{"id":"https://openalex.org/W3137783340","doi":"https://doi.org/10.1371/journal.ppat.1009422","title":"The antioxidant response favors Leishmania parasites survival, limits inflammation and reprograms the host cell metabolism","display_name":"The antioxidant response favors Leishmania parasites survival, limits inflammation and reprograms the host cell metabolism","publication_year":2021,"publication_date":"2021-03-25","ids":{"openalex":"https://openalex.org/W3137783340","doi":"https://doi.org/10.1371/journal.ppat.1009422","mag":"3137783340","pmid":"https://pubmed.ncbi.nlm.nih.gov/33765083","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7993605"},"language":"en","primary_location":{"id":"doi:10.1371/journal.ppat.1009422","doi":"https://doi.org/10.1371/journal.ppat.1009422","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1009422","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1009422&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1009422&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068633550","display_name":"Marta Reverte","orcid":"https://orcid.org/0000-0001-6207-5110","observed_orcids":["https://orcid.org/0000-0001-6207-5110"]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Marta Reverte","raw_affiliation_strings":["Department of Biochemistry, University of Lausanne, Epalinges, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-6207-5110","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Lausanne, Epalinges, Switzerland","institution_ids":["https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018403058","display_name":"Remzi Onur Eren","orcid":"https://orcid.org/0000-0003-2795-0156","observed_orcids":["https://orcid.org/0000-0003-2795-0156"]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Remzi Onur Eren","raw_affiliation_strings":["Department of Biochemistry, University of Lausanne, Epalinges, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Lausanne, Epalinges, Switzerland","institution_ids":["https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038918141","display_name":"Baijayanti Jha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Baijayanti Jha","raw_affiliation_strings":["Department of Biochemistry, University of Lausanne, Epalinges, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Lausanne, Epalinges, Switzerland","institution_ids":["https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060803148","display_name":"Chantal Desponds","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Chantal Desponds","raw_affiliation_strings":["Department of Biochemistry, University of Lausanne, Epalinges, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Lausanne, Epalinges, Switzerland","institution_ids":["https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083453748","display_name":"Tiia Sn\u00e4k\u00e4","orcid":"https://orcid.org/0000-0001-6149-2166","observed_orcids":["https://orcid.org/0000-0001-6149-2166"]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Tiia Sn\u00e4k\u00e4","raw_affiliation_strings":["Department of Biochemistry, University of Lausanne, Epalinges, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-6149-2166","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Lausanne, Epalinges, Switzerland","institution_ids":["https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056823000","display_name":"Florence Pr\u00e9vel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Florence Prevel","raw_affiliation_strings":["Department of Biochemistry, University of Lausanne, Epalinges, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Lausanne, Epalinges, Switzerland","institution_ids":["https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107338728","display_name":"Nathalie Isorce","orcid":"https://orcid.org/0000-0001-7494-8273","observed_orcids":["https://orcid.org/0000-0001-7494-8273","https://orcid.org/0000-0002-6053-7139"]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Nathalie Isorce","raw_affiliation_strings":["Department of Biochemistry, University of Lausanne, Epalinges, Switzerland"],"raw_orcid":"https://orcid.org/0000-0001-7494-8273","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Lausanne, Epalinges, Switzerland","institution_ids":["https://openalex.org/I97565354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051353151","display_name":"Lon\u2010Fye Lye","orcid":"https://orcid.org/0000-0003-0704-3532","observed_orcids":["https://orcid.org/0000-0003-0704-3532"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lon-Fye Lye","raw_affiliation_strings":["Department of Molecular Microbiology, School of Medicine, Washington University, St. Louis, Missouri, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-0704-3532","affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology, School of Medicine, Washington University, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075252995","display_name":"Katherine L. Owens","orcid":"https://orcid.org/0000-0002-5695-0203","observed_orcids":["https://orcid.org/0000-0002-5695-0203"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine L. Owens","raw_affiliation_strings":["Department of Molecular Microbiology, School of Medicine, Washington University, St. Louis, Missouri, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology, School of Medicine, Washington University, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042740998","display_name":"Ulisses Gazos Lopes","orcid":"https://orcid.org/0000-0002-0216-3482","observed_orcids":["https://orcid.org/0000-0002-0216-3482"]},"institutions":[{"id":"https://openalex.org/I122140584","display_name":"Universidade Federal do Rio de Janeiro","ror":"https://ror.org/03490as77","country_code":"BR","type":"education","lineage":["https://openalex.org/I122140584"]},{"id":"https://openalex.org/I4387153105","display_name":"Instituto de Biof\u00edsica Carlos Chagas Filho","ror":"https://ror.org/051xsx468","country_code":"BR","type":"facility","lineage":["https://openalex.org/I122140584","https://openalex.org/I4387153105"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ulisses Gazos Lopes","raw_affiliation_strings":["Carlos Chagas Filho Biophysics Institute, Center of Health Science, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carlos Chagas Filho Biophysics Institute, Center of Health Science, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil","institution_ids":["https://openalex.org/I122140584","https://openalex.org/I4387153105"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007063454","display_name":"Stephen M. Beverley","orcid":"https://orcid.org/0000-0001-5319-0811","observed_orcids":["https://orcid.org/0000-0001-5319-0811"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen M. Beverley","raw_affiliation_strings":["Department of Molecular Microbiology, School of Medicine, Washington University, St. Louis, Missouri, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-5319-0811","affiliations":[{"raw_affiliation_string":"Department of Molecular Microbiology, School of Medicine, Washington University, St. Louis, Missouri, United States of America","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086140548","display_name":"Nicolas J. Fasel","orcid":"https://orcid.org/0000-0003-0136-7245","observed_orcids":["https://orcid.org/0000-0003-0136-7245"]},"institutions":[{"id":"https://openalex.org/I97565354","display_name":"University of Lausanne","ror":"https://ror.org/019whta54","country_code":"CH","type":"education","lineage":["https://openalex.org/I97565354"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Nicolas Fasel","raw_affiliation_strings":["Department of Biochemistry, University of Lausanne, Epalinges, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-0136-7245","affiliations":[{"raw_affiliation_string":"Department of Biochemistry, University of Lausanne, Epalinges, Switzerland","institution_ids":["https://openalex.org/I97565354"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5086140548"],"corresponding_institution_ids":["https://openalex.org/I97565354"],"apc_list":{"value":2575,"currency":"USD","value_usd":2575},"apc_paid":{"value":2180,"currency":"EUR","value_usd":2351},"fwci":5.1121,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.95897004,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"17","issue":"3","first_page":"e1009422","last_page":"e1009422"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10823","display_name":"Research on Leishmaniasis Studies","score":0.9628999829292297,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11332","display_name":"Genomics, phytochemicals, and oxidative stress","score":0.009100000374019146,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12107","display_name":"Leprosy Research and Treatment","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leishmania","display_name":"Leishmania","score":0.9620000123977661},{"id":"https://openalex.org/keywords/nrf2","display_name":"Nrf2","score":0.843999981880188},{"id":"https://openalex.org/keywords/antioxidant-response","display_name":"antioxidant response","score":0.7889999747276306},{"id":"https://openalex.org/keywords/respiratory-burst","display_name":"respiratory burst","score":0.8050000071525574},{"id":"https://openalex.org/keywords/nadph-oxidase-2","display_name":"NADPH oxidase 2","score":0.9169999957084656},{"id":"https://openalex.org/keywords/src-family-kinases","display_name":"Src family kinases","score":0.9150000214576721},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.7699999809265137},{"id":"https://openalex.org/keywords/chronic-leishmaniasis","display_name":"chronic leishmaniasis","score":0.8700000047683716},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.8450000286102295},{"id":"https://openalex.org/keywords/parasite-survival","display_name":"parasite survival","score":0.6949999928474426},{"id":"https://openalex.org/keywords/host-parasite-interactions","display_name":"host-parasite interactions","score":0.7680000066757202}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7354234457015991},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6832044124603271},{"id":"https://openalex.org/C2781092759","wikidata":"https://www.wikidata.org/wiki/Q524818","display_name":"Leishmania","level":3,"score":0.6197648048400879},{"id":"https://openalex.org/C153726182","wikidata":"https://www.wikidata.org/wiki/Q3720909","display_name":"Intracellular parasite","level":3,"score":0.6020181775093079},{"id":"https://openalex.org/C2779719074","wikidata":"https://www.wikidata.org/wiki/Q2038057","display_name":"NADPH oxidase","level":3,"score":0.5524439811706543},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5370115041732788},{"id":"https://openalex.org/C48349386","wikidata":"https://www.wikidata.org/wiki/Q424361","display_name":"Reactive oxygen species","level":2,"score":0.48720425367355347},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4868018329143524},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.4860966205596924},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4515036344528198},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.4405277967453003},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.43969377875328064},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.43245190382003784},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.4120730757713318},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2919884920120239},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1460506021976471},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.10675975680351257},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C136764020","wikidata":"https://www.wikidata.org/wiki/Q466","display_name":"World Wide Web","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006790","descriptor_name":"Host-Parasite Interactions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007891","descriptor_name":"Leishmania","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007891","descriptor_name":"Leishmania","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D007896","descriptor_name":"Leishmaniasis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007896","descriptor_name":"Leishmaniasis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051267","descriptor_name":"NF-E2-Related Factor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.ppat.1009422","doi":"https://doi.org/10.1371/journal.ppat.1009422","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1009422","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1009422&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},{"id":"pmid:33765083","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33765083","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS pathogens","raw_type":"Journal Article"},{"id":"pmh:oai:USBKOELN.ub.uni-koeln.de:58706","doi":null,"is_oa":false,"landing_page_url":"https://kups.ub.uni-koeln.de/58706/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400371","display_name":"K\u00f6lner Universit\u00e4ts PublikationsServer (Universit\u00e4t zu K\u00f6ln)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210115942","host_organization_name":"Rhenish Institute for Environmental Research","host_organization_lineage":["https://openalex.org/I4210115942"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"doc-type:article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7993605","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7993605/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Pathog","raw_type":"Text"},{"id":"pmh:oai:serval.unil.ch:BIB_0AB06B72AE21","doi":null,"is_oa":true,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_0AB06B72AE21","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens, vol. 17, no. 3, pp. e1009422","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unil.ch:iris/112299","doi":null,"is_oa":true,"landing_page_url":"https://iris.unil.ch/handle/iris/112299","pdf_url":"https://iris.unil.ch/bitstreams/4a991272-c93b-442f-89ad-f643297270ab/download","source":{"id":"https://openalex.org/S7407055444","display_name":"IRIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"},{"id":"pmh:oai:doaj.org/article:0afbb9684d2240dd949e1accd28bc3af","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/0afbb9684d2240dd949e1accd28bc3af","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Pathogens, Vol 17, Iss 3, p e1009422 (2021)","raw_type":"article"},{"id":"pmh:oai:serval.unil.ch:BIB_39100A74EFAC","doi":null,"is_oa":false,"landing_page_url":"https://serval.unil.ch/notice/serval:BIB_39100A74EFAC","pdf_url":null,"source":{"id":"https://openalex.org/S4306401797","display_name":"SERVAL (Universit\u00e9 de Lausanne)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210093590","host_organization_name":"Swiss School of Archaeology in Greece","host_organization_lineage":["https://openalex.org/I4210093590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS pathogens, vol. 17, no. 3, pp. e1009422","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1371/journal.ppat.1009422","doi":"https://doi.org/10.1371/journal.ppat.1009422","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.ppat.1009422","pdf_url":"https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1009422&type=printable","source":{"id":"https://openalex.org/S2004986","display_name":"PLoS Pathogens","issn_l":"1553-7366","issn":["1553-7366","1553-7374"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Pathogens","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8999999761581421}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1229435578","display_name":null,"funder_award_id":"R01AI-30222-02","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3470607767","display_name":"Leishmania RNA viruses and pathogenesis","funder_award_id":"R01AI130222","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4031091260","display_name":"Impact of viral infections on metastatic leishmaniases","funder_award_id":"173180","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G4726753337","display_name":null,"funder_award_id":"IZRJZ3_164176/1","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G72925236","display_name":"GLYCOSYLATION MUTANTS OF LEISHMANIA","funder_award_id":"R01AI031078","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320323831","display_name":"Universit\u00e9 de Lausanne","ror":"https://ror.org/019whta54"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3137783340.pdf","grobid_xml":"https://content.openalex.org/works/W3137783340.grobid-xml"},"referenced_works_count":97,"referenced_works":["https://openalex.org/W344068791","https://openalex.org/W1658843865","https://openalex.org/W1711766747","https://openalex.org/W1925193485","https://openalex.org/W1970935798","https://openalex.org/W1971080924","https://openalex.org/W1974755487","https://openalex.org/W1988593777","https://openalex.org/W1991631628","https://openalex.org/W1994302475","https://openalex.org/W1995984781","https://openalex.org/W1996544875","https://openalex.org/W2001153614","https://openalex.org/W2003628236","https://openalex.org/W2007127544","https://openalex.org/W2012796686","https://openalex.org/W2015899986","https://openalex.org/W2021992999","https://openalex.org/W2027791250","https://openalex.org/W2032062125","https://openalex.org/W2034083035","https://openalex.org/W2039316360","https://openalex.org/W2040114786","https://openalex.org/W2048098925","https://openalex.org/W2052203880","https://openalex.org/W2053063855","https://openalex.org/W2054330377","https://openalex.org/W2055348159","https://openalex.org/W2056311872","https://openalex.org/W2059944694","https://openalex.org/W2065773854","https://openalex.org/W2067736150","https://openalex.org/W2076361525","https://openalex.org/W2079000049","https://openalex.org/W2079299887","https://openalex.org/W2080951592","https://openalex.org/W2084644507","https://openalex.org/W2089262366","https://openalex.org/W2090895449","https://openalex.org/W2092323527","https://openalex.org/W2093142867","https://openalex.org/W2096261918","https://openalex.org/W2096851991","https://openalex.org/W2103154829","https://openalex.org/W2107689875","https://openalex.org/W2111627816","https://openalex.org/W2113913716","https://openalex.org/W2117800935","https://openalex.org/W2119018101","https://openalex.org/W2119625669","https://openalex.org/W2119665154","https://openalex.org/W2131743762","https://openalex.org/W2134724797","https://openalex.org/W2140452134","https://openalex.org/W2153071302","https://openalex.org/W2158577448","https://openalex.org/W2161982997","https://openalex.org/W2162680854","https://openalex.org/W2167717185","https://openalex.org/W2168068417","https://openalex.org/W2168450407","https://openalex.org/W2170488331","https://openalex.org/W2267343775","https://openalex.org/W2346475789","https://openalex.org/W2400239628","https://openalex.org/W2414692392","https://openalex.org/W2466403012","https://openalex.org/W2512161459","https://openalex.org/W2522255974","https://openalex.org/W2576831217","https://openalex.org/W2577803396","https://openalex.org/W2610139647","https://openalex.org/W2611475096","https://openalex.org/W2613483874","https://openalex.org/W2626102211","https://openalex.org/W2752005712","https://openalex.org/W2752454940","https://openalex.org/W2774227589","https://openalex.org/W2780932379","https://openalex.org/W2784623703","https://openalex.org/W2789362784","https://openalex.org/W2808557803","https://openalex.org/W2883569076","https://openalex.org/W2914111323","https://openalex.org/W2937443955","https://openalex.org/W2952170413","https://openalex.org/W2954326961","https://openalex.org/W2958386701","https://openalex.org/W2965412560","https://openalex.org/W2981960076","https://openalex.org/W2990037291","https://openalex.org/W2991457258","https://openalex.org/W2995385482","https://openalex.org/W3019785310","https://openalex.org/W3108095894","https://openalex.org/W3153744650","https://openalex.org/W6737186731"],"related_works":["https://openalex.org/W4404039150","https://openalex.org/W2998859862","https://openalex.org/W4399660365","https://openalex.org/W7127295561","https://openalex.org/W3207590372","https://openalex.org/W4402331030","https://openalex.org/W4411500821","https://openalex.org/W4386830036","https://openalex.org/W3152265807","https://openalex.org/W2752005712"],"abstract_inverted_index":{"The":[0,45],"oxidative":[1],"burst":[2,18],"generated":[3],"by":[4,113],"the":[5,21,26,30,36,63,78,139,147,155,161],"host":[6,106,156],"immune":[7],"system":[8],"can":[9],"restrict":[10],"intracellular":[11,39],"parasite":[12,125],"entry":[13,64],"and":[14,29,93,103,131,154],"growth.":[15],"While":[16],"this":[17,33],"leads":[19],"to":[20,62],"induction":[22],"of":[23,32,38,56,65,96,138,142,160],"antioxidative":[24],"enzymes,":[25],"molecular":[27],"mechanisms":[28],"consequences":[31],"counter-response":[34],"on":[35,87],"life":[37],"human":[40,79],"parasites":[41],"are":[42],"largely":[43],"unknown.":[44],"transcription":[46],"factor":[47,49],"NF-E2-related":[48],"(NRF2)":[50],"could":[51],"be":[52],"a":[53,88,114],"key":[54],"mediator":[55],"antioxidant":[57],"signaling":[58,101],"during":[59],"infection":[60,76],"due":[61],"parasites.":[66],"Here,":[67],"we":[68],"showed":[69],"that":[70],"NRF2":[71,122,143],"was":[72,85],"strongly":[73],"upregulated":[74],"in":[75,119,144],"with":[77],"Leishmania":[80],"protozoan":[81],"parasites,":[82],"its":[83],"activation":[84,123],"dependent":[86],"NADPH":[89],"oxidase":[90],"2":[91],"(NOX2)":[92],"SRC":[94],"family":[95],"protein":[97],"tyrosine":[98],"kinases":[99],"(SFKs)":[100],"pathway":[102],"it":[104],"reprogrammed":[105],"cell":[107],"metabolism.":[108],"In":[109],"inflammatory":[110],"leishmaniasis":[111],"caused":[112],"viral":[115],"endosymbiont":[116],"inducing":[117],"TNF-\u03b1":[118,129,162],"chronic":[120],"leishmaniasis,":[121],"promoted":[124],"persistence":[126],"but":[127],"limited":[128],"production":[130],"tissue":[132],"destruction.":[133],"These":[134],"data":[135],"provided":[136],"evidence":[137],"dual":[140],"role":[141],"protecting":[145],"both":[146],"invading":[148],"pathogen":[149],"from":[150,157],"reactive":[151],"oxygen":[152],"species":[153],"an":[158],"excess":[159],"destructive":[163],"pro-inflammatory":[164],"cytokine.":[165]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2021-03-29T00:00:00"}
