{"id":"https://openalex.org/W3136779476","doi":"https://doi.org/10.1096/fj.202002415r","title":"Molecular mechanisms of voiding dysfunction in a novel mouse model of acute urinary retention","display_name":"Molecular mechanisms of voiding dysfunction in a novel mouse model of acute urinary retention","publication_year":2021,"publication_date":"2021-03-20","ids":{"openalex":"https://openalex.org/W3136779476","doi":"https://doi.org/10.1096/fj.202002415r","mag":"3136779476","pmid":"https://pubmed.ncbi.nlm.nih.gov/33742688","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9844132"},"language":"en","primary_location":{"id":"doi:10.1096/fj.202002415r","doi":"https://doi.org/10.1096/fj.202002415r","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fj.202002415r","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9844132","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101474739","display_name":"Xiang Xie","orcid":"https://orcid.org/0009-0006-5138-4851","observed_orcids":["https://orcid.org/0009-0006-5138-4851"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xiang Xie","raw_affiliation_strings":["Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School Boston MA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School Boston MA USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Huan Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Huan Chen","raw_affiliation_strings":["Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School Boston MA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School Boston MA USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052218498","display_name":"Lanlan Zhang","orcid":"https://orcid.org/0000-0001-8128-0590","observed_orcids":["https://orcid.org/0000-0001-8128-0590"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lanlan Zhang","raw_affiliation_strings":["Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School Boston MA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School Boston MA USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066894243","display_name":"Daniel Chan","orcid":"https://orcid.org/0000-0002-7507-3218","observed_orcids":["https://orcid.org/0000-0002-7507-3218"]},"institutions":[{"id":"https://openalex.org/I27804330","display_name":"Brown University","ror":"https://ror.org/05gq02987","country_code":"US","type":"education","lineage":["https://openalex.org/I27804330"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Chan","raw_affiliation_strings":["Brown University/Harvard Summer Research Program in Kidney Medicine Providence RI USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brown University/Harvard Summer Research Program in Kidney Medicine Providence RI USA","institution_ids":["https://openalex.org/I27804330"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087929660","display_name":"Warren G. Hill","orcid":"https://orcid.org/0000-0002-2772-7264","observed_orcids":["https://orcid.org/0000-0002-2772-7264"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Warren G. Hill","raw_affiliation_strings":["Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School Boston MA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School Boston MA USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082440110","display_name":"Mark L. Zeidel","orcid":"https://orcid.org/0000-0002-5190-9770","observed_orcids":["https://orcid.org/0000-0002-5190-9770"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark L. Zeidel","raw_affiliation_strings":["Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School Boston MA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School Boston MA USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060216484","display_name":"Weiqun Yu","orcid":"https://orcid.org/0000-0001-8102-8918","observed_orcids":["https://orcid.org/0000-0001-8102-8918"]},"institutions":[{"id":"https://openalex.org/I1316535847","display_name":"Beth Israel Deaconess Medical Center","ror":"https://ror.org/04drvxt59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316535847"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Weiqun Yu","raw_affiliation_strings":["Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School Boston MA USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine Beth Israel Deaconess Medical Center and Harvard Medical School Boston MA USA","institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5060216484"],"corresponding_institution_ids":["https://openalex.org/I1316535847","https://openalex.org/I136199984"],"apc_list":{"value":2500,"currency":"USD","value_usd":2500},"apc_paid":null,"fwci":2.1827,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.85862786,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"35","issue":"4","first_page":"e21447","last_page":"e21447"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10279","display_name":"Urinary Bladder and Prostate Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10418","display_name":"Pelvic floor disorders treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11815","display_name":"Urological Disorders and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/acute-urinary-retention","display_name":"acute urinary retention","score":0.9990000128746033},{"id":"https://openalex.org/keywords/voiding-dysfunction","display_name":"voiding dysfunction","score":0.8960000276565552},{"id":"https://openalex.org/keywords/bladder-injury","display_name":"bladder injury","score":0.7129999995231628},{"id":"https://openalex.org/keywords/urothelial-barrier","display_name":"urothelial barrier","score":0.6959999799728394},{"id":"https://openalex.org/keywords/acetylcholine-signaling","display_name":"acetylcholine signaling","score":0.9470000267028809},{"id":"https://openalex.org/keywords/purinergic-signaling","display_name":"purinergic signaling","score":0.9990000128746033},{"id":"https://openalex.org/keywords/beta1-integrin","display_name":"beta1 integrin","score":0.8960000276565552},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.847000002861023},{"id":"https://openalex.org/keywords/mechanotransduction","display_name":"mechanotransduction","score":0.9990000128746033},{"id":"https://openalex.org/keywords/bladder-remodeling","display_name":"bladder remodeling","score":0.7829999923706055},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.6729999780654907},{"id":"https://openalex.org/keywords/overactive-bladder","display_name":"overactive bladder","score":0.5979999899864197},{"id":"https://openalex.org/keywords/incontinence","display_name":"incontinence","score":0.7210000157356262}],"concepts":[{"id":"https://openalex.org/C39133596","wikidata":"https://www.wikidata.org/wiki/Q5165683","display_name":"Contractility","level":2,"score":0.7580469846725464},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.5626531839370728},{"id":"https://openalex.org/C2777310793","wikidata":"https://www.wikidata.org/wiki/Q1725675","display_name":"Lamina propria","level":3,"score":0.5269732475280762},{"id":"https://openalex.org/C2779762690","wikidata":"https://www.wikidata.org/wiki/Q9382","display_name":"Urinary bladder","level":2,"score":0.5118464827537537},{"id":"https://openalex.org/C163415756","wikidata":"https://www.wikidata.org/wiki/Q126473","display_name":"Contraction (grammar)","level":2,"score":0.48183003067970276},{"id":"https://openalex.org/C131631996","wikidata":"https://www.wikidata.org/wiki/Q1141325","display_name":"Lumen (anatomy)","level":2,"score":0.4805307984352112},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46638917922973633},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.45997878909111023},{"id":"https://openalex.org/C2777085111","wikidata":"https://www.wikidata.org/wiki/Q9386","display_name":"Urethra","level":2,"score":0.4280073940753937},{"id":"https://openalex.org/C2775910092","wikidata":"https://www.wikidata.org/wiki/Q180623","display_name":"Acetylcholine","level":2,"score":0.42688241600990295},{"id":"https://openalex.org/C2779091618","wikidata":"https://www.wikidata.org/wiki/Q1366695","display_name":"Urinary retention","level":2,"score":0.41929495334625244},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4162503778934479},{"id":"https://openalex.org/C181104049","wikidata":"https://www.wikidata.org/wiki/Q11936292","display_name":"Mechanotransduction","level":2,"score":0.4150822162628174},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4129111170768738},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3510003685951233},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.26440638303756714},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21956390142440796},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2118217647075653},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.1037830114364624}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001743","descriptor_name":"Urinary Bladder","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":false},{"descriptor_ui":"D001743","descriptor_name":"Urinary Bladder","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001743","descriptor_name":"Urinary Bladder","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009130","descriptor_name":"Muscle, Smooth","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D014563","descriptor_name":"Urodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016055","descriptor_name":"Urinary Retention","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016055","descriptor_name":"Urinary Retention","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1096/fj.202002415r","doi":"https://doi.org/10.1096/fj.202002415r","is_oa":false,"landing_page_url":"https://doi.org/10.1096/fj.202002415r","pdf_url":null,"source":{"id":"https://openalex.org/S25293849","display_name":"The FASEB Journal","issn_l":"0892-6638","issn":["0892-6638","1530-6860"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FASEB Journal","raw_type":"journal-article"},{"id":"pmid:33742688","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33742688","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FASEB journal : official publication of the Federation of American Societies for Experimental Biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9844132","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9844132","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"FASEB J","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9844132","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9844132","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"FASEB J","raw_type":"Text"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3984369825","display_name":"Targeting Cav1.2 to treat Ketamine-Induced Pathology","funder_award_id":"U18DA052346","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G8909345397","display_name":"Role of Insulin Receptor-mediated Signaling In Underactive Bladder","funder_award_id":"R21AG064633","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W40824052","https://openalex.org/W247177564","https://openalex.org/W1499622587","https://openalex.org/W1768863927","https://openalex.org/W1821245682","https://openalex.org/W1875040637","https://openalex.org/W1887660085","https://openalex.org/W1926796983","https://openalex.org/W1968702196","https://openalex.org/W1968860914","https://openalex.org/W1968878967","https://openalex.org/W1970686926","https://openalex.org/W1974802657","https://openalex.org/W1985496306","https://openalex.org/W1991274401","https://openalex.org/W1993505627","https://openalex.org/W1994127892","https://openalex.org/W2008841347","https://openalex.org/W2011962188","https://openalex.org/W2035697399","https://openalex.org/W2039230817","https://openalex.org/W2040855568","https://openalex.org/W2042039248","https://openalex.org/W2046977882","https://openalex.org/W2050691913","https://openalex.org/W2056617300","https://openalex.org/W2057629069","https://openalex.org/W2058839812","https://openalex.org/W2061191313","https://openalex.org/W2063963111","https://openalex.org/W2066782314","https://openalex.org/W2093429069","https://openalex.org/W2105303645","https://openalex.org/W2108582536","https://openalex.org/W2124774083","https://openalex.org/W2129362053","https://openalex.org/W2159406283","https://openalex.org/W2160553852","https://openalex.org/W2167060203","https://openalex.org/W2171006813","https://openalex.org/W2171957474","https://openalex.org/W2288256636","https://openalex.org/W2335258962","https://openalex.org/W2408834821","https://openalex.org/W2412333589","https://openalex.org/W2437120877","https://openalex.org/W2468007041","https://openalex.org/W2514175439","https://openalex.org/W2745575071","https://openalex.org/W2747252678","https://openalex.org/W2762765054","https://openalex.org/W2763554453","https://openalex.org/W2899823918","https://openalex.org/W2958680844","https://openalex.org/W2961687057","https://openalex.org/W2969903473","https://openalex.org/W3082280244","https://openalex.org/W4249152240","https://openalex.org/W4297819262","https://openalex.org/W4299485640"],"related_works":["https://openalex.org/W2375752578","https://openalex.org/W1968702196","https://openalex.org/W1993505627","https://openalex.org/W1863692898","https://openalex.org/W6945917682","https://openalex.org/W2021963840","https://openalex.org/W2773029168","https://openalex.org/W7113464336","https://openalex.org/W4248362778","https://openalex.org/W1964449285"],"abstract_inverted_index":{"Acute":[0],"urinary":[1],"retention":[2],"(AUR)":[3],"is":[4],"a":[5,11,211],"common":[6],"urological":[7],"emergency":[8],"and":[9,29,65,111,127,147,179,202,223,237],"affects":[10],"significant":[12],"patient":[13],"population.":[14],"The":[15],"inability":[16],"to":[17,22,25,40,78,99,118,171,193,220],"eliminate":[18],"urine":[19,42],"may":[20],"lead":[21],"permanent":[23],"damage":[24],"the":[26,36,41,47,63,67,75,104,231,244],"bladder's":[27],"structure":[28],"functioning.":[30],"However,":[31],"we":[32,57],"know":[33],"little":[34],"about":[35],"underlying":[37],"molecular":[38,245],"sequelae":[39],"retention.":[43],"To":[44],"closely":[45],"mirror":[46],"potential":[48],"high":[49],"pressures":[50],"that":[51,164,186,247],"patients":[52],"with":[53,89,129,140],"AUR":[54,122,225,235],"could":[55],"experience,":[56],"catheterized":[58],"anesthetized":[59],"female":[60],"mice":[61,157],"via":[62],"urethra":[64],"filled":[66],"bladder":[68,76,105,165],"by":[69],"pumping":[70],"saline":[71],"(25":[72],"\u00b5L/min)":[73],"into":[74,243],"lumen":[77,106],"50":[79],"cm":[80,83],"or":[81,93],"80":[82,94],"water":[84,87],"pressure.":[85,132],"A":[86],"column":[88],"designated":[90],"height":[91],"(50":[92],"cm)":[95],"was":[96,135],"then":[97],"adjusted":[98],"maintain":[100],"constant":[101],"pressure":[102],"in":[103],"for":[107],"30":[108],"minutes.":[109],"Functional":[110],"morphological":[112],"evaluations":[113],"were":[114,183,208],"performed":[115],"from":[116,155],"0":[117],"24":[119],"hours":[120],"after":[121],"treatment.":[123],"Mice":[124],"exhibited":[125],"incontinence":[126],"overactivity":[128],"diminished":[130,160],"voiding":[131,166],"Significant":[133],"injury":[134],"confirmed":[136],"which":[137,228],"revealed":[138],"bladders":[139],"disrupted":[141],"urothelial":[142],"barrier,":[143],"edematous":[144],"lamina":[145],"propria,":[146],"distorted":[148],"muscle":[149,153],"bundles.":[150],"Bladder":[151],"smooth":[152],"(BSM)":[154],"pressure-treated":[156],"have":[158],"significantly":[159],"contraction":[161],"force,":[162],"suggesting":[163,210],"dysfunction":[167],"can":[168],"be":[169],"attributed":[170],"impaired":[172,194],"BSM":[173,195],"contractility.":[174,196],"Indeed,":[175],"dysregulation":[176],"of":[177,189,200,233],"acetylcholine":[178],"purinergic":[180],"signaling":[181],"pathways":[182,191,207],"demonstrated,":[184],"indicating":[185],"reduced":[187],"efficacy":[188],"these":[190],"contributes":[192],"Finally,":[197],"altered":[198],"expression":[199],"\u03b21-integrin":[201],"extracellular":[203],"matrix":[204],"mediated":[205],"mechanotransduction":[206],"detected,":[209],"profound":[212],"remodeling":[213],"process.":[214],"These":[215],"data":[216,239],"demonstrated":[217],"an":[218],"easy":[219],"perform,":[221],"quantifiable,":[222],"reproducible":[224],"mouse":[226],"model,":[227],"mimics":[229],"well":[230],"characteristics":[232],"human":[234],"patients,":[236],"our":[238],"generate":[240],"new":[241],"insights":[242],"mechanisms":[246],"occur":[248],"following":[249],"AUR.":[250]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-03-29T00:00:00"}