{"id":"https://openalex.org/W3137598576","doi":"https://doi.org/10.1111/psyp.13804","title":"Stress and aging: A neurovisceral integration perspective","display_name":"Stress and aging: A neurovisceral integration perspective","publication_year":2021,"publication_date":"2021-03-15","ids":{"openalex":"https://openalex.org/W3137598576","doi":"https://doi.org/10.1111/psyp.13804","mag":"3137598576","pmid":"https://pubmed.ncbi.nlm.nih.gov/33723899"},"language":"en","primary_location":{"id":"doi:10.1111/psyp.13804","doi":"https://doi.org/10.1111/psyp.13804","is_oa":true,"landing_page_url":"https://doi.org/10.1111/psyp.13804","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/psyp.13804","source":{"id":"https://openalex.org/S167723465","display_name":"Psychophysiology","issn_l":"0048-5772","issn":["0048-5772","1469-8986"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","erih-plus","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychophysiology","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/psyp.13804","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5009459441","display_name":"Julian Francis Thayer","orcid":"https://orcid.org/0000-0001-9385-3421","observed_orcids":["https://orcid.org/0000-0001-9385-3421"]},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julian F. Thayer","raw_affiliation_strings":["Department of Psychological Science, University of California, Irvine, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychological Science, University of California, Irvine, CA, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048937263","display_name":"Mara Mather","orcid":"https://orcid.org/0000-0003-4331-6112","observed_orcids":["https://orcid.org/0000-0003-4331-6112"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mara Mather","raw_affiliation_strings":["Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA","Department of Psychology, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]},{"raw_affiliation_string":"Department of Psychology, Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040105646","display_name":"Julian Koenig","orcid":"https://orcid.org/0000-0003-1009-9625","observed_orcids":["https://orcid.org/0000-0003-1009-9625"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["CH","DE"],"is_corresponding":true,"raw_author_name":"Julian Koenig","raw_affiliation_strings":["Section for Experimental Child and Adolescent Psychiatry, Department of Child and Adolescent Psychiatry, Centre for Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany","University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland"],"raw_orcid":"https://orcid.org/0000-0003-1009-9625","affiliations":[{"raw_affiliation_string":"Section for Experimental Child and Adolescent Psychiatry, Department of Child and Adolescent Psychiatry, Centre for Psychosocial Medicine, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"University Hospital of Child and Adolescent Psychiatry and Psychotherapy, University of Bern, Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5040105646"],"corresponding_institution_ids":["https://openalex.org/I118564535","https://openalex.org/I223822909"],"apc_list":{"value":3700,"currency":"USD","value_usd":3700},"apc_paid":{"value":3700,"currency":"USD","value_usd":3700},"fwci":2.7698,"has_fulltext":true,"cited_by_count":98,"citation_normalized_percentile":{"value":0.93720122,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"58","issue":"7","first_page":"e13804","last_page":"e13804"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10745","display_name":"Heart Rate Variability and Autonomic Control","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12580","display_name":"Vagus Nerve Stimulation Research","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10529","display_name":"Stress Responses and Cortisol","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2802","display_name":"Behavioral Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stress","display_name":"stress","score":0.824999988079071},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.859000027179718},{"id":"https://openalex.org/keywords/neurovisceral-integration","display_name":"neurovisceral integration","score":0.9490000009536743},{"id":"https://openalex.org/keywords/brain-heart-interaction","display_name":"heart-brain interaction","score":0.949999988079071},{"id":"https://openalex.org/keywords/vagus-nerve","display_name":"vagus nerve","score":0.9990000128746033},{"id":"https://openalex.org/keywords/emotion-regulation","display_name":"emotion regulation","score":0.9369999766349792},{"id":"https://openalex.org/keywords/stress-regulation","display_name":"stress regulation","score":0.984000027179718},{"id":"https://openalex.org/keywords/age-related-decline","display_name":"age-related decline","score":0.7879999876022339},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9169999957084656},{"id":"https://openalex.org/keywords/ethnic-differences","display_name":"ethnic differences","score":0.7879999876022339},{"id":"https://openalex.org/keywords/brain-health","display_name":"brain health","score":0.5889999866485596},{"id":"https://openalex.org/keywords/cardiovascular-health","display_name":"cardiovascular health","score":0.9520000219345093}],"concepts":[{"id":"https://openalex.org/C44725695","wikidata":"https://www.wikidata.org/wiki/Q288156","display_name":"Normative","level":2,"score":0.7455852627754211},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.7362266778945923},{"id":"https://openalex.org/C12713177","wikidata":"https://www.wikidata.org/wiki/Q1900281","display_name":"Perspective (graphical)","level":2,"score":0.6195164322853088},{"id":"https://openalex.org/C27415008","wikidata":"https://www.wikidata.org/wiki/Q7256382","display_name":"Psychological intervention","level":2,"score":0.4373146593570709},{"id":"https://openalex.org/C3017819807","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Healthy aging","level":2,"score":0.4367062747478485},{"id":"https://openalex.org/C21036866","wikidata":"https://www.wikidata.org/wiki/Q181767","display_name":"Stress (linguistics)","level":2,"score":0.43156665563583374},{"id":"https://openalex.org/C137176749","wikidata":"https://www.wikidata.org/wiki/Q4105337","display_name":"Psychological resilience","level":2,"score":0.415530800819397},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.20216664671897888},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.19624581933021545},{"id":"https://openalex.org/C77805123","wikidata":"https://www.wikidata.org/wiki/Q161272","display_name":"Social psychology","level":1,"score":0.19317960739135742},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.17085519433021545},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000080103","descriptor_name":"Emotional Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000082642","descriptor_name":"Brain Cortical Thickness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001341","descriptor_name":"Autonomic Nervous System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006321","descriptor_name":"Heart","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013315","descriptor_name":"Stress, Psychological","qualifier_ui":"Q000523","qualifier_name":"psychology","is_major_topic":false},{"descriptor_ui":"D014630","descriptor_name":"Vagus Nerve","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/psyp.13804","doi":"https://doi.org/10.1111/psyp.13804","is_oa":true,"landing_page_url":"https://doi.org/10.1111/psyp.13804","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/psyp.13804","source":{"id":"https://openalex.org/S167723465","display_name":"Psychophysiology","issn_l":"0048-5772","issn":["0048-5772","1469-8986"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","erih-plus","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychophysiology","raw_type":"journal-article"},{"id":"pmid:33723899","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33723899","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychophysiology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.mpg.de:item_3724875","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/21.11116/0000-0013-6837-9","pdf_url":null,"source":{"id":"https://openalex.org/S4306400654","display_name":"MPG.PuRe (Max Planck Society)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Psychophysiology","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1111/psyp.13804","doi":"https://doi.org/10.1111/psyp.13804","is_oa":true,"landing_page_url":"https://doi.org/10.1111/psyp.13804","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/psyp.13804","source":{"id":"https://openalex.org/S167723465","display_name":"Psychophysiology","issn_l":"0048-5772","issn":["0048-5772","1469-8986"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","erih-plus","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Psychophysiology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3137598576.pdf","grobid_xml":"https://content.openalex.org/works/W3137598576.grobid-xml"},"referenced_works_count":106,"referenced_works":["https://openalex.org/W140218113","https://openalex.org/W756325778","https://openalex.org/W1963163807","https://openalex.org/W1969571804","https://openalex.org/W1971599073","https://openalex.org/W1974251554","https://openalex.org/W1974284263","https://openalex.org/W1981153636","https://openalex.org/W1981783265","https://openalex.org/W1985349171","https://openalex.org/W1994846325","https://openalex.org/W2001062140","https://openalex.org/W2009375902","https://openalex.org/W2022575477","https://openalex.org/W2024311012","https://openalex.org/W2025078777","https://openalex.org/W2027858501","https://openalex.org/W2032958479","https://openalex.org/W2034545996","https://openalex.org/W2043939337","https://openalex.org/W2050876878","https://openalex.org/W2052307202","https://openalex.org/W2054391536","https://openalex.org/W2068786546","https://openalex.org/W2070955680","https://openalex.org/W2093912976","https://openalex.org/W2096215189","https://openalex.org/W2098335992","https://openalex.org/W2100355433","https://openalex.org/W2102178526","https://openalex.org/W2103069600","https://openalex.org/W2104396432","https://openalex.org/W2111936080","https://openalex.org/W2116769635","https://openalex.org/W2118095834","https://openalex.org/W2124648012","https://openalex.org/W2125790298","https://openalex.org/W2127613563","https://openalex.org/W2129030266","https://openalex.org/W2130111393","https://openalex.org/W2136019660","https://openalex.org/W2136429434","https://openalex.org/W2139433132","https://openalex.org/W2142483243","https://openalex.org/W2143213483","https://openalex.org/W2144789364","https://openalex.org/W2148021084","https://openalex.org/W2149189429","https://openalex.org/W2149915148","https://openalex.org/W2151227751","https://openalex.org/W2151634569","https://openalex.org/W2152264416","https://openalex.org/W2163665783","https://openalex.org/W2172343406","https://openalex.org/W2205907895","https://openalex.org/W2320464338","https://openalex.org/W2327079361","https://openalex.org/W2332774740","https://openalex.org/W2334787351","https://openalex.org/W2369104392","https://openalex.org/W2409284958","https://openalex.org/W2409629706","https://openalex.org/W2418981993","https://openalex.org/W2477122034","https://openalex.org/W2485071546","https://openalex.org/W2492742720","https://openalex.org/W2500340790","https://openalex.org/W2502374373","https://openalex.org/W2522887733","https://openalex.org/W2587469802","https://openalex.org/W2589100236","https://openalex.org/W2618328878","https://openalex.org/W2625940930","https://openalex.org/W2754503389","https://openalex.org/W2766821676","https://openalex.org/W2773478070","https://openalex.org/W2777977781","https://openalex.org/W2789908176","https://openalex.org/W2802220643","https://openalex.org/W2810442103","https://openalex.org/W2886364980","https://openalex.org/W2900319448","https://openalex.org/W2902760119","https://openalex.org/W2906498468","https://openalex.org/W2919683812","https://openalex.org/W2922348554","https://openalex.org/W2965606172","https://openalex.org/W2968561506","https://openalex.org/W2972090202","https://openalex.org/W2972114189","https://openalex.org/W2988547412","https://openalex.org/W3011341967","https://openalex.org/W3024945859","https://openalex.org/W3033661040","https://openalex.org/W3034615495","https://openalex.org/W3083453839","https://openalex.org/W3090937016","https://openalex.org/W3098723315","https://openalex.org/W3110071838","https://openalex.org/W3119250782","https://openalex.org/W3137226137","https://openalex.org/W4230385176","https://openalex.org/W4242040410","https://openalex.org/W4388315243","https://openalex.org/W6615646393","https://openalex.org/W6633662851"],"related_works":["https://openalex.org/W4390065234","https://openalex.org/W7130359837","https://openalex.org/W4405923509","https://openalex.org/W4413722330","https://openalex.org/W4291475999","https://openalex.org/W2752326235","https://openalex.org/W7172267803","https://openalex.org/W7160864922","https://openalex.org/W4390065494","https://openalex.org/W41806935"],"abstract_inverted_index":{"Darwin":[0],"emphasized":[1],"the":[2,6,9,24,27,33,39,44,52,58,66,78,152],"intimate":[3],"relationship":[4],"between":[5,31,154],"brain":[7,25,118],"and":[8,26,57,83,124,134,156],"heart":[10,122],"over":[11],"150":[12],"years":[13],"ago.":[14],"Healthy":[15],"aging":[16,56],"is":[17,88],"associated":[18],"with":[19,55,70],"significant":[20,132],"changes":[21,30,54,69],"in":[22],"both":[23],"heart.":[28],"The":[29],"these,":[32],"two":[34],"most":[35],"important":[36],"organs":[37],"of":[38,80],"body,":[40],"are":[41,142],"linked":[42],"via":[43],"vagus":[45],"nerve.":[46],"In":[47,113],"this":[48],"review,":[49],"we":[50],"examine":[51],"normative":[53],"effect":[59],"that":[60,85,94,106,116,131,139],"stress":[61,86,104,155],"may":[62,99,150],"have":[63,95],"on":[64,77],"how":[65,148],"brain-heart":[67],"connection":[68],"age.":[71],"We":[72,127],"provide":[73],"a":[74],"framework":[75],"based":[76],"concept":[79],"neurovisceral":[81],"integration":[82],"propose":[84],"regulation":[87,98,105],"emotion":[89,97],"regulation.":[90],"As":[91],"such,":[92],"studies":[93,141],"investigated":[96],"yield":[100],"insights":[101],"into":[102],"successful":[103],"helps":[107],"protect":[108],"people":[109],"from":[110],"age-related":[111],"decline.":[112],"addition,":[114],"interventions":[115],"improve":[117,121],"health":[119,123],"also":[120],"vice":[125],"versa.":[126],"conclude":[128],"by":[129],"noting":[130],"sex":[133],"ethnic":[135],"differences":[136],"exist":[137],"but":[138],"future":[140],"needed":[143],"to":[144],"more":[145],"fully":[146],"explicate":[147],"they":[149],"moderate":[151],"associations":[153],"aging.":[157]},"counts_by_year":[{"year":2026,"cited_by_count":19},{"year":2025,"cited_by_count":21},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":23},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":7}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-03-29T00:00:00"}