{"id":"https://openalex.org/W3137522513","doi":"https://doi.org/10.21203/rs.3.rs-306630/v1","title":"Clinical Features of Patients With Major Depressive Disorder and Bipolar Disorder Depressive Episodes With Mixed Features","display_name":"Clinical Features of Patients With Major Depressive Disorder and Bipolar Disorder Depressive Episodes With Mixed Features","publication_year":2021,"publication_date":"2021-03-17","ids":{"openalex":"https://openalex.org/W3137522513","doi":"https://doi.org/10.21203/rs.3.rs-306630/v1","mag":"3137522513"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-306630/v1","doi":"https://doi.org/10.21203/rs.3.rs-306630/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-306630/v1","pdf_url":"https://www.researchsquare.com/article/rs-306630/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-306630/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Hong Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210147103","display_name":"Beijing HuiLongGuan Hospital","ror":"https://ror.org/03wgqqb38","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210110145","https://openalex.org/I4210135108","https://openalex.org/I4210147103"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong Wang","raw_affiliation_strings":["Beijing Huilongguan Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Huilongguan Hospital","institution_ids":["https://openalex.org/I4210147103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013380275","display_name":"Yan-Xia Xiao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210147103","display_name":"Beijing HuiLongGuan Hospital","ror":"https://ror.org/03wgqqb38","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210110145","https://openalex.org/I4210135108","https://openalex.org/I4210147103"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan-Xia Xiao","raw_affiliation_strings":["Beijing Huilongguan Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Huilongguan Hospital","institution_ids":["https://openalex.org/I4210147103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075806531","display_name":"Jingge Du","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210147103","display_name":"Beijing HuiLongGuan Hospital","ror":"https://ror.org/03wgqqb38","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210110145","https://openalex.org/I4210135108","https://openalex.org/I4210147103"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing-Ge Du","raw_affiliation_strings":["Beijing Huilongguan Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Huilongguan Hospital","institution_ids":["https://openalex.org/I4210147103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083553501","display_name":"Xia Du","orcid":"https://orcid.org/0000-0002-6474-6579","observed_orcids":["https://orcid.org/0000-0002-6474-6579"]},"institutions":[{"id":"https://openalex.org/I4210147103","display_name":"Beijing HuiLongGuan Hospital","ror":"https://ror.org/03wgqqb38","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210110145","https://openalex.org/I4210135108","https://openalex.org/I4210147103"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xia Du","raw_affiliation_strings":["Beijing Huilongguan Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Huilongguan Hospital","institution_ids":["https://openalex.org/I4210147103"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100443700","display_name":"Lin Chen","orcid":"https://orcid.org/0000-0002-0658-9931","observed_orcids":["https://orcid.org/0000-0002-0658-9931"]},"institutions":[{"id":"https://openalex.org/I4210147103","display_name":"Beijing HuiLongGuan Hospital","ror":"https://ror.org/03wgqqb38","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210110145","https://openalex.org/I4210135108","https://openalex.org/I4210147103"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lin Chen","raw_affiliation_strings":["Beijing Huilongguan Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Beijing Huilongguan Hospital","institution_ids":["https://openalex.org/I4210147103"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5100443700"],"corresponding_institution_ids":["https://openalex.org/I4210147103"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10854","display_name":"Bipolar Disorder and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11093","display_name":"Personality Disorders and Psychopathology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.8700000047683716},{"id":"https://openalex.org/keywords/mixed-features","display_name":"mixed features","score":0.9440000057220459},{"id":"https://openalex.org/keywords/melancholic-features","display_name":"melancholic features","score":0.6359999775886536},{"id":"https://openalex.org/keywords/clinical-characteristics","display_name":"clinical features","score":0.5130000114440918},{"id":"https://openalex.org/keywords/prevalence","display_name":"prevalence","score":0.7990000247955322},{"id":"https://openalex.org/keywords/risk-factors","display_name":"risk factors","score":0.8529999852180481},{"id":"https://openalex.org/keywords/marital-status","display_name":"marital status","score":0.7699999809265137},{"id":"https://openalex.org/keywords/prior-hospitalization","display_name":"prior hospitalization","score":0.7990000247955322},{"id":"https://openalex.org/keywords/age-of-onset","display_name":"age of onset","score":0.5109999775886536}],"concepts":[{"id":"https://openalex.org/C2776174506","wikidata":"https://www.wikidata.org/wiki/Q131755","display_name":"Bipolar disorder","level":3,"score":0.7654815912246704},{"id":"https://openalex.org/C2780051608","wikidata":"https://www.wikidata.org/wiki/Q42844","display_name":"Major depressive disorder","level":3,"score":0.6146637201309204},{"id":"https://openalex.org/C2778609679","wikidata":"https://www.wikidata.org/wiki/Q4915474","display_name":"Bipolar I disorder","level":5,"score":0.578755795955658},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.5245637893676758},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.4951905310153961},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.4857052266597748},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4440455734729767},{"id":"https://openalex.org/C2781354955","wikidata":"https://www.wikidata.org/wiki/Q11920938","display_name":"Marital status","level":3,"score":0.44325703382492065},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.41239219903945923},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.40029552578926086},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2829883098602295},{"id":"https://openalex.org/C2776809841","wikidata":"https://www.wikidata.org/wiki/Q185935","display_name":"Mania","level":4,"score":0.24770724773406982},{"id":"https://openalex.org/C2780733359","wikidata":"https://www.wikidata.org/wiki/Q331769","display_name":"Mood","level":2,"score":0.10670176148414612},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.07711577415466309},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-306630/v1","doi":"https://doi.org/10.21203/rs.3.rs-306630/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-306630/v1","pdf_url":"https://www.researchsquare.com/article/rs-306630/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-306630/v1","doi":"https://doi.org/10.21203/rs.3.rs-306630/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-306630/v1","pdf_url":"https://www.researchsquare.com/article/rs-306630/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3137522513.pdf","grobid_xml":"https://content.openalex.org/works/W3137522513.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2807662482","https://openalex.org/W2751789231","https://openalex.org/W7116902334","https://openalex.org/W2915732028","https://openalex.org/W7002299417","https://openalex.org/W4294201848","https://openalex.org/W1972566307","https://openalex.org/W1995679382","https://openalex.org/W7204730617","https://openalex.org/W2051239765"],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"To":[2],"investigate":[3],"the":[4,11,44,56,68,87,104,108],"clinical":[5,8,47],"phenomenology":[6],"and":[7,18,58,81,95,130,134,140,152,178,186],"features":[9,48,73,106,110,143],"of":[10,14,28,46,61,71,171],"new":[12],"concept":[13],"major":[15,32,78,92,175],"depressive":[16,21,33,38,79,84,93,100,176,181],"disorder":[17,20,34,37,80,83,94,99,177,180],"bipolar":[19,36,82,98,179],"episodes":[22,39,182],"with":[23,31,49,103,123,158,174,183],"mixed":[24,52,72,109,159,184],"features.Methods:":[25],"A":[26],"total":[27],"357":[29],"patients":[30,122,173],"or":[35,50],"were":[40],"assessed,":[41],"we":[42],"compared":[43],"differences":[45],"without":[51],"features.Results:":[53],"According":[54],"to":[55],"Diagnostic":[57],"Statistical":[59],"Manual":[60],"Mental":[62],"Disorders,":[63],"Fifth":[64],"Edition":[65],"(DSM-5)":[66],"criteria,":[67],"overall":[69],"prevalence":[70,88],"was":[74,89,156],"9.52%":[75],"(34/357)":[76],"in":[77,91,97,172],"episodes;":[85],"specifically,":[86],"6.0%":[90],"23.3%":[96],"episodes.":[101],"Compared":[102],"non-mixed":[105],"group,":[107],"group":[111],"had":[112],"more":[113,121,131],"single":[114],"individuals":[115],"(P=0.002),":[116],"earlier":[117],"onset":[118,125],"age":[119,126],"(P=0.003),":[120],"an":[124],"<25":[127],"years":[128],"(P=0.001),":[129],"previous":[132,153,164],"incidences":[133],"prior":[135],"hospitalizations":[136],"(P<0.001,":[137],"P=0.004,":[138],"respectively),":[139],"fewer":[141],"melancholic":[142],"(P=0.013).Logistic":[144],"regression":[145],"analysis":[146],"showed":[147],"that":[148,163],"marital":[149,187],"status":[150,188],"(OR=0.237)":[151],"incidence":[154,165],"(OR=1.478)":[155],"associated":[157],"features.Conclusion:":[160],"It":[161],"indicates":[162],"may":[166,189],"be":[167,190],"a":[168,191],"risk":[169],"factor":[170],"features,":[185],"protective":[192],"factor.":[193]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-03-29T00:00:00"}