{"id":"https://openalex.org/W3136872053","doi":"https://doi.org/10.12890/2021_002345","title":"Use of Brentuximab Vedotin in a Non-HIV Patient with Primary Effusion Lymphoma","display_name":"Use of Brentuximab Vedotin in a Non-HIV Patient with Primary Effusion Lymphoma","publication_year":2021,"publication_date":"2021-02-22","ids":{"openalex":"https://openalex.org/W3136872053","doi":"https://doi.org/10.12890/2021_002345","mag":"3136872053","pmid":"https://pubmed.ncbi.nlm.nih.gov/33768081","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7977055"},"language":"en","primary_location":{"id":"doi:10.12890/2021_002345","doi":"https://doi.org/10.12890/2021_002345","is_oa":true,"landing_page_url":"https://doi.org/10.12890/2021_002345","pdf_url":"https://www.ejcrim.com/index.php/EJCRIM/article/download/2345/2569","source":{"id":"https://openalex.org/S2737828108","display_name":"European Journal of Case Reports in Internal Medicine","issn_l":"2284-2594","issn":["2284-2594"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310317697","host_organization_name":"SMC MEDIA SRL","host_organization_lineage":["https://openalex.org/P4310317697"],"host_organization_lineage_names":["SMC MEDIA SRL"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Case Reports in Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.ejcrim.com/index.php/EJCRIM/article/download/2345/2569","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086446891","display_name":"Joana Raquel Monteiro Ferra","orcid":"https://orcid.org/0000-0003-4301-6013","observed_orcids":["https://orcid.org/0000-0003-4301-6013"]},"institutions":[{"id":"https://openalex.org/I4210106487","display_name":"Hospital de Egas Moniz","ror":"https://ror.org/012habm93","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210106487"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Joana Ferra","raw_affiliation_strings":["Pneumology Department, Hospital Egas Moniz, Centro Hospitalar Lisboa Ocidental, E.P.E., Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pneumology Department, Hospital Egas Moniz, Centro Hospitalar Lisboa Ocidental, E.P.E., Portugal","institution_ids":["https://openalex.org/I4210106487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062286411","display_name":"Filipa Mousinho","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124394","display_name":"Centro Hospitalar de Lisboa Ocidental","ror":"https://ror.org/036ypft38","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210124394"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Filipa Mousinho","raw_affiliation_strings":["Hematology Department, Hospital S\u00e3o Francisco Xavier, Centro Hospitalar Lisboa Ocidental, E.P.E., Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Department, Hospital S\u00e3o Francisco Xavier, Centro Hospitalar Lisboa Ocidental, E.P.E., Portugal","institution_ids":["https://openalex.org/I4210124394"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068224964","display_name":"Francisca Miranda","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124394","display_name":"Centro Hospitalar de Lisboa Ocidental","ror":"https://ror.org/036ypft38","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210124394"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Francisca Miranda","raw_affiliation_strings":["Hematology Department, Hospital S\u00e3o Francisco Xavier, Centro Hospitalar Lisboa Ocidental, E.P.E., Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Department, Hospital S\u00e3o Francisco Xavier, Centro Hospitalar Lisboa Ocidental, E.P.E., Portugal","institution_ids":["https://openalex.org/I4210124394"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062411926","display_name":"Sandra Andr\u00e9","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106487","display_name":"Hospital de Egas Moniz","ror":"https://ror.org/012habm93","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210106487"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Sandra Andr\u00e9","raw_affiliation_strings":["Pneumology Department, Hospital Egas Moniz, Centro Hospitalar Lisboa Ocidental, E.P.E., Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pneumology Department, Hospital Egas Moniz, Centro Hospitalar Lisboa Ocidental, E.P.E., Portugal","institution_ids":["https://openalex.org/I4210106487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055666816","display_name":"Celina Afonso","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210124394","display_name":"Centro Hospitalar de Lisboa Ocidental","ror":"https://ror.org/036ypft38","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210124394"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Celina Afonso","raw_affiliation_strings":["Hematology Department, Hospital S\u00e3o Francisco Xavier, Centro Hospitalar Lisboa Ocidental, E.P.E., Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Department, Hospital S\u00e3o Francisco Xavier, Centro Hospitalar Lisboa Ocidental, E.P.E., Portugal","institution_ids":["https://openalex.org/I4210124394"]}]},{"author_position":"last","author":{"id":null,"display_name":"Fernando Nogueira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106487","display_name":"Hospital de Egas Moniz","ror":"https://ror.org/012habm93","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210106487"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Fernando Nogueira","raw_affiliation_strings":["Pneumology Department, Hospital Egas Moniz, Centro Hospitalar Lisboa Ocidental, E.P.E., Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pneumology Department, Hospital Egas Moniz, Centro Hospitalar Lisboa Ocidental, E.P.E., Portugal","institution_ids":["https://openalex.org/I4210106487"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":300,"currency":"EUR","value_usd":323},"apc_paid":{"value":300,"currency":"EUR","value_usd":323},"fwci":0.5002,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.62738098,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"8","issue":"2","first_page":"002345","last_page":"002345"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12212","display_name":"CNS Lymphoma Diagnosis and Treatment","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/primary-effusion-lymphoma","display_name":"primary effusion lymphoma","score":0.968999981880188},{"id":"https://openalex.org/keywords/brentuximab-vedotin","display_name":"brentuximab vedotin","score":1.0},{"id":"https://openalex.org/keywords/cd30","display_name":"CD30","score":0.7799999713897705},{"id":"https://openalex.org/keywords/large-b-cell-lymphoma","display_name":"large B-cell lymphoma","score":0.8980000019073486},{"id":"https://openalex.org/keywords/relapsed-lymphoma","display_name":"relapsed lymphoma","score":0.8230000138282776},{"id":"https://openalex.org/keywords/non-hiv-patients","display_name":"non-HIV patients","score":0.7089999914169312},{"id":"https://openalex.org/keywords/immunocompromised-patients","display_name":"immunocompromised patients","score":0.9309999942779541},{"id":"https://openalex.org/keywords/targeted-therapy","display_name":"targeted therapy","score":0.7850000262260437},{"id":"https://openalex.org/keywords/chop-chemotherapy","display_name":"CHOP chemotherapy","score":0.6800000071525574}],"concepts":[{"id":"https://openalex.org/C2779594685","wikidata":"https://www.wikidata.org/wiki/Q3832899","display_name":"Primary effusion lymphoma","level":3,"score":0.9311327934265137},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9242025017738342},{"id":"https://openalex.org/C2778191690","wikidata":"https://www.wikidata.org/wiki/Q422324","display_name":"Brentuximab vedotin","level":4,"score":0.9097716808319092},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.6505548357963562},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5674968361854553},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5361902713775635},{"id":"https://openalex.org/C2779725641","wikidata":"https://www.wikidata.org/wiki/Q1076228","display_name":"CHOP","level":3,"score":0.5077239274978638},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.4946255385875702},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.44989436864852905},{"id":"https://openalex.org/C2779634585","wikidata":"https://www.wikidata.org/wiki/Q1334541","display_name":"Pleural effusion","level":2,"score":0.41288959980010986},{"id":"https://openalex.org/C167135981","wikidata":"https://www.wikidata.org/wiki/Q2146302","display_name":"Retrospective cohort study","level":2,"score":0.4102003574371338},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2185307741165161},{"id":"https://openalex.org/C70905583","wikidata":"https://www.wikidata.org/wiki/Q3648608","display_name":"CD30","level":3,"score":0.17769241333007812}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.12890/2021_002345","doi":"https://doi.org/10.12890/2021_002345","is_oa":true,"landing_page_url":"https://doi.org/10.12890/2021_002345","pdf_url":"https://www.ejcrim.com/index.php/EJCRIM/article/download/2345/2569","source":{"id":"https://openalex.org/S2737828108","display_name":"European Journal of Case Reports in Internal Medicine","issn_l":"2284-2594","issn":["2284-2594"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310317697","host_organization_name":"SMC MEDIA SRL","host_organization_lineage":["https://openalex.org/P4310317697"],"host_organization_lineage_names":["SMC MEDIA SRL"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Case Reports in Internal Medicine","raw_type":"journal-article"},{"id":"pmid:33768081","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33768081","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of case reports in internal medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7977055","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7977055/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Eur J Case Rep Intern Med","raw_type":"Text"},{"id":"pmh:oai:eprints.bice.rm.cnr.it:21176","doi":null,"is_oa":false,"landing_page_url":"http://eprints.bice.rm.cnr.it/21176/1/2345-Article%20Text-20766-1-10-20210218.pdf","pdf_url":"http://eprints.bice.rm.cnr.it/21176/1/2345-Article%20Text-20766-1-10-20210218.pdf","source":{"id":"https://openalex.org/S4306402297","display_name":"CNR SOLAR (Scientific Open-access Literature Archive and Repository) (University of Southampton)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I43439940","host_organization_name":"University of Southampton","host_organization_lineage":["https://openalex.org/I43439940"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:ba5db930856f4cdcb1e875567445ccd4","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/ba5db930856f4cdcb1e875567445ccd4","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"European Journal of Case Reports in Internal Medicine (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.12890/2021_002345","doi":"https://doi.org/10.12890/2021_002345","is_oa":true,"landing_page_url":"https://doi.org/10.12890/2021_002345","pdf_url":"https://www.ejcrim.com/index.php/EJCRIM/article/download/2345/2569","source":{"id":"https://openalex.org/S2737828108","display_name":"European Journal of Case Reports in Internal Medicine","issn_l":"2284-2594","issn":["2284-2594"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","poland-20","vabb-shw"],"host_organization":"https://openalex.org/P4310317697","host_organization_name":"SMC MEDIA SRL","host_organization_lineage":["https://openalex.org/P4310317697"],"host_organization_lineage_names":["SMC MEDIA SRL"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Case Reports in Internal Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3136872053.pdf","grobid_xml":"https://content.openalex.org/works/W3136872053.grobid-xml"},"referenced_works_count":5,"referenced_works":["https://openalex.org/W2035414276","https://openalex.org/W2058697232","https://openalex.org/W2124878002","https://openalex.org/W2811482900","https://openalex.org/W2920410645"],"related_works":["https://openalex.org/W2914340689","https://openalex.org/W2920410645","https://openalex.org/W2548543097","https://openalex.org/W2124878002","https://openalex.org/W2109736752","https://openalex.org/W2111948306","https://openalex.org/W2910546959","https://openalex.org/W2966628592","https://openalex.org/W4247470225","https://openalex.org/W2806110387"],"abstract_inverted_index":{"Primary":[0,91],"effusion":[1,14,92,129,143],"lymphoma":[2,10,93,130,144],"is":[3,20,53,94],"a":[4,68,95,138,158],"rare":[5,96],"and":[6,60,125],"aggressive":[7],"large":[8,41],"B-cell":[9],"presenting":[11],"as":[12],"malignant":[13],"with":[15,71,76,83,114,131,141,149],"poor":[16],"prognosis.":[17],"Although":[18],"it":[19,26],"more":[21],"prevalent":[22],"among":[23],"HIV":[24],"patients,":[25,100],"has":[27,117],"also":[28],"been":[29,118],"described":[30],"in":[31,98,120,126,162],"non-HIV":[32,69,99,139],"immunocompromised":[33],"individuals.":[34],"Given":[35],"its":[36],"rarity,":[37],"there":[38,102],"are":[39,103],"no":[40,104],"randomized":[42],"trials":[43,106],"regarding":[44,107],"the":[45,65,135,154],"best":[46],"therapeutic":[47,108,160],"option.":[48],"The":[49],"choice":[50],"of":[51,67,137,157,165],"therapy":[52,113],"based":[54],"on":[55],"retrospective":[56],"studies,":[57],"case":[58,66,136],"reports":[59],"preclinical":[61],"data.":[62],"We":[63],"present":[64,134],"patient":[70,140],"relapsed":[72],"disease":[73],"after":[74],"treatment":[75],"CHOP":[77],"who":[78,145],"was":[79,146],"then":[80],"successfully":[81,147],"treated":[82,148],"brentuximab":[84,115,150],"vedotin,":[85,151],"achieving":[86],"complete":[87],"remission.":[88],"LEARNING":[89],"POINTS:":[90],"entity":[97],"so":[101],"clinical":[105],"options":[109],"or":[110],"management":[111],"decisions.Targeted":[112],"vedotin":[116],"used":[119],"other":[121],"CD30":[122],"positive":[123],"malignancies":[124],"HIV-related":[127],"primary":[128,142],"good":[132],"outcomes.We":[133],"which":[152],"highlights":[153],"potential":[155],"role":[156],"new":[159],"approach":[161],"this":[163],"subgroup":[164],"patients.":[166]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-03-29T00:00:00"}