{"id":"https://openalex.org/W3137520455","doi":"https://doi.org/10.1158/1078-0432.ccr-20-4217","title":"Single-cell Spatial Proteomic Revelations on the Multiparametric MRI Heterogeneity of Clinically Significant Prostate Cancer","display_name":"Single-cell Spatial Proteomic Revelations on the Multiparametric MRI Heterogeneity of Clinically Significant Prostate Cancer","publication_year":2021,"publication_date":"2021-03-26","ids":{"openalex":"https://openalex.org/W3137520455","doi":"https://doi.org/10.1158/1078-0432.ccr-20-4217","mag":"3137520455","pmid":"https://pubmed.ncbi.nlm.nih.gov/33771855"},"language":"en","primary_location":{"id":"doi:10.1158/1078-0432.ccr-20-4217","doi":"https://doi.org/10.1158/1078-0432.ccr-20-4217","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-20-4217","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083027775","display_name":"Russell Kent Pachynski","orcid":"https://orcid.org/0000-0002-8966-7631","observed_orcids":["https://orcid.org/0000-0002-8966-7631"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Russell K. Pachynski","raw_affiliation_strings":["1Molecular Oncology, Division of Oncology, Department of Medicine, Washington University, St Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Molecular Oncology, Division of Oncology, Department of Medicine, Washington University, St Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100779047","display_name":"Eric H. Kim","orcid":"https://orcid.org/0000-0002-0284-8342","observed_orcids":["https://orcid.org/0000-0002-0284-8342"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric H. Kim","raw_affiliation_strings":["2Division of Urological Surgery, Department of Surgery, Washington University, St. Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"2Division of Urological Surgery, Department of Surgery, Washington University, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021285159","display_name":"Natalia Miheecheva","orcid":"https://orcid.org/0000-0002-6487-5514","observed_orcids":["https://orcid.org/0000-0002-6487-5514"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Natalia Miheecheva","raw_affiliation_strings":["3BostonGene Corporation, Waltham, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3BostonGene Corporation, Waltham, Massachusetts","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090334093","display_name":"Nikita Kotlov","orcid":"https://orcid.org/0000-0002-6393-7357","observed_orcids":["https://orcid.org/0000-0002-6393-7357"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nikita Kotlov","raw_affiliation_strings":["3BostonGene Corporation, Waltham, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0002-6393-7357","affiliations":[{"raw_affiliation_string":"3BostonGene Corporation, Waltham, Massachusetts","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007218532","display_name":"Akshaya Ramachandran","orcid":"https://orcid.org/0000-0002-8727-2046","observed_orcids":["https://orcid.org/0000-0002-8727-2046"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Akshaya Ramachandran","raw_affiliation_strings":["1Molecular Oncology, Division of Oncology, Department of Medicine, Washington University, St Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Molecular Oncology, Division of Oncology, Department of Medicine, Washington University, St Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019399611","display_name":"Ekaterina Postovalova","orcid":"https://orcid.org/0000-0002-3413-3122","observed_orcids":["https://orcid.org/0000-0002-3413-3122"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ekaterina Postovalova","raw_affiliation_strings":["3BostonGene Corporation, Waltham, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0002-3413-3122","affiliations":[{"raw_affiliation_string":"3BostonGene Corporation, Waltham, Massachusetts","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014774251","display_name":"Ilia Galkin","orcid":"https://orcid.org/0000-0001-8492-6596","observed_orcids":["https://orcid.org/0000-0001-8492-6596"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ilia Galkin","raw_affiliation_strings":["3BostonGene Corporation, Waltham, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3BostonGene Corporation, Waltham, Massachusetts","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090352244","display_name":"Viktor Svekolkin","orcid":"https://orcid.org/0000-0001-5763-7246","observed_orcids":["https://orcid.org/0000-0001-5763-7246"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Viktor Svekolkin","raw_affiliation_strings":["3BostonGene Corporation, Waltham, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3BostonGene Corporation, Waltham, Massachusetts","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075861153","display_name":"Yang Lyu","orcid":"https://orcid.org/0000-0002-4353-0082","observed_orcids":["https://orcid.org/0000-0002-4353-0082"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yang Lyu","raw_affiliation_strings":["1Molecular Oncology, Division of Oncology, Department of Medicine, Washington University, St Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1Molecular Oncology, Division of Oncology, Department of Medicine, Washington University, St Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045964615","display_name":"Qiong Zou","orcid":"https://orcid.org/0000-0001-6308-2259","observed_orcids":["https://orcid.org/0000-0001-6308-2259"]},"institutions":[{"id":"https://openalex.org/I139660479","display_name":"Central South University","ror":"https://ror.org/00f1zfq44","country_code":"CN","type":"education","lineage":["https://openalex.org/I139660479"]},{"id":"https://openalex.org/I4210156904","display_name":"Third Xiangya Hospital","ror":"https://ror.org/05akvb491","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156904"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiong Zou","raw_affiliation_strings":["4Department of Pathology, The Third Xiangya Hospital, Central South University, Changsha, Hunan Province, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"4Department of Pathology, The Third Xiangya Hospital, Central South University, Changsha, Hunan Province, P.R. China","institution_ids":["https://openalex.org/I139660479","https://openalex.org/I4210156904"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022036531","display_name":"Dengfeng Cao","orcid":"https://orcid.org/0000-0002-6551-2723","observed_orcids":["https://orcid.org/0000-0002-6551-2723"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dengfeng Cao","raw_affiliation_strings":["5Department of Pathology and Immunology, Washington University, St. Louis, Missouri"],"raw_orcid":"https://orcid.org/0000-0002-6551-2723","affiliations":[{"raw_affiliation_string":"5Department of Pathology and Immunology, Washington University, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074798932","display_name":"Joseph P. Gaut","orcid":"https://orcid.org/0000-0002-9580-3951","observed_orcids":["https://orcid.org/0000-0002-9580-3951"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Gaut","raw_affiliation_strings":["5Department of Pathology and Immunology, Washington University, St. Louis, Missouri"],"raw_orcid":"https://orcid.org/0000-0002-9580-3951","affiliations":[{"raw_affiliation_string":"5Department of Pathology and Immunology, Washington University, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010134057","display_name":"Joseph E. Ippolito","orcid":"https://orcid.org/0000-0003-1913-5573","observed_orcids":["https://orcid.org/0000-0003-1913-5573"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph E. Ippolito","raw_affiliation_strings":["6Department of Radiology, Washington University, St. Louis, Missouri"],"raw_orcid":"https://orcid.org/0000-0003-1913-5573","affiliations":[{"raw_affiliation_string":"6Department of Radiology, Washington University, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045749988","display_name":"Alexander Bagaev","orcid":"https://orcid.org/0000-0002-8680-854X","observed_orcids":["https://orcid.org/0000-0002-8680-854X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander Bagaev","raw_affiliation_strings":["3BostonGene Corporation, Waltham, Massachusetts"],"raw_orcid":"https://orcid.org/0000-0002-8680-854X","affiliations":[{"raw_affiliation_string":"3BostonGene Corporation, Waltham, Massachusetts","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046077742","display_name":"Maria Bruttan","orcid":"https://orcid.org/0000-0002-3021-1760","observed_orcids":["https://orcid.org/0000-0002-3021-1760"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Bruttan","raw_affiliation_strings":["3BostonGene Corporation, Waltham, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3BostonGene Corporation, Waltham, Massachusetts","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052754173","display_name":"Olga S. Gancharova","orcid":"https://orcid.org/0000-0001-7441-1062","observed_orcids":["https://orcid.org/0000-0001-7441-1062"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Olga Gancharova","raw_affiliation_strings":["3BostonGene Corporation, Waltham, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3BostonGene Corporation, Waltham, Massachusetts","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015633466","display_name":"Krystle J. Nomie","orcid":"https://orcid.org/0000-0002-3479-8247","observed_orcids":["https://orcid.org/0000-0002-3479-8247"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Krystle Nomie","raw_affiliation_strings":["3BostonGene Corporation, Waltham, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3BostonGene Corporation, Waltham, Massachusetts","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030217610","display_name":"Maria V. Tsiper","orcid":"https://orcid.org/0000-0002-4472-3978","observed_orcids":["https://orcid.org/0000-0002-4472-3978"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria Tsiper","raw_affiliation_strings":["3BostonGene Corporation, Waltham, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3BostonGene Corporation, Waltham, Massachusetts","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086081364","display_name":"Gerald L. Andriole","orcid":"https://orcid.org/0000-0003-4033-2352","observed_orcids":["https://orcid.org/0000-0003-4033-2352"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerald L. Andriole","raw_affiliation_strings":["2Division of Urological Surgery, Department of Surgery, Washington University, St. Louis, Missouri"],"raw_orcid":"https://orcid.org/0000-0003-4033-2352","affiliations":[{"raw_affiliation_string":"2Division of Urological Surgery, Department of Surgery, Washington University, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090991116","display_name":"Ravshan I. Ataullakhanov","orcid":"https://orcid.org/0000-0002-4767-6409","observed_orcids":["https://orcid.org/0000-0002-4767-6409"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ravshan Ataullakhanov","raw_affiliation_strings":["3BostonGene Corporation, Waltham, Massachusetts"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"3BostonGene Corporation, Waltham, Massachusetts","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021734597","display_name":"James J.-D. Hsieh","orcid":"https://orcid.org/0000-0003-3595-0551","observed_orcids":["https://orcid.org/0000-0003-3595-0551"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James J. Hsieh","raw_affiliation_strings":["1Molecular Oncology, Division of Oncology, Department of Medicine, Washington University, St Louis, Missouri"],"raw_orcid":"https://orcid.org/0000-0003-3595-0551","affiliations":[{"raw_affiliation_string":"1Molecular Oncology, Division of Oncology, Department of Medicine, Washington University, St Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5021734597","https://openalex.org/A5090991116"],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":null,"apc_paid":null,"fwci":3.7196,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.94334509,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"27","issue":"12","first_page":"3478","last_page":"3490"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.5835000276565552,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.5835000276565552,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10124","display_name":"Prostate Cancer Diagnosis and Treatment","score":0.32760000228881836,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12422","display_name":"Radiomics and Machine Learning in Medical Imaging","score":0.01360000018030405,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clinically-significant-prostate-cancer","display_name":"clinically significant prostate cancer","score":0.9819999933242798},{"id":"https://openalex.org/keywords/multiparametric-mri","display_name":"multiparametric MRI","score":0.9129999876022339},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"tumor heterogeneity","score":0.8610000014305115},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.6259999871253967},{"id":"https://openalex.org/keywords/immune-infiltration","display_name":"immune cell infiltration","score":0.781000018119812},{"id":"https://openalex.org/keywords/tumor-immune-interactions","display_name":"tumor-immune interactions","score":0.796999990940094},{"id":"https://openalex.org/keywords/tumor-recurrence","display_name":"tumor recurrence","score":0.46399998664855957},{"id":"https://openalex.org/keywords/single-cell-spatial-proteomics","display_name":"single-cell spatial proteomics","score":0.6830000281333923},{"id":"https://openalex.org/keywords/multiplex-immunofluorescence","display_name":"multiplex immunofluorescence","score":0.828000009059906},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.6589999794960022},{"id":"https://openalex.org/keywords/survival-outcomes","display_name":"survival outcomes","score":0.4099999964237213}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.8860394954681396},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7706747055053711},{"id":"https://openalex.org/C2779466945","wikidata":"https://www.wikidata.org/wiki/Q1765251","display_name":"Prostatectomy","level":4,"score":0.7269195914268494},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.7261180877685547},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.7184606790542603},{"id":"https://openalex.org/C52124034","wikidata":"https://www.wikidata.org/wiki/Q557179","display_name":"Stroma","level":3,"score":0.44389963150024414},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.40973296761512756},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.38198113441467285},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3343943655490875},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2641201317310333},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.25175565481185913}],"mesh":[{"descriptor_ui":"D000081364","descriptor_name":"Multiparametric Magnetic Resonance Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D017753","descriptor_name":"Ecosystem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1158/1078-0432.ccr-20-4217","doi":"https://doi.org/10.1158/1078-0432.ccr-20-4217","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1078-0432.ccr-20-4217","pdf_url":null,"source":{"id":"https://openalex.org/S183149254","display_name":"Clinical Cancer Research","issn_l":"1078-0432","issn":["1078-0432","1557-3265"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Cancer Research","raw_type":"journal-article"},{"id":"pmid:33771855","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33771855","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1827911007","https://openalex.org/W1901129140","https://openalex.org/W1993835819","https://openalex.org/W2009720434","https://openalex.org/W2012693272","https://openalex.org/W2015038952","https://openalex.org/W2023624509","https://openalex.org/W2038264173","https://openalex.org/W2059797892","https://openalex.org/W2083927153","https://openalex.org/W2086630627","https://openalex.org/W2087828746","https://openalex.org/W2092281468","https://openalex.org/W2099540110","https://openalex.org/W2109923019","https://openalex.org/W2120310071","https://openalex.org/W2135880722","https://openalex.org/W2146051023","https://openalex.org/W2179438025","https://openalex.org/W2256034989","https://openalex.org/W2291326553","https://openalex.org/W2345204866","https://openalex.org/W2486380238","https://openalex.org/W2514108517","https://openalex.org/W2538778252","https://openalex.org/W2554542443","https://openalex.org/W2565750686","https://openalex.org/W2566859523","https://openalex.org/W2736868640","https://openalex.org/W2792294713","https://openalex.org/W2792765253","https://openalex.org/W2897747180","https://openalex.org/W2911026448","https://openalex.org/W2911652114","https://openalex.org/W2916926326","https://openalex.org/W2922242638","https://openalex.org/W2922294599","https://openalex.org/W2935069581","https://openalex.org/W2949747738","https://openalex.org/W2952783314","https://openalex.org/W2961869653","https://openalex.org/W2964121744","https://openalex.org/W2971586050","https://openalex.org/W3003257820","https://openalex.org/W3048873723","https://openalex.org/W3103145119","https://openalex.org/W3111067936","https://openalex.org/W6674851884"],"related_works":["https://openalex.org/W3030689165","https://openalex.org/W4225292988","https://openalex.org/W4405331137","https://openalex.org/W4220933016","https://openalex.org/W4282975995","https://openalex.org/W3084712316","https://openalex.org/W2949747738","https://openalex.org/W7154597736","https://openalex.org/W2911652114","https://openalex.org/W4389672576"],"abstract_inverted_index":{"PURPOSE:":[0],"Multiparametric":[1],"MRI":[2],"(mpMRI)":[3],"has":[4],"become":[5],"an":[6],"indispensable":[7],"radiographic":[8,35],"tool":[9],"in":[10,37,97,100,136,141,154,178,204,214],"diagnosing":[11],"prostate":[12,24,102,114,118,163,180,198,250],"cancer.":[13,181],"However,":[14],"mpMRI":[15,149,255],"fails":[16],"to":[17,77,248,254],"visualize":[18],"approximately":[19],"15%":[20],"of":[21,33,122,132,148],"clinically":[22,48,217],"significant":[23,152],"cancer":[25,103,115,164,183,199],"(csPCa).":[26],"The":[27,194],"molecular,":[28,234],"cellular,":[29,235],"and":[30,53,65,82,90,116,126,161,211,236],"spatial":[31,63],"underpinnings":[32],"such":[34],"heterogeneity":[36],"csPCa":[38,55,210,222],"are":[39],"unclear.":[40],"EXPERIMENTAL":[41],"DESIGN:":[42],"We":[43],"examined":[44],"tumor":[45,80,93],"tissues":[46],"from":[47],"matched":[49,218],"patients":[50,208,219],"with":[51,84,184,209,220,240],"mpMRI-invisible":[52,101,113,162,179,221,244],"mpMRI-visible":[54,98,160,207,241],"who":[56],"underwent":[57],"radical":[58],"prostatectomy.":[59],"Multiplex":[60],"immunofluorescence":[61],"single-cell":[62],"imaging":[64],"gene":[66],"expression":[67,170],"profiling":[68,171],"were":[69,75,95,110,246],"performed.":[70],"Artificial":[71],"intelligence-based":[72],"analytic":[73],"algorithms":[74],"developed":[76],"examine":[78],"the":[79,137,142,205,215,225],"ecosystem":[81],"integrate":[83],"corresponding":[85],"transcriptomics.":[86],"RESULTS:":[87],"More":[88],"complex":[89],"compact":[91],"epithelial":[92],"architectures":[94],"found":[96],"than":[99],"tumors.":[104],"In":[105],"contrast,":[106],"similar":[107,247],"stromal":[108,175,186],"patterns":[109],"detected":[111,158],"between":[112,159],"normal":[117,249],"tissues.":[119],"Furthermore,":[120],"quantification":[121],"immune":[123,133,155],"cell":[124,134],"composition":[125],"tumor-immune":[127],"interactions":[128],"demonstrated":[129],"a":[130,173,189],"lack":[131],"infiltration":[135],"malignant":[138],"but":[139],"not":[140],"adjacent":[143],"nonmalignant":[144],"tissue":[145],"compartments,":[146],"irrespective":[147],"visibility.":[150],"No":[151],"difference":[153],"profiles":[156],"was":[157],"within":[165,193],"our":[166],"patient":[167],"cohort,":[168],"whereas":[169,243],"identified":[172,232],"24-gene":[174],"signature":[176,187],"enriched":[177],"Prostate":[182],"strong":[185],"exhibited":[188],"favorable":[190],"survival":[191],"outcome":[192],"Cancer":[195],"Genome":[196],"Atlas":[197],"cohort.":[200],"Notably,":[201],"five":[202],"recurrences":[203],"8":[206,216],"no":[212],"recurrence":[213],"occurred":[223],"during":[224],"5-year":[226],"follow-up":[227],"post-prostatectomy.":[228],"CONCLUSIONS:":[229],"Our":[230],"study":[231],"distinct":[233],"structural":[237],"characteristics":[238],"associated":[239],"csPCa,":[242],"tumors":[245],"tissue,":[251],"likely":[252],"contributing":[253],"invisibility.":[256]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-03-29T00:00:00"}
