{"id":"https://openalex.org/W3136918293","doi":"https://doi.org/10.1016/j.ejmech.2021.113352","title":"Insertion of metal carbenes into the anilinic N\u2013H bond of unprotected aminobenzenesulfonamides delivers low nanomolar inhibitors of human carbonic anhydrase IX and XII isoforms","display_name":"Insertion of metal carbenes into the anilinic N\u2013H bond of unprotected aminobenzenesulfonamides delivers low nanomolar inhibitors of human carbonic anhydrase IX and XII isoforms","publication_year":2021,"publication_date":"2021-03-18","ids":{"openalex":"https://openalex.org/W3136918293","doi":"https://doi.org/10.1016/j.ejmech.2021.113352","mag":"3136918293","pmid":"https://pubmed.ncbi.nlm.nih.gov/33774343"},"language":"en","primary_location":{"id":"doi:10.1016/j.ejmech.2021.113352","doi":"https://doi.org/10.1016/j.ejmech.2021.113352","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejmech.2021.113352","pdf_url":null,"source":{"id":"https://openalex.org/S4210169613","display_name":"European Journal of Medicinal Chemistry","issn_l":"0223-5234","issn":["0223-5234","1768-3254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012998612","display_name":"Tatiana V. Sharonova","orcid":"https://orcid.org/0000-0002-5372-1253","observed_orcids":["https://orcid.org/0000-0002-5372-1253"]},"institutions":[{"id":"https://openalex.org/I172901346","display_name":"St Petersburg University","ror":"https://ror.org/023znxa73","country_code":"RU","type":"education","lineage":["https://openalex.org/I172901346"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Tatiana Sharonova","raw_affiliation_strings":["Saint Petersburg State University, Saint Petersburg, 199034, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saint Petersburg State University, Saint Petersburg, 199034, Russian Federation","institution_ids":["https://openalex.org/I172901346"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Polina Paramonova","orcid":"https://orcid.org/0000-0003-0130-2599","observed_orcids":["https://orcid.org/0000-0003-0130-2599"]},"institutions":[{"id":"https://openalex.org/I172901346","display_name":"St Petersburg University","ror":"https://ror.org/023znxa73","country_code":"RU","type":"education","lineage":["https://openalex.org/I172901346"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Polina Paramonova","raw_affiliation_strings":["Saint Petersburg State University, Saint Petersburg, 199034, Russian Federation"],"raw_orcid":"https://orcid.org/0000-0003-0130-2599","affiliations":[{"raw_affiliation_string":"Saint Petersburg State University, Saint Petersburg, 199034, Russian Federation","institution_ids":["https://openalex.org/I172901346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086790197","display_name":"Stanislav Kalinin","orcid":"https://orcid.org/0000-0002-6421-1208","observed_orcids":["https://orcid.org/0000-0002-6421-1208"]},"institutions":[{"id":"https://openalex.org/I172901346","display_name":"St Petersburg University","ror":"https://ror.org/023znxa73","country_code":"RU","type":"education","lineage":["https://openalex.org/I172901346"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Stanislav Kalinin","raw_affiliation_strings":["Saint Petersburg State University, Saint Petersburg, 199034, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saint Petersburg State University, Saint Petersburg, 199034, Russian Federation","institution_ids":["https://openalex.org/I172901346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073857649","display_name":"Alexander Siyasatovich Bunev","orcid":"https://orcid.org/0000-0001-6408-8329","observed_orcids":["https://orcid.org/0000-0001-6408-8329"]},"institutions":[{"id":"https://openalex.org/I3129553732","display_name":"Togliatti State University","ror":"https://ror.org/03e2ja558","country_code":"RU","type":"education","lineage":["https://openalex.org/I3129553732"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Alexander Bunev","raw_affiliation_strings":["Medicinal Chemistry Center, Togliatti State University, Togliatti, 445020, Russian Federation"],"raw_orcid":"https://orcid.org/0000-0001-6408-8329","affiliations":[{"raw_affiliation_string":"Medicinal Chemistry Center, Togliatti State University, Togliatti, 445020, Russian Federation","institution_ids":["https://openalex.org/I3129553732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020354820","display_name":"Rovshan \u0415. Gasanov","orcid":"https://orcid.org/0009-0001-0237-9398","observed_orcids":["https://orcid.org/0009-0001-0237-9398"]},"institutions":[{"id":"https://openalex.org/I3129553732","display_name":"Togliatti State University","ror":"https://ror.org/03e2ja558","country_code":"RU","type":"education","lineage":["https://openalex.org/I3129553732"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Rovshan \u0415. Gasanov","raw_affiliation_strings":["Medicinal Chemistry Center, Togliatti State University, Togliatti, 445020, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicinal Chemistry Center, Togliatti State University, Togliatti, 445020, Russian Federation","institution_ids":["https://openalex.org/I3129553732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018378636","display_name":"Alessio Nocentini","orcid":"https://orcid.org/0000-0003-3342-702X","observed_orcids":["https://orcid.org/0000-0003-3342-702X"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessio Nocentini","raw_affiliation_strings":["Neurofarba Department, Universita degli Studi di Firenze, Florence, 50019, Italy"],"raw_orcid":"https://orcid.org/0000-0003-3342-702X","affiliations":[{"raw_affiliation_string":"Neurofarba Department, Universita degli Studi di Firenze, Florence, 50019, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049341154","display_name":"Vladimir V. Sharoyko","orcid":"https://orcid.org/0000-0002-3717-0471","observed_orcids":["https://orcid.org/0000-0002-3717-0471"]},"institutions":[{"id":"https://openalex.org/I172901346","display_name":"St Petersburg University","ror":"https://ror.org/023znxa73","country_code":"RU","type":"education","lineage":["https://openalex.org/I172901346"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Vladimir Sharoyko","raw_affiliation_strings":["Saint Petersburg State University, Saint Petersburg, 199034, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saint Petersburg State University, Saint Petersburg, 199034, Russian Federation","institution_ids":["https://openalex.org/I172901346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073129203","display_name":"Tatiana B. Tennikova","orcid":"https://orcid.org/0000-0002-9029-2056","observed_orcids":["https://orcid.org/0000-0002-9029-2056"]},"institutions":[{"id":"https://openalex.org/I172901346","display_name":"St Petersburg University","ror":"https://ror.org/023znxa73","country_code":"RU","type":"education","lineage":["https://openalex.org/I172901346"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Tatiana B. Tennikova","raw_affiliation_strings":["Saint Petersburg State University, Saint Petersburg, 199034, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saint Petersburg State University, Saint Petersburg, 199034, Russian Federation","institution_ids":["https://openalex.org/I172901346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068847009","display_name":"Dmitry Viktorovich Dar\u2019in","orcid":"https://orcid.org/0000-0002-0413-7413","observed_orcids":["https://orcid.org/0000-0002-0413-7413"]},"institutions":[{"id":"https://openalex.org/I172901346","display_name":"St Petersburg University","ror":"https://ror.org/023znxa73","country_code":"RU","type":"education","lineage":["https://openalex.org/I172901346"]}],"countries":["RU"],"is_corresponding":false,"raw_author_name":"Dmitry Dar\u2019in","raw_affiliation_strings":["Saint Petersburg State University, Saint Petersburg, 199034, Russian Federation"],"raw_orcid":"https://orcid.org/0000-0002-0413-7413","affiliations":[{"raw_affiliation_string":"Saint Petersburg State University, Saint Petersburg, 199034, Russian Federation","institution_ids":["https://openalex.org/I172901346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035013697","display_name":"Claudiu Trandafir Supuran","orcid":"https://orcid.org/0000-0003-4262-0323","observed_orcids":["https://orcid.org/0000-0003-4262-0323"]},"institutions":[{"id":"https://openalex.org/I45084792","display_name":"University of Florence","ror":"https://ror.org/04jr1s763","country_code":"IT","type":"education","lineage":["https://openalex.org/I45084792"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Claudiu T. Supuran","raw_affiliation_strings":["Neurofarba Department, Universita degli Studi di Firenze, Florence, 50019, Italy. Electronic address: claudiu.supuran@unifi.it","Neurofarba Department, Universita degli Studi di Firenze, Florence, 50019, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurofarba Department, Universita degli Studi di Firenze, Florence, 50019, Italy. Electronic address: claudiu.supuran@unifi.it","institution_ids":["https://openalex.org/I45084792"]},{"raw_affiliation_string":"Neurofarba Department, Universita degli Studi di Firenze, Florence, 50019, Italy","institution_ids":["https://openalex.org/I45084792"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049458503","display_name":"Mikhail Krasavin","orcid":"https://orcid.org/0000-0002-0200-4772","observed_orcids":["https://orcid.org/0000-0002-0200-4772"]},"institutions":[{"id":"https://openalex.org/I172901346","display_name":"St Petersburg University","ror":"https://ror.org/023znxa73","country_code":"RU","type":"education","lineage":["https://openalex.org/I172901346"]}],"countries":["RU"],"is_corresponding":true,"raw_author_name":"Mikhail Krasavin","raw_affiliation_strings":["Saint Petersburg State University, Saint Petersburg, 199034, Russian Federation. Electronic address: m.krasavin@spbu.ru","Saint Petersburg State University, Saint Petersburg, 199034, Russian Federation"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saint Petersburg State University, Saint Petersburg, 199034, Russian Federation. Electronic address: m.krasavin@spbu.ru","institution_ids":["https://openalex.org/I172901346"]},{"raw_affiliation_string":"Saint Petersburg State University, Saint Petersburg, 199034, Russian Federation","institution_ids":["https://openalex.org/I172901346"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5035013697","https://openalex.org/A5049458503"],"corresponding_institution_ids":["https://openalex.org/I172901346","https://openalex.org/I45084792"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":0.4905,"has_fulltext":false,"cited_by_count":10,"citation_normalized_percentile":{"value":0.53487726,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":96},"biblio":{"volume":"218","issue":null,"first_page":"113352","last_page":"113352"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12412","display_name":"Enzyme function and inhibition","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12412","display_name":"Enzyme function and inhibition","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11593","display_name":"Carbon dioxide utilization in catalysis","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1508","display_name":"Process Chemistry and Technology"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metal-carbene-complexes","display_name":"carbene complexes","score":0.9649999737739563},{"id":"https://openalex.org/keywords/n-h-insertion","display_name":"N-H insertion","score":0.7940000295639038},{"id":"https://openalex.org/keywords/sulfonamide-synthesis","display_name":"sulfonamide synthesis","score":0.7820000052452087},{"id":"https://openalex.org/keywords/carbonic-anhydrase-inhibitors","display_name":"carbonic anhydrase inhibitors","score":0.9190000295639038},{"id":"https://openalex.org/keywords/carbonic-anhydrase-ix","display_name":"carbonic anhydrase IX","score":0.972000002861023},{"id":"https://openalex.org/keywords/carbonic-anhydrase-xii","display_name":"carbonic anhydrase XII","score":0.9990000128746033},{"id":"https://openalex.org/keywords/carbonic-anhydrase-ii","display_name":"carbonic anhydrase II","score":0.9070000052452087},{"id":"https://openalex.org/keywords/carbonic-anhydrase-i","display_name":"carbonic anhydrase I","score":0.875},{"id":"https://openalex.org/keywords/sulfanilamide","display_name":"sulfanilamide","score":0.7639999985694885},{"id":"https://openalex.org/keywords/antiproliferative-activity","display_name":"antiproliferative activity","score":0.843999981880188},{"id":"https://openalex.org/keywords/cancer-cell-growth","display_name":"cancer cell growth","score":0.5619999766349792},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.746999979019165},{"id":"https://openalex.org/keywords/thioredoxin-reductase-inhibition","display_name":"thioredoxin reductase inhibition","score":0.9039999842643738},{"id":"https://openalex.org/keywords/michael-acceptors","display_name":"Michael acceptors","score":0.8360000252723694}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9073642492294312},{"id":"https://openalex.org/C2775914622","wikidata":"https://www.wikidata.org/wiki/Q284089","display_name":"Carbonic anhydrase","level":3,"score":0.8045437932014465},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5922892093658447},{"id":"https://openalex.org/C119795356","wikidata":"https://www.wikidata.org/wiki/Q407801","display_name":"Isozyme","level":3,"score":0.5640126466751099},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5446793437004089},{"id":"https://openalex.org/C2781200679","wikidata":"https://www.wikidata.org/wiki/Q3048282","display_name":"Sulfamide","level":2,"score":0.5176277756690979},{"id":"https://openalex.org/C2781039511","wikidata":"https://www.wikidata.org/wiki/Q3208529","display_name":"Sulfonamide","level":2,"score":0.5104776620864868},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4648192524909973},{"id":"https://openalex.org/C2779056493","wikidata":"https://www.wikidata.org/wiki/Q423423","display_name":"Sulfanilamide","level":2,"score":0.4518274664878845},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.4437270760536194},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.43418318033218384},{"id":"https://openalex.org/C180577832","wikidata":"https://www.wikidata.org/wiki/Q127920","display_name":"Covalent bond","level":2,"score":0.4112669825553894},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000071231","descriptor_name":"Carbonic Anhydrase IX","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D000071231","descriptor_name":"Carbonic Anhydrase IX","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002256","descriptor_name":"Carbonic Anhydrases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002257","descriptor_name":"Carbonic Anhydrase Inhibitors","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D002257","descriptor_name":"Carbonic Anhydrase Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002257","descriptor_name":"Carbonic Anhydrase Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004354","descriptor_name":"Drug Screening Assays, Antitumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008697","descriptor_name":"Methane","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D008697","descriptor_name":"Methane","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008697","descriptor_name":"Methane","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D056831","descriptor_name":"Coordination Complexes","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":false},{"descriptor_ui":"D056831","descriptor_name":"Coordination Complexes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D056831","descriptor_name":"Coordination Complexes","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D062365","descriptor_name":"Aminobenzoates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D062365","descriptor_name":"Aminobenzoates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.ejmech.2021.113352","doi":"https://doi.org/10.1016/j.ejmech.2021.113352","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.ejmech.2021.113352","pdf_url":null,"source":{"id":"https://openalex.org/S4210169613","display_name":"European Journal of Medicinal Chemistry","issn_l":"0223-5234","issn":["0223-5234","1768-3254"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:33774343","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33774343","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of medicinal chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:flore.unifi.it:2158/1262736","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2158/1262736","pdf_url":null,"source":{"id":"https://openalex.org/S4306402033","display_name":"Florence Research (University of Florence)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45084792","host_organization_name":"University of Florence","host_organization_lineage":["https://openalex.org/I45084792"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2660969687","display_name":null,"funder_award_id":"33-90017","funder_id":"https://openalex.org/F4320321079","funder_display_name":"Russian Foundation for Basic Research"},{"id":"https://openalex.org/G4859610318","display_name":null,"funder_award_id":"19\\u201333-90017","funder_id":"https://openalex.org/F4320321079","funder_display_name":"Russian Foundation for Basic Research"}],"funders":[{"id":"https://openalex.org/F4320321079","display_name":"Russian Foundation for Basic Research","ror":"https://ror.org/02mh1ke95"},{"id":"https://openalex.org/F4320321912","display_name":"Ministry of Education and Science of the Russian Federation","ror":"https://ror.org/00ghqgy32"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":81,"referenced_works":["https://openalex.org/W128248222","https://openalex.org/W176484652","https://openalex.org/W1573899446","https://openalex.org/W1886003831","https://openalex.org/W1923974573","https://openalex.org/W1970221679","https://openalex.org/W1972547175","https://openalex.org/W1975117491","https://openalex.org/W1986266721","https://openalex.org/W1988781906","https://openalex.org/W1988812376","https://openalex.org/W2009119714","https://openalex.org/W2009420676","https://openalex.org/W2015770767","https://openalex.org/W2025161230","https://openalex.org/W2025667580","https://openalex.org/W2027133190","https://openalex.org/W2038681095","https://openalex.org/W2047178318","https://openalex.org/W2073322616","https://openalex.org/W2081343472","https://openalex.org/W2103252860","https://openalex.org/W2128102076","https://openalex.org/W2136299255","https://openalex.org/W2139157096","https://openalex.org/W2144971758","https://openalex.org/W2172449893","https://openalex.org/W2186736649","https://openalex.org/W2221513807","https://openalex.org/W2397681412","https://openalex.org/W2471456962","https://openalex.org/W2508831178","https://openalex.org/W2540663276","https://openalex.org/W2588869820","https://openalex.org/W2595355649","https://openalex.org/W2597601939","https://openalex.org/W2605693728","https://openalex.org/W2754564069","https://openalex.org/W2758526445","https://openalex.org/W2767759051","https://openalex.org/W2774836366","https://openalex.org/W2783760997","https://openalex.org/W2797246868","https://openalex.org/W2884238300","https://openalex.org/W2891476079","https://openalex.org/W2891625480","https://openalex.org/W2901821976","https://openalex.org/W2914860519","https://openalex.org/W2922289291","https://openalex.org/W2930966670","https://openalex.org/W2945849210","https://openalex.org/W2948888612","https://openalex.org/W2949486591","https://openalex.org/W2950644969","https://openalex.org/W2966672702","https://openalex.org/W2969912029","https://openalex.org/W2970140438","https://openalex.org/W2971319311","https://openalex.org/W2971881719","https://openalex.org/W2972020168","https://openalex.org/W2993617459","https://openalex.org/W2995728553","https://openalex.org/W3000433028","https://openalex.org/W3014913757","https://openalex.org/W3019341990","https://openalex.org/W3022373424","https://openalex.org/W3024156832","https://openalex.org/W3033841507","https://openalex.org/W3036591694","https://openalex.org/W3040612831","https://openalex.org/W3044674918","https://openalex.org/W3047040017","https://openalex.org/W3092990449","https://openalex.org/W3109682492","https://openalex.org/W3112626892","https://openalex.org/W3118704054","https://openalex.org/W3122442460","https://openalex.org/W3160034163","https://openalex.org/W4205533048","https://openalex.org/W4229754631","https://openalex.org/W4244529273"],"related_works":["https://openalex.org/W2089687855","https://openalex.org/W2423759650","https://openalex.org/W2135572561","https://openalex.org/W2001293975","https://openalex.org/W2273836722","https://openalex.org/W2033235454","https://openalex.org/W2087246081","https://openalex.org/W2752355257","https://openalex.org/W4380576709","https://openalex.org/W2550065046"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-03-29T00:00:00"}
