{"id":"https://openalex.org/W3136931672","doi":"https://doi.org/10.1038/s41525-021-00186-9","title":"Non-secretory multiple myeloma with unusual TFG-ALK fusion showed dramatic response to ALK inhibition","display_name":"Non-secretory multiple myeloma with unusual TFG-ALK fusion showed dramatic response to ALK inhibition","publication_year":2021,"publication_date":"2021-03-17","ids":{"openalex":"https://openalex.org/W3136931672","doi":"https://doi.org/10.1038/s41525-021-00186-9","mag":"3136931672","pmid":"https://pubmed.ncbi.nlm.nih.gov/33731690","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7969947"},"language":"en","primary_location":{"id":"doi:10.1038/s41525-021-00186-9","doi":"https://doi.org/10.1038/s41525-021-00186-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41525-021-00186-9","pdf_url":"https://www.nature.com/articles/s41525-021-00186-9.pdf","source":{"id":"https://openalex.org/S2737523697","display_name":"npj Genomic Medicine","issn_l":"2056-7944","issn":["2056-7944"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Genomic Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s41525-021-00186-9.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007845498","display_name":"Ashiq Masood","orcid":"https://orcid.org/0000-0002-1848-1178","observed_orcids":["https://orcid.org/0000-0002-1848-1178"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ashiq Masood","raw_affiliation_strings":["Division of Hematology/Oncology and Cell Therapy, Rush University Medical Center, Chicago, IL, 60612, USA. Ashiq_Masood@rush.edu","Rush Precision Oncology Program, Rush University Medical Center, Chicago, IL, 60612, USA. Ashiq_Masood@rush.edu","Division of Hematology/Oncology and Cell Therapy, Rush University Medical Center, Chicago, IL, 60612, USA"],"raw_orcid":"https://orcid.org/0000-0002-1848-1178","affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology and Cell Therapy, Rush University Medical Center, Chicago, IL, 60612, USA. Ashiq_Masood@rush.edu","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"Rush Precision Oncology Program, Rush University Medical Center, Chicago, IL, 60612, USA. Ashiq_Masood@rush.edu","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"Division of Hematology/Oncology and Cell Therapy, Rush University Medical Center, Chicago, IL, 60612, USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028337739","display_name":"Trevor N. Christ","orcid":"https://orcid.org/0000-0002-7287-3201","observed_orcids":["https://orcid.org/0000-0002-7287-3201"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trevor Christ","raw_affiliation_strings":["Department of Pharmacy, Rush University Medical Center, Chicago, IL, 60612, USA","Rush Precision Oncology Program, Rush University Medical Center, Chicago, IL, 60612, USA"],"raw_orcid":"https://orcid.org/0000-0002-7287-3201","affiliations":[{"raw_affiliation_string":"Department of Pharmacy, Rush University Medical Center, Chicago, IL, 60612, USA","institution_ids":["https://openalex.org/I1285301757"]},{"raw_affiliation_string":"Rush Precision Oncology Program, Rush University Medical Center, Chicago, IL, 60612, USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019331204","display_name":"Samia Asif","orcid":"https://orcid.org/0000-0002-8466-6410","observed_orcids":["https://orcid.org/0000-0002-8466-6410"]},"institutions":[{"id":"https://openalex.org/I75421653","display_name":"University of Missouri\u2013Kansas City","ror":"https://ror.org/01w0d5g70","country_code":"US","type":"education","lineage":["https://openalex.org/I75421653"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Samia Asif","raw_affiliation_strings":["Department of Medicine, University of Missouri-Kansas City School of Medicine, Kansas City, MO, 12 64108, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Missouri-Kansas City School of Medicine, Kansas City, MO, 12 64108, USA","institution_ids":["https://openalex.org/I75421653"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041099411","display_name":"Priya Rajakumar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Priya Rajakumar","raw_affiliation_strings":["Division of Hematology/Oncology and Cell Therapy, Rush University Medical Center, Chicago, IL, 60612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology and Cell Therapy, Rush University Medical Center, Chicago, IL, 60612, USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022729609","display_name":"Beth A. Gustafson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210137478","display_name":"Saint Luke's Hospital","ror":"https://ror.org/04k1cm432","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1339091601","https://openalex.org/I4210137478","https://openalex.org/I75421653"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Beth A. Gustafson","raw_affiliation_strings":["Precision Oncology Program, St Luke's Cancer Institute, Kansas City, MO, 64111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Precision Oncology Program, St Luke's Cancer Institute, Kansas City, MO, 64111, USA","institution_ids":["https://openalex.org/I4210137478"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039680248","display_name":"Leyla Osman Shune","orcid":"https://orcid.org/0000-0003-1650-1873","observed_orcids":["https://orcid.org/0000-0003-1650-1873"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leyla O. Shune","raw_affiliation_strings":["Department of Hematologic Malignancies and Cellular Therapeutics, University of Kansas Medical Center, Kansas, KS, 66205, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematologic Malignancies and Cellular Therapeutics, University of Kansas Medical Center, Kansas, KS, 66205, USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054698030","display_name":"Ameen Abdulla Salahudeen","orcid":"https://orcid.org/0000-0001-9037-3481","observed_orcids":["https://orcid.org/0000-0001-9037-3481"]},"institutions":[{"id":"https://openalex.org/I4210114883","display_name":"Tempus Labs (United States)","ror":"https://ror.org/01gbymr57","country_code":"US","type":"company","lineage":["https://openalex.org/I4210114883"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ameen Salahudeen","raw_affiliation_strings":["Tempus Labs, Inc, Chicago, IL, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Tempus Labs, Inc, Chicago, IL, USA","institution_ids":["https://openalex.org/I4210114883"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037425425","display_name":"Drew Nedvad","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Drew Nedvad","raw_affiliation_strings":["MAWD Pathology Group, North Kansas City, MO, 64116, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"MAWD Pathology Group, North Kansas City, MO, 64116, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073780820","display_name":"Suparna Nanua","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1339091601","display_name":"Saint Luke's Health System","ror":"https://ror.org/0127qs140","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1339091601"]},{"id":"https://openalex.org/I4210137478","display_name":"Saint Luke's Hospital","ror":"https://ror.org/04k1cm432","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1339091601","https://openalex.org/I4210137478","https://openalex.org/I75421653"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suparna Nanua","raw_affiliation_strings":["Department of Pathology, St Luke's Cancer institute, Kansas City, MO, 64111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, St Luke's Cancer institute, Kansas City, MO, 64111, USA","institution_ids":["https://openalex.org/I1339091601","https://openalex.org/I4210137478"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029205753","display_name":"Agne Paner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Agne Paner","raw_affiliation_strings":["Division of Hematology/Oncology and Cell Therapy, Rush University Medical Center, Chicago, IL, 60612, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology and Cell Therapy, Rush University Medical Center, Chicago, IL, 60612, USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003177689","display_name":"Timothy Michael Kuzel","orcid":"https://orcid.org/0000-0002-7523-2397","observed_orcids":["https://orcid.org/0000-0002-7523-2397"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Timothy M. Kuzel","raw_affiliation_strings":["Division of Hematology/Oncology and Cell Therapy, Rush University Medical Center, Chicago, IL, 60612, USA"],"raw_orcid":"https://orcid.org/0000-0002-7523-2397","affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology and Cell Therapy, Rush University Medical Center, Chicago, IL, 60612, USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030770357","display_name":"Mia Alyce Levy","orcid":"https://orcid.org/0000-0002-5944-2730","observed_orcids":["https://orcid.org/0000-0002-5944-2730"]},"institutions":[{"id":"https://openalex.org/I1285301757","display_name":"Rush University Medical Center","ror":"https://ror.org/01j7c0b24","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285301757"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mia Levy","raw_affiliation_strings":["Division of Hematology/Oncology and Cell Therapy, Rush University Medical Center, Chicago, IL, 60612, USA"],"raw_orcid":"https://orcid.org/0000-0002-5944-2730","affiliations":[{"raw_affiliation_string":"Division of Hematology/Oncology and Cell Therapy, Rush University Medical Center, Chicago, IL, 60612, USA","institution_ids":["https://openalex.org/I1285301757"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035315479","display_name":"Janakiraman Subramanian","orcid":"https://orcid.org/0000-0003-0083-9896","observed_orcids":["https://orcid.org/0000-0003-0083-9896"]},"institutions":[{"id":"https://openalex.org/I4210137478","display_name":"Saint Luke's Hospital","ror":"https://ror.org/04k1cm432","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1339091601","https://openalex.org/I4210137478","https://openalex.org/I75421653"]},{"id":"https://openalex.org/I75421653","display_name":"University of Missouri\u2013Kansas City","ror":"https://ror.org/01w0d5g70","country_code":"US","type":"education","lineage":["https://openalex.org/I75421653"]},{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janakiraman Subramanian","raw_affiliation_strings":["Division of Oncology, Saint Luke's Cancer Institute, University of Missouri School of Medicine, Kansas City, MO, 64111, USA","Precision Oncology Program, St Luke's Cancer Institute, Kansas City, MO, 64111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncology, Saint Luke's Cancer Institute, University of Missouri School of Medicine, Kansas City, MO, 64111, USA","institution_ids":["https://openalex.org/I75421653","https://openalex.org/I76835614"]},{"raw_affiliation_string":"Precision Oncology Program, St Luke's Cancer Institute, Kansas City, MO, 64111, USA","institution_ids":["https://openalex.org/I4210137478"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032260744","display_name":"Shahzad Raza","orcid":"https://orcid.org/0000-0002-2739-2265","observed_orcids":["https://orcid.org/0000-0002-2739-2265"]},"institutions":[{"id":"https://openalex.org/I75421653","display_name":"University of Missouri\u2013Kansas City","ror":"https://ror.org/01w0d5g70","country_code":"US","type":"education","lineage":["https://openalex.org/I75421653"]},{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shahzad Raza","raw_affiliation_strings":["Division of Oncology, Saint Luke's Cancer Institute, University of Missouri School of Medicine, Kansas City, MO, 64111, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncology, Saint Luke's Cancer Institute, University of Missouri School of Medicine, Kansas City, MO, 64111, USA","institution_ids":["https://openalex.org/I75421653","https://openalex.org/I76835614"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5007845498"],"corresponding_institution_ids":["https://openalex.org/I1285301757"],"apc_list":{"value":3490,"currency":"USD","value_usd":3490},"apc_paid":{"value":3490,"currency":"USD","value_usd":3490},"fwci":1.1406,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.76837264,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"6","issue":"1","first_page":"23","last_page":"23"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10649","display_name":"Multiple Myeloma Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/non-secretory-multiple-myeloma","display_name":"non-secretory multiple myeloma","score":1.0},{"id":"https://openalex.org/keywords/alk-inhibitors","display_name":"ALK inhibitors","score":0.878000020980835},{"id":"https://openalex.org/keywords/alk-inhibition","display_name":"ALK inhibition","score":0.7329999804496765},{"id":"https://openalex.org/keywords/relapsed-refractory-multiple-myeloma","display_name":"relapsed/refractory multiple myeloma","score":0.9110000133514404},{"id":"https://openalex.org/keywords/brain-metastases","display_name":"brain metastases","score":0.9959999918937683},{"id":"https://openalex.org/keywords/molecular-profiling","display_name":"molecular profiling","score":0.890999972820282}],"concepts":[{"id":"https://openalex.org/C117643217","wikidata":"https://www.wikidata.org/wiki/Q17824987","display_name":"Anaplastic lymphoma kinase","level":4,"score":0.829028308391571},{"id":"https://openalex.org/C2776364478","wikidata":"https://www.wikidata.org/wiki/Q467635","display_name":"Multiple myeloma","level":2,"score":0.673486590385437},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5793922543525696},{"id":"https://openalex.org/C111829193","wikidata":"https://www.wikidata.org/wiki/Q1108970","display_name":"Fusion gene","level":3,"score":0.557429850101471},{"id":"https://openalex.org/C163864487","wikidata":"https://www.wikidata.org/wiki/Q6901461","display_name":"Monoclonal","level":4,"score":0.4935492277145386},{"id":"https://openalex.org/C36394416","wikidata":"https://www.wikidata.org/wiki/Q949267","display_name":"Immunoglobulin light chain","level":3,"score":0.47876110672950745},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.4749881327152252},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4742754399776459},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.449594646692276},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.41181570291519165},{"id":"https://openalex.org/C542903549","wikidata":"https://www.wikidata.org/wiki/Q422248","display_name":"Monoclonal antibody","level":3,"score":0.394214391708374},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.35856688022613525},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3170406222343445},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.2629268765449524},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.24782776832580566},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19122129678726196},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.10396027565002441},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08321258425712585},{"id":"https://openalex.org/C2776232967","wikidata":"https://www.wikidata.org/wiki/Q6743514","display_name":"Malignant pleural effusion","level":3,"score":0.0},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.0},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1038/s41525-021-00186-9","doi":"https://doi.org/10.1038/s41525-021-00186-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41525-021-00186-9","pdf_url":"https://www.nature.com/articles/s41525-021-00186-9.pdf","source":{"id":"https://openalex.org/S2737523697","display_name":"npj Genomic Medicine","issn_l":"2056-7944","issn":["2056-7944"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Genomic Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7969947","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7969947","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ Genom Med","raw_type":"Text"},{"id":"pmid:33731690","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33731690","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NPJ genomic medicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:31e8f416ebe34f07bee1c287af92fbac","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/31e8f416ebe34f07bee1c287af92fbac","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"npj Genomic Medicine, Vol 6, Iss 1, Pp 1-5 (2021)","raw_type":"article"},{"id":"pmh:oai:scholarworks.indianapolis.iu.edu:1805/46311","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1805/46311","pdf_url":null,"source":{"id":"https://openalex.org/S4306400987","display_name":"IUScholarWorks (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1038/s41525-021-00186-9","doi":"https://doi.org/10.1038/s41525-021-00186-9","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s41525-021-00186-9","pdf_url":"https://www.nature.com/articles/s41525-021-00186-9.pdf","source":{"id":"https://openalex.org/S2737523697","display_name":"npj Genomic Medicine","issn_l":"2056-7944","issn":["2056-7944"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319908","host_organization_name":"Nature Portfolio","host_organization_lineage":["https://openalex.org/P4310319908","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Nature Portfolio","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"npj Genomic Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320307765","display_name":"Pfizer","ror":"https://ror.org/01xdqrp08"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3136931672.pdf","grobid_xml":"https://content.openalex.org/works/W3136931672.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1519176158","https://openalex.org/W1974656498","https://openalex.org/W1999574084","https://openalex.org/W2038477042","https://openalex.org/W2068703815","https://openalex.org/W2091493266","https://openalex.org/W2097198003","https://openalex.org/W2099096012","https://openalex.org/W2103441770","https://openalex.org/W2106347414","https://openalex.org/W2124985265","https://openalex.org/W2160088903","https://openalex.org/W2201132281","https://openalex.org/W2223615728","https://openalex.org/W2765750906","https://openalex.org/W2790451805","https://openalex.org/W2798071966","https://openalex.org/W2899668190","https://openalex.org/W2940735748","https://openalex.org/W2965256357"],"related_works":["https://openalex.org/W4387253881","https://openalex.org/W2979428087","https://openalex.org/W2561795969","https://openalex.org/W4402004320","https://openalex.org/W4400103971","https://openalex.org/W2726279303","https://openalex.org/W4416527879","https://openalex.org/W4364359165","https://openalex.org/W2980729133","https://openalex.org/W321896519"],"abstract_inverted_index":{"Non-secretory":[0],"multiple":[1,9],"myeloma":[2,10],"(NSMM)":[3],"constitutes":[4],"a":[5,51,54,65,69],"distinct":[6],"entity":[7],"of":[8,15,23,42,53,91],"characterized":[11],"by":[12],"the":[13,28,35,88],"absence":[14,22],"detectable":[16],"monoclonal":[17],"protein":[18],"and":[19,30,40,58,71],"rarely":[20],"an":[21],"free":[24],"light":[25],"chains":[26],"in":[27,94],"serum":[29],"urine.":[31],"Given":[32],"its":[33],"rarity,":[34],"genomic":[36],"landscape,":[37],"clinical":[38],"course,":[39],"prognosis":[41],"NSSM":[43],"are":[44],"not":[45],"well":[46],"characterized.":[47],"Here,":[48],"we":[49],"report":[50],"case":[52,86],"patient":[55],"with":[56,61],"relapsed":[57],"refractory":[59],"NSMM":[60],"brain":[62],"metastasis":[63],"harboring":[64],"TFG-ALK":[66],"fusion":[67],"showing":[68],"dramatic":[70],"durable":[72],"(over":[73],"two":[74],"years)":[75],"response":[76],"to":[77],"commercially":[78],"available":[79],"anaplastic":[80],"lymphoma":[81],"kinase":[82],"(ALK)":[83],"inhibitors.":[84],"The":[85],"emphasizes":[87],"beneficial":[89],"role":[90],"molecular":[92],"profiling":[93],"this":[95],"target-poor":[96],"disease.":[97]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2021-03-29T00:00:00"}