{"id":"https://openalex.org/W3136688855","doi":"https://doi.org/10.1186/s12989-021-00405-2","title":"Effects of metal nanoparticles on tight junction-associated proteins via HIF-1\u03b1/miR-29b/MMPs pathway in human epidermal keratinocytes","display_name":"Effects of metal nanoparticles on tight junction-associated proteins via HIF-1\u03b1/miR-29b/MMPs pathway in human epidermal keratinocytes","publication_year":2021,"publication_date":"2021-03-19","ids":{"openalex":"https://openalex.org/W3136688855","doi":"https://doi.org/10.1186/s12989-021-00405-2","mag":"3136688855","pmid":"https://pubmed.ncbi.nlm.nih.gov/33740985","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7980342"},"language":"en","primary_location":{"id":"doi:10.1186/s12989-021-00405-2","doi":"https://doi.org/10.1186/s12989-021-00405-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12989-021-00405-2","pdf_url":"https://particleandfibretoxicology.biomedcentral.com/counter/pdf/10.1186/s12989-021-00405-2","source":{"id":"https://openalex.org/S189275214","display_name":"Particle and Fibre Toxicology","issn_l":"1743-8977","issn":["1743-8977"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Particle and Fibre Toxicology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://particleandfibretoxicology.biomedcentral.com/counter/pdf/10.1186/s12989-021-00405-2","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003794405","display_name":"Jiali Yuan","orcid":"https://orcid.org/0000-0003-2236-0827","observed_orcids":["https://orcid.org/0000-0003-2236-0827"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiali Yuan","raw_affiliation_strings":["Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, 485 E. Gray Street, Louisville, KY, 40202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, 485 E. Gray Street, Louisville, KY, 40202, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100333788","display_name":"Yue Zhang","orcid":"https://orcid.org/0000-0002-3148-8833","observed_orcids":["https://orcid.org/0000-0002-3148-8833"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yue Zhang","raw_affiliation_strings":["Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, 485 E. Gray Street, Louisville, KY, 40202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, 485 E. Gray Street, Louisville, KY, 40202, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017244097","display_name":"Yuanbao Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuanbao Zhang","raw_affiliation_strings":["Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, 485 E. Gray Street, Louisville, KY, 40202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, 485 E. Gray Street, Louisville, KY, 40202, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022706237","display_name":"Yiqun Mo","orcid":"https://orcid.org/0000-0003-2598-9268","observed_orcids":["https://orcid.org/0000-0003-2598-9268"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yiqun Mo","raw_affiliation_strings":["Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, 485 E. Gray Street, Louisville, KY, 40202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, 485 E. Gray Street, Louisville, KY, 40202, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003371947","display_name":"Qunwei Zhang","orcid":"https://orcid.org/0000-0001-8609-9192","observed_orcids":["https://orcid.org/0000-0001-8609-9192"]},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Qunwei Zhang","raw_affiliation_strings":["Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, 485 E. Gray Street, Louisville, KY, 40202, USA. Qunwei.Zhang@louisville.edu","Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, 485 E. Gray Street, Louisville, KY, 40202, USA"],"raw_orcid":"https://orcid.org/0000-0001-8609-9192","affiliations":[{"raw_affiliation_string":"Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, 485 E. Gray Street, Louisville, KY, 40202, USA. Qunwei.Zhang@louisville.edu","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"Department of Environmental and Occupational Health Sciences, School of Public Health and Information Sciences, University of Louisville, 485 E. Gray Street, Louisville, KY, 40202, USA","institution_ids":["https://openalex.org/I142740786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5003371947"],"corresponding_institution_ids":["https://openalex.org/I142740786"],"apc_list":{"value":3490,"currency":"USD","value_usd":3490},"apc_paid":{"value":3490,"currency":"USD","value_usd":3490},"fwci":2.5038,"has_fulltext":true,"cited_by_count":43,"citation_normalized_percentile":{"value":0.90213342,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"18","issue":"1","first_page":"13","last_page":"13"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.8345000147819519,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10079","display_name":"Nanoparticles: synthesis and applications","score":0.8345000147819519,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10790","display_name":"Heavy Metal Exposure and Toxicity","score":0.07159999758005142,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11033","display_name":"Contact Dermatitis and Allergies","score":0.02669999934732914,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metal-nanoparticles","display_name":"metal nanoparticles","score":0.9729999899864197},{"id":"https://openalex.org/keywords/nickel-nanoparticles","display_name":"nickel nanoparticles","score":0.9879999756813049},{"id":"https://openalex.org/keywords/titanium-dioxide-nanoparticles","display_name":"titanium dioxide nanoparticles","score":0.9909999966621399},{"id":"https://openalex.org/keywords/epidermal-keratinocytes","display_name":"epidermal keratinocytes","score":0.8090000152587891},{"id":"https://openalex.org/keywords/tight-junction-proteins","display_name":"tight junction proteins","score":0.8799999952316284},{"id":"https://openalex.org/keywords/hif-1alpha","display_name":"HIF-1\u03b1","score":0.9850000143051147},{"id":"https://openalex.org/keywords/mir-29b","display_name":"miR-29b","score":0.9879999756813049},{"id":"https://openalex.org/keywords/mmp-2","display_name":"MMP-2","score":0.8980000019073486},{"id":"https://openalex.org/keywords/mmp-9","display_name":"MMP-9","score":1.0},{"id":"https://openalex.org/keywords/timp-1","display_name":"TIMP-1","score":0.9940000176429749},{"id":"https://openalex.org/keywords/timp-2","display_name":"TIMP-2","score":0.9940000176429749},{"id":"https://openalex.org/keywords/skin-penetration","display_name":"skin penetration","score":0.5600000023841858},{"id":"https://openalex.org/keywords/nanoparticle-toxicity","display_name":"nanoparticle toxicity","score":0.7599999904632568},{"id":"https://openalex.org/keywords/dermal-exposure","display_name":"dermal exposure","score":0.5080000162124634},{"id":"https://openalex.org/keywords/hacat-cells","display_name":"HaCaT keratinocytes","score":0.6610000133514404},{"id":"https://openalex.org/keywords/skin-barrier-integrity","display_name":"skin barrier integrity","score":0.33500000834465027}],"concepts":[{"id":"https://openalex.org/C118995209","wikidata":"https://www.wikidata.org/wiki/Q5636366","display_name":"HaCaT","level":3,"score":0.9353580474853516},{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.7423536777496338},{"id":"https://openalex.org/C109523444","wikidata":"https://www.wikidata.org/wiki/Q424216","display_name":"Matrix metalloproteinase","level":2,"score":0.5455280542373657},{"id":"https://openalex.org/C2777459323","wikidata":"https://www.wikidata.org/wiki/Q5259911","display_name":"Human skin","level":2,"score":0.4876822233200073},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4833221435546875},{"id":"https://openalex.org/C2778370115","wikidata":"https://www.wikidata.org/wiki/Q2038676","display_name":"Stratum corneum","level":2,"score":0.4637620449066162},{"id":"https://openalex.org/C204258353","wikidata":"https://www.wikidata.org/wiki/Q7670282","display_name":"THP1 cell line","level":3,"score":0.4472441077232361},{"id":"https://openalex.org/C2776458125","wikidata":"https://www.wikidata.org/wiki/Q1827343","display_name":"Epidermis (zoology)","level":2,"score":0.4341660737991333},{"id":"https://openalex.org/C2777074287","wikidata":"https://www.wikidata.org/wiki/Q1473931","display_name":"Keratinocyte","level":3,"score":0.42703476548194885},{"id":"https://openalex.org/C2777624698","wikidata":"https://www.wikidata.org/wiki/Q505531","display_name":"Dermis","level":2,"score":0.4117678999900818},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4095191955566406},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.35990726947784424},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.28692495822906494},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.24996879696846008},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21415939927101135},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.14964202046394348},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.10099038481712341},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.08303973078727722},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.07755893468856812},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019108","descriptor_name":"Tight Junctions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020782","descriptor_name":"Matrix Metalloproteinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053768","descriptor_name":"Metal Nanoparticles","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D062725","descriptor_name":"Tight Junction Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1186/s12989-021-00405-2","doi":"https://doi.org/10.1186/s12989-021-00405-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12989-021-00405-2","pdf_url":"https://particleandfibretoxicology.biomedcentral.com/counter/pdf/10.1186/s12989-021-00405-2","source":{"id":"https://openalex.org/S189275214","display_name":"Particle and Fibre Toxicology","issn_l":"1743-8977","issn":["1743-8977"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Particle and Fibre Toxicology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7980342","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7980342","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Part Fibre Toxicol","raw_type":"Text"},{"id":"pmid:33740985","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33740985","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Particle and fibre toxicology","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:857bed7b5f5b4d3caeeec14ce8d15f91","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/857bed7b5f5b4d3caeeec14ce8d15f91","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Particle and Fibre Toxicology, Vol 18, Iss 1, Pp 1-22 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s12989-021-00405-2","doi":"https://doi.org/10.1186/s12989-021-00405-2","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12989-021-00405-2","pdf_url":"https://particleandfibretoxicology.biomedcentral.com/counter/pdf/10.1186/s12989-021-00405-2","source":{"id":"https://openalex.org/S189275214","display_name":"Particle and Fibre Toxicology","issn_l":"1743-8977","issn":["1743-8977"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Particle and Fibre Toxicology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1427689408","display_name":"Mechanisms underlying metal nanoparticle-induced lung injury and fibrosis","funder_award_id":"R01HL147856","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2910795567","display_name":null,"funder_award_id":"KSEF-148-RED-502-16-381","funder_id":"https://openalex.org/F4320314483","funder_display_name":"Kentucky Science and Engineering Foundation"},{"id":"https://openalex.org/G3814953631","display_name":null,"funder_award_id":"ES030283","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G5557517102","display_name":"Mechanisms of carcinogenic effects of nickel nanoparticles","funder_award_id":"R21ES028911","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G6089806557","display_name":null,"funder_award_id":"ES023693","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G6375765615","display_name":null,"funder_award_id":"HL147856","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7566664120","display_name":"The role of microRNA miR-21 in nickel nanoparticles-induced MMPs production","funder_award_id":"R15ES023693","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G7622478204","display_name":null,"funder_award_id":"ES028911","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G8204022981","display_name":"University of Louisville Center for Integrative Environmental Health Sciences","funder_award_id":"P30ES030283","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320314483","display_name":"Kentucky Science and Engineering Foundation","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3136688855.pdf","grobid_xml":"https://content.openalex.org/works/W3136688855.grobid-xml"},"referenced_works_count":121,"referenced_works":["https://openalex.org/W144423133","https://openalex.org/W1487413042","https://openalex.org/W1491678226","https://openalex.org/W1492802368","https://openalex.org/W1565818905","https://openalex.org/W1582192688","https://openalex.org/W1822588585","https://openalex.org/W1955736456","https://openalex.org/W1964351040","https://openalex.org/W1964508300","https://openalex.org/W1967260690","https://openalex.org/W1967850671","https://openalex.org/W1970049962","https://openalex.org/W1970490335","https://openalex.org/W1977326112","https://openalex.org/W1982365221","https://openalex.org/W1985367097","https://openalex.org/W1987825791","https://openalex.org/W1988286540","https://openalex.org/W1988377666","https://openalex.org/W1988433301","https://openalex.org/W1988542962","https://openalex.org/W1988804288","https://openalex.org/W1993996670","https://openalex.org/W1994971225","https://openalex.org/W1997934335","https://openalex.org/W2002740306","https://openalex.org/W2002771508","https://openalex.org/W2005422908","https://openalex.org/W2007138098","https://openalex.org/W2007372157","https://openalex.org/W2011361700","https://openalex.org/W2011569383","https://openalex.org/W2012726986","https://openalex.org/W2012909222","https://openalex.org/W2015117848","https://openalex.org/W2017517432","https://openalex.org/W2017650033","https://openalex.org/W2021059770","https://openalex.org/W2022288191","https://openalex.org/W2023746097","https://openalex.org/W2024486369","https://openalex.org/W2026570544","https://openalex.org/W2034964056","https://openalex.org/W2036092318","https://openalex.org/W2040486446","https://openalex.org/W2047516222","https://openalex.org/W2049212394","https://openalex.org/W2055080697","https://openalex.org/W2055856392","https://openalex.org/W2062227583","https://openalex.org/W2062607371","https://openalex.org/W2063748338","https://openalex.org/W2064231568","https://openalex.org/W2064718926","https://openalex.org/W2067556685","https://openalex.org/W2068498906","https://openalex.org/W2072535567","https://openalex.org/W2072538818","https://openalex.org/W2073793907","https://openalex.org/W2083381199","https://openalex.org/W2083511611","https://openalex.org/W2088159423","https://openalex.org/W2089714089","https://openalex.org/W2092378032","https://openalex.org/W2094656637","https://openalex.org/W2098541430","https://openalex.org/W2100218575","https://openalex.org/W2101952777","https://openalex.org/W2105852599","https://openalex.org/W2110605441","https://openalex.org/W2114570899","https://openalex.org/W2116000203","https://openalex.org/W2122368908","https://openalex.org/W2132024007","https://openalex.org/W2135935424","https://openalex.org/W2135967573","https://openalex.org/W2137496554","https://openalex.org/W2140054614","https://openalex.org/W2155078044","https://openalex.org/W2172266351","https://openalex.org/W2192598996","https://openalex.org/W2335007088","https://openalex.org/W2337369609","https://openalex.org/W2463268415","https://openalex.org/W2508050027","https://openalex.org/W2548615408","https://openalex.org/W2765939096","https://openalex.org/W2770247709","https://openalex.org/W2770329432","https://openalex.org/W2773856220","https://openalex.org/W2783457569","https://openalex.org/W2790421782","https://openalex.org/W2790608299","https://openalex.org/W2797320652","https://openalex.org/W2896843732","https://openalex.org/W2897741492","https://openalex.org/W2901270606","https://openalex.org/W2904375707","https://openalex.org/W2904956459","https://openalex.org/W2912886076","https://openalex.org/W2913481174","https://openalex.org/W2945516876","https://openalex.org/W2947126976","https://openalex.org/W2948132192","https://openalex.org/W2949934853","https://openalex.org/W2972476602","https://openalex.org/W2972803321","https://openalex.org/W2973202397","https://openalex.org/W2974104685","https://openalex.org/W2989810103","https://openalex.org/W2995663437","https://openalex.org/W3008891868","https://openalex.org/W3022525688","https://openalex.org/W3026708344","https://openalex.org/W3033246761","https://openalex.org/W3035392077","https://openalex.org/W3083478401","https://openalex.org/W3084685188","https://openalex.org/W3168182028","https://openalex.org/W4243283824"],"related_works":["https://openalex.org/W2886600801","https://openalex.org/W1967850671","https://openalex.org/W1988542962","https://openalex.org/W2172266351","https://openalex.org/W3000252645","https://openalex.org/W3083478401","https://openalex.org/W4401894656","https://openalex.org/W2046660653","https://openalex.org/W1513946969","https://openalex.org/W4366262821"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"The":[2,18,367,403],"increasing":[3],"use":[4],"of":[5,20,61,76,112,121,129,151,168,187,199,237,280,285,296,309,318,324,341,377,405,432,447,465,473,484,500,506,522,537,549],"metal":[6,21,54,62,82],"nanoparticles":[7,22,63],"in":[8,105,251,266,302,306,338,363,553],"industry":[9],"and":[10,39,102,119,123,125,136,189,203,222,254,270,275,278,282,313,315,320,343,351,386,395,407,415,424,443,463,467,469,495,498,502,504,508,532,535],"biomedicine":[11],"raises":[12],"the":[13,25,31,37,41,45,56,59,95,110,117,127,139,159,185,197,213,220,232,260,276,283,307,316,339],"risk":[14],"for":[15,155,170],"unintentional":[16],"exposure.":[17],"ability":[19],"to":[23,34,53,81,108,145,165,182,195,218,247,299,326,392,399,488],"penetrate":[24],"skin":[26,51,65,554],"ranges":[27],"from":[28,390,397],"stopping":[29],"at":[30,379,383],"stratum":[32],"corneum":[33],"passing":[35],"below":[36],"dermis":[38],"entering":[40],"systemic":[42],"circulation.":[43],"Despite":[44],"potential":[46],"health":[47],"risks":[48],"associated":[49,90],"with":[50,94,434],"exposure":[52,75,265,323,458,483],"nanoparticles,":[55,83,87],"mechanisms":[57,233],"underlying":[58,234],"toxicity":[60],"on":[64,116,126],"keratinocytes":[66,79,487,555],"remain":[67],"unclear.":[68],"In":[69,138,158,541],"this":[70],"study,":[71],"we":[72,241],"proposed":[73],"that":[74,371,482,546],"human":[77,485],"epidermal":[78,486],"(HaCaT)":[80],"such":[84,347,411],"as":[85,291,348,412,418,420],"nickel":[86],"dysregulates":[88],"tight-junction":[89],"proteins":[91,202,288,410,552],"by":[92,191,207,225,454,525],"interacting":[93],"HIF-1\u03b1/miR-29b/MMPs":[96,558],"axis.":[97],"Methods":[98],"We":[99],"performed":[100],"dose-response":[101,140],"time-response":[103,160,368],"studies":[104,369],"HaCaT":[106,261,297,452],"cells":[107,142,162,179,262,298,325,433,453],"observe":[109],"effects":[111],"Nano-Ni":[113,152,169,264,300,333,357,372,457,489],"or":[114,148,153,174,194],"Nano-TiO2":[115,154,327,354],"expression":[118,128,186,198,277,284,308,340,404,462],"activity":[120,464,499],"MMP-2":[122,221,319,378,466,501,531],"MMP-9,":[124,311],"tight":[130,200,238,286,344,408,474,509,538,550],"junction-associated":[131,201,239,287,345,409,475,510,539,551],"proteins,":[132,240,346],"TIMP-1,":[133,312],"TIMP-2,":[134],"miR-29b,":[135],"HIF-1\u03b1.":[137],"studies,":[141,161],"were":[143,163,180,216,273,289],"exposed":[144,164],"0,":[146],"10,":[147],"20":[149,166],"\u03bcg/mL":[150,167],"24":[156,380,391],"h.":[157,176],"12,":[171,384],"24,":[172,385],"48,":[173],"72":[175,393,400],"After":[177],"treatment,":[178],"collected":[181,217],"either":[183],"assess":[184],"mRNAs":[188],"miR-29b":[190,342,406,441,507,513,523],"real-time":[192],"PCR":[193],"determine":[196],"HIF-1\u03b1":[204,244,249,364,436,492,518],"nuclear":[205,365,493,519],"accumulation":[206,250,494],"Western":[208],"blot":[209],"and/or":[210],"immunofluorescent":[211],"staining;":[212],"conditioned":[214,271],"media":[215,272],"evaluate":[219],"MMP-9":[223,382,468,503,533],"activities":[224,279,317],"gelatin":[226],"zymography":[227],"assay.":[228],"To":[229],"further":[230],"investigate":[231],"Nano-Ni-induced":[235,440,460,471,512,517,530,547],"dysregulation":[236,548],"employed":[242],"a":[243,256,303,335,360,435,448],"inhibitor,":[245,437],"CAY10585,":[246,438],"perturb":[248],"one":[252],"experiment,":[253],"transfected":[255],"miR-29b-3p":[257,449,526],"mimic":[258,450,527],"into":[259,451],"before":[263,456],"another":[267],"experiment.":[268],"Cells":[269],"collected,":[274],"MMPs":[281],"determined":[290],"described":[292],"above.":[293],"Results":[294],"Exposure":[295],"resulted":[301],"dose-dependent":[304,336,361],"increase":[305,362],"MMP-2,":[310],"TIMP-2":[314,396],"MMP-9.":[321],"However,":[322],"did":[328,355],"not":[329],"cause":[330],"these":[331],"effects.":[332],"caused":[334,359,373,490],"decrease":[337],"ZO-1,":[349,413],"occludin,":[350,414],"claudin-1,":[352],"while":[353],"not.":[356],"also":[358],"accumulation.":[366,520],"showed":[370],"significantly":[374],"increased":[375,461,491,496],"expressions":[376],"h,":[381,388,394],"48":[387],"TIMP-1":[389],"12":[398,421],"h":[401,422],"post-exposure.":[402],"claudin-1":[416],"decreased":[417],"early":[419],"post-exposure,":[423],"their":[425],"levels":[426],"declined":[427],"gradually":[428],"over":[429],"time.":[430],"Pretreatment":[431],"abolished":[439,529],"down-regulation":[442,472,505,514,536],"MMP-2/9":[444],"up-regulation.":[445],"Introduction":[446],"transfection":[455,528],"ameliorated":[459],"restored":[470],"proteins.":[476,511,540],"Conclusion":[477],"Our":[478],"study":[479],"herein":[480],"demonstrated":[481,545],"transcription":[497],"was":[515,556],"through":[516],"Restoration":[521],"level":[524],"activation":[534],"summary,":[542],"our":[543],"results":[544],"via":[557],"pathway.":[559]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-03-29T00:00:00"}
