{"id":"https://openalex.org/W3136761682","doi":"https://doi.org/10.3389/fendo.2021.632674","title":"Safety of Ovaleap\u00ae (Follitropin Alfa) in Infertile Women Undergoing Superovulation for Assisted Reproductive Technologies: A Multinational Comparative, Prospective Cohort Study","display_name":"Safety of Ovaleap\u00ae (Follitropin Alfa) in Infertile Women Undergoing Superovulation for Assisted Reproductive Technologies: A Multinational Comparative, Prospective Cohort Study","publication_year":2021,"publication_date":"2021-03-16","ids":{"openalex":"https://openalex.org/W3136761682","doi":"https://doi.org/10.3389/fendo.2021.632674","mag":"3136761682","pmid":"https://pubmed.ncbi.nlm.nih.gov/33815290","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8010350"},"language":"en","primary_location":{"id":"doi:10.3389/fendo.2021.632674","doi":"https://doi.org/10.3389/fendo.2021.632674","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2021.632674","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2021.632674/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fendo.2021.632674/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091544341","display_name":"Sigal Kaplan","orcid":"https://orcid.org/0000-0002-3352-8480","observed_orcids":["https://orcid.org/0000-0002-3352-8480"]},"institutions":[{"id":"https://openalex.org/I4210109720","display_name":"Teva Pharmaceuticals (Israel)","ror":"https://ror.org/01wfv3m53","country_code":"IL","type":"company","lineage":["https://openalex.org/I4210109720"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Sigal Kaplan","raw_affiliation_strings":["Global Patient Safety & Pharmacovigilance, Teva Pharmaceutical Industries Ltd., Netanya, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Global Patient Safety & Pharmacovigilance, Teva Pharmaceutical Industries Ltd., Netanya, Israel","institution_ids":["https://openalex.org/I4210109720"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076173142","display_name":"Rachel Levy-Toledano","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rachel Levy-Toledano","raw_affiliation_strings":["RLT Media Consulting, Boulogne Billancourt, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"RLT Media Consulting, Boulogne Billancourt, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010753379","display_name":"Miranda Davies","orcid":"https://orcid.org/0000-0003-2949-8378","observed_orcids":["https://orcid.org/0000-0003-2949-8378"]},"institutions":[{"id":"https://openalex.org/I4210140975","display_name":"Drug Safety Research Unit","ror":"https://ror.org/04a8rag37","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210140975"]},{"id":"https://openalex.org/I63072094","display_name":"University of Portsmouth","ror":"https://ror.org/03ykbk197","country_code":"GB","type":"education","lineage":["https://openalex.org/I63072094"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Miranda Davies","raw_affiliation_strings":["Drug Safety Research Unit, Southampton, United Kingdom","School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Safety Research Unit, Southampton, United Kingdom","institution_ids":["https://openalex.org/I4210140975"]},{"raw_affiliation_string":"School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, United Kingdom","institution_ids":["https://openalex.org/I63072094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047829867","display_name":"Debabrata Roy","orcid":"https://orcid.org/0000-0003-2803-6323","observed_orcids":["https://orcid.org/0000-0003-2803-6323"]},"institutions":[{"id":"https://openalex.org/I4210140975","display_name":"Drug Safety Research Unit","ror":"https://ror.org/04a8rag37","country_code":"GB","type":"nonprofit","lineage":["https://openalex.org/I4210140975"]},{"id":"https://openalex.org/I63072094","display_name":"University of Portsmouth","ror":"https://ror.org/03ykbk197","country_code":"GB","type":"education","lineage":["https://openalex.org/I63072094"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Debabrata Roy","raw_affiliation_strings":["Drug Safety Research Unit, Southampton, United Kingdom","School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Drug Safety Research Unit, Southampton, United Kingdom","institution_ids":["https://openalex.org/I4210140975"]},{"raw_affiliation_string":"School of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, United Kingdom","institution_ids":["https://openalex.org/I63072094"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035798173","display_name":"Colin M. Howles","orcid":"https://orcid.org/0000-0002-0006-136X","observed_orcids":["https://orcid.org/0000-0002-0006-136X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Colin M. Howles","raw_affiliation_strings":["Medical Department, Theramex Ltd., London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Department, Theramex Ltd., London, United Kingdom","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020869039","display_name":"Amir Lass","orcid":"https://orcid.org/0000-0003-4660-622X","observed_orcids":["https://orcid.org/0000-0003-4660-622X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amir Lass","raw_affiliation_strings":["Medical Department, Theramex Ltd., London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Department, Theramex Ltd., London, United Kingdom","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5091544341"],"corresponding_institution_ids":["https://openalex.org/I4210109720"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":0.6771,"has_fulltext":true,"cited_by_count":7,"citation_normalized_percentile":{"value":0.61656536,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"12","issue":null,"first_page":"632674","last_page":"632674"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11156","display_name":"Reproductive Health and Technologies","score":0.4535999894142151,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11156","display_name":"Reproductive Health and Technologies","score":0.4535999894142151,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10390","display_name":"Ovarian function and disorders","score":0.1956000030040741,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11732","display_name":"Assisted Reproductive Technology and Twin Pregnancy","score":0.16990000009536743,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/follitropin-alfa","display_name":"follitropin alfa","score":0.9950000047683716},{"id":"https://openalex.org/keywords/gonal-f","display_name":"Gonal-F","score":0.8360000252723694},{"id":"https://openalex.org/keywords/recombinant-fsh","display_name":"recombinant FSH","score":0.906000018119812},{"id":"https://openalex.org/keywords/biosimilars","display_name":"biosimilars","score":0.9259999990463257},{"id":"https://openalex.org/keywords/ovarian-hyperstimulation-syndrome","display_name":"ovarian hyperstimulation syndrome","score":0.8759999871253967},{"id":"https://openalex.org/keywords/superovulation","display_name":"superovulation","score":0.8550000190734863},{"id":"https://openalex.org/keywords/ovulation-induction","display_name":"ovulation induction","score":0.8140000104904175},{"id":"https://openalex.org/keywords/infertility","display_name":"infertility","score":0.7879999876022339},{"id":"https://openalex.org/keywords/assisted-reproductive-technology","display_name":"assisted reproduction","score":0.9079999923706055},{"id":"https://openalex.org/keywords/live-birth-rate","display_name":"live birth rate","score":0.7519999742507935},{"id":"https://openalex.org/keywords/clinical-pregnancy-rate","display_name":"clinical pregnancy rate","score":0.9440000057220459},{"id":"https://openalex.org/keywords/embryo-transfer","display_name":"embryo transfer","score":0.6110000014305115},{"id":"https://openalex.org/keywords/treatment-safety","display_name":"treatment safety","score":0.45399999618530273},{"id":"https://openalex.org/keywords/treatment-effectiveness","display_name":"treatment effectiveness","score":0.5260000228881836}],"concepts":[{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.6354557275772095},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5906447768211365},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.47371286153793335},{"id":"https://openalex.org/C500014431","wikidata":"https://www.wikidata.org/wiki/Q25862","display_name":"Assisted reproductive technology","level":4,"score":0.464013934135437},{"id":"https://openalex.org/C2777688143","wikidata":"https://www.wikidata.org/wiki/Q179399","display_name":"Infertility","level":3,"score":0.3942660987377167},{"id":"https://openalex.org/C131872663","wikidata":"https://www.wikidata.org/wiki/Q5284418","display_name":"Obstetrics","level":1,"score":0.36281532049179077},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.2828824818134308},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2695976495742798},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25644993782043457},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005307","descriptor_name":"Fertilization in Vitro","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D005640","descriptor_name":"Follicle Stimulating Hormone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007247","descriptor_name":"Infertility, Female","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D007391","descriptor_name":"International Cooperation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010062","descriptor_name":"Ovulation Induction","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012044","descriptor_name":"Regression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013480","descriptor_name":"Superovulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015337","descriptor_name":"Multicenter Studies as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016471","descriptor_name":"Ovarian Hyperstimulation Syndrome","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D016471","descriptor_name":"Ovarian Hyperstimulation Syndrome","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D027724","descriptor_name":"Reproductive Techniques, Assisted","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D043373","descriptor_name":"Follicle Stimulating Hormone, Human","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D043373","descriptor_name":"Follicle Stimulating Hormone, Human","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.3389/fendo.2021.632674","doi":"https://doi.org/10.3389/fendo.2021.632674","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2021.632674","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2021.632674/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},{"id":"pmid:33815290","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33815290","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in endocrinology","raw_type":"Comparative Study"},{"id":"pmh:oai:pubmedcentral.nih.gov:8010350","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8010350/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Endocrinol (Lausanne)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:d6d4ad01a388443caa739ced3ce5c3bb","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d6d4ad01a388443caa739ced3ce5c3bb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Endocrinology, Vol 12 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fendo.2021.632674","doi":"https://doi.org/10.3389/fendo.2021.632674","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fendo.2021.632674","pdf_url":"https://www.frontiersin.org/articles/10.3389/fendo.2021.632674/pdf","source":{"id":"https://openalex.org/S2597401208","display_name":"Frontiers in Endocrinology","issn_l":"1664-2392","issn":["1664-2392"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Endocrinology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320308970","display_name":"Teva Pharmaceutical Industries","ror":"https://ror.org/01wfv3m53"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3136761682.pdf","grobid_xml":"https://content.openalex.org/works/W3136761682.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W36186264","https://openalex.org/W1909377197","https://openalex.org/W1941922500","https://openalex.org/W1970180069","https://openalex.org/W2022165602","https://openalex.org/W2095812006","https://openalex.org/W2096913021","https://openalex.org/W2098067089","https://openalex.org/W2099401266","https://openalex.org/W2102259585","https://openalex.org/W2110865742","https://openalex.org/W2143564115","https://openalex.org/W2146737098","https://openalex.org/W2159789980","https://openalex.org/W2228325863","https://openalex.org/W2414366951","https://openalex.org/W2471895188","https://openalex.org/W2526795301","https://openalex.org/W2605998378","https://openalex.org/W2753450121","https://openalex.org/W2884012955","https://openalex.org/W2891240559","https://openalex.org/W2914014812","https://openalex.org/W2966585969","https://openalex.org/W3007733752","https://openalex.org/W3019225928","https://openalex.org/W3028772142","https://openalex.org/W3086142078","https://openalex.org/W3092895617","https://openalex.org/W3092948321","https://openalex.org/W3093029263","https://openalex.org/W4300765875"],"related_works":["https://openalex.org/W3190959293","https://openalex.org/W2414366951","https://openalex.org/W3028772142","https://openalex.org/W2228325863","https://openalex.org/W2974964658","https://openalex.org/W3115301282","https://openalex.org/W6958225134","https://openalex.org/W7099122545","https://openalex.org/W6939596291","https://openalex.org/W3092948321"],"abstract_inverted_index":{"Background":[0],"Ovaleap\u00ae":[1,37,52,89,176,201,278,347,358],"(follitropin":[2],"alfa),":[3],"a":[4,11,66,284,360],"recombinant":[5],"human":[6],"follicle":[7,99],"stimulating":[8,100],"hormone,":[9],"is":[10,18],"biosimilar":[12,361],"medicinal":[13],"product":[14],"to":[15,30,39,98,362],"Gonal-f\u00ae":[16,40,91,183,211,280,349],"and":[17,34,95,119,160,177,203,269,279,305,307,313,333,340,348,351,355],"used":[19],"for":[20,60,82,92,142,186,236,260,266,273,291],"ovarian":[21,93,115],"stimulation.":[22],"The":[23,103,108,130,188,243],"main":[24],"objective":[25],"of":[26,36,51,114,132,170,191,246,331,357],"this":[27],"study":[28,69,325],"was":[29,65,106,111,123,153,193,223,250],"assess":[31],"the":[32,120,139,200,210,220,253,277,316,323,328,353],"safety":[33,354],"effectiveness":[35,356],"compared":[38],"in":[41,45,55,71,199,209,215,252,276,315],"one":[42],"treatment":[43,148,255],"cycle":[44],"routine":[46],"clinical":[47,300],"practice.":[48],"Methods":[49],"Safety":[50],"Follitropin":[53],"alfa":[54],"Infertile":[56],"women":[57,79,172,179],"undergoing":[58,80],"superovulation":[59,81],"Assisted":[61],"reproductive":[62,84],"technologies":[63],"(SOFIA)":[64],"prospective":[67],"cohort":[68,202],"conducted":[70],"six":[72],"European":[73],"countries.":[74],"Eligible":[75],"patients":[76,295],"were":[77,87,96,164,174,181,184,303,311],"infertile":[78],"assisted":[83],"technology,":[85],"who":[86,173,180,296],"administered":[88,175,182],"or":[90,135],"stimulation":[94],"na\u00efve":[97],"hormone":[101],"treatment.":[102],"recruitment":[104],"ratio":[105,141],"1:1.":[107],"primary":[109],"endpoint":[110,122],"incidence":[112,144,152,189,217,244,329],"proportion":[113,190,218,245],"hyperstimulation":[116],"syndrome":[117],"(OHSS)":[118],"secondary":[121],"OHSS":[124,143,151,192,216,247,332,334],"severity":[125,248],"(Grades":[126],"I,":[127,262],"II,":[128,268],"III).":[129],"effect":[131,149],"risk":[133],"factors":[134],"potential":[136,238],"confounders":[137],"on":[138,150],"odds":[140],"as":[145,147,336,338,359],"well":[146,337],"explored":[154],"using":[155],"univariate":[156,234],"logistic":[157],"regression.":[158],"Pregnancy":[159],"live":[161,308,341],"birth":[162,309,342],"rates":[163,302,310],"also":[165],"assessed.":[166],"Results":[167],"A":[168],"total":[169],"408":[171],"409":[178],"eligible":[185],"analysis.":[187],"5.1%":[194],"(95%":[195,205],"CI:":[196,206],"3.4,":[197],"7.7)":[198],"3.2%":[204],"1.9,":[207],"5.4)":[208],"cohort.":[212],"This":[213],"difference":[214,287],"between":[219,346],"two":[221,254,317],"cohorts":[222],"not":[224],"statistically":[225],"significant":[226,285],"neither":[227],"before":[228],"(p":[229,240,288],"=":[230,289],"0.159)":[231],"nor":[232],"after":[233],"adjustment":[235],"each":[237,292],"confounder":[239],">":[241],"0.05).":[242],"grades":[249],"similar":[251,345],"groups":[256],"(3.4%":[257],"versus":[258,264,271],"2.0%":[259],"Grade":[261,267,274],"1.2%":[263],"1.0%":[265],"0.5%":[270],"0.2%":[272],"III,":[275],"cohorts,":[281,318],"respectively),":[282],"without":[283],"statistical":[286],"0.865,":[290],"grade).":[293],"Among":[294],"had":[297],"embryo":[298],"transfer,":[299],"pregnancy":[301,339],"33%":[304],"31%":[306],"27%":[312],"26%,":[314],"respectively.":[319],"Conclusions":[320],"Findings":[321],"from":[322],"SOFIA":[324],"indicate":[326],"that":[327],"proportions":[330],"severity,":[335],"rates,":[343],"are":[344],"treatments":[350],"corroborate":[352],"Gonal-f\u00ae.":[363]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":2}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-03-29T00:00:00"}