{"id":"https://openalex.org/W3137870461","doi":"https://doi.org/10.1371/journal.pone.0247701","title":"Anti-CD19 CAR T cells potently redirected to kill solid tumor cells","display_name":"Anti-CD19 CAR T cells potently redirected to kill solid tumor cells","publication_year":2021,"publication_date":"2021-03-18","ids":{"openalex":"https://openalex.org/W3137870461","doi":"https://doi.org/10.1371/journal.pone.0247701","mag":"3137870461","pmid":"https://pubmed.ncbi.nlm.nih.gov/33735268","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7971483"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0247701","doi":"https://doi.org/10.1371/journal.pone.0247701","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0247701","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0247701&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0247701&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110220480","display_name":"Christine M. Ambrose","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christine Ambrose","raw_affiliation_strings":["Aleta Biotherapeutics, Natick, MA USA","Aleta Biotherapeutics, Natick, MA, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aleta Biotherapeutics, Natick, MA USA","institution_ids":[]},{"raw_affiliation_string":"Aleta Biotherapeutics, Natick, MA, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105423086","display_name":"Lihe Su","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lihe Su","raw_affiliation_strings":["Aleta Biotherapeutics, Natick, MA USA","Aleta Biotherapeutics, Natick, MA, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aleta Biotherapeutics, Natick, MA USA","institution_ids":[]},{"raw_affiliation_string":"Aleta Biotherapeutics, Natick, MA, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075464709","display_name":"Lan Wu","orcid":"https://orcid.org/0000-0002-1966-2501","observed_orcids":["https://orcid.org/0000-0002-1966-2501"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lan Wu","raw_affiliation_strings":["Aleta Biotherapeutics, Natick, MA USA","Aleta Biotherapeutics, Natick, MA, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aleta Biotherapeutics, Natick, MA USA","institution_ids":[]},{"raw_affiliation_string":"Aleta Biotherapeutics, Natick, MA, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032841439","display_name":"Fay J. Dufort","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fay J. Dufort","raw_affiliation_strings":["Aleta Biotherapeutics, Natick, MA USA","Aleta Biotherapeutics, Natick, MA, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aleta Biotherapeutics, Natick, MA USA","institution_ids":[]},{"raw_affiliation_string":"Aleta Biotherapeutics, Natick, MA, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014017269","display_name":"Thomas Sanford","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas Sanford","raw_affiliation_strings":["Aleta Biotherapeutics, Natick, MA USA","Aleta Biotherapeutics, Natick, MA, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aleta Biotherapeutics, Natick, MA USA","institution_ids":[]},{"raw_affiliation_string":"Aleta Biotherapeutics, Natick, MA, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071364701","display_name":"Alyssa Birt","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alyssa Birt","raw_affiliation_strings":["Aleta Biotherapeutics, Natick, MA USA","Aleta Biotherapeutics, Natick, MA, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aleta Biotherapeutics, Natick, MA USA","institution_ids":[]},{"raw_affiliation_string":"Aleta Biotherapeutics, Natick, MA, United States of America","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032180677","display_name":"Benjamin J. Hackel","orcid":"https://orcid.org/0000-0003-3561-9463","observed_orcids":["https://orcid.org/0000-0003-3561-9463"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin Hackel","raw_affiliation_strings":["University of Minnesota, Minneapolis, MN USA","University of Minnesota, Minneapolis, MN, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Minnesota, Minneapolis, MN USA","institution_ids":["https://openalex.org/I130238516"]},{"raw_affiliation_string":"University of Minnesota, Minneapolis, MN, United States of America","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023054875","display_name":"Andreas A. Hombach","orcid":"https://orcid.org/0000-0001-9328-8442","observed_orcids":["https://orcid.org/0000-0001-9328-8442"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Andreas Hombach","raw_affiliation_strings":["University of Cologne, K\u00f6ln, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Cologne, K\u00f6ln, Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081176216","display_name":"Hinrich Abken","orcid":"https://orcid.org/0000-0002-4302-3240","observed_orcids":["https://orcid.org/0000-0002-4302-3240"]},"institutions":[{"id":"https://openalex.org/I180923762","display_name":"University of Cologne","ror":"https://ror.org/00rcxh774","country_code":"DE","type":"education","lineage":["https://openalex.org/I180923762"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hinrich Abken","raw_affiliation_strings":["University of Cologne, K\u00f6ln, Germany"],"raw_orcid":"https://orcid.org/0000-0002-4302-3240","affiliations":[{"raw_affiliation_string":"University of Cologne, K\u00f6ln, Germany","institution_ids":["https://openalex.org/I180923762"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010673550","display_name":"Roy R. Lobb","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Roy R. Lobb","raw_affiliation_strings":["Aleta Biotherapeutics, Natick, MA USA","Aleta Biotherapeutics, Natick, MA, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aleta Biotherapeutics, Natick, MA USA","institution_ids":[]},{"raw_affiliation_string":"Aleta Biotherapeutics, Natick, MA, United States of America","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051450662","display_name":"Paul D. Rennert","orcid":"https://orcid.org/0000-0002-4573-3764","observed_orcids":["https://orcid.org/0000-0002-4573-3764"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Paul D. Rennert","raw_affiliation_strings":["Aleta Biotherapeutics, Natick, MA USA","Aleta Biotherapeutics, Natick, MA, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-4573-3764","affiliations":[{"raw_affiliation_string":"Aleta Biotherapeutics, Natick, MA USA","institution_ids":[]},{"raw_affiliation_string":"Aleta Biotherapeutics, Natick, MA, United States of America","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5051450662"],"corresponding_institution_ids":[],"apc_list":{"value":1749,"currency":"USD","value_usd":1749},"apc_paid":{"value":1749,"currency":"USD","value_usd":1749},"fwci":1.257,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.82837719,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"16","issue":"3","first_page":"e0247701","last_page":"e0247701"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/car-t-cell-therapy","display_name":"CAR T-cell therapy","score":0.8109999895095825},{"id":"https://openalex.org/keywords/cd19","display_name":"CD19","score":0.8309999704360962},{"id":"https://openalex.org/keywords/her2","display_name":"HER2","score":0.6420000195503235},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.8040000200271606},{"id":"https://openalex.org/keywords/tumor-antigen-targeting","display_name":"tumor antigen targeting","score":0.5419999957084656},{"id":"https://openalex.org/keywords/t-cell-expansion","display_name":"T cell expansion","score":0.6230000257492065},{"id":"https://openalex.org/keywords/t-cell-persistence","display_name":"T cell persistence","score":0.9760000109672546},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.5249999761581421},{"id":"https://openalex.org/keywords/tumor-cell-killing","display_name":"tumor cell killing","score":0.5820000171661377},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.44200000166893005}],"concepts":[{"id":"https://openalex.org/C2778957590","wikidata":"https://www.wikidata.org/wiki/Q798033","display_name":"CD19","level":3,"score":0.8004083037376404},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.6333138942718506},{"id":"https://openalex.org/C3875195","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"Chimeric antigen receptor","level":4,"score":0.5674952268600464},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5011136531829834},{"id":"https://openalex.org/C10882517","wikidata":"https://www.wikidata.org/wiki/Q15268054","display_name":"Cell therapy","level":3,"score":0.4783051311969757},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4460669755935669},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4413304030895233},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4321900010108948},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.396334171295166},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33955276012420654},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.26635825634002686},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.14746150374412537},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10867223143577576}],"mesh":[{"descriptor_ui":"D000076962","descriptor_name":"Receptors, Chimeric Antigen","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000076962","descriptor_name":"Receptors, Chimeric Antigen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003602","descriptor_name":"Cytotoxicity, Immunologic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008213","descriptor_name":"Lymphocyte Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016086","descriptor_name":"Lentivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016086","descriptor_name":"Lentivirus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016219","descriptor_name":"Immunotherapy, Adoptive","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016393","descriptor_name":"Lymphoma, B-Cell","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018719","descriptor_name":"Erb-b2 Receptor Tyrosine Kinases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018941","descriptor_name":"Antigens, CD19","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018941","descriptor_name":"Antigens, CD19","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D066246","descriptor_name":"ErbB Receptors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0247701","doi":"https://doi.org/10.1371/journal.pone.0247701","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0247701","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0247701&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},{"id":"doi:10.1101/2020.03.25.007658","doi":"https://doi.org/10.1101/2020.03.25.007658","is_oa":true,"landing_page_url":"https://doi.org/10.1101/2020.03.25.007658","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2021/03/02/2020.03.25.007658.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},{"id":"pmh:oai:pubmedcentral.nih.gov:7971483","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7971483","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:33735268","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33735268","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:USBKOELN.ub.uni-koeln.de:58685","doi":null,"is_oa":false,"landing_page_url":"https://kups.ub.uni-koeln.de/58685/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400371","display_name":"K\u00f6lner Universit\u00e4ts PublikationsServer (Universit\u00e4t zu K\u00f6ln)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115942","host_organization_name":"Rhenish Institute for Environmental Research","host_organization_lineage":["https://openalex.org/I4210115942"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"doc-type:article"},{"id":"pmh:oai:doaj.org/article:79b29881299c40a5997a27b51c18789e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/79b29881299c40a5997a27b51c18789e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 16, Iss 3, p e0247701 (2021)","raw_type":"article"},{"id":"pmh:oai:epub.uni-regensburg.de:56019","doi":null,"is_oa":false,"landing_page_url":"https://epub.uni-regensburg.de/56019/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401229","display_name":"University of Regensburg Publication Server (University of Regensburg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I60668342","host_organization_name":"University of Regensburg","host_organization_lineage":["https://openalex.org/I60668342"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0247701","doi":"https://doi.org/10.1371/journal.pone.0247701","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0247701","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0247701&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309636","display_name":"University of Minnesota","ror":"https://ror.org/03grvy078"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3137870461.pdf","grobid_xml":"https://content.openalex.org/works/W3137870461.grobid-xml"},"referenced_works_count":81,"referenced_works":["https://openalex.org/W81509564","https://openalex.org/W1989566870","https://openalex.org/W2006174096","https://openalex.org/W2009166328","https://openalex.org/W2038426832","https://openalex.org/W2060007608","https://openalex.org/W2063170571","https://openalex.org/W2091966730","https://openalex.org/W2101341126","https://openalex.org/W2105879190","https://openalex.org/W2109659694","https://openalex.org/W2115465690","https://openalex.org/W2116897841","https://openalex.org/W2126769212","https://openalex.org/W2127424425","https://openalex.org/W2129702476","https://openalex.org/W2145985838","https://openalex.org/W2149748445","https://openalex.org/W2154628725","https://openalex.org/W2169579205","https://openalex.org/W2258336271","https://openalex.org/W2339327563","https://openalex.org/W2398243892","https://openalex.org/W2466387665","https://openalex.org/W2567424265","https://openalex.org/W2605626471","https://openalex.org/W2612946884","https://openalex.org/W2734751581","https://openalex.org/W2738678436","https://openalex.org/W2739972212","https://openalex.org/W2750298560","https://openalex.org/W2769445535","https://openalex.org/W2801641802","https://openalex.org/W2805456004","https://openalex.org/W2883190832","https://openalex.org/W2883912039","https://openalex.org/W2888063816","https://openalex.org/W2889157625","https://openalex.org/W2889691274","https://openalex.org/W2892188605","https://openalex.org/W2897977935","https://openalex.org/W2899237873","https://openalex.org/W2899694188","https://openalex.org/W2899700403","https://openalex.org/W2905496875","https://openalex.org/W2906041357","https://openalex.org/W2907702391","https://openalex.org/W2915488292","https://openalex.org/W2916790786","https://openalex.org/W2917285914","https://openalex.org/W2919881382","https://openalex.org/W2920899965","https://openalex.org/W2921866483","https://openalex.org/W2922494421","https://openalex.org/W2936551248","https://openalex.org/W2948879734","https://openalex.org/W2949232578","https://openalex.org/W2950131747","https://openalex.org/W2955613310","https://openalex.org/W2956092422","https://openalex.org/W2956329092","https://openalex.org/W2957969985","https://openalex.org/W2958460383","https://openalex.org/W2959588651","https://openalex.org/W2963298310","https://openalex.org/W2965262659","https://openalex.org/W2972704891","https://openalex.org/W2976820106","https://openalex.org/W2984320350","https://openalex.org/W2992738455","https://openalex.org/W2993876604","https://openalex.org/W2998563599","https://openalex.org/W2998795792","https://openalex.org/W3000155410","https://openalex.org/W3000282923","https://openalex.org/W3000311037","https://openalex.org/W3014980845","https://openalex.org/W3016844795","https://openalex.org/W3027610189","https://openalex.org/W3028773865","https://openalex.org/W3043123256"],"related_works":["https://openalex.org/W3013873993","https://openalex.org/W3119501045","https://openalex.org/W2739581271","https://openalex.org/W2886328387","https://openalex.org/W2994344620","https://openalex.org/W2955613310","https://openalex.org/W2891290569","https://openalex.org/W2912867144","https://openalex.org/W3027108080","https://openalex.org/W3170465535"],"abstract_inverted_index":{"Successful":[0],"CAR":[1,13,73],"T":[2,14,56,74,102,148],"cell":[3,15,57,65,103,157],"therapy":[4,39,66],"for":[5,36,153],"the":[6,21,69,115,123,131],"treatment":[7],"of":[8,33,71,111,125],"solid":[9,155],"tumors":[10],"requires":[11],"exemplary":[12],"expansion,":[16,86],"persistence":[17,87],"and":[18,20,47,88,107],"fitness,":[19],"ability":[22,70],"to":[23,76,84,96,137,164],"target":[24],"tumor":[25,98,140,156,166],"antigens":[26,141,167],"safely.":[27],"Here":[28],"we":[29],"address":[30],"this":[31],"constellation":[32],"critical":[34,151],"attributes":[35,152],"successful":[37,154],"cellular":[38],"by":[40],"using":[41],"integrated":[42],"technologies":[43],"that":[44,58,135],"simplify":[45],"development":[46],"derisk":[48],"clinical":[49],"translation.":[50],"We":[51],"have":[52,142],"developed":[53],"a":[54,60],"CAR-CD19":[55,101,147],"secretes":[59],"CD19-anti-Her2":[61],"bridging":[62,92,117],"protein.":[63],"This":[64,159],"strategy":[67],"exploits":[68],"CD19-targeting":[72],"cells":[75,83,149],"interact":[77],"with":[78],"CD19":[79],"on":[80,168],"normal":[81],"B":[82],"drive":[85],"fitness.":[89],"The":[90],"secreted":[91,116],"protein":[93,118],"potently":[94],"binds":[95],"Her2-positive":[97],"cells,":[99],"mediating":[100],"cytotoxicity":[104],"in":[105,108],"vitro":[106],"vivo.":[109],"Because":[110],"its":[112],"short":[113],"half-life,":[114],"will":[119],"selectively":[120],"accumulate":[121],"at":[122,130],"site":[124],"highest":[126],"antigen":[127],"expression,":[128],"ie.":[129],"tumor.":[132],"Bridging":[133],"proteins":[134],"bind":[136],"multiple":[138],"different":[139],"been":[143],"created.":[144],"Therefore,":[145],"antigen-bridging":[146],"incorporate":[150],"therapy.":[158],"platform":[160],"can":[161],"be":[162],"exploited":[163],"attack":[165],"any":[169],"cancer.":[170]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2021-03-29T00:00:00"}