{"id":"https://openalex.org/W3136903732","doi":"https://doi.org/10.4292/wjgpt.v12.i2.32","title":"Histopathological evaluation of long-term tenofovir disoproxil fumarate treatment in patients with hepatitis be antigen-negative chronic hepatitis B","display_name":"Histopathological evaluation of long-term tenofovir disoproxil fumarate treatment in patients with hepatitis be antigen-negative chronic hepatitis B","publication_year":2021,"publication_date":"2021-03-18","ids":{"openalex":"https://openalex.org/W3136903732","doi":"https://doi.org/10.4292/wjgpt.v12.i2.32","mag":"3136903732","pmid":"https://pubmed.ncbi.nlm.nih.gov/33815864","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8008959"},"language":"en","primary_location":{"id":"doi:10.4292/wjgpt.v12.i2.32","doi":"https://doi.org/10.4292/wjgpt.v12.i2.32","is_oa":true,"landing_page_url":"https://doi.org/10.4292/wjgpt.v12.i2.32","pdf_url":null,"source":{"id":"https://openalex.org/S175885803","display_name":"World Journal of Gastrointestinal Pharmacology and Therapeutics","issn_l":"2150-5349","issn":["2150-5349"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastrointestinal Pharmacology and Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.4292/wjgpt.v12.i2.32","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004607386","display_name":"Bahri Abayl\u0131","orcid":"https://orcid.org/0000-0001-5583-8642","observed_orcids":["https://orcid.org/0000-0001-5583-8642"]},"institutions":[{"id":"https://openalex.org/I4391012566","display_name":"Seyhan Devlet Hastanesi","ror":"https://ror.org/02cwcxm13","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4391012566"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Bahri Abayli","raw_affiliation_strings":["Seyhan Devlet Hastanesi, Adana 090, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seyhan Devlet Hastanesi, Adana 090, Turkey","institution_ids":["https://openalex.org/I4391012566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024976662","display_name":"Cansu Abayl\u0131","orcid":"https://orcid.org/0000-0001-8510-1748","observed_orcids":["https://orcid.org/0000-0001-8510-1748"]},"institutions":[{"id":"https://openalex.org/I4391012566","display_name":"Seyhan Devlet Hastanesi","ror":"https://ror.org/02cwcxm13","country_code":"TR","type":"healthcare","lineage":["https://openalex.org/I4391012566"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Cansu Abayl\u0131","raw_affiliation_strings":["Seyhan Devlet Hastanesi, Adana 090, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seyhan Devlet Hastanesi, Adana 090, Turkey","institution_ids":["https://openalex.org/I4391012566"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5005258313","display_name":"Genco Gen\u00e7dal","orcid":"https://orcid.org/0000-0002-5856-5384","observed_orcids":["https://orcid.org/0000-0002-5856-5384"]},"institutions":[{"id":"https://openalex.org/I1351752","display_name":"Ko\u00e7 University","ror":"https://ror.org/00jzwgz36","country_code":"TR","type":"education","lineage":["https://openalex.org/I1351752"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Genco Gencdal","raw_affiliation_strings":["Department of Gastroenterology, Hepatology and Liver Transplantation, Koc University, School of Medicine, \u0130stanbul 34300, Turkey. gencogencdal@yahoo.co.uk"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, Hepatology and Liver Transplantation, Koc University, School of Medicine, \u0130stanbul 34300, Turkey. gencogencdal@yahoo.co.uk","institution_ids":["https://openalex.org/I1351752"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5428,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.58565012,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"12","issue":"2","first_page":"32","last_page":"39"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10340","display_name":"Hepatitis B Virus Studies","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10151","display_name":"Hepatitis C virus research","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tenofovir-disoproxil-fumarate","display_name":"tenofovir disoproxil fumarate","score":0.9959999918937683},{"id":"https://openalex.org/keywords/hbeag-negative-chronic-hepatitis-b","display_name":"HBeAg-negative hepatitis B","score":0.9750000238418579},{"id":"https://openalex.org/keywords/long-term-antiviral-therapy","display_name":"long-term antiviral therapy","score":0.8149999976158142},{"id":"https://openalex.org/keywords/liver-histopathology","display_name":"liver histopathology","score":0.8980000019073486},{"id":"https://openalex.org/keywords/liver-biopsy","display_name":"liver biopsy","score":0.5989999771118164},{"id":"https://openalex.org/keywords/ishak-score","display_name":"Ishak score","score":0.7839999794960022},{"id":"https://openalex.org/keywords/histologic-activity-index","display_name":"histologic activity index","score":0.9409999847412109},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.7940000295639038},{"id":"https://openalex.org/keywords/necroinflammation","display_name":"necroinflammation","score":0.8320000171661377},{"id":"https://openalex.org/keywords/histological-response","display_name":"histological response","score":0.7369999885559082}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8709524869918823},{"id":"https://openalex.org/C2779344132","wikidata":"https://www.wikidata.org/wiki/Q155954","display_name":"Tenofovir","level":3,"score":0.6982991099357605},{"id":"https://openalex.org/C3020491458","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Chronic hepatitis","level":3,"score":0.5430225729942322},{"id":"https://openalex.org/C2776029263","wikidata":"https://www.wikidata.org/wiki/Q131742","display_name":"Hepatitis","level":2,"score":0.5136277079582214},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.45976677536964417},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.40434756875038147},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.396716445684433},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3550790250301361},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34140175580978394},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.14972832798957825},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.10497209429740906}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.4292/wjgpt.v12.i2.32","doi":"https://doi.org/10.4292/wjgpt.v12.i2.32","is_oa":true,"landing_page_url":"https://doi.org/10.4292/wjgpt.v12.i2.32","pdf_url":null,"source":{"id":"https://openalex.org/S175885803","display_name":"World Journal of Gastrointestinal Pharmacology and Therapeutics","issn_l":"2150-5349","issn":["2150-5349"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastrointestinal Pharmacology and Therapeutics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8008959","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8008959/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8008959/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World J Gastrointest Pharmacol Ther","raw_type":"Text"},{"id":"pmid:33815864","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33815864","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World journal of gastrointestinal pharmacology and therapeutics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4292/wjgpt.v12.i2.32","doi":"https://doi.org/10.4292/wjgpt.v12.i2.32","is_oa":true,"landing_page_url":"https://doi.org/10.4292/wjgpt.v12.i2.32","pdf_url":null,"source":{"id":"https://openalex.org/S175885803","display_name":"World Journal of Gastrointestinal Pharmacology and Therapeutics","issn_l":"2150-5349","issn":["2150-5349"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310315735","host_organization_name":"Baishideng Publishing Group","host_organization_lineage":["https://openalex.org/P4310315735"],"host_organization_lineage_names":["Baishideng Publishing Group"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"World Journal of Gastrointestinal Pharmacology and Therapeutics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3136903732.pdf","grobid_xml":"https://content.openalex.org/works/W3136903732.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W577533421","https://openalex.org/W1589696242","https://openalex.org/W1964491003","https://openalex.org/W1969878531","https://openalex.org/W2004100607","https://openalex.org/W2090738619","https://openalex.org/W2093604720","https://openalex.org/W2106256464","https://openalex.org/W2107889266","https://openalex.org/W2116578828","https://openalex.org/W2119648403","https://openalex.org/W2174723704","https://openalex.org/W2605785536","https://openalex.org/W2888528561","https://openalex.org/W3008330046"],"related_works":["https://openalex.org/W3008330046","https://openalex.org/W2119648403","https://openalex.org/W4221059023","https://openalex.org/W3182954259","https://openalex.org/W2947410103","https://openalex.org/W2897227872","https://openalex.org/W2009509017","https://openalex.org/W2090738619","https://openalex.org/W3161275459","https://openalex.org/W4397049955"],"abstract_inverted_index":{"BACKGROUND:":[0],"Hepatitis":[1],"B":[2,18,51],"virus":[3],"is":[4],"a":[5,195,200],"universal":[6],"health":[7],"problem.":[8],"There":[9],"are":[10,232],"approximately":[11,21],"250":[12],"million":[13],"people":[14,25],"living":[15],"with":[16,44,72,79],"hepatitis":[17,45,50],"worldwide,":[19],"and":[20,38,95,160,199],"600000":[22],"of":[23,42,90,101,110,135,141,147,153,191,202,216,222,230],"these":[24],"die":[26],"every":[27],"year":[28],"due":[29],"to":[30,207],"the":[31,36,86,118,136,144,149,154,161,203,214,220],"virus.":[32],"AIM:":[33],"To":[34,211],"compare":[35],"pretreatment":[37,208],"post-treatment":[39],"histopathological":[40],"results":[41],"patients":[43,91,114,137,155,231],"be":[46],"antigen":[47],"(HBeAg)-negative":[48],"chronic":[49],"(CHB)":[52],"who":[53,75],"had":[54],"been":[55],"receiving":[56],"tenofovir":[57],"disoproxil":[58],"fumarate":[59],"(TDF)":[60],"treatment":[61,94,103,193],"at":[62,66],"our":[63],"clinic":[64],"for":[65],"least":[67],"5":[68,99,139,145,189],"years.":[69],"METHODS:":[70],"Patients":[71],"HBeAg-negative":[73,112],"CHB":[74,113],"were":[76,83,104,115],"being":[77],"treated":[78],"TDF":[80,93,102,183,192],"(245":[81],"mg/d)":[82],"included":[84,116],"in":[85,117,132,175],"study.":[87],"Liver":[88,186],"biopsies":[89,97,187],"before":[92],"liver":[96,209,223],"after":[98,138,181,188],"years":[100,140,146,190],"retrospectively":[105],"compared.":[106],"RESULTS:":[107],"A":[108,171],"total":[109],"50":[111],"study":[119],"(mean":[120],"age:":[121],"47.9":[122],"\u00b1":[123,158,169],"10.4":[124],"years,":[125],"men:":[126],"27.54%).":[127],"Histological":[128],"improvement":[129,221],"was":[130,156,167,179],"observed":[131],"78%":[133],"(39)":[134],"treatment.":[142,184],"After":[143],"treatment,":[148],"mean":[150,162],"Ishak":[151,176],"score":[152,166,178,205],"1.3":[157],"1.3,":[159],"histologic":[163],"activity":[164],"index":[165],"4.1":[168],"2.8.":[170],"1.53":[172],"point":[173],"reduction":[174],"fibrosis":[177],"detected":[180],"long-term":[182,225],"CONCLUSION:":[185],"revealed":[194],"significant":[196],"histological":[197],"response":[198],"regression":[201],"necroinflammatory":[204],"compared":[206],"biopsies.":[210],"better":[212],"understand":[213],"effects":[215],"antiviral":[217],"treatments":[218],"on":[219],"histology,":[224],"studies":[226],"involving":[227],"larger":[228],"numbers":[229],"needed.":[233]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2021-03-29T00:00:00"}
