{"id":"https://openalex.org/W3137435641","doi":"https://doi.org/10.1186/s13567-021-00914-0","title":"A broadly neutralizing monoclonal antibody induces broad protection against heterogeneous PRRSV strains in piglets","display_name":"A broadly neutralizing monoclonal antibody induces broad protection against heterogeneous PRRSV strains in piglets","publication_year":2021,"publication_date":"2021-03-16","ids":{"openalex":"https://openalex.org/W3137435641","doi":"https://doi.org/10.1186/s13567-021-00914-0","mag":"3137435641","pmid":"https://pubmed.ncbi.nlm.nih.gov/33726857","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7962380"},"language":"en","primary_location":{"id":"doi:10.1186/s13567-021-00914-0","doi":"https://doi.org/10.1186/s13567-021-00914-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13567-021-00914-0","pdf_url":"https://veterinaryresearch.biomedcentral.com/counter/pdf/10.1186/s13567-021-00914-0","source":{"id":"https://openalex.org/S134003780","display_name":"Veterinary Research","issn_l":"0928-4249","issn":["0928-4249","1297-9716"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://veterinaryresearch.biomedcentral.com/counter/pdf/10.1186/s13567-021-00914-0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100373995","display_name":"Zhigang Zhang","orcid":"https://orcid.org/0000-0002-4974-5850","observed_orcids":["https://orcid.org/0000-0002-4974-5850"]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhigang Zhang","raw_affiliation_strings":["Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Xianyang, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Xianyang, Shaanxi, China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111164543","display_name":"Tianshu Zhai","orcid":"https://orcid.org/0009-0004-8986-5656","observed_orcids":["https://orcid.org/0009-0004-8986-5656"]},"institutions":[{"id":"https://openalex.org/I4210127270","display_name":"China Institute of Veterinary Drug Control","ror":"https://ror.org/03jt74a36","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210127270"]},{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tianshu Zhai","raw_affiliation_strings":["China Institute of Veterinary Drug Control, Beijing, 100081, China","Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Xianyang, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"China Institute of Veterinary Drug Control, Beijing, 100081, China","institution_ids":["https://openalex.org/I4210127270"]},{"raw_affiliation_string":"Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Xianyang, Shaanxi, China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064409086","display_name":"Mingshuo Li","orcid":"https://orcid.org/0009-0000-1529-6295","observed_orcids":["https://orcid.org/0009-0000-1529-6295","https://orcid.org/0009-0007-7094-3812"]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingshuo Li","raw_affiliation_strings":["Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Xianyang, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Xianyang, Shaanxi, China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052305380","display_name":"Kun Zhang","orcid":"https://orcid.org/0000-0002-2324-9381","observed_orcids":["https://orcid.org/0000-0002-2324-9381"]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kun Zhang","raw_affiliation_strings":["Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Xianyang, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Xianyang, Shaanxi, China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000762551","display_name":"Jingrui Li","orcid":"https://orcid.org/0000-0001-5906-5114","observed_orcids":["https://orcid.org/0000-0001-5906-5114","https://orcid.org/0009-0007-9402-5127"]},"institutions":[{"id":"https://openalex.org/I4391768222","display_name":"State Key Laboratory of Plant Physiology and Biochemistry","ror":"https://ror.org/02yjhrp74","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4391768222","https://openalex.org/I52158045","https://openalex.org/I76130692"]},{"id":"https://openalex.org/I52158045","display_name":"China Agricultural University","ror":"https://ror.org/04v3ywz14","country_code":"CN","type":"education","lineage":["https://openalex.org/I52158045"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingrui Li","raw_affiliation_strings":["State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing, 100193, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing, 100193, China","institution_ids":["https://openalex.org/I4391768222","https://openalex.org/I52158045"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104856666","display_name":"Xu Zheng","orcid":"https://orcid.org/0009-0005-8058-752X","observed_orcids":["https://orcid.org/0009-0005-8058-752X"]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xu Zheng","raw_affiliation_strings":["Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Xianyang, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Xianyang, Shaanxi, China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071448720","display_name":"Chaonan Tian","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chaonan Tian","raw_affiliation_strings":["Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Xianyang, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Xianyang, Shaanxi, China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037485632","display_name":"Rui Chen","orcid":"https://orcid.org/0000-0002-6128-1657","observed_orcids":["https://orcid.org/0000-0002-6128-1657"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rui Chen","raw_affiliation_strings":["Shaanxi Innolever Biotechnology Co., Ltd., Yangling, Xianyang, 712100, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shaanxi Innolever Biotechnology Co., Ltd., Yangling, Xianyang, 712100, Shaanxi, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082401959","display_name":"Jianhui Dong","orcid":"https://orcid.org/0009-0002-8280-600X","observed_orcids":["https://orcid.org/0009-0002-8280-600X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jianhui Dong","raw_affiliation_strings":["Shaanxi Innolever Biotechnology Co., Ltd., Yangling, Xianyang, 712100, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shaanxi Innolever Biotechnology Co., Ltd., Yangling, Xianyang, 712100, Shaanxi, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077898323","display_name":"En\u2010Min Zhou","orcid":"https://orcid.org/0000-0001-8942-013X","observed_orcids":["https://orcid.org/0000-0001-8942-013X"]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"En-Min Zhou","raw_affiliation_strings":["Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Xianyang, Shaanxi, China. zhouem@nwsuaf.edu.cn","Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Xianyang, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Xianyang, Shaanxi, China. zhouem@nwsuaf.edu.cn","institution_ids":["https://openalex.org/I89652312"]},{"raw_affiliation_string":"Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Xianyang, Shaanxi, China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056436450","display_name":"Yuchen Nan","orcid":"https://orcid.org/0000-0002-4442-8004","observed_orcids":["https://orcid.org/0000-0002-4442-8004"]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuchen Nan","raw_affiliation_strings":["Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Xianyang, Shaanxi, China. nanyuchen2015@nwsuaf.edu.cn","Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Xianyang, Shaanxi, China"],"raw_orcid":"https://orcid.org/0000-0002-4442-8004","affiliations":[{"raw_affiliation_string":"Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Xianyang, Shaanxi, China. nanyuchen2015@nwsuaf.edu.cn","institution_ids":["https://openalex.org/I89652312"]},{"raw_affiliation_string":"Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Xianyang, Shaanxi, China","institution_ids":["https://openalex.org/I89652312"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101518092","display_name":"Chunyan Wu","orcid":"https://orcid.org/0000-0001-7018-7331","observed_orcids":["https://orcid.org/0000-0001-7018-7331"]},"institutions":[{"id":"https://openalex.org/I89652312","display_name":"Northwest A&F University","ror":"https://ror.org/0051rme32","country_code":"CN","type":"education","lineage":["https://openalex.org/I89652312"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chunyan Wu","raw_affiliation_strings":["Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Xianyang, Shaanxi, China. chunyanwu@nwsuaf.edu.cn","Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Xianyang, Shaanxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Xianyang, Shaanxi, China. chunyanwu@nwsuaf.edu.cn","institution_ids":["https://openalex.org/I89652312"]},{"raw_affiliation_string":"Department of Preventive Veterinary Medicine, College of Veterinary Medicine, Northwest A&F University, Yangling, Xianyang, Shaanxi, China","institution_ids":["https://openalex.org/I89652312"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5056436450","https://openalex.org/A5077898323","https://openalex.org/A5101518092"],"corresponding_institution_ids":["https://openalex.org/I89652312"],"apc_list":{"value":1840,"currency":"USD","value_usd":1840},"apc_paid":{"value":1840,"currency":"USD","value_usd":1840},"fwci":2.9004,"has_fulltext":true,"cited_by_count":33,"citation_normalized_percentile":{"value":0.89577421,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"52","issue":"1","first_page":"45","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11135","display_name":"Virology and Viral Diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11560","display_name":"Animal Disease Management and Epidemiology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/porcine-reproductive-and-respiratory-syndrome-virus","display_name":"porcine reproductive and respiratory syndrome virus","score":0.9070000052452087},{"id":"https://openalex.org/keywords/prrsv-1","display_name":"PRRSV-1","score":0.9390000104904175},{"id":"https://openalex.org/keywords/prrsv-2","display_name":"PRRSV-2","score":0.9990000128746033},{"id":"https://openalex.org/keywords/monoclonal-antibodies","display_name":"monoclonal antibodies","score":0.8220000267028809},{"id":"https://openalex.org/keywords/broadly-neutralizing-antibodies","display_name":"broadly neutralizing antibodies","score":0.7289999723434448},{"id":"https://openalex.org/keywords/cross-protection","display_name":"cross-protection","score":0.9269999861717224},{"id":"https://openalex.org/keywords/porcine-alveolar-macrophages","display_name":"porcine alveolar macrophages","score":0.9269999861717224},{"id":"https://openalex.org/keywords/lung-transcriptome","display_name":"lung transcriptome","score":0.6740000247955322},{"id":"https://openalex.org/keywords/viral-pathogenesis","display_name":"viral pathogenesis","score":0.6759999990463257},{"id":"https://openalex.org/keywords/piglets","display_name":"piglets","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8114839792251587},{"id":"https://openalex.org/C2779819720","wikidata":"https://www.wikidata.org/wiki/Q1760147","display_name":"Porcine reproductive and respiratory syndrome virus","level":3,"score":0.7656732797622681},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.7230033874511719},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.6607301235198975},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.5655462145805359},{"id":"https://openalex.org/C2779261636","wikidata":"https://www.wikidata.org/wiki/Q7003054","display_name":"Neutralizing antibody","level":3,"score":0.5228376984596252},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.47951939702033997},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4752219319343567},{"id":"https://openalex.org/C2780115692","wikidata":"https://www.wikidata.org/wiki/Q5747302","display_name":"Heterologous","level":3,"score":0.4606587290763855},{"id":"https://openalex.org/C2777991845","wikidata":"https://www.wikidata.org/wiki/Q2396793","display_name":"Isotype","level":4,"score":0.4594669044017792},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.34547826647758484},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.33305883407592773},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.3265981376171112},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.06578412652015686}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000911","descriptor_name":"Antibodies, Monoclonal","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D013552","descriptor_name":"Swine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014765","descriptor_name":"Viral Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019316","descriptor_name":"Porcine respiratory and reproductive syndrome virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D019318","descriptor_name":"Porcine Reproductive and Respiratory Syndrome","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D034421","descriptor_name":"Sus scrofa","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1186/s13567-021-00914-0","doi":"https://doi.org/10.1186/s13567-021-00914-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13567-021-00914-0","pdf_url":"https://veterinaryresearch.biomedcentral.com/counter/pdf/10.1186/s13567-021-00914-0","source":{"id":"https://openalex.org/S134003780","display_name":"Veterinary Research","issn_l":"0928-4249","issn":["0928-4249","1297-9716"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary Research","raw_type":"journal-article"},{"id":"pmid:33726857","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33726857","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7962380","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7962380/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Vet Res","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-03175950v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.science/hal-03175950","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Veterinary Research, 2021, 52 (1), pp.45. ⟨10.1186/s13567-021-00914-0⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:422fc3de498b47ae925fdd9f6ab535ba","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/422fc3de498b47ae925fdd9f6ab535ba","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Veterinary Research, Vol 52, Iss 1, Pp 1-23 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13567-021-00914-0","doi":"https://doi.org/10.1186/s13567-021-00914-0","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13567-021-00914-0","pdf_url":"https://veterinaryresearch.biomedcentral.com/counter/pdf/10.1186/s13567-021-00914-0","source":{"id":"https://openalex.org/S134003780","display_name":"Veterinary Research","issn_l":"0928-4249","issn":["0928-4249","1297-9716"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Veterinary Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9476000070571899,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8307033268","display_name":null,"funder_award_id":"2017YFD0501004","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3137435641.pdf","grobid_xml":"https://content.openalex.org/works/W3137435641.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W21029601","https://openalex.org/W603214802","https://openalex.org/W991683603","https://openalex.org/W1977085700","https://openalex.org/W1982722566","https://openalex.org/W1992489909","https://openalex.org/W1999423095","https://openalex.org/W2005514695","https://openalex.org/W2005604615","https://openalex.org/W2005829501","https://openalex.org/W2014570432","https://openalex.org/W2014689076","https://openalex.org/W2015503939","https://openalex.org/W2022506220","https://openalex.org/W2028468507","https://openalex.org/W2031123850","https://openalex.org/W2033745025","https://openalex.org/W2040654802","https://openalex.org/W2041931942","https://openalex.org/W2046274883","https://openalex.org/W2050602325","https://openalex.org/W2051013202","https://openalex.org/W2060286793","https://openalex.org/W2067508599","https://openalex.org/W2071154020","https://openalex.org/W2071365881","https://openalex.org/W2073846154","https://openalex.org/W2075164045","https://openalex.org/W2078215357","https://openalex.org/W2078533322","https://openalex.org/W2081771153","https://openalex.org/W2083431289","https://openalex.org/W2084209996","https://openalex.org/W2089662435","https://openalex.org/W2089912966","https://openalex.org/W2100160011","https://openalex.org/W2103692755","https://openalex.org/W2106222929","https://openalex.org/W2107496089","https://openalex.org/W2128738205","https://openalex.org/W2132247530","https://openalex.org/W2140296277","https://openalex.org/W2153733982","https://openalex.org/W2161261138","https://openalex.org/W2168287609","https://openalex.org/W2174353003","https://openalex.org/W2342453318","https://openalex.org/W2412714253","https://openalex.org/W2547976151","https://openalex.org/W2596249817","https://openalex.org/W2609748306","https://openalex.org/W2620721366","https://openalex.org/W2746352180","https://openalex.org/W2785431220","https://openalex.org/W2787928770","https://openalex.org/W2790874563","https://openalex.org/W2791887519","https://openalex.org/W2805716990","https://openalex.org/W2886415078","https://openalex.org/W2897739446","https://openalex.org/W2905240024","https://openalex.org/W2907938859","https://openalex.org/W2924242609","https://openalex.org/W3001437588","https://openalex.org/W3026530948","https://openalex.org/W3038665096","https://openalex.org/W3048414603","https://openalex.org/W4211119448","https://openalex.org/W4234442647","https://openalex.org/W4391200699"],"related_works":["https://openalex.org/W4414064949","https://openalex.org/W3186140426","https://openalex.org/W3001437588","https://openalex.org/W1999423095","https://openalex.org/W2924242609","https://openalex.org/W4392766134","https://openalex.org/W2787928770","https://openalex.org/W3150642186","https://openalex.org/W4400424246","https://openalex.org/W3131271276"],"abstract_inverted_index":{"Neutralizing":[0],"antibodies":[1],"(NAbs)":[2],"have":[3,199],"attracted":[4],"attention":[5],"as":[6],"tools":[7],"for":[8,148,266],"achieving":[9,267],"PRRSV":[10,26,34,83,87,123,157,203,268],"control":[11],"and":[12,50,55,75,101,184,189,194,270],"prevention,":[13],"but":[14],"viral":[15],"antigenic":[16],"variation":[17],"undermines":[18],"the":[19,42,66,77,96,111,156,179,226],"abilities":[20],"of":[21,68,72,79,95,135,141,169,197,228],"NAbs":[22],"elicited":[23],"by":[24],"attenuated":[25],"vaccines":[27],"to":[28,144,175,186,262],"confer":[29,231],"full":[30],"protection":[31],"against":[32,53,233],"heterogeneous":[33,240],"field":[35],"isolates.":[36],"As":[37],"demonstrated":[38],"in":[39,58,61,92,104,128,160,192,202],"this":[40],"study,":[41],"monoclonal":[43],"antibody":[44],"(mAb)":[45],"mAb-PN9cx3":[46,73,153,256],"exhibited":[47],"broad-spectrum":[48],"recognition":[49],"neutralizing":[51],"activities":[52],"PRRSV-1":[54],"PRRSV-2":[56,241],"strains":[57],"vitro.":[59],"Furthermore,":[60],"vivo":[62],"experiments":[63],"revealed":[64],"that":[65,152,177,230,247],"administration":[67],"two":[69],"10-mg":[70],"doses":[71],"before":[74],"after":[76],"inoculation":[78],"piglets":[80,142],"with":[81,110,114,239],"heterologous":[82],"isolates":[84],"(HP-PRRSV-JXA1":[85],"or":[86],"NADC30-like":[88,206],"strain":[89],"HNhx)":[90],"resulted":[91],"significant":[93],"reduction":[94],"PRRSV-induced":[97],"pulmonary":[98],"pathological":[99],"changes":[100],"virus":[102],"loads":[103],"porcine":[105],"alveolar":[106],"macrophages":[107],"(PAMs)":[108],"compared":[109],"results":[112],"obtained":[113],"mAb-treated":[115],"isotype":[116],"controls.":[117],"Moreover,":[118],"minimal":[119],"hilar":[120],"lymph":[121],"node":[122],"antigen":[124],"levels":[125],"were":[126],"observed":[127],"mAb-PN9cx3-treated":[129],"piglets.":[130],"A":[131,163],"transcriptome":[132],"profile":[133],"analysis":[134,168],"PAMs":[136],"extracted":[137],"from":[138,237],"lung":[139],"tissues":[140],"belonging":[143],"different":[145],"groups":[146],"(except":[147],"antibody-isotype":[149],"controls)":[150],"indicated":[151],"treatment":[154],"reversed":[155],"infection-induced":[158],"alterations":[159],"expression":[161],"profiles.":[162],"gene":[164,211],"ontology":[165],"(GO)":[166],"enrichment":[167],"these":[170],"genes":[171],"traced":[172],"their":[173,190],"functions":[174,191],"pathways":[176,212],"included":[178],"immune":[180],"response,":[181,183],"inflammatory":[182],"response":[185],"steroid":[187],"hormone,":[188],"oogenesis":[193],"positive":[195],"regulation":[196],"angiogenesis":[198],"been":[200,251],"implicated":[201],"pathogenesis.":[204],"Overall,":[205],"HNhx":[207],"infection":[208,238],"affected":[209],"more":[210],"than":[213],"HP-PRRSV":[214],"infection.":[215],"In":[216],"conclusion,":[217],"our":[218,263],"research":[219],"describes":[220],"a":[221,245,259],"novel":[222],"immunologic":[223],"approach":[224],"involving":[225],"use":[227],"mAbs":[229],"cross-protection":[232],"serious":[234],"illness":[235],"resulting":[236],"isolates,":[242],"which":[243],"is":[244],"feat":[246],"has":[248],"not":[249],"yet":[250],"achieved":[252],"through":[253],"vaccination.":[254],"Ultimately,":[255],"will":[257],"be":[258],"powerful":[260],"addition":[261],"current":[264],"arsenal":[265],"prevention":[269],"eradication.":[271]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-03-29T00:00:00"}