{"id":"https://openalex.org/W3137076865","doi":"https://doi.org/10.1016/j.jsxm.2021.01.059","title":"089 Mirabegron for Erectile Dysfunction","display_name":"089 Mirabegron for Erectile Dysfunction","publication_year":2021,"publication_date":"2021-03-01","ids":{"openalex":"https://openalex.org/W3137076865","doi":"https://doi.org/10.1016/j.jsxm.2021.01.059","mag":"3137076865"},"language":"en","primary_location":{"id":"doi:10.1016/j.jsxm.2021.01.059","doi":"https://doi.org/10.1016/j.jsxm.2021.01.059","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jsxm.2021.01.059","pdf_url":null,"source":{"id":"https://openalex.org/S159512450","display_name":"The Journal of Sexual Medicine","issn_l":"1743-6095","issn":["1743-6095","1743-6109"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Sexual Medicine","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5075098112","display_name":"Serkan Karakus","orcid":"https://orcid.org/0000-0001-8913-5822","observed_orcids":["https://orcid.org/0000-0001-8913-5822"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Karakus","raw_affiliation_strings":["The Brady Urological Institute at Johns Hopkins"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Brady Urological Institute at Johns Hopkins","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084060127","display_name":"Biljana Musicki","orcid":"https://orcid.org/0000-0002-0437-980X","observed_orcids":["https://orcid.org/0000-0002-0437-980X"]},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]},{"id":"https://openalex.org/I2799853436","display_name":"Johns Hopkins Medicine","ror":"https://ror.org/037zgn354","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799853436"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B. Musicki","raw_affiliation_strings":["The Brady Urological Institute at Johns Hopkins"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Brady Urological Institute at Johns Hopkins","institution_ids":["https://openalex.org/I145311948","https://openalex.org/I2799853436"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3250,"currency":"USD","value_usd":3250},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"Supplement_1","first_page":"S47","last_page":"S47"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10459","display_name":"Sexual function and dysfunction studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10459","display_name":"Sexual function and dysfunction studies","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11815","display_name":"Urological Disorders and Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mirabegron","display_name":"mirabegron","score":1.0},{"id":"https://openalex.org/keywords/erectile-dysfunction","display_name":"erectile dysfunction","score":1.0},{"id":"https://openalex.org/keywords/beta3-adrenergic-agonists","display_name":"beta3-adrenergic agonists","score":0.8870000243186951},{"id":"https://openalex.org/keywords/corpus-cavernosum","display_name":"corpus cavernosum","score":0.871999979019165},{"id":"https://openalex.org/keywords/phosphodiesterase-5-inhibitors","display_name":"phosphodiesterase-5 inhibitors","score":0.7450000047683716},{"id":"https://openalex.org/keywords/camp-pka-signaling","display_name":"cAMP/PKA signaling","score":0.781000018119812},{"id":"https://openalex.org/keywords/nitric-oxide","display_name":"nitric oxide","score":0.7070000171661377},{"id":"https://openalex.org/keywords/hydrogen-sulfide","display_name":"hydrogen sulfide","score":0.9580000042915344},{"id":"https://openalex.org/keywords/penile-erection","display_name":"penile erection","score":0.6639999747276306},{"id":"https://openalex.org/keywords/overactive-bladder","display_name":"overactive bladder","score":0.9639999866485596}],"concepts":[{"id":"https://openalex.org/C2778164427","wikidata":"https://www.wikidata.org/wiki/Q3702534","display_name":"Mirabegron","level":4,"score":0.9884280562400818},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7537782788276672},{"id":"https://openalex.org/C2779929075","wikidata":"https://www.wikidata.org/wiki/Q184674","display_name":"Erectile dysfunction","level":2,"score":0.7534044981002808},{"id":"https://openalex.org/C2778941218","wikidata":"https://www.wikidata.org/wiki/Q331231","display_name":"Overactive bladder","level":3,"score":0.6974193453788757},{"id":"https://openalex.org/C2779478474","wikidata":"https://www.wikidata.org/wiki/Q446372","display_name":"Lower urinary tract symptoms","level":4,"score":0.5746752023696899},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.5512609481811523},{"id":"https://openalex.org/C74534348","wikidata":"https://www.wikidata.org/wiki/Q410798","display_name":"cGMP-specific phosphodiesterase type 5","level":3,"score":0.5382364392280579},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.4349524974822998},{"id":"https://openalex.org/C2776494729","wikidata":"https://www.wikidata.org/wiki/Q1848900","display_name":"Contraindication","level":3,"score":0.42138439416885376},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.391169935464859},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36555665731430054},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.35337263345718384},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.24903947114944458},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.1063292920589447},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jsxm.2021.01.059","doi":"https://doi.org/10.1016/j.jsxm.2021.01.059","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.jsxm.2021.01.059","pdf_url":null,"source":{"id":"https://openalex.org/S159512450","display_name":"The Journal of Sexual Medicine","issn_l":"1743-6095","issn":["1743-6095","1743-6109"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Sexual Medicine","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9476000070571899,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8100000023841858,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7211891931","https://openalex.org/W2343814599","https://openalex.org/W3176637935","https://openalex.org/W2951808427","https://openalex.org/W2342110502","https://openalex.org/W2605924878","https://openalex.org/W1945095845","https://openalex.org/W2975280207","https://openalex.org/W4302579763","https://openalex.org/W2161608104"],"abstract_inverted_index":{"PDE5":[0,26],"inhibitor":[1,27],"is":[2,18,32,47,93,97],"the":[3,14,84,98,107],"only":[4],"approved":[5,105],"oral":[6],"medication":[7,24],"to":[8],"treat":[9],"erectile":[10],"dysfunction":[11],"(ED)":[12],"in":[13,40,91,133],"US.":[15],"However,":[16,83],"there":[17,31],"a":[19,33,125,143],"need":[20],"for":[21,106,146],"an":[22],"alternative":[23],"when":[25],"treatment":[28,108],"fails":[29],"or":[30],"contraindication.":[34],"The":[35,113],"\u03b23-adrenoceptor":[36,50,87,100,138],"has":[37,103],"been":[38,104],"shown":[39],"human":[41],"corpus":[42],"cavernosum":[43],"(CC).":[44],"CC":[45,136],"relaxation":[46],"induced":[48],"by":[49,77],"activation":[51,65,139],"via":[52,137],"cAMP-PKA":[53,56],"dependent":[54],"and/or":[55],"independent":[57],"pathway.":[58,82],"Preclinical":[59],"studies":[60],"suggested":[61],"mechanisms":[62],"such":[63,119],"as":[64,120],"of":[66,71,86,109,115],"K+":[67],"channels":[68],"and":[69,80,122,135,140],"closure":[70],"voltage-gated":[72],"Ca2+":[73],"channels,":[74],"cGMP":[75],"accumulation":[76],"NO":[78],"release":[79],"H2S":[81],"role":[85],"on":[88],"penile":[89],"erection":[90],"men":[92],"still":[94],"unclear.":[95],"Mirabegron":[96,129],"first":[99],"agonist":[101],"that":[102],"overactive":[110],"bladder":[111,134],"(OAB).":[112],"disorders":[114],"lower":[116],"genitourinary":[117],"tract":[118],"OAB":[121],"ED":[123],"share":[124],"common":[126],"pathophysiologic":[127],"mechanism.":[128],"may":[130],"act":[131],"simultaneously":[132],"can":[141],"offer":[142],"pharmacologic":[144],"target":[145],"ED.":[147]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-08-28T12:50:07.497085","created_date":"2021-03-29T00:00:00"}