{"id":"https://openalex.org/W3136767774","doi":"https://doi.org/10.1093/infdis/jiab153","title":"Antibody Responses to Severe Acute Respiratory Syndrome Coronavirus 2 in the Serum and Cerebrospinal Fluid of Patients With Coronavirus Disease 2019 and Neurological Symptoms","display_name":"Antibody Responses to Severe Acute Respiratory Syndrome Coronavirus 2 in the Serum and Cerebrospinal Fluid of Patients With Coronavirus Disease 2019 and Neurological Symptoms","publication_year":2021,"publication_date":"2021-03-19","ids":{"openalex":"https://openalex.org/W3136767774","doi":"https://doi.org/10.1093/infdis/jiab153","mag":"3136767774","pmid":"https://pubmed.ncbi.nlm.nih.gov/33744954","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8083780"},"language":"en","primary_location":{"id":"doi:10.1093/infdis/jiab153","doi":"https://doi.org/10.1093/infdis/jiab153","is_oa":true,"landing_page_url":"https://doi.org/10.1093/infdis/jiab153","pdf_url":"https://academic.oup.com/jid/article-pdf/225/6/965/42897057/jiab153.pdf","source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/jid/article-pdf/225/6/965/42897057/jiab153.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050139717","display_name":"Janet L. Cunningham","orcid":"https://orcid.org/0000-0001-7876-7779","observed_orcids":["https://orcid.org/0000-0001-7876-7779"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Janet L Cunningham","raw_affiliation_strings":["Department of Neuroscience, Psychiatry, Uppsala University, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Psychiatry, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082425238","display_name":"Johan Virhammar","orcid":"https://orcid.org/0000-0001-9901-2949","observed_orcids":["https://orcid.org/0000-0001-9901-2949"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Johan Virhammar","raw_affiliation_strings":["Department of Neuroscience, Neurology, Uppsala University, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Neurology, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079057845","display_name":"Bengt J. R\u00f6nnberg","orcid":"https://orcid.org/0000-0003-0229-093X","observed_orcids":["https://orcid.org/0000-0003-0229-093X"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I1342360035","display_name":"Uppsala University Hospital","ror":"https://ror.org/01apvbh93","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1342360035"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Bengt R\u00f6nnberg","raw_affiliation_strings":["Department of Medical Biochemistry and Microbiology, Zoonosis Science Center, Uppsala University, Uppsala, Sweden","Laboratory of Clinical Microbiology at Uppsala University Hospital, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry and Microbiology, Zoonosis Science Center, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]},{"raw_affiliation_string":"Laboratory of Clinical Microbiology at Uppsala University Hospital, Uppsala, Sweden","institution_ids":["https://openalex.org/I1342360035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032186481","display_name":"Xaqu\u00edn Castro Dopico","orcid":"https://orcid.org/0000-0002-9005-6774","observed_orcids":["https://orcid.org/0000-0002-9005-6774"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Xaquin Castro Dopico","raw_affiliation_strings":["Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082674255","display_name":"Linda Kolstad","orcid":"https://orcid.org/0000-0003-4539-1394","observed_orcids":["https://orcid.org/0000-0003-4539-1394"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Linda Kolstad","raw_affiliation_strings":["Department of Medical Biochemistry and Microbiology, Zoonosis Science Center, Uppsala University, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry and Microbiology, Zoonosis Science Center, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081317499","display_name":"Bo Albinsson","orcid":"https://orcid.org/0000-0002-1184-9267","observed_orcids":["https://orcid.org/0000-0002-1184-9267"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I1342360035","display_name":"Uppsala University Hospital","ror":"https://ror.org/01apvbh93","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I1342360035"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Bo Albinsson","raw_affiliation_strings":["Department of Medical Biochemistry and Microbiology, Zoonosis Science Center, Uppsala University, Uppsala, Sweden","Laboratory of Clinical Microbiology at Uppsala University Hospital, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry and Microbiology, Zoonosis Science Center, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]},{"raw_affiliation_string":"Laboratory of Clinical Microbiology at Uppsala University Hospital, Uppsala, Sweden","institution_ids":["https://openalex.org/I1342360035"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078487749","display_name":"Eva Kumlien","orcid":"https://orcid.org/0000-0002-1952-8791","observed_orcids":["https://orcid.org/0000-0002-1952-8791"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Eva Kumlien","raw_affiliation_strings":["Department of Neuroscience, Neurology, Uppsala University, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Neurology, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017577398","display_name":"Anja N\u00e4\u00e4s","orcid":"https://orcid.org/0000-0002-2636-3518","observed_orcids":["https://orcid.org/0000-0002-2636-3518"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Anja N\u00e4\u00e4s","raw_affiliation_strings":["Department of Medical Sciences, Section of Infectious Diseases, Uppsala University, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Sciences, Section of Infectious Diseases, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054295819","display_name":"Andrea Klang","orcid":"https://orcid.org/0000-0001-5352-5757","observed_orcids":["https://orcid.org/0000-0001-5352-5757","https://orcid.org/0000-0002-5975-0960"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Andrea Klang","raw_affiliation_strings":["Department of Neuroscience, Rehabilitation Medicine, Uppsala University, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Rehabilitation Medicine, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090268339","display_name":"Gabriel Westman","orcid":"https://orcid.org/0000-0001-9402-772X","observed_orcids":["https://orcid.org/0000-0001-9402-772X"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Gabriel Westman","raw_affiliation_strings":["Department of Medical Sciences, Section of Infectious Diseases, Uppsala University, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Sciences, Section of Infectious Diseases, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079766290","display_name":"Henrik Zetterberg","orcid":"https://orcid.org/0000-0003-3930-4354","observed_orcids":["https://orcid.org/0000-0003-3930-4354","https://orcid.org/0000-0002-4671-6763"]},"institutions":[{"id":"https://openalex.org/I2801112325","display_name":"Sahlgrenska University Hospital","ror":"https://ror.org/04vgqjj36","country_code":"SE","type":"healthcare","lineage":["https://openalex.org/I2801112325"]},{"id":"https://openalex.org/I4210126463","display_name":"UK Dementia Research Institute","ror":"https://ror.org/02wedp412","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210126463"]},{"id":"https://openalex.org/I4210151618","display_name":"National Hospital for Neurology and Neurosurgery","ror":"https://ror.org/048b34d51","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1340918713","https://openalex.org/I4210151618"]},{"id":"https://openalex.org/I4405260083","display_name":"UCL Queen Square Institute of Neurology","ror":"https://ror.org/0370htr03","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I45129253","display_name":"University College London","ror":"https://ror.org/02jx3x895","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I45129253"]},{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["GB","SE"],"is_corresponding":false,"raw_author_name":"Henrik Zetterberg","raw_affiliation_strings":["Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, M\u00f6lndal, Sweden","Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, United Kingdom","Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, M\u00f6lndal, Sweden","UK Dementia Research Institute at UCL, London, United Kingdom"],"raw_orcid":"https://orcid.org/0000-0003-3930-4354","affiliations":[{"raw_affiliation_string":"Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, M\u00f6lndal, Sweden","institution_ids":["https://openalex.org/I2801112325"]},{"raw_affiliation_string":"Department of Neurodegenerative Disease, UCL Institute of Neurology, Queen Square, London, United Kingdom","institution_ids":["https://openalex.org/I4210151618","https://openalex.org/I4405260083","https://openalex.org/I45129253"]},{"raw_affiliation_string":"Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, M\u00f6lndal, Sweden","institution_ids":["https://openalex.org/I881427289"]},{"raw_affiliation_string":"UK Dementia Research Institute at UCL, London, United Kingdom","institution_ids":["https://openalex.org/I4210126463","https://openalex.org/I45129253"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086044054","display_name":"Robert Frithiof","orcid":"https://orcid.org/0000-0003-2278-7951","observed_orcids":["https://orcid.org/0000-0003-2278-7951"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Robert Frithiof","raw_affiliation_strings":["Department of Surgical Sciences, Anaesthesiology and Intensive Care, Uppsala University, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgical Sciences, Anaesthesiology and Intensive Care, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009181517","display_name":"\u00c5ke Lundkvist","orcid":"https://orcid.org/0000-0001-8608-6551","observed_orcids":["https://orcid.org/0000-0001-8608-6551"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"\u00c5ke Lundkvist","raw_affiliation_strings":["Department of Medical Biochemistry and Microbiology, Zoonosis Science Center, Uppsala University, Uppsala, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Biochemistry and Microbiology, Zoonosis Science Center, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083386185","display_name":"Gunilla B. Karlsson Hedestam","orcid":"https://orcid.org/0000-0001-7255-9047","observed_orcids":["https://orcid.org/0000-0001-7255-9047"]},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Gunilla B Karlsson Hedestam","raw_affiliation_strings":["Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045262598","display_name":"Elham Rostami","orcid":"https://orcid.org/0000-0003-1218-6247","observed_orcids":["https://orcid.org/0000-0003-1218-6247"]},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]},{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Elham Rostami","raw_affiliation_strings":["Department of Neuroscience, Karolinska Institute, Stockholm, Sweden","Department of Neuroscience, Neurosurgery, Uppsala University, Uppsala, Sweden"],"raw_orcid":"https://orcid.org/0000-0003-1218-6247","affiliations":[{"raw_affiliation_string":"Department of Neuroscience, Karolinska Institute, Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Department of Neuroscience, Neurosurgery, Uppsala University, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5045262598"],"corresponding_institution_ids":["https://openalex.org/I123387679","https://openalex.org/I28166907"],"apc_list":{"value":4052,"currency":"USD","value_usd":4052},"apc_paid":{"value":4052,"currency":"USD","value_usd":4052},"fwci":1.2758,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.8315537,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"225","issue":"6","first_page":"965","last_page":"970"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.5454000234603882,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.5454000234603882,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11368","display_name":"Long-Term Effects of COVID-19","score":0.41280001401901245,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.027899999171495438,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sars-cov-2","display_name":"SARS-CoV-2","score":0.9919999837875366},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9950000047683716},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-antibodies","display_name":"cerebrospinal fluid antibodies","score":0.9110000133514404},{"id":"https://openalex.org/keywords/serum-antibodies","display_name":"serum antibodies","score":0.6610000133514404},{"id":"https://openalex.org/keywords/igg","display_name":"IgG","score":0.7149999737739563},{"id":"https://openalex.org/keywords/spike-protein","display_name":"spike protein","score":0.8420000076293945},{"id":"https://openalex.org/keywords/neurological-symptoms","display_name":"neurological symptoms","score":0.9729999899864197},{"id":"https://openalex.org/keywords/central-nervous-system-injury","display_name":"central nervous system injury","score":0.7739999890327454},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.9259999990463257},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.8476117253303528},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.696395218372345},{"id":"https://openalex.org/C2777648638","wikidata":"https://www.wikidata.org/wiki/Q57751738","display_name":"Coronavirus","level":5,"score":0.6937013268470764},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6774914860725403},{"id":"https://openalex.org/C45189115","wikidata":"https://www.wikidata.org/wiki/Q502159","display_name":"Serology","level":3,"score":0.6502335071563721},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5557404160499573},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.5546212196350098},{"id":"https://openalex.org/C2780898057","wikidata":"https://www.wikidata.org/wiki/Q79448","display_name":"Immunoglobulin G","level":3,"score":0.46155333518981934},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.4320957064628601},{"id":"https://openalex.org/C2776178081","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Respiratory disease","level":3,"score":0.42310768365859985},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4061531126499176},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.28349268436431885},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.2608005404472351},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22947856783866882},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.0914258360862732},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.08535420894622803}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000914","descriptor_name":"Antibodies, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000917","descriptor_name":"Antibody Formation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":true},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D009422","descriptor_name":"Nervous System Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000134","qualifier_name":"cerebrospinal fluid","is_major_topic":false},{"descriptor_ui":"D057134","descriptor_name":"Antibodies, Neutralizing","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D064370","descriptor_name":"Spike Glycoprotein, Coronavirus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1093/infdis/jiab153","doi":"https://doi.org/10.1093/infdis/jiab153","is_oa":true,"landing_page_url":"https://doi.org/10.1093/infdis/jiab153","pdf_url":"https://academic.oup.com/jid/article-pdf/225/6/965/42897057/jiab153.pdf","source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Infectious Diseases","raw_type":"journal-article"},{"id":"pmid:33744954","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33744954","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of infectious diseases","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8083780","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8083780/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Infect Dis","raw_type":"Text"},{"id":"pmh:oai:DiVA.org:uu-441362","doi":null,"is_oa":true,"landing_page_url":"http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-441362","pdf_url":null,"source":{"id":"https://openalex.org/S4306401559","display_name":"KTH Publication Database DiVA (KTH Royal Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I86987016","host_organization_name":"KTH Royal Institute of Technology","host_organization_lineage":["https://openalex.org/I86987016"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:eprints.ucl.ac.uk.OAI2:10126082","doi":null,"is_oa":false,"landing_page_url":"https://discovery.ucl.ac.uk/id/eprint/10126082/","pdf_url":null,"source":{"id":"https://openalex.org/S4306400024","display_name":"UCL Discovery (University College London)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I45129253","host_organization_name":"University College London","host_organization_lineage":["https://openalex.org/I45129253"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"The Journal of Infectious Diseases (2021) (In press).","raw_type":"Article"},{"id":"pmh:oai:pure.atira.dk:publications/5ba7ab7f-71dc-4199-9010-1b1a51ecca03","doi":null,"is_oa":true,"landing_page_url":"https://pure.au.dk/portal/en/publications/5ba7ab7f-71dc-4199-9010-1b1a51ecca03","pdf_url":null,"source":null,"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cunningham, J L, Virhammar, J, Ronnberg, B, Dopico, X C, Kolstad, L, Albinsson, B, Kumlien, E, Naas, A, Klang, A, Westman, G, Zetterberg, H, Frithiof, R, Lundkvist, A, Karlsson Hedestam, G B & Rostami, E 2022, 'Antibody Responses to Severe Acute Respiratory Syndrome Coronavirus 2 in the Serum and Cerebrospinal Fluid of Patients with Coronavirus Disease 2019 and Neurological Symptoms', Journal of Infectious Diseases, vol. 225, no. 6, pp. 965-970. https://doi.org/10.1093/infdis/jiab153","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1093/infdis/jiab153","doi":"https://doi.org/10.1093/infdis/jiab153","is_oa":true,"landing_page_url":"https://doi.org/10.1093/infdis/jiab153","pdf_url":"https://academic.oup.com/jid/article-pdf/225/6/965/42897057/jiab153.pdf","source":{"id":"https://openalex.org/S54542293","display_name":"The Journal of Infectious Diseases","issn_l":"0022-1899","issn":["0022-1899","1537-6613"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[{"id":"https://openalex.org/G1943697781","display_name":null,"funder_award_id":"681712","funder_id":"https://openalex.org/F4320334678","funder_display_name":"European Research Council"},{"id":"https://openalex.org/G292763017","display_name":null,"funder_award_id":"201809\u20132016862","funder_id":"https://openalex.org/F4320307132","funder_display_name":"Alzheimer's Drug Discovery Foundation"},{"id":"https://openalex.org/G3809224024","display_name":null,"funder_award_id":"201809-2016862","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4960203590","display_name":null,"funder_award_id":"201809-2016862","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G5111822078","display_name":null,"funder_award_id":"681712","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G6069138294","display_name":null,"funder_award_id":"02532","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G6427258204","display_name":"Acute kidney injury - mechanisms and novel therapeutic targets in large animal models","funder_award_id":"2014-02569","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G6645697472","display_name":"Genetic basis for antibody diversity","funder_award_id":"2017-00968","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G6958338825","display_name":"Pathways to Alzheimer's disease","funder_award_id":"681712","funder_id":"https://openalex.org/F4320338335","funder_display_name":"H2020 European Research Council"},{"id":"https://openalex.org/G712881263","display_name":null,"funder_award_id":"2018-","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G7198253607","display_name":null,"funder_award_id":"ALFGBG-720931","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G77402223","display_name":"Towards Pandemic Preparedness: Assessing the reassortment dynamics of influenza A viruses","funder_award_id":"2018-02569","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G844907251","display_name":"Acute kidney injury - mechanisms and novel therapeutic targets in large animal models","funder_award_id":"2014-07606","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"},{"id":"https://openalex.org/G8653344385","display_name":"What determines amyloid beta aggregation and toxicity in Alzheimer\u2019s disease?","funder_award_id":"2018-02532","funder_id":"https://openalex.org/F4320322581","funder_display_name":"Vetenskapsr\u00e5det"}],"funders":[{"id":"https://openalex.org/F4320307132","display_name":"Alzheimer's Drug Discovery Foundation","ror":"https://ror.org/0185drb55"},{"id":"https://openalex.org/F4320314888","display_name":"Open Medicine Foundation","ror":"https://ror.org/059xqr255"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320322128","display_name":"Svenska S\u00e4llskapet f\u00f6r Medicinsk Forskning","ror":"https://ror.org/0433fd238"},{"id":"https://openalex.org/F4320322581","display_name":"Vetenskapsr\u00e5det","ror":"https://ror.org/03zttf063"},{"id":"https://openalex.org/F4320334678","display_name":"European Research Council","ror":"https://ror.org/0472cxd90"},{"id":"https://openalex.org/F4320338335","display_name":"H2020 European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3136767774.pdf","grobid_xml":"https://content.openalex.org/works/W3136767774.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W2787848674","https://openalex.org/W3007643904","https://openalex.org/W3014310029","https://openalex.org/W3030793095","https://openalex.org/W3034422573","https://openalex.org/W3035502447","https://openalex.org/W3037539912","https://openalex.org/W3048232903","https://openalex.org/W3049168646","https://openalex.org/W3089322801","https://openalex.org/W3090507780","https://openalex.org/W3093730175","https://openalex.org/W3096431816","https://openalex.org/W3114190045","https://openalex.org/W6784663430"],"related_works":["https://openalex.org/W6998654281","https://openalex.org/W4388007557","https://openalex.org/W4405424239","https://openalex.org/W7007918404","https://openalex.org/W4310603552","https://openalex.org/W4408920387","https://openalex.org/W4414205529","https://openalex.org/W3082477076","https://openalex.org/W3160611305","https://openalex.org/W3168524889"],"abstract_inverted_index":{"Antibody":[0],"responses":[1],"to":[2],"severe":[3],"acute":[4],"respiratory":[5],"syndrome":[6],"coronavirus":[7,21],"2":[8,30,62],"(SARS-CoV-2)":[9],"in":[10,44,48,51,53,57,61,71,94],"serum":[11,49,73],"and":[12,24,50,74,103],"cerebrospinal":[13],"fluid":[14],"(CSF)":[15],"samples":[16],"from":[17],"16":[18],"patients":[19,47,63,85],"with":[20,64,78,86],"disease":[22,79],"2019":[23],"neurological":[25],"symptoms":[26],"were":[27,76],"assessed":[28],"using":[29],"independent":[31],"methods.":[32],"Immunoglobulin":[33],"G":[34],"(IgG)":[35],"specific":[36],"for":[37,111],"the":[38,107],"virus":[39],"spike":[40],"protein":[41],"was":[42,59],"found":[43],"81%":[45],"of":[46,69,89,115],"56%":[52],"CSF.":[54],"SARS-CoV-2":[55],"IgG":[56,70],"CSF":[58,75,95,98,104],"observed":[60],"negative":[65],"serological":[66],"findings.":[67],"Levels":[68],"both":[72],"associated":[77],"severity":[80],"(P":[81,100],"<":[82],".05).":[83],"All":[84],"elevated":[87],"markers":[88,114],"central":[90],"nervous":[91],"system":[92],"damage":[93,113],"also":[96],"had":[97,106],"antibodies":[99,105],"=":[101],".002),":[102],"highest":[108],"predictive":[109],"value":[110],"neuronal":[112],"all":[116],"tested":[117],"clinical":[118],"variables.":[119]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-03-29T00:00:00"}