{"id":"https://openalex.org/W3136895060","doi":"https://doi.org/10.5451/unibas-007157179","title":"The immune modulatory role of interferon lambda on human B-cell functions","display_name":"The immune modulatory role of interferon lambda on human B-cell functions","publication_year":2019,"publication_date":"2019-01-01","ids":{"openalex":"https://openalex.org/W3136895060","doi":"https://doi.org/10.5451/unibas-007157179","mag":"3136895060"},"language":"en","primary_location":{"id":"pmh:oai:edoc.unibas.ch:72231","doi":null,"is_oa":true,"landing_page_url":"https://edoc.unibas.ch/72231/1/PhD%20Thesis_Yaseen.pdf","pdf_url":"https://edoc.unibas.ch/72231/1/PhD%20Thesis_Yaseen.pdf","source":{"id":"https://openalex.org/S4306401836","display_name":"edoc (University of Basel)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1850255","host_organization_name":"University of Basel","host_organization_lineage":["https://openalex.org/I1850255"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://edoc.unibas.ch/72231/1/PhD%20Thesis_Yaseen.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069760348","display_name":"Mohammedyaseen Syedbasha","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Syedbasha, Mohammedyaseen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5069760348"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-lambda","display_name":"interferon lambda","score":1.0},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.7549999952316284},{"id":"https://openalex.org/keywords/interferon-lambda-receptor-1","display_name":"interferon lambda receptor 1","score":0.8379999995231628},{"id":"https://openalex.org/keywords/ligand-receptor-binding-affinity","display_name":"ligand-receptor binding affinity","score":0.9390000104904175},{"id":"https://openalex.org/keywords/small-molecule-screening","display_name":"small molecule screening","score":0.6129999756813049},{"id":"https://openalex.org/keywords/mtorc1-signaling","display_name":"mTORC1 signaling","score":0.8399999737739563},{"id":"https://openalex.org/keywords/b-cell-receptor-signaling","display_name":"B cell receptor signaling","score":0.7910000085830688},{"id":"https://openalex.org/keywords/phosphatidylinositol-3-kinase","display_name":"phosphatidylinositol 3-kinase","score":0.8360000252723694},{"id":"https://openalex.org/keywords/interferon-stimulated-genes","display_name":"interferon-stimulated genes","score":0.8240000009536743},{"id":"https://openalex.org/keywords/cell-cycle-progression","display_name":"cell cycle progression","score":0.6489999890327454},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.3409999907016754},{"id":"https://openalex.org/keywords/memory-b-cells","display_name":"memory B cells","score":0.5049999952316284},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.40700000524520874},{"id":"https://openalex.org/keywords/antiviral-response","display_name":"antiviral response","score":0.7820000052452087},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.4009999930858612}],"concepts":[{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.6458178162574768},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6117895245552063},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5889168381690979},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5514673590660095},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5044413805007935},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.45579394698143005},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.43590599298477173},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3458365201950073},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3324536979198456},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.18683186173439026}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:edoc.unibas.ch:72231","doi":null,"is_oa":true,"landing_page_url":"https://edoc.unibas.ch/72231/1/PhD%20Thesis_Yaseen.pdf","pdf_url":"https://edoc.unibas.ch/72231/1/PhD%20Thesis_Yaseen.pdf","source":{"id":"https://openalex.org/S4306401836","display_name":"edoc (University of Basel)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1850255","host_organization_name":"University of Basel","host_organization_lineage":["https://openalex.org/I1850255"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"doi:10.5451/unibas-007157179","doi":"https://doi.org/10.5451/unibas-007157179","is_oa":true,"landing_page_url":"https://doi.org/10.5451/unibas-007157179","pdf_url":null,"source":{"id":"https://openalex.org/S4306401836","display_name":"edoc (University of Basel)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1850255","host_organization_name":"University of Basel","host_organization_lineage":["https://openalex.org/I1850255"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},{"id":"mag:3136895060","doi":null,"is_oa":false,"landing_page_url":"https://edoc.unibas.ch/72231/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:edoc.unibas.ch:72231","doi":null,"is_oa":true,"landing_page_url":"https://edoc.unibas.ch/72231/1/PhD%20Thesis_Yaseen.pdf","pdf_url":"https://edoc.unibas.ch/72231/1/PhD%20Thesis_Yaseen.pdf","source":{"id":"https://openalex.org/S4306401836","display_name":"edoc (University of Basel)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1850255","host_organization_name":"University of Basel","host_organization_lineage":["https://openalex.org/I1850255"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.8048999905586243,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2267437091","display_name":null,"funder_award_id":"PZ00P3_154709 / 1","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"},{"id":"https://openalex.org/G6068708709","display_name":"Blockade of interferon-? of signalling \u2013 a novel class of adjuvants to improve vaccine-induced antibody responses","funder_award_id":"154709","funder_id":"https://openalex.org/F4320320924","funder_display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320310466","display_name":"Universit\u00e4t Basel","ror":"https://ror.org/02s6k3f65"},{"id":"https://openalex.org/F4320320924","display_name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","ror":"https://ror.org/00yjd3n13"},{"id":"https://openalex.org/F4320321421","display_name":"Albert-Ludwigs-Universit\u00e4t Freiburg","ror":"https://ror.org/0245cg223"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3136895060.pdf","grobid_xml":"https://content.openalex.org/works/W3136895060.grobid-xml"},"referenced_works_count":296,"referenced_works":["https://openalex.org/W29902740","https://openalex.org/W796590349","https://openalex.org/W1485900506","https://openalex.org/W1502575492","https://openalex.org/W1509149404","https://openalex.org/W1521708716","https://openalex.org/W1531708107","https://openalex.org/W1533182067","https://openalex.org/W1544174173","https://openalex.org/W1570272764","https://openalex.org/W1572017168","https://openalex.org/W1608858938","https://openalex.org/W1668086213","https://openalex.org/W1690696145","https://openalex.org/W1788079032","https://openalex.org/W1793506120","https://openalex.org/W1830966545","https://openalex.org/W1834477603","https://openalex.org/W1852581154","https://openalex.org/W1869537815","https://openalex.org/W1877580702","https://openalex.org/W1919378623","https://openalex.org/W1936662132","https://openalex.org/W1964733610","https://openalex.org/W1965154773","https://openalex.org/W1965662580","https://openalex.org/W1966025802","https://openalex.org/W1967351936","https://openalex.org/W1970728276","https://openalex.org/W1971259949","https://openalex.org/W1973221350","https://openalex.org/W1973309978","https://openalex.org/W1973548013","https://openalex.org/W1974748046","https://openalex.org/W1975213528","https://openalex.org/W1976269285","https://openalex.org/W1977715087","https://openalex.org/W1979001780","https://openalex.org/W1979692277","https://openalex.org/W1980825137","https://openalex.org/W1980882260","https://openalex.org/W1984242783","https://openalex.org/W1984372001","https://openalex.org/W1986616881","https://openalex.org/W1987009823","https://openalex.org/W1988050497","https://openalex.org/W1989228700","https://openalex.org/W1990599681","https://openalex.org/W1990992084","https://openalex.org/W1991780615","https://openalex.org/W1992114061","https://openalex.org/W1992170852","https://openalex.org/W1993467483","https://openalex.org/W1993879781","https://openalex.org/W1994292458","https://openalex.org/W1994485971","https://openalex.org/W1995687278","https://openalex.org/W1996432689","https://openalex.org/W1997097856","https://openalex.org/W1999811667","https://openalex.org/W2000500659","https://openalex.org/W2001781369","https://openalex.org/W2002144356","https://openalex.org/W2002556978","https://openalex.org/W2004068381","https://openalex.org/W2004218622","https://openalex.org/W2004643409","https://openalex.org/W2006328907","https://openalex.org/W2006980279","https://openalex.org/W2007736853","https://openalex.org/W2013202475","https://openalex.org/W2014188630","https://openalex.org/W2016263364","https://openalex.org/W2016749309","https://openalex.org/W2017013905","https://openalex.org/W2017083690","https://openalex.org/W2017634591","https://openalex.org/W2017712298","https://openalex.org/W2017851751","https://openalex.org/W2019447967","https://openalex.org/W2021797151","https://openalex.org/W2022291234","https://openalex.org/W2023399402","https://openalex.org/W2026243283","https://openalex.org/W2026614040","https://openalex.org/W2028362431","https://openalex.org/W2031762568","https://openalex.org/W2031913105","https://openalex.org/W2032523448","https://openalex.org/W2032980717","https://openalex.org/W2034275921","https://openalex.org/W2034310945","https://openalex.org/W2034966611","https://openalex.org/W2037863726","https://openalex.org/W2038195307","https://openalex.org/W2038733695","https://openalex.org/W2039162574","https://openalex.org/W2041308494","https://openalex.org/W2041978403","https://openalex.org/W2043308266","https://openalex.org/W2043948827","https://openalex.org/W2043964131","https://openalex.org/W2045067923","https://openalex.org/W2046517086","https://openalex.org/W2047984410","https://openalex.org/W2048246423","https://openalex.org/W2048963159","https://openalex.org/W2049748343","https://openalex.org/W2050696207","https://openalex.org/W2050965729","https://openalex.org/W2051272096","https://openalex.org/W2052732921","https://openalex.org/W2053341712","https://openalex.org/W2053503974","https://openalex.org/W2055364909","https://openalex.org/W2056284616","https://openalex.org/W2057106513","https://openalex.org/W2057754334","https://openalex.org/W2058538904","https://openalex.org/W2058702124","https://openalex.org/W2060905299","https://openalex.org/W2061462777","https://openalex.org/W2062064156","https://openalex.org/W2062429849","https://openalex.org/W2062550809","https://openalex.org/W2063285149","https://openalex.org/W2063683957","https://openalex.org/W2064251575","https://openalex.org/W2064876347","https://openalex.org/W2066298786","https://openalex.org/W2066659565","https://openalex.org/W2068111141","https://openalex.org/W2068931925","https://openalex.org/W2071191299","https://openalex.org/W2072479690","https://openalex.org/W2072731749","https://openalex.org/W2076321236","https://openalex.org/W2076748557","https://openalex.org/W2077131484","https://openalex.org/W2077656241","https://openalex.org/W2078489986","https://openalex.org/W2078844752","https://openalex.org/W2079295092","https://openalex.org/W2079380665","https://openalex.org/W2079611196","https://openalex.org/W2079771032","https://openalex.org/W2080100938","https://openalex.org/W2080324261","https://openalex.org/W2080899810","https://openalex.org/W2082889122","https://openalex.org/W2083162205","https://openalex.org/W2083423629","https://openalex.org/W2086239621","https://openalex.org/W2086338749","https://openalex.org/W2086409213","https://openalex.org/W2086414517","https://openalex.org/W2088338867","https://openalex.org/W2091129202","https://openalex.org/W2091632868","https://openalex.org/W2093262780","https://openalex.org/W2095070541","https://openalex.org/W2095298675","https://openalex.org/W2095920219","https://openalex.org/W2097556922","https://openalex.org/W2097584797","https://openalex.org/W2098664515","https://openalex.org/W2099031084","https://openalex.org/W2101083009","https://openalex.org/W2102180105","https://openalex.org/W2102235987","https://openalex.org/W2104688763","https://openalex.org/W2105842551","https://openalex.org/W2105982486","https://openalex.org/W2106833115","https://openalex.org/W2107031229","https://openalex.org/W2107830237","https://openalex.org/W2108358296","https://openalex.org/W2108473659","https://openalex.org/W2108477457","https://openalex.org/W2111344966","https://openalex.org/W2111357931","https://openalex.org/W2112220625","https://openalex.org/W2113588421","https://openalex.org/W2114104545","https://openalex.org/W2114860838","https://openalex.org/W2115655607","https://openalex.org/W2116954175","https://openalex.org/W2117028091","https://openalex.org/W2117927592","https://openalex.org/W2120379717","https://openalex.org/W2120783853","https://openalex.org/W2121412731","https://openalex.org/W2123586959","https://openalex.org/W2124020935","https://openalex.org/W2126398084","https://openalex.org/W2127245371","https://openalex.org/W2127821993","https://openalex.org/W2129585918","https://openalex.org/W2130410032","https://openalex.org/W2130549992","https://openalex.org/W2131103696","https://openalex.org/W2131733302","https://openalex.org/W2132439466","https://openalex.org/W2133402546","https://openalex.org/W2134138119","https://openalex.org/W2134644492","https://openalex.org/W2136187101","https://openalex.org/W2136676465","https://openalex.org/W2139237097","https://openalex.org/W2139636324","https://openalex.org/W2140191892","https://openalex.org/W2141706180","https://openalex.org/W2143112776","https://openalex.org/W2143364414","https://openalex.org/W2143875917","https://openalex.org/W2143952529","https://openalex.org/W2146512944","https://openalex.org/W2149345160","https://openalex.org/W2149737545","https://openalex.org/W2150343213","https://openalex.org/W2150351516","https://openalex.org/W2153398168","https://openalex.org/W2157135427","https://openalex.org/W2158717742","https://openalex.org/W2159163240","https://openalex.org/W2162614494","https://openalex.org/W2163586656","https://openalex.org/W2163671315","https://openalex.org/W2164121384","https://openalex.org/W2164917731","https://openalex.org/W2165667087","https://openalex.org/W2165804863","https://openalex.org/W2165899828","https://openalex.org/W2166250722","https://openalex.org/W2166840738","https://openalex.org/W2167034585","https://openalex.org/W2167423357","https://openalex.org/W2169456326","https://openalex.org/W2170182039","https://openalex.org/W2171334847","https://openalex.org/W2172292246","https://openalex.org/W2174246816","https://openalex.org/W2182536415","https://openalex.org/W2197369680","https://openalex.org/W2209458064","https://openalex.org/W2213262959","https://openalex.org/W2222144602","https://openalex.org/W2244406944","https://openalex.org/W2260507520","https://openalex.org/W2264030030","https://openalex.org/W2273547594","https://openalex.org/W2275249553","https://openalex.org/W2277297461","https://openalex.org/W2288694532","https://openalex.org/W2301127062","https://openalex.org/W2328746135","https://openalex.org/W2410495494","https://openalex.org/W2463032998","https://openalex.org/W2471243967","https://openalex.org/W2488623126","https://openalex.org/W2510960647","https://openalex.org/W2510979876","https://openalex.org/W2517547699","https://openalex.org/W2519286313","https://openalex.org/W2520162260","https://openalex.org/W2528369300","https://openalex.org/W2528662867","https://openalex.org/W2529608238","https://openalex.org/W2530292134","https://openalex.org/W2536322725","https://openalex.org/W2538848459","https://openalex.org/W2554739988","https://openalex.org/W2557197752","https://openalex.org/W2593038077","https://openalex.org/W2593816418","https://openalex.org/W2616112277","https://openalex.org/W2616524644","https://openalex.org/W2625779183","https://openalex.org/W2691302849","https://openalex.org/W2744377419","https://openalex.org/W2745352569","https://openalex.org/W2759638244","https://openalex.org/W2763533536","https://openalex.org/W2794337296","https://openalex.org/W2798242933","https://openalex.org/W2811318883","https://openalex.org/W2905090539","https://openalex.org/W2909107489","https://openalex.org/W2920819460","https://openalex.org/W2923545753","https://openalex.org/W2951912016","https://openalex.org/W2958829040","https://openalex.org/W2970141704","https://openalex.org/W4234363463","https://openalex.org/W4238567307","https://openalex.org/W4246504300"],"related_works":["https://openalex.org/W3091971470","https://openalex.org/W2264030030","https://openalex.org/W2593038077","https://openalex.org/W2051803500","https://openalex.org/W3022536911","https://openalex.org/W2902767932","https://openalex.org/W2328746135","https://openalex.org/W2594689595","https://openalex.org/W2913830662","https://openalex.org/W4313383385"],"abstract_inverted_index":{"Interferon":[0],"lambda":[1,57],"(IFN-L)":[2],"mediates":[3],"a":[4,21,79,138,176,243],"crucial":[5],"antiviral":[6],"response":[7,195,237,244],"to":[8,49,96,99,110,121,136,152,191,196,198,220,223,238,245,254,318,398],"protect":[9],"the":[10,30,39,68,82,142,148,154,165,182,187,193,207,226,256,265,277,280,306,323,331,352,362,405],"host":[11],"cells":[12,363],"during":[13],"viral":[14],"infection,":[15],"as":[16,18,20,78,368],"well":[17],"functioning":[19],"potential":[22,155],"immune":[23,31,188,257],"modulator.":[24],"In":[25,38,181,388],"this":[26,131,337,389],"thesis,":[27],"we":[28,42,66,104,185,247,391],"investigated":[29],"modulatory":[32,258],"role":[33,259,378],"of":[34,81,141,167,179,209,251,260,267,284,354,379,407],"IFN-L":[35,51,159,168,261,278,302,321,329,340,349,380,395],"in":[36,46,112,262,274,289,381,418],"B-cells.":[37,263],"first":[40],"part,":[41,184],"established":[43],"an":[44,172],"ELISA-based":[45],"vitro":[47,275],"assays":[48],"study":[50],"ligands":[52],"and":[53,62,84,101,130,206,213,231,271,301,339,373,400,414],"its":[54],"receptor":[55,58,69,85,293],"(Interferon":[56],"1":[59],"-":[60,70,73,114],"IFNLR1":[61,97,113,127],"IL10R2)":[63],"interactions.":[64,116],"First,":[65],"determined":[67],"ligand":[71,83],"(IFNLR1":[72],"IFN-L1-3)":[74],"dissociation":[75],"constant":[76],"(KD)":[77],"measure":[80],"binding":[86,94,128],"affinity.":[87],"We":[88,144],"found":[89,219],"that":[90,401],"IFN-L1":[91],"showed":[92,242],"higher":[93],"affinity":[95],"compared":[98],"IFN-L2":[100],"IFN-L3.":[102],"Further,":[103],"screened":[105,186],"antagonistic":[106],"peptides,":[107],"which":[108,170],"act":[109],"interfere":[111],"IFN-Ls":[115,124],"The":[117,299,377],"peptides":[118],"are":[119],"designed":[120],"compete":[122],"with":[123,201,297],"at":[125],"their":[126],"sites":[129],"experiment":[132],"thus":[133],"allowed":[134],"us":[135,164],"develop":[137],"molecular":[139],"understanding":[140],"interaction.":[143],"have":[145,392],"also":[146],"performed":[147,248],"small":[149],"molecules":[150],"screen":[151],"identify":[153],"substances":[156],"targeting":[157],"for":[158,175],"signaling,":[160],"it":[161,314,402],"will":[162],"allow":[163],"modulation":[166],"signaling":[169,303],"is":[171],"interesting":[173],"target":[174,283],"broad":[177],"range":[178],"applications.":[180],"second":[183],"cell":[189,333,346,415],"populations":[190],"understand":[192],"direct":[194],"IFN-L,":[197,246],"resolve":[199],"discrepancies":[200],"previously":[202,385],"reported":[203],"data.":[204],"B-cells":[205,217,241,356,399,409],"subpopulations":[208],"na\u00efve,":[210],"class":[211],"switched":[212,215],"non-class":[214],"memory":[216],"were":[218],"directly":[221],"respond":[222],"IFN-Ls.":[224,239],"On":[225,264],"other":[227],"hand,":[228],"T-cells,":[229],"NK-cells":[230],"monocytes":[232],"did":[233,342],"not":[234,343,386],"show":[235],"any":[236,345],"Since":[240],"transcriptomic":[249],"profiling":[250],"sorted":[252],"B-cell,":[253],"examine":[255],"basis":[266],"B-cell":[268,292],"transcriptome":[269],"analysis":[270],"follow":[272],"up":[273],"experiments,":[276],"increases":[279],"mTORC1":[281,307,324,338,413],"(mammalian/mechanistic":[282],"rapamycin":[285],"complex":[286],"1)":[287],"activity":[288,325],"B-cells,":[290],"upon":[291,359],"(BCR)":[294],"cross":[295],"linking":[296],"anti-IgM.":[298],"BCR":[300],"cascade":[304],"engage":[305],"pathway":[308],"via":[309,327,412],"phosphoinositide":[310],"3-kinase":[311],"(PI3K).":[312],"However,":[313],"needs":[315],"further":[316,350],"evaluation":[317],"see":[319],"if":[320],"increase":[322],"indirectly":[326],"ISGs.":[328],"enhances":[330],"BCR-induced":[332],"cycle":[334,416],"progress":[335],"though":[336],"alone":[341],"induce":[344],"proliferation.":[347],"Consequently":[348],"boosts":[351,404],"differentiation":[353,383,406],"na\u00efve":[355,408],"into":[357,410],"plasmablasts":[358,411],"BCR-activation,":[360],"so":[361],"gain":[364],"effector":[365],"functions":[366],"such":[367],"cytokines":[369],"release":[370],"(IL-6,":[371],"IL-10)":[372],"antibody":[374],"production":[375],"(IgM).":[376],"plasmablast":[382],"was":[384],"known.":[387],"study,":[390],"shown":[393],"how":[394],"functionally":[396],"binds":[397],"systematically":[403],"progression":[417],"BCR-activated":[419],"cells.":[420]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-03-29T00:00:00"}
