{"id":"https://openalex.org/W3136866469","doi":"https://doi.org/10.1155/2021/6693268","title":"Efficacy and Safety of Runzao Zhiyang Capsule as an Add-On Therapy for Chronic Eczema: A Systematic Review and Meta-Analysis","display_name":"Efficacy and Safety of Runzao Zhiyang Capsule as an Add-On Therapy for Chronic Eczema: A Systematic Review and Meta-Analysis","publication_year":2021,"publication_date":"2021-03-17","ids":{"openalex":"https://openalex.org/W3136866469","doi":"https://doi.org/10.1155/2021/6693268","mag":"3136866469","pmid":"https://pubmed.ncbi.nlm.nih.gov/33815560","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7990555"},"language":"en","primary_location":{"id":"doi:10.1155/2021/6693268","doi":"https://doi.org/10.1155/2021/6693268","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2021/6693268","pdf_url":"https://downloads.hindawi.com/journals/ecam/2021/6693268.pdf","source":{"id":"https://openalex.org/S15444899","display_name":"Evidence-based Complementary and Alternative Medicine","issn_l":"1741-427X","issn":["1741-427X","1741-4288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evidence-Based Complementary and Alternative Medicine","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/ecam/2021/6693268.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109595997","display_name":"Li Ming","orcid":"https://orcid.org/0000-0003-3489-5650","observed_orcids":["https://orcid.org/0000-0003-3489-5650"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210147433","display_name":"Beijing Friendship Hospital","ror":"https://ror.org/053qy4437","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ming Li","raw_affiliation_strings":["Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0003-3489-5650","affiliations":[{"raw_affiliation_string":"Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210147433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083376342","display_name":"Boyang Zhou","orcid":"https://orcid.org/0000-0002-7962-3897","observed_orcids":["https://orcid.org/0000-0002-7962-3897"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210147433","display_name":"Beijing Friendship Hospital","ror":"https://ror.org/053qy4437","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Boyang Zhou","raw_affiliation_strings":["Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0002-7962-3897","affiliations":[{"raw_affiliation_string":"Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210147433"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101912391","display_name":"Lihong Zhou","orcid":"https://orcid.org/0000-0003-1150-5701","observed_orcids":["https://orcid.org/0000-0003-1150-5701"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210147433","display_name":"Beijing Friendship Hospital","ror":"https://ror.org/053qy4437","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147433"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lihong Zhou","raw_affiliation_strings":["Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0003-1150-5701","affiliations":[{"raw_affiliation_string":"Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210147433"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100343207","display_name":"Linfeng Li","orcid":"https://orcid.org/0000-0002-8736-6464","observed_orcids":["https://orcid.org/0000-0002-8736-6464"]},"institutions":[{"id":"https://openalex.org/I183519381","display_name":"Capital Medical University","ror":"https://ror.org/013xs5b60","country_code":"CN","type":"education","lineage":["https://openalex.org/I183519381"]},{"id":"https://openalex.org/I4210147433","display_name":"Beijing Friendship Hospital","ror":"https://ror.org/053qy4437","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210147433"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Linfeng Li","raw_affiliation_strings":["Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0002-8736-6464","affiliations":[{"raw_affiliation_string":"Department of Dermatology, Beijing Friendship Hospital, Capital Medical University, Beijing, China","institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210147433"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100343207"],"corresponding_institution_ids":["https://openalex.org/I183519381","https://openalex.org/I4210147433"],"apc_list":{"value":2550,"currency":"USD","value_usd":2550},"apc_paid":{"value":2550,"currency":"USD","value_usd":2550},"fwci":0.0442,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.11361738,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":"2021","issue":null,"first_page":"1","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.9286999702453613,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.9286999702453613,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13444","display_name":"Medical Research and Treatments","score":0.047600001096725464,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12647","display_name":"Traditional Chinese Medicine Studies","score":0.007000000216066837,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-eczema","display_name":"chronic eczema","score":0.9869999885559082},{"id":"https://openalex.org/keywords/atopic-dermatitis","display_name":"atopic dermatitis","score":0.8389999866485596},{"id":"https://openalex.org/keywords/chinese-herbal-medicine","display_name":"Chinese herbal medicine","score":0.9200000166893005},{"id":"https://openalex.org/keywords/adjunctive-therapy","display_name":"adjunctive therapy","score":0.9860000014305115},{"id":"https://openalex.org/keywords/antihistamines","display_name":"antihistamines","score":0.8140000104904175},{"id":"https://openalex.org/keywords/pruritus","display_name":"pruritus","score":0.8109999895095825},{"id":"https://openalex.org/keywords/eczema-area-and-severity-index","display_name":"Eczema Area and Severity Index","score":0.9039999842643738},{"id":"https://openalex.org/keywords/total-serum-ige","display_name":"total IgE","score":0.8610000014305115},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.4339999854564667},{"id":"https://openalex.org/keywords/adverse-events","display_name":"adverse events","score":0.6299999952316284},{"id":"https://openalex.org/keywords/risk-of-bias-assessment","display_name":"risk of bias assessment","score":0.5189999938011169},{"id":"https://openalex.org/keywords/quality-of-evidence","display_name":"quality of evidence","score":0.3930000066757202},{"id":"https://openalex.org/keywords/risk-of-overstatement","display_name":"risk of overstatement","score":0.3310000002384186}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7433010339736938},{"id":"https://openalex.org/C2776478404","wikidata":"https://www.wikidata.org/wiki/Q1105187","display_name":"Cochrane Library","level":3,"score":0.6992271542549133},{"id":"https://openalex.org/C14184104","wikidata":"https://www.wikidata.org/wiki/Q1362526","display_name":"Visual analogue scale","level":2,"score":0.5752182602882385},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.5741520524024963},{"id":"https://openalex.org/C95190672","wikidata":"https://www.wikidata.org/wiki/Q815382","display_name":"Meta-analysis","level":2,"score":0.5674380660057068},{"id":"https://openalex.org/C3020774429","wikidata":"https://www.wikidata.org/wiki/Q1201886","display_name":"Web of science","level":3,"score":0.5668914318084717},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5148033499717712},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.4626762270927429},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.42997226119041443},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.24180516600608826},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1155/2021/6693268","doi":"https://doi.org/10.1155/2021/6693268","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2021/6693268","pdf_url":"https://downloads.hindawi.com/journals/ecam/2021/6693268.pdf","source":{"id":"https://openalex.org/S15444899","display_name":"Evidence-based Complementary and Alternative Medicine","issn_l":"1741-427X","issn":["1741-427X","1741-4288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evidence-Based Complementary and Alternative Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7990555","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7990555","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evid Based Complement Alternat Med","raw_type":"Text"},{"id":"pmid:33815560","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33815560","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evidence-based complementary and alternative medicine : eCAM","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:2344a871ad444d3bbec27b743b5ceb26","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/2344a871ad444d3bbec27b743b5ceb26","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Evidence-Based Complementary and Alternative Medicine, Vol 2021 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/2021/6693268","doi":"https://doi.org/10.1155/2021/6693268","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2021/6693268","pdf_url":"https://downloads.hindawi.com/journals/ecam/2021/6693268.pdf","source":{"id":"https://openalex.org/S15444899","display_name":"Evidence-based Complementary and Alternative Medicine","issn_l":"1741-427X","issn":["1741-427X","1741-4288"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","poland-20"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Evidence-Based Complementary and Alternative Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/systematic-review","display_name":"Systematic Review"},{"id":"https://openalex.org/study-designs/meta-analysis","display_name":"Meta-Analysis"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3136866469.pdf","grobid_xml":"https://content.openalex.org/works/W3136866469.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1483879387","https://openalex.org/W1527957830","https://openalex.org/W1998785248","https://openalex.org/W2002098523","https://openalex.org/W2012046106","https://openalex.org/W2044344623","https://openalex.org/W2056774840","https://openalex.org/W2089467255","https://openalex.org/W2090385274","https://openalex.org/W2097901958","https://openalex.org/W2098923148","https://openalex.org/W2117359358","https://openalex.org/W2144226595","https://openalex.org/W2287712487","https://openalex.org/W2490471244","https://openalex.org/W2576440140","https://openalex.org/W2586378708","https://openalex.org/W2588681363","https://openalex.org/W2599869888","https://openalex.org/W2801208468","https://openalex.org/W2885934404","https://openalex.org/W2914925137","https://openalex.org/W2935880477","https://openalex.org/W2950324172","https://openalex.org/W2969943791","https://openalex.org/W2970249050","https://openalex.org/W2978324492","https://openalex.org/W3007825879","https://openalex.org/W3013158053","https://openalex.org/W3018392386","https://openalex.org/W3093558022","https://openalex.org/W3119038672"],"related_works":["https://openalex.org/W7117313240","https://openalex.org/W2950324172","https://openalex.org/W4386127146","https://openalex.org/W4296187716","https://openalex.org/W3018392386","https://openalex.org/W4413833299","https://openalex.org/W2384913396","https://openalex.org/W3153680487","https://openalex.org/W3211071631","https://openalex.org/W2374974217"],"abstract_inverted_index":{"Background.":[0],"Runzao":[1],"Zhiyang":[2],"capsule":[3],"(RZC),":[4],"an":[5,34,56,299],"oral":[6,129],"Chinese":[7],"herbal":[8],"medicine,":[9],"has":[10],"been":[11],"widely":[12],"used":[13,95],"for":[14,19,40,59,171],"chronic":[15,41,60,122,309],"eczema":[16,61,123],"in":[17,187,199,268,285],"China":[18],"many":[20],"years.":[21],"This":[22],"study":[23],"aims":[24],"to":[25,37,71,96,146,162,178,215,229,242,260,302,325,339],"evaluate":[26],"the":[27,49,98,102,135,194,200,220,233,247,269,286,329,341],"efficacy":[28,50,137],"and":[29,51,86,152,166,219,246,289,311,334],"safety":[30,52],"of":[31,53,84,91,101,115,249,277,321,328],"RZC":[32,54,131,201,270,287,297],"as":[33,55,298],"add-on":[35,57,300],"therapy":[36,58,301],"conventional":[38,303],"treatment":[39,304],"eczema.":[42],"Methods.":[43],"Randomized":[44],"controlled":[45],"trials":[46],"(RCTs)":[47],"assessing":[48],"were":[62,107,124,184],"retrieved":[63],"from":[64,68,318],"eight":[65],"literature":[66],"databases":[67],"their":[69],"inception":[70],"31":[72],"August,":[73],"2020,":[74],"including":[75],"CNKI,":[76],"WanFang,":[77],"VIP,":[78],"Sinomed,":[79],"PubMed,":[80],"Cochrane":[81,89],"Library,":[82],"Web":[83],"Science,":[85],"Embase.":[87],"The":[88,105],"risk":[90],"bias":[92],"tool":[93],"was":[94,132,206,294],"assess":[97],"methodological":[99],"quality":[100,327],"included":[103,330],"studies.":[104],"data":[106],"analyzed":[108],"by":[109],"RevMan5.3":[110],"software.":[111],"Results.":[112],"A":[113],"total":[114,136,251],"18":[116],"RCTs":[117,336],"involving":[118],"1896":[119],"patients":[120],"with":[121,127,193,203,272],"included.":[125],"Compared":[126,192],"no":[128,290,314],"treatment,":[130],"superior":[133],"on":[134,308],"rate":[138],"(TER)":[139],"(RR":[140,209],"=":[141,157,174,210,224,237,254],"1.45,":[142],"95%":[143,159,212,226,239,257],"CI:":[144,160,213,227,240,258],"1.23":[145],"1.72,":[147],"P<0.0001":[148],"),":[149,165,218,232,245],"Eczema":[150],"Area":[151],"Severity":[153],"Index":[154],"(EASI)":[155],"(MD":[156,173,223,236,253],"\u22120.73,":[158],"\u22120.90":[161],"\u22120.56,":[163],"P<0.00001":[164,217,244,263],"Visual":[167],"Analogue":[168],"Scale":[169],"(VAS)":[170],"pruritus":[172],"\u22122.76,":[175],"95%CI:":[176],"\u22124.53":[177],"\u22120.99,":[179],"P=0.002":[180],").":[181],"Similar":[182],"results":[183],"also":[185],"seen":[186],"a":[188],"randomized,":[189],"placebo-controlled":[190],"trial.":[191],"antihistamine":[195],"(AH)":[196],"group,":[197,288],"TER":[198],"combined":[202,271],"AH":[204,273],"group":[205],"significantly":[207,267],"higher":[208],"1.32,":[211],"1.21":[214],"1.43,":[216],"EASI":[221],"score":[222,235],"\u22120.29,":[225],"\u22120.38":[228],"\u22120.20,":[230],"P<0.001":[231],"VAS":[234],"\u22120.19,":[238],"\u22120.23":[241],"\u22120.15,":[243],"level":[248],"serum":[250],"IgE":[252],"\u22129.83":[255],"ng/ml,":[256,262],"\u221211.66":[259],"\u22128.00":[261],")":[264],"decreased":[265],"more":[266,283,332],"group.":[274],"In":[275],"terms":[276],"safety,":[278],"mild":[279],"gastrointestinal":[280],"diseases":[281],"occurred":[282],"frequently":[284],"serious":[291],"adverse":[292],"effect":[293,317],"reported.":[295],"Conclusions.":[296],"shows":[305],"good":[306],"effects":[307],"eczema,":[310],"there":[312],"is":[313],"severe":[315],"side":[316],"short-term":[319],"use":[320],"RZC.":[322],"However,":[323],"due":[324],"suboptimal":[326],"studies,":[331],"large-sample":[333],"high-quality":[335],"are":[337],"needed":[338],"improve":[340],"evidence":[342],"quality.":[343]},"counts_by_year":[{"year":2023,"cited_by_count":1}],"updated_date":"2026-10-28T10:33:24.094632","created_date":"2021-03-29T00:00:00"}
