{"id":"https://openalex.org/W313786763","doi":"https://doi.org/10.1007/978-3-642-57721-5_7","title":"Cytokine release regarding different perfusion systems and its effect on S100B protein levels","display_name":"Cytokine release regarding different perfusion systems and its effect on S100B protein levels","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W313786763","doi":"https://doi.org/10.1007/978-3-642-57721-5_7","mag":"313786763"},"language":"en","primary_location":{"id":"doi:10.1007/978-3-642-57721-5_7","doi":"https://doi.org/10.1007/978-3-642-57721-5_7","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-642-57721-5_7","pdf_url":null,"source":{"id":"https://openalex.org/S4306463955","display_name":"Steinkopff eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Perspectives of the Extracorporeal Circulation","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W620847360","display_name":"Current Perspectives of the Extracorporeal Circulation"},"type":"book-chapter","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014970786","display_name":"J\u00f6rg Babin\u2013Ebell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"J\u00f6rg Babin-Ebell","raw_affiliation_strings":["Klinik und Poliklinik f\u00fcr Herz- und Thoraxchirurgie, Universit\u00e4t W\u00fcrzburg, Josef-Schneider-Str. 6, D-97080, W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinik und Poliklinik f\u00fcr Herz- und Thoraxchirurgie, Universit\u00e4t W\u00fcrzburg, Josef-Schneider-Str. 6, D-97080, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101","https://openalex.org/I4210126310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113522379","display_name":"M. Misoph","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"M. Misoph","raw_affiliation_strings":["Klinik und Poliklinik f\u00fcr Herz- und Thoraxchirurgie, Universit\u00e4t W\u00fcrzburg, Josef-Schneider-Str. 6, D-97080, W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinik und Poliklinik f\u00fcr Herz- und Thoraxchirurgie, Universit\u00e4t W\u00fcrzburg, Josef-Schneider-Str. 6, D-97080, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101","https://openalex.org/I4210126310"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074443532","display_name":"Olaf Elert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25974101","display_name":"University of W\u00fcrzburg","ror":"https://ror.org/00fbnyb24","country_code":"DE","type":"education","lineage":["https://openalex.org/I25974101"]},{"id":"https://openalex.org/I4210126310","display_name":"Universit\u00e4tsklinikum W\u00fcrzburg","ror":"https://ror.org/03pvr2g57","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210126310"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"O. Elert","raw_affiliation_strings":["Klinik und Poliklinik f\u00fcr Herz- und Thoraxchirurgie, Universit\u00e4t W\u00fcrzburg, Josef-Schneider-Str. 6, D-97080, W\u00fcrzburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Klinik und Poliklinik f\u00fcr Herz- und Thoraxchirurgie, Universit\u00e4t W\u00fcrzburg, Josef-Schneider-Str. 6, D-97080, W\u00fcrzburg, Germany","institution_ids":["https://openalex.org/I25974101","https://openalex.org/I4210126310"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.445,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.85389095,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"67","last_page":"75"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11055","display_name":"Cardiac and Coronary Surgery Techniques","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11055","display_name":"Cardiac and Coronary Surgery Techniques","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12030","display_name":"S100 Proteins and Annexins","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiopulmonary-bypass","display_name":"cardiopulmonary bypass","score":0.8949999809265137},{"id":"https://openalex.org/keywords/cytokine-production","display_name":"cytokine production","score":0.8259999752044678},{"id":"https://openalex.org/keywords/s100b","display_name":"S100B","score":0.9380000233650208},{"id":"https://openalex.org/keywords/perfusion-system","display_name":"perfusion system","score":0.9259999990463257},{"id":"https://openalex.org/keywords/endothelial-injury","display_name":"endothelial injury","score":0.925000011920929},{"id":"https://openalex.org/keywords/vascular-permeability","display_name":"vascular permeability","score":0.9649999737739563},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5049999952316284},{"id":"https://openalex.org/keywords/organ-dysfunction","display_name":"organ dysfunction","score":0.6589999794960022},{"id":"https://openalex.org/keywords/neurological-deficit","display_name":"neurological deficit","score":0.40700000524520874}],"concepts":[{"id":"https://openalex.org/C2776825266","wikidata":"https://www.wikidata.org/wiki/Q1410794","display_name":"Fibrinolysis","level":2,"score":0.7241584062576294},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.662915825843811},{"id":"https://openalex.org/C111684460","wikidata":"https://www.wikidata.org/wiki/Q334848","display_name":"Complement system","level":3,"score":0.619829535484314},{"id":"https://openalex.org/C2778881276","wikidata":"https://www.wikidata.org/wiki/Q552304","display_name":"Cardiopulmonary bypass","level":2,"score":0.6139799952507019},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5424801111221313},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.5320796966552734},{"id":"https://openalex.org/C2776246508","wikidata":"https://www.wikidata.org/wiki/Q5376428","display_name":"Endothelial activation","level":3,"score":0.5178146958351135},{"id":"https://openalex.org/C2780972559","wikidata":"https://www.wikidata.org/wiki/Q550061","display_name":"Endothelial dysfunction","level":2,"score":0.4841785728931427},{"id":"https://openalex.org/C2778426790","wikidata":"https://www.wikidata.org/wiki/Q1649580","display_name":"Organ dysfunction","level":3,"score":0.4825572371482849},{"id":"https://openalex.org/C2778382381","wikidata":"https://www.wikidata.org/wiki/Q179217","display_name":"Coagulation","level":2,"score":0.4750901758670807},{"id":"https://openalex.org/C113045295","wikidata":"https://www.wikidata.org/wiki/Q7916465","display_name":"Vascular permeability","level":2,"score":0.4699842035770416},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4696117043495178},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4515655040740967},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.42775338888168335},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.4150657653808594},{"id":"https://openalex.org/C2778384902","wikidata":"https://www.wikidata.org/wiki/Q183134","display_name":"Sepsis","level":2,"score":0.29267722368240356},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.28082436323165894},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27171701192855835}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1007/978-3-642-57721-5_7","doi":"https://doi.org/10.1007/978-3-642-57721-5_7","is_oa":false,"landing_page_url":"https://doi.org/10.1007/978-3-642-57721-5_7","pdf_url":null,"source":{"id":"https://openalex.org/S4306463955","display_name":"Steinkopff eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"ebook platform"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Current Perspectives of the Extracorporeal Circulation","raw_type":"book-chapter"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":22,"referenced_works":["https://openalex.org/W161035681","https://openalex.org/W1924411287","https://openalex.org/W1981154728","https://openalex.org/W1981713291","https://openalex.org/W1983389143","https://openalex.org/W1992612372","https://openalex.org/W1992878306","https://openalex.org/W2008097925","https://openalex.org/W2039434903","https://openalex.org/W2039597310","https://openalex.org/W2041959806","https://openalex.org/W2064587466","https://openalex.org/W2070598634","https://openalex.org/W2073674753","https://openalex.org/W2075297226","https://openalex.org/W2087876639","https://openalex.org/W2088203721","https://openalex.org/W2104436652","https://openalex.org/W2132479041","https://openalex.org/W2135252918","https://openalex.org/W2409056966","https://openalex.org/W2410330794"],"related_works":["https://openalex.org/W1159805072","https://openalex.org/W2089758120","https://openalex.org/W4319456891","https://openalex.org/W2035959902","https://openalex.org/W2153963616","https://openalex.org/W2084002478","https://openalex.org/W2197940885","https://openalex.org/W2373029736","https://openalex.org/W2384020027","https://openalex.org/W7099397690"],"abstract_inverted_index":{"During":[0],"cardiopulmonary":[1],"bypass":[2],"(CPB),":[3],"blood":[4],"is":[5,52,113],"exposed":[6],"to":[7,18,54,91],"foreign":[8],"surfaces":[9],"and":[10,30,34,61,74,95,106,115],"abnormal":[11,15],"sheer":[12],"forces.":[13],"These":[14,100],"conditions":[16],"lead":[17],"an":[19],"activation":[20],"of":[21,31,71,86],"coagulation":[22],"(9),":[23,25],"fibrinolysis":[24],"the":[26,32,84,109,116,122],"complement":[27],"pathway":[28],"(2)":[29],"cellular":[33],"humoral":[35],"immune":[36],"system":[37],"(15),":[38],"finally":[39],"resulting":[40],"in":[41],"a":[42],"general":[43],"inflammatory":[44],"reaction.":[45],"Clinically,":[46],"this":[47],"so-called":[48],"\u201cpost":[49],"pump":[50],"response\u201d":[51],"linked":[53],"myocardial":[55],"dysfunction,":[56],"respiratory":[57],"distress,":[58],"renal":[59],"failure,":[60],"neurological":[62],"deficits.":[63],"All":[64],"these":[65],"clinical":[66],"aspects":[67],"are":[68,89],"mostly":[69],"consequences":[70],"endothelial":[72],"injury":[73,94],"increased":[75],"vascular":[76,93],"permeability":[77],"\u2014":[78],"at":[79],"least":[80],"partly":[81],"caused":[82],"by":[83,104,108],"release":[85],"cytokines,":[87],"which":[88],"known":[90],"mediate":[92],"organ":[96],"dysfunction":[97],"(4,":[98],"14).":[99],"keywords":[101,117],"were":[102],"added":[103],"machine":[105],"not":[107],"authors.":[110],"This":[111],"process":[112],"experimental":[114],"may":[118],"be":[119],"updated":[120],"as":[121],"learning":[123],"algorithm":[124],"improves.":[125]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
