit\u00e0 di Roma"}],"funders":[{"id":"https://openalex.org/F4320322510","display_name":"Sapienza Universit\u00e0 di Roma","ror":"https://ror.org/02be6w209"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3137910158.pdf","grobid_xml":"https://content.openalex.org/works/W3137910158.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1945032888","https://openalex.org/W1979125224","https://openalex.org/W2059411043","https://openalex.org/W2097683496","https://openalex.org/W2114343065","https://openalex.org/W2122837483","https://openalex.org/W2163480486","https://openalex.org/W2165921475","https://openalex.org/W2170008898","https://openalex.org/W2179049074","https://openalex.org/W2283047483","https://openalex.org/W2299219969","https://openalex.org/W2330998918","https://openalex.org/W2333245858","https://openalex.org/W2334598588","https://openalex.org/W2477271322","https://openalex.org/W2482220870","https://openalex.org/W2519202964","https://openalex.org/W2531060677","https://openalex.org/W2547320292","https://openalex.org/W2556648133","https://openalex.org/W2594404528","https://openalex.org/W2602832336","https://openalex.org/W2607464846","https://openalex.org/W2743227519","https://openalex.org/W2750163795","https://openalex.org/W2762067000","https://openalex.org/W2762370509","https://openalex.org/W2793515307","https://openalex.org/W2799113834","https://openalex.org/W2883780752","https://openalex.org/W2886882464","https://openalex.org/W2908209260","https://openalex.org/W2919484619","https://openalex.org/W2921688389","https://openalex.org/W2955486707","https://openalex.org/W2988641104","https://openalex.org/W2992769968","https://openalex.org/W2994698045","https://openalex.org/W2995454807","https://openalex.org/W2997512765","https://openalex.org/W2997741393","https://openalex.org/W3004779459","https://openalex.org/W3012540615","https://openalex.org/W3017356540","https://openalex.org/W3035130918","https://openalex.org/W3093909210","https://openalex.org/W4246380462","https://openalex.org/W6684715665","https://openalex.org/W6702471160"],"related_works":["https://openalex.org/W2886141666","https://openalex.org/W3122825072","https://openalex.org/W3163076021","https://openalex.org/W3182238336","https://openalex.org/W2026210897","https://openalex.org/W4392240512","https://openalex.org/W2335517510","https://openalex.org/W2283047483","https://openalex.org/W2953571465","https://openalex.org/W3042306985"],"abstract_inverted_index":{"Ovarian":[0],"cancer":[1,58,133,192],"(OC)":[2],"is":[3,41,52],"the":[4,12,30,71,127,164,188],"most":[5],"aggressive":[6],"gynecological":[7],"tumor":[8,98],"worldwide":[9],"and,":[10],"notwithstanding":[11],"increment":[13],"in":[14,84,90,147,151,168,194],"conventional":[15],"treatments,":[16],"many":[17],"resistance":[18,134],"mechanisms":[19],"arise,":[20],"this":[21],"leading":[22],"to":[23,37,44,111,143,182],"cure":[24],"failure":[25],"and":[26,63,106,114,121,159,186],"patient":[27,46],"death.":[28],"So,":[29],"use":[31],"of":[32,74,129,132,166,190],"novel":[33,77],"adjuvant":[34],"drugs":[35,56],"able":[36],"counteract":[38],"these":[39],"pathways":[40],"urgently":[42],"needed":[43],"improve":[45,183],"overall":[47],"survival.":[48],"A":[49],"growing":[50],"interest":[51],"focused":[53],"on":[54],"epigenetic":[55],"for":[57],"therapy,":[59],"such":[60],"as":[61,79,178],"Bromodomain":[62],"Extra-Terminal":[64],"motif":[65],"inhibitors":[66],"(BETi).":[67],"Here,":[68],"we":[69],"investigate":[70],"antitumor":[72,171],"effects":[73,124],"OTX015,":[75],"a":[76,80],"BETi,":[78],"single":[81],"agent":[82],"or":[83],"combination":[85],"with":[86,196],"ionizing":[87],"radiation":[88],"(IR)":[89],"OC":[91,148,170],"cellular":[92],"models.":[93],"OTX015":[94,117,177],"treatment":[95],"significantly":[96,145],"reduced":[97],"cell":[99,103],"proliferation":[100],"by":[101,125],"triggering":[102],"cycle":[104],"arrest":[105],"apoptosis":[107],"that":[108],"were":[109],"linked":[110],"nucleolar":[112],"stress":[113],"DNA":[115],"damage.":[116],"impaired":[118],"migration":[119],"capacity":[120],"potentiated":[122],"IR":[123],"reducing":[126],"expression":[128,140],"different":[130],"drivers":[131],"mechanisms,":[135],"including":[136],"GNL3":[137,167],"gene,":[138],"whose":[139],"was":[141],"found":[142],"be":[144],"higher":[146],"biopsies":[149],"than":[150],"normal":[152],"ovarian":[153],"tissues.":[154],"Gene":[155],"specific":[156],"knocking":[157],"down":[158],"computational":[160],"network":[161],"analysis":[162],"confirmed":[163],"centrality":[165],"OTX015-mediated":[169],"effects.":[172],"Altogether,":[173],"our":[174],"findings":[175],"suggest":[176],"an":[179],"effective":[180],"option":[181],"therapeutic":[184],"strategies":[185],"overcome":[187],"development":[189],"resistant":[191],"cells":[193],"patients":[195],"OC.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-03-29T00:00:00"}