{"id":"https://openalex.org/W3136684164","doi":"https://doi.org/10.1038/s41388-021-01705-9","title":"Hepatic stellate cells promote intrahepatic cholangiocarcinoma progression via NR4A2/osteopontin/Wnt signaling axis","display_name":"Hepatic stellate cells promote intrahepatic cholangiocarcinoma progression via NR4A2/osteopontin/Wnt signaling axis","publication_year":2021,"publication_date":"2021-03-19","ids":{"openalex":"https://openalex.org/W3136684164","doi":"https://doi.org/10.1038/s41388-021-01705-9","mag":"3136684164","pmid":"https://pubmed.ncbi.nlm.nih.gov/33742120"},"language":"it","primary_location":{"id":"doi:10.1038/s41388-021-01705-9","doi":"https://doi.org/10.1038/s41388-021-01705-9","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41388-021-01705-9","pdf_url":null,"source":{"id":"https://openalex.org/S128439998","display_name":"Oncogene","issn_l":"0950-9232","issn":["0950-9232","1476-5594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024726679","display_name":"Chuyu Jing","orcid":"https://orcid.org/0000-0001-8057-4677","observed_orcids":["https://orcid.org/0000-0001-8057-4677"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chu-Yu Jing","raw_affiliation_strings":["The Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Key Laboratory for Carcinogenesis and Cancer Invasion, The Chinese Ministry of Education, 180 Fenglin Road, Shanghai, 200032, China"],"raw_orcid":"https://orcid.org/0000-0001-8057-4677","affiliations":[{"raw_affiliation_string":"The Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Key Laboratory for Carcinogenesis and Cancer Invasion, The Chinese Ministry of Education, 180 Fenglin Road, Shanghai, 200032, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059815800","display_name":"Yi\u2010Peng Fu","orcid":"https://orcid.org/0000-0002-4229-6714","observed_orcids":["https://orcid.org/0000-0002-4229-6714"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210146205","display_name":"Obstetrics and Gynecology Hospital of Fudan University","ror":"https://ror.org/04rhdtb47","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210146205"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yi-Peng Fu","raw_affiliation_strings":["Department of Breast Surgery, The Obstetrics & Gynecology Hospital of Fudan University, 419 Fangxie Road, Shanghai, 200090, China. fyp0076@163.com","Department of Breast Surgery, The Obstetrics & Gynecology Hospital of Fudan University, 419 Fangxie Road, Shanghai, 200090, China"],"raw_orcid":"https://orcid.org/0000-0002-4229-6714","affiliations":[{"raw_affiliation_string":"Department of Breast Surgery, The Obstetrics & Gynecology Hospital of Fudan University, 419 Fangxie Road, Shanghai, 200090, China. fyp0076@163.com","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210146205"]},{"raw_affiliation_string":"Department of Breast Surgery, The Obstetrics & Gynecology Hospital of Fudan University, 419 Fangxie Road, Shanghai, 200090, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210146205"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047283623","display_name":"Cheng Zhou","orcid":"https://orcid.org/0000-0002-1557-4694","observed_orcids":["https://orcid.org/0000-0002-1557-4694"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Cheng Zhou","raw_affiliation_strings":["Department of Liver Surgery and Transplantation, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China","The Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Key Laboratory for Carcinogenesis and Cancer Invasion, The Chinese Ministry of Education, 180 Fenglin Road, Shanghai, 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Liver Surgery and Transplantation, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]},{"raw_affiliation_string":"The Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Key Laboratory for Carcinogenesis and Cancer Invasion, The Chinese Ministry of Education, 180 Fenglin Road, Shanghai, 200032, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101697319","display_name":"Meixia Zhang","orcid":"https://orcid.org/0000-0003-0978-4721","observed_orcids":["https://orcid.org/0000-0003-0978-4721"]},"institutions":[{"id":"https://openalex.org/I4210164024","display_name":"First Affiliated Hospital of Nanchang University","ror":"https://ror.org/05gbwr869","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210164024"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mei-Xia Zhang","raw_affiliation_strings":["Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, 17 Yongwaizheng Street, Nanchang, 330006, Jiangxi, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, 17 Yongwaizheng Street, Nanchang, 330006, Jiangxi, China","institution_ids":["https://openalex.org/I4210164024"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047695175","display_name":"Yong Yi","orcid":"https://orcid.org/0000-0003-0847-2590","observed_orcids":["https://orcid.org/0000-0003-0847-2590"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yong Yi","raw_affiliation_strings":["Department of Liver Surgery and Transplantation, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China","The Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Key Laboratory for Carcinogenesis and Cancer Invasion, The Chinese Ministry of Education, 180 Fenglin Road, Shanghai, 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Liver Surgery and Transplantation, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]},{"raw_affiliation_string":"The Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Key Laboratory for Carcinogenesis and Cancer Invasion, The Chinese Ministry of Education, 180 Fenglin Road, Shanghai, 200032, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036227462","display_name":"Jinlong Huang","orcid":"https://orcid.org/0000-0002-4179-5001","observed_orcids":["https://orcid.org/0000-0002-4179-5001"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jin-Long Huang","raw_affiliation_strings":["Department of Liver Surgery and Transplantation, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China","The Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Key Laboratory for Carcinogenesis and Cancer Invasion, The Chinese Ministry of Education, 180 Fenglin Road, Shanghai, 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Liver Surgery and Transplantation, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]},{"raw_affiliation_string":"The Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Key Laboratory for Carcinogenesis and Cancer Invasion, The Chinese Ministry of Education, 180 Fenglin Road, Shanghai, 200032, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102028262","display_name":"Wei Gan","orcid":"https://orcid.org/0000-0003-2795-8289","observed_orcids":["https://orcid.org/0000-0003-2795-8289"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Gan","raw_affiliation_strings":["Department of Liver Surgery and Transplantation, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China","The Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Key Laboratory for Carcinogenesis and Cancer Invasion, The Chinese Ministry of Education, 180 Fenglin Road, Shanghai, 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Liver Surgery and Transplantation, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]},{"raw_affiliation_string":"The Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Key Laboratory for Carcinogenesis and Cancer Invasion, The Chinese Ministry of Education, 180 Fenglin Road, Shanghai, 200032, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100390011","display_name":"Juan Zhang","orcid":"https://orcid.org/0000-0001-6337-4438","observed_orcids":["https://orcid.org/0000-0001-6337-4438"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Juan Zhang","raw_affiliation_strings":["The Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Key Laboratory for Carcinogenesis and Cancer Invasion, The Chinese Ministry of Education, 180 Fenglin Road, Shanghai, 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Key Laboratory for Carcinogenesis and Cancer Invasion, The Chinese Ministry of Education, 180 Fenglin Road, Shanghai, 200032, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073486071","display_name":"Su-Su Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Su-Su Zheng","raw_affiliation_strings":["The Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Key Laboratory for Carcinogenesis and Cancer Invasion, The Chinese Ministry of Education, 180 Fenglin Road, Shanghai, 200032, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Key Laboratory for Carcinogenesis and Cancer Invasion, The Chinese Ministry of Education, 180 Fenglin Road, Shanghai, 200032, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102881023","display_name":"Boheng Zhang","orcid":"https://orcid.org/0000-0002-9603-7179","observed_orcids":["https://orcid.org/0000-0002-9603-7179"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Bo-Heng Zhang","raw_affiliation_strings":["Center for Evidence-Based Medicine, Shanghai Medical School, Fudan University, 138 Yixueyuan Road, Shanghai, 200032, China. zhang.boheng@zs-hospital.sh.cn","The Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Key Laboratory for Carcinogenesis and Cancer Invasion, The Chinese Ministry of Education, 180 Fenglin Road, Shanghai, 200032, China. zhang.boheng@zs-hospital.sh.cn","The Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Key Laboratory for Carcinogenesis and Cancer Invasion, The Chinese Ministry of Education, 180 Fenglin Road, Shanghai, 200032, China"],"raw_orcid":"https://orcid.org/0000-0002-9603-7179","affiliations":[{"raw_affiliation_string":"Center for Evidence-Based Medicine, Shanghai Medical School, Fudan University, 138 Yixueyuan Road, Shanghai, 200032, China. zhang.boheng@zs-hospital.sh.cn","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"raw_affiliation_string":"The Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Key Laboratory for Carcinogenesis and Cancer Invasion, The Chinese Ministry of Education, 180 Fenglin Road, Shanghai, 200032, China. zhang.boheng@zs-hospital.sh.cn","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210127074"]},{"raw_affiliation_string":"The Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Key Laboratory for Carcinogenesis and Cancer Invasion, The Chinese Ministry of Education, 180 Fenglin Road, Shanghai, 200032, China","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086674805","display_name":"Shuang\u2013Jian Qiu","orcid":"https://orcid.org/0000-0003-2056-6127","observed_orcids":["https://orcid.org/0000-0003-2056-6127"]},"institutions":[{"id":"https://openalex.org/I133868755","display_name":"Shanghai Medical College of Fudan University","ror":"https://ror.org/01zntxs11","country_code":"CN","type":"education","lineage":["https://openalex.org/I133868755","https://openalex.org/I24943067"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Shuang-Jian Qiu","raw_affiliation_strings":["Department of Liver Surgery and Transplantation, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China. qiu.shuangjian@zs-hospital.sh.cn","The Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Key Laboratory for Carcinogenesis and Cancer Invasion, The Chinese Ministry of Education, 180 Fenglin Road, Shanghai, 200032, China. qiu.shuangjian@zs-hospital.sh.cn","Department of Liver Surgery and Transplantation, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China"],"raw_orcid":"https://orcid.org/0000-0003-2056-6127","affiliations":[{"raw_affiliation_string":"Department of Liver Surgery and Transplantation, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China. qiu.shuangjian@zs-hospital.sh.cn","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]},{"raw_affiliation_string":"The Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Key Laboratory for Carcinogenesis and Cancer Invasion, The Chinese Ministry of Education, 180 Fenglin Road, Shanghai, 200032, China. qiu.shuangjian@zs-hospital.sh.cn","institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210127074"]},{"raw_affiliation_string":"Department of Liver Surgery and Transplantation, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5059815800","https://openalex.org/A5086674805","https://openalex.org/A5102881023"],"corresponding_institution_ids":["https://openalex.org/I133868755","https://openalex.org/I24943067","https://openalex.org/I4210127074","https://openalex.org/I4210146205"],"apc_list":{"value":4990,"currency":"USD","value_usd":4990},"apc_paid":null,"fwci":4.329,"has_fulltext":false,"cited_by_count":24,"citation_normalized_percentile":{"value":0.9544589,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"40","issue":"16","first_page":"2910","last_page":"2922"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11364","display_name":"Cholangiocarcinoma and Gallbladder Cancer Studies","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10073","display_name":"Hepatocellular Carcinoma Treatment and Prognosis","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intrahepatic-cholangiocarcinoma","display_name":"intrahepatic cholangiocarcinoma","score":0.996999979019165},{"id":"https://openalex.org/keywords/hepatic-stellate-cells","display_name":"hepatic stellate cells","score":1.0},{"id":"https://openalex.org/keywords/nurr1","display_name":"Nurr1","score":0.9829999804496765},{"id":"https://openalex.org/keywords/osteopontin","display_name":"osteopontin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/wnt-beta-catenin-signaling","display_name":"Wnt/\u03b2-catenin signaling","score":0.9959999918937683},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9290000200271606},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7429999709129333},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.5720000267028809},{"id":"https://openalex.org/keywords/metastasis","display_name":"metastasis","score":0.8849999904632568},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8640000224113464},{"id":"https://openalex.org/keywords/tumor-stroma-interactions","display_name":"tumor-stroma interactions","score":0.3799999952316284},{"id":"https://openalex.org/keywords/co-culture-model","display_name":"co-culture model","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.7920619249343872},{"id":"https://openalex.org/C2780804394","wikidata":"https://www.wikidata.org/wiki/Q411994","display_name":"Osteopontin","level":2,"score":0.7725769281387329},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.732080340385437},{"id":"https://openalex.org/C176891718","wikidata":"https://www.wikidata.org/wiki/Q1997459","display_name":"Hepatic stellate cell","level":2,"score":0.7034097909927368},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6861451864242554},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5074345469474792},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.486366331577301},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.43389737606048584},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4181615114212036},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3849548399448395},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3198778033256531},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.19269949197769165},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.16526472568511963},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10310098528862},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.07219591736793518}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018281","descriptor_name":"Cholangiocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D018281","descriptor_name":"Cholangiocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053495","descriptor_name":"Osteopontin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D055166","descriptor_name":"Hepatic Stellate Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D060449","descriptor_name":"Wnt Signaling Pathway","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1038/s41388-021-01705-9","doi":"https://doi.org/10.1038/s41388-021-01705-9","is_oa":false,"landing_page_url":"https://doi.org/10.1038/s41388-021-01705-9","pdf_url":null,"source":{"id":"https://openalex.org/S128439998","display_name":"Oncogene","issn_l":"0950-9232","issn":["0950-9232","1476-5594"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"journal-article"},{"id":"pmid:33742120","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33742120","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Oncogene","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1488793600","https://openalex.org/W1493921738","https://openalex.org/W1973020652","https://openalex.org/W1981895579","https://openalex.org/W1983669063","https://openalex.org/W1989266995","https://openalex.org/W1999363650","https://openalex.org/W2011387799","https://openalex.org/W2020718759","https://openalex.org/W2026727204","https://openalex.org/W2027230549","https://openalex.org/W2032118946","https://openalex.org/W2034584820","https://openalex.org/W2045945310","https://openalex.org/W2048802787","https://openalex.org/W2050394650","https://openalex.org/W2053645995","https://openalex.org/W2062628269","https://openalex.org/W2062726330","https://openalex.org/W2071416644","https://openalex.org/W2082010244","https://openalex.org/W2097489402","https://openalex.org/W2100039832","https://openalex.org/W2103403418","https://openalex.org/W2113462070","https://openalex.org/W2118011591","https://openalex.org/W2125245877","https://openalex.org/W2164203667","https://openalex.org/W2171908040","https://openalex.org/W2257916459","https://openalex.org/W2277748889","https://openalex.org/W2309818502","https://openalex.org/W2310005049","https://openalex.org/W2477709189","https://openalex.org/W2512899508","https://openalex.org/W2518448021","https://openalex.org/W2581079813","https://openalex.org/W2792707531","https://openalex.org/W2886210666","https://openalex.org/W2892899495","https://openalex.org/W2894049502","https://openalex.org/W2894717949","https://openalex.org/W2898079638","https://openalex.org/W2923282967","https://openalex.org/W2923934428","https://openalex.org/W2924865280","https://openalex.org/W2990986086","https://openalex.org/W4250733104"],"related_works":["https://openalex.org/W2071416644","https://openalex.org/W2312981105","https://openalex.org/W2080125915","https://openalex.org/W1972347370","https://openalex.org/W3006475031","https://openalex.org/W2792707531","https://openalex.org/W2059070178","https://openalex.org/W2034584820","https://openalex.org/W2589379589","https://openalex.org/W2998451816"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-03-29T00:00:00"}