{"id":"https://openalex.org/W3137839366","doi":"https://doi.org/10.1186/s10194-021-01231-9","title":"Comparison of pregnenolone sulfate, pregnanolone and estradiol levels between patients with menstrually-related migraine and controls: an exploratory study","display_name":"Comparison of pregnenolone sulfate, pregnanolone and estradiol levels between patients with menstrually-related migraine and controls: an exploratory study","publication_year":2021,"publication_date":"2021-03-23","ids":{"openalex":"https://openalex.org/W3137839366","doi":"https://doi.org/10.1186/s10194-021-01231-9","mag":"3137839366","pmid":"https://pubmed.ncbi.nlm.nih.gov/33757421","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7989028"},"language":"en","primary_location":{"id":"doi:10.1186/s10194-021-01231-9","doi":"https://doi.org/10.1186/s10194-021-01231-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s10194-021-01231-9","pdf_url":"https://thejournalofheadacheandpain.biomedcentral.com/counter/pdf/10.1186/s10194-021-01231-9","source":{"id":"https://openalex.org/S143427143","display_name":"The Journal of Headache and Pain","issn_l":"1129-2369","issn":["1129-2369","1129-2377"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Headache and Pain","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://thejournalofheadacheandpain.biomedcentral.com/counter/pdf/10.1186/s10194-021-01231-9","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049195055","display_name":"Cecilia Rustichelli","orcid":"https://orcid.org/0000-0001-8917-9980","observed_orcids":["https://orcid.org/0000-0001-8917-9980"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cecilia Rustichelli","raw_affiliation_strings":["Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Life Sciences, University of Modena and Reggio Emilia, Modena, Italy","institution_ids":["https://openalex.org/I122346577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019399975","display_name":"Elisa Bellei","orcid":"https://orcid.org/0000-0002-6801-0446","observed_orcids":["https://orcid.org/0000-0002-6801-0446"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Elisa Bellei","raw_affiliation_strings":["Department of Surgery, Medicine, Dentistry and Morphological Sciences with Transplant Surgery, Oncology and Regenerative Medicine Relevance, University of Modena and Reggio Emilia, Modena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Medicine, Dentistry and Morphological Sciences with Transplant Surgery, Oncology and Regenerative Medicine Relevance, University of Modena and Reggio Emilia, Modena, Italy","institution_ids":["https://openalex.org/I122346577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062899092","display_name":"Stefania Bergamini","orcid":"https://orcid.org/0000-0003-1020-9580","observed_orcids":["https://orcid.org/0000-0003-1020-9580"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefania Bergamini","raw_affiliation_strings":["Department of Surgery, Medicine, Dentistry and Morphological Sciences with Transplant Surgery, Oncology and Regenerative Medicine Relevance, University of Modena and Reggio Emilia, Modena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Medicine, Dentistry and Morphological Sciences with Transplant Surgery, Oncology and Regenerative Medicine Relevance, University of Modena and Reggio Emilia, Modena, Italy","institution_ids":["https://openalex.org/I122346577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069328169","display_name":"Emanuela Monari","orcid":"https://orcid.org/0000-0003-0924-4928","observed_orcids":["https://orcid.org/0000-0003-0924-4928"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Emanuela Monari","raw_affiliation_strings":["Department of Surgery, Medicine, Dentistry and Morphological Sciences with Transplant Surgery, Oncology and Regenerative Medicine Relevance, University of Modena and Reggio Emilia, Modena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Medicine, Dentistry and Morphological Sciences with Transplant Surgery, Oncology and Regenerative Medicine Relevance, University of Modena and Reggio Emilia, Modena, Italy","institution_ids":["https://openalex.org/I122346577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073272065","display_name":"Flavia Lo Castro","orcid":"https://orcid.org/0000-0002-8572-3421","observed_orcids":["https://orcid.org/0000-0002-8572-3421"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Flavia Lo Castro","raw_affiliation_strings":["School of Pharmacology and Clinical Toxicology, University of Modena and Reggio Emilia, Modena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Pharmacology and Clinical Toxicology, University of Modena and Reggio Emilia, Modena, Italy","institution_ids":["https://openalex.org/I122346577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019112995","display_name":"Carlo Baraldi","orcid":"https://orcid.org/0000-0001-8432-1888","observed_orcids":["https://orcid.org/0000-0001-8432-1888"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carlo Baraldi","raw_affiliation_strings":["Department of Biomedical, Metabolic and Neural Sciences, Unit of Medical Toxicology, Headache Centre and Drug Abuse; University of Modena and Reggio Emilia, Via del Pozzo, 71, 41124, Modena, Italy","Department of Biomedical, Metabolic and Neural Sciences, Unit of Medical Toxicology, Headache Centre and Drug Abuse","University of Modena and Reggio Emilia, Via del Pozzo, 71, 41124, Modena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical, Metabolic and Neural Sciences, Unit of Medical Toxicology, Headache Centre and Drug Abuse; University of Modena and Reggio Emilia, Via del Pozzo, 71, 41124, Modena, Italy","institution_ids":["https://openalex.org/I122346577"]},{"raw_affiliation_string":"Department of Biomedical, Metabolic and Neural Sciences, Unit of Medical Toxicology, Headache Centre and Drug Abuse","institution_ids":[]},{"raw_affiliation_string":"University of Modena and Reggio Emilia, Via del Pozzo, 71, 41124, Modena, Italy","institution_ids":["https://openalex.org/I122346577"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069189039","display_name":"Aldo Tomasi","orcid":"https://orcid.org/0000-0002-1356-3430","observed_orcids":["https://orcid.org/0000-0002-1356-3430"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Aldo Tomasi","raw_affiliation_strings":["Department of Surgery, Medicine, Dentistry and Morphological Sciences with Transplant Surgery, Oncology and Regenerative Medicine Relevance, University of Modena and Reggio Emilia, Modena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Medicine, Dentistry and Morphological Sciences with Transplant Surgery, Oncology and Regenerative Medicine Relevance, University of Modena and Reggio Emilia, Modena, Italy","institution_ids":["https://openalex.org/I122346577"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081170326","display_name":"Anna Ferrari","orcid":"https://orcid.org/0000-0001-9536-3995","observed_orcids":["https://orcid.org/0000-0001-9536-3995"]},"institutions":[{"id":"https://openalex.org/I122346577","display_name":"University of Modena and Reggio Emilia","ror":"https://ror.org/02d4c4y02","country_code":"IT","type":"education","lineage":["https://openalex.org/I122346577"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Anna Ferrari","raw_affiliation_strings":["Department of Biomedical, Metabolic and Neural Sciences, Unit of Medical Toxicology, Headache Centre and Drug Abuse; University of Modena and Reggio Emilia, Via del Pozzo, 71, 41124, Modena, Italy. anna.ferrari@unimore.it","Department of Biomedical, Metabolic and Neural Sciences, Unit of Medical Toxicology, Headache Centre and Drug Abuse","University of Modena and Reggio Emilia, Via del Pozzo, 71, 41124, Modena, Italy"],"raw_orcid":"https://orcid.org/0000-0001-9536-3995","affiliations":[{"raw_affiliation_string":"Department of Biomedical, Metabolic and Neural Sciences, Unit of Medical Toxicology, Headache Centre and Drug Abuse; University of Modena and Reggio Emilia, Via del Pozzo, 71, 41124, Modena, Italy. anna.ferrari@unimore.it","institution_ids":["https://openalex.org/I122346577"]},{"raw_affiliation_string":"Department of Biomedical, Metabolic and Neural Sciences, Unit of Medical Toxicology, Headache Centre and Drug Abuse","institution_ids":[]},{"raw_affiliation_string":"University of Modena and Reggio Emilia, Via del Pozzo, 71, 41124, Modena, Italy","institution_ids":["https://openalex.org/I122346577"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5081170326"],"corresponding_institution_ids":["https://openalex.org/I122346577"],"apc_list":{"value":2990,"currency":"USD","value_usd":2990},"apc_paid":{"value":2860,"currency":"EUR","value_usd":3084},"fwci":1.2491,"has_fulltext":true,"cited_by_count":15,"citation_normalized_percentile":{"value":0.76451475,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"22","issue":"1","first_page":"13","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10498","display_name":"Migraine and Headache Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12054","display_name":"Menstrual Health and Disorders","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pregnenolone-sulfate","display_name":"pregnenolone sulfate","score":0.8889999985694885},{"id":"https://openalex.org/keywords/pregnanolone","display_name":"pregnanolone","score":0.9990000128746033},{"id":"https://openalex.org/keywords/estradiol","display_name":"estradiol","score":0.9959999918937683},{"id":"https://openalex.org/keywords/neurosteroids","display_name":"neurosteroids","score":0.9810000061988831},{"id":"https://openalex.org/keywords/gaba-a-receptor","display_name":"GABAA receptor","score":0.800000011920929},{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.9959999918937683},{"id":"https://openalex.org/keywords/positive-allosteric-modulators","display_name":"positive allosteric modulators","score":0.7839999794960022},{"id":"https://openalex.org/keywords/women","display_name":"women","score":0.4169999957084656},{"id":"https://openalex.org/keywords/migraine-history","display_name":"migraine history","score":0.7059999704360962},{"id":"https://openalex.org/keywords/age","display_name":"age","score":0.7160000205039978}],"concepts":[{"id":"https://openalex.org/C2780957381","wikidata":"https://www.wikidata.org/wiki/Q7239912","display_name":"Pregnenolone sulfate","level":5,"score":0.9366673231124878},{"id":"https://openalex.org/C2776801781","wikidata":"https://www.wikidata.org/wiki/Q18344323","display_name":"Pregnanolone","level":5,"score":0.8059834837913513},{"id":"https://openalex.org/C44796713","wikidata":"https://www.wikidata.org/wiki/Q2659374","display_name":"Neuroactive steroid","level":4,"score":0.7382360100746155},{"id":"https://openalex.org/C2778541695","wikidata":"https://www.wikidata.org/wiki/Q133823","display_name":"Migraine","level":2,"score":0.7063453197479248},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6927046775817871},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.682364821434021},{"id":"https://openalex.org/C2780193516","wikidata":"https://www.wikidata.org/wiki/Q412158","display_name":"Pregnenolone","level":4,"score":0.6292296648025513},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5364829301834106},{"id":"https://openalex.org/C2780564907","wikidata":"https://www.wikidata.org/wiki/Q6844299","display_name":"Migraine treatment","level":3,"score":0.4655381441116333},{"id":"https://openalex.org/C168258287","wikidata":"https://www.wikidata.org/wiki/Q60147","display_name":"GABAA receptor","level":3,"score":0.38090062141418457},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.27195489406585693},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.1618291437625885},{"id":"https://openalex.org/C2780902042","wikidata":"https://www.wikidata.org/wiki/Q177911","display_name":"Steroid","level":3,"score":0.07763653993606567}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004958","descriptor_name":"Estradiol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008881","descriptor_name":"Migraine Disorders","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011280","descriptor_name":"Pregnanolone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011284","descriptor_name":"Pregnenolone","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1186/s10194-021-01231-9","doi":"https://doi.org/10.1186/s10194-021-01231-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s10194-021-01231-9","pdf_url":"https://thejournalofheadacheandpain.biomedcentral.com/counter/pdf/10.1186/s10194-021-01231-9","source":{"id":"https://openalex.org/S143427143","display_name":"The Journal of Headache and Pain","issn_l":"1129-2369","issn":["1129-2369","1129-2377"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Headache and Pain","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7989028","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7989028","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Headache Pain","raw_type":"Text"},{"id":"pmid:33757421","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33757421","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The journal of headache and pain","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unimore.it:11380/1238900","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11380/1238900","pdf_url":"https://iris.unimore.it/bitstream/11380/1238900/1/2021_TJHP_Comparison%20PregS%20Preg%20Estra%20between%20MRM%20FAC.pdf","source":{"id":"https://openalex.org/S4306400718","display_name":"IRIS UNIMORE (University of Modena and Reggio Emilia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122346577","host_organization_name":"University of Modena and Reggio Emilia","host_organization_lineage":["https://openalex.org/I122346577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:4810e6def3b248a093bc5a3395dc4483","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/4810e6def3b248a093bc5a3395dc4483","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Journal of Headache and Pain, Vol 22, Iss 1, Pp 1-6 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s10194-021-01231-9","doi":"https://doi.org/10.1186/s10194-021-01231-9","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s10194-021-01231-9","pdf_url":"https://thejournalofheadacheandpain.biomedcentral.com/counter/pdf/10.1186/s10194-021-01231-9","source":{"id":"https://openalex.org/S143427143","display_name":"The Journal of Headache and Pain","issn_l":"1129-2369","issn":["1129-2369","1129-2377"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Headache and Pain","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7400000095367432,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G2871572566","display_name":null,"funder_award_id":"A.012@FONDRESNOM@CONISTER98- CUP:E99C20000120007","funder_id":"https://openalex.org/F4320311022","funder_display_name":"Universit\u00e0 Degli Studi di Modena e Reggio Emila"}],"funders":[{"id":"https://openalex.org/F4320309744","display_name":"Fondazione Cassa di Risparmio di Modena","ror":"https://ror.org/03cen5169"},{"id":"https://openalex.org/F4320311022","display_name":"Universit\u00e0 Degli Studi di Modena e Reggio Emila","ror":"https://ror.org/02d4c4y02"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3137839366.pdf","grobid_xml":"https://content.openalex.org/works/W3137839366.grobid-xml"},"referenced_works_count":25,"referenced_works":["https://openalex.org/W1963591991","https://openalex.org/W1995243512","https://openalex.org/W1997203921","https://openalex.org/W2045563070","https://openalex.org/W2048547196","https://openalex.org/W2083973091","https://openalex.org/W2412343472","https://openalex.org/W2734337694","https://openalex.org/W2765936018","https://openalex.org/W2785892713","https://openalex.org/W2792790171","https://openalex.org/W2797246261","https://openalex.org/W2801085490","https://openalex.org/W2897852904","https://openalex.org/W2900459288","https://openalex.org/W2936004119","https://openalex.org/W2939309394","https://openalex.org/W2972418944","https://openalex.org/W2987202912","https://openalex.org/W2997573921","https://openalex.org/W3003830787","https://openalex.org/W3027339981","https://openalex.org/W3029894904","https://openalex.org/W3037278485","https://openalex.org/W3039063966"],"related_works":["https://openalex.org/W6977060474","https://openalex.org/W3200686922","https://openalex.org/W3037278485","https://openalex.org/W3128353309","https://openalex.org/W2946967647","https://openalex.org/W3177131252","https://openalex.org/W2411693232","https://openalex.org/W4406818757","https://openalex.org/W2081554758","https://openalex.org/W2791891207"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Neurosteroids":[2],"affect":[3],"the":[4,19,42,45,83,118,176,199,210,225,237,253],"balance":[5],"between":[6,41],"neuroexcitation":[7],"and":[8,26,33,35,48,52,69,88,112,160,202,216],"neuroinhibition":[9],"but":[10],"have":[11],"been":[12],"little":[13],"studied":[14],"in":[15,28,82,117,122,175,214,229,261],"migraine.":[16],"We":[17],"compared":[18],"serum":[20,90,145],"levels":[21,43,91,101,108,137,146,171,190,260],"of":[22,44,50,109,152,191,198,209,248,256],"pregnenolone":[23,110,143,169,203],"sulfate,":[24,204],"pregnanolone":[25,89,113],"estradiol":[27,100,136],"women":[29,56],"with":[30,64,150,236,245],"menstrually-related":[31,65],"migraine":[32,51,66,153,230,240,262],"controls":[34,73,123],"analysed":[36,93],"if":[37],"a":[38,194,205,242,246],"correlation":[39],"existed":[40],"three":[46],"hormones":[47],"history":[49,151],"age.":[53],"Methods":[54],"Thirty":[55],"(mean":[57,74],"age":[58,75,161],"\u00b1":[59,62,76,79],"SD:":[60,77],"33.5":[61],"7.1)":[63],"(MM":[67],"group)":[68],"30":[70],"aged-":[71],"matched":[72],"30.9":[78],"7.9)":[80],"participated":[81],"exploratory":[84],"study.":[85],"Pregnenolone":[86],"sulfate":[87,111,144,170],"were":[92,114,138,147,172],"by":[94,102],"liquid":[95],"chromatography-tandem":[96],"mass":[97],"spectrometry,":[98],"while":[99,135,168],"enzyme-linked":[103],"immunosorbent":[104],"assay.":[105],"Results":[106],"Serum":[107],"significantly":[115],"lower":[116],"MM":[119,141],"group":[120,178],"than":[121],"(pregnenolone":[124],"sulfate:":[125],"P":[126,130,157,165,182],"=":[127,131,155,158,163,166,180,183],"0.0328;":[128],"pregnanolone:":[129],"0.0271,":[132],"Student\u2019s":[133],"t-test),":[134],"similar.":[139],"In":[140],"group,":[142],"negatively":[148],"correlated":[149],"(R2":[154,162,179],"0.1369;":[156],"0.0482)":[159],"0.2826,":[164],"0.0025)":[167],"not":[173],"age-related":[174],"control":[177],"0.04436,":[181],"0.4337,":[184],"linear":[185],"regression":[186],"analysis).":[187],"Conclusion":[188],"Low":[189],"both":[192],"pregnanolone,":[193],"positive":[195,206],"allosteric":[196,207],"modulator":[197,208],"GABAA":[200],"receptor,":[201,212],"NMDA":[211],"involved":[213],"memory":[215],"learning,":[217],"could":[218],"contribute":[219],"either":[220],"to":[221],"headache":[222],"pain":[223],"or":[224],"cognitive":[226],"dysfunctions":[227],"reported":[228],"patients.":[231],"Overall,":[232],"our":[233],"results":[234],"agree":[235],"hypothesis":[238],"that":[239],"is":[241],"disorder":[243],"associated":[244],"loss":[247],"neurohormonal":[249],"integrity,":[250],"thus":[251],"supporting":[252],"therapeutic":[254],"potential":[255],"restoring":[257],"low":[258],"neurosteroid":[259],"treatment.":[263]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-03-29T00:00:00"}