{"id":"https://openalex.org/W3136626802","doi":"https://doi.org/10.3390/ijms22073331","title":"Hypoxia Inducible Factor 1A Supports a Pro-Fibrotic Phenotype Loop in Idiopathic Pulmonary Fibrosis","display_name":"Hypoxia Inducible Factor 1A Supports a Pro-Fibrotic Phenotype Loop in Idiopathic Pulmonary Fibrosis","publication_year":2021,"publication_date":"2021-03-24","ids":{"openalex":"https://openalex.org/W3136626802","doi":"https://doi.org/10.3390/ijms22073331","mag":"3136626802","pmid":"https://pubmed.ncbi.nlm.nih.gov/33805152","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8078165"},"language":"en","primary_location":{"id":"doi:10.3390/ijms22073331","doi":"https://doi.org/10.3390/ijms22073331","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms22073331","pdf_url":"https://www.mdpi.com/1422-0067/22/7/3331/pdf?version=1616595103","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/22/7/3331/pdf?version=1616595103","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005436600","display_name":"Gali Epstein Shochet","orcid":"https://orcid.org/0000-0002-3417-9171","observed_orcids":["https://orcid.org/0000-0002-3417-9171"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2801839060","display_name":"Meir Medical Center","ror":"https://ror.org/04pc7j325","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2801839060"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Gali Epstein Shochet","raw_affiliation_strings":["Pulmonary Department, Meir Medical Center, Kfar Saba 4428164, Israel","Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary Department, Meir Medical Center, Kfar Saba 4428164, Israel","institution_ids":["https://openalex.org/I2801839060"]},{"raw_affiliation_string":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082676463","display_name":"Becky Bardenstein-Wald","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Becky Bardenstein-Wald","raw_affiliation_strings":["Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081305741","display_name":"Mary McElroy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210094381","display_name":"Charles River Laboratories (United Kingdom)","ror":"https://ror.org/00q2mch05","country_code":"GB","type":"company","lineage":["https://openalex.org/I4210094381","https://openalex.org/I4210126295"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mary McElroy","raw_affiliation_strings":["Respiratory Pharmacology, Charles River Laboratories, Edinburgh EH33 2NE, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Respiratory Pharmacology, Charles River Laboratories, Edinburgh EH33 2NE, UK","institution_ids":["https://openalex.org/I4210094381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025771976","display_name":"Andrew Kukuy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2799810450","display_name":"Sheba Medical Center","ror":"https://ror.org/020rzx487","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2799810450"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Andrew Kukuy","raw_affiliation_strings":["The Leviev Heart Institute, Sheba Medical Center, Ramat Gan 5262000, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Leviev Heart Institute, Sheba Medical Center, Ramat Gan 5262000, Israel","institution_ids":["https://openalex.org/I2799810450"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014092211","display_name":"Mark W. Surber","orcid":"https://orcid.org/0000-0001-8868-9233","observed_orcids":["https://orcid.org/0000-0001-8868-9233"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark Surber","raw_affiliation_strings":["Avalyn Pharma, 701 Pike Street suite 1500, Seattle, WA 98101, USA"],"raw_orcid":"https://orcid.org/0000-0001-8868-9233","affiliations":[{"raw_affiliation_string":"Avalyn Pharma, 701 Pike Street suite 1500, Seattle, WA 98101, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Evgeny Edelstein","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801839060","display_name":"Meir Medical Center","ror":"https://ror.org/04pc7j325","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2801839060"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Evgeny Edelstein","raw_affiliation_strings":["Pathology Department, Meir Medical Center, Kfar Saba 4428164, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology Department, Meir Medical Center, Kfar Saba 4428164, Israel","institution_ids":["https://openalex.org/I2801839060"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006649927","display_name":"Barak Pertzov","orcid":"https://orcid.org/0000-0002-3077-3616","observed_orcids":["https://orcid.org/0000-0002-3077-3616"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2800389475","display_name":"Rabin Medical Center","ror":"https://ror.org/01vjtf564","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2800389475","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Barak Pertzov","raw_affiliation_strings":["Pulmonary Division, Rabin Medical Center, Petach Tikva 4941492, Israel","Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel"],"raw_orcid":"https://orcid.org/0000-0002-3077-3616","affiliations":[{"raw_affiliation_string":"Pulmonary Division, Rabin Medical Center, Petach Tikva 4941492, Israel","institution_ids":["https://openalex.org/I2800389475"]},{"raw_affiliation_string":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053064966","display_name":"Mordechai Reuven Kramer","orcid":"https://orcid.org/0000-0003-2376-2393","observed_orcids":["https://orcid.org/0000-0003-2376-2393"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2800389475","display_name":"Rabin Medical Center","ror":"https://ror.org/01vjtf564","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2800389475","https://openalex.org/I64767286"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Mordechai Reuven Kramer","raw_affiliation_strings":["Pulmonary Division, Rabin Medical Center, Petach Tikva 4941492, Israel","Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary Division, Rabin Medical Center, Petach Tikva 4941492, Israel","institution_ids":["https://openalex.org/I2800389475"]},{"raw_affiliation_string":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046803053","display_name":"David Shitrit","orcid":"https://orcid.org/0000-0002-2331-5270","observed_orcids":["https://orcid.org/0000-0002-2331-5270"]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]},{"id":"https://openalex.org/I2801839060","display_name":"Meir Medical Center","ror":"https://ror.org/04pc7j325","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2801839060"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"David Shitrit","raw_affiliation_strings":["Pulmonary Department, Meir Medical Center, Kfar Saba 4428164, Israel","Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pulmonary Department, Meir Medical Center, Kfar Saba 4428164, Israel","institution_ids":["https://openalex.org/I2801839060"]},{"raw_affiliation_string":"Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 69978, Israel","institution_ids":["https://openalex.org/I16391192"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5005436600"],"corresponding_institution_ids":["https://openalex.org/I16391192","https://openalex.org/I2801839060"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2160},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2160},"fwci":4.9781,"has_fulltext":true,"cited_by_count":61,"citation_normalized_percentile":{"value":0.96357564,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":100},"biblio":{"volume":"22","issue":"7","first_page":"3331","last_page":"3331"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/idiopathic-pulmonary-fibrosis","display_name":"idiopathic pulmonary fibrosis","score":1.0},{"id":"https://openalex.org/keywords/hypoxia-inducible-factor-1alpha","display_name":"hypoxia-inducible factor-1\u03b1","score":0.9179999828338623},{"id":"https://openalex.org/keywords/nintedanib","display_name":"nintedanib","score":0.9909999966621399},{"id":"https://openalex.org/keywords/lung-fibroblasts","display_name":"lung fibroblasts","score":0.9129999876022339},{"id":"https://openalex.org/keywords/fibrosis","display_name":"fibrosis","score":0.3190000057220459},{"id":"https://openalex.org/keywords/bleomycin-induced-pulmonary-fibrosis","display_name":"bleomycin-induced lung fibrosis","score":0.7310000061988831},{"id":"https://openalex.org/keywords/plasminogen-activator-inhibitor-1","display_name":"plasminogen activator inhibitor-1","score":0.8289999961853027},{"id":"https://openalex.org/keywords/vegf-a","display_name":"VEGF-A","score":0.8510000109672546},{"id":"https://openalex.org/keywords/timp-1","display_name":"TIMP-1","score":0.9959999918937683},{"id":"https://openalex.org/keywords/alveolar-macrophages","display_name":"alveolar macrophages","score":0.9309999942779541},{"id":"https://openalex.org/keywords/extracellular-matrix","display_name":"extracellular matrix","score":0.9399999976158142},{"id":"https://openalex.org/keywords/antifibrotic-therapy","display_name":"antifibrotic therapy","score":0.7549999952316284}],"concepts":[{"id":"https://openalex.org/C2780171596","wikidata":"https://www.wikidata.org/wiki/Q15149723","display_name":"Nintedanib","level":4,"score":0.9678744077682495},{"id":"https://openalex.org/C2778341716","wikidata":"https://www.wikidata.org/wiki/Q2290446","display_name":"Idiopathic pulmonary fibrosis","level":3,"score":0.89837646484375},{"id":"https://openalex.org/C2781244666","wikidata":"https://www.wikidata.org/wiki/Q32446","display_name":"Pulmonary fibrosis","level":3,"score":0.5787034630775452},{"id":"https://openalex.org/C2777543607","wikidata":"https://www.wikidata.org/wiki/Q1153419","display_name":"Interstitial lung disease","level":3,"score":0.5600486993789673},{"id":"https://openalex.org/C2776232574","wikidata":"https://www.wikidata.org/wiki/Q415571","display_name":"Bleomycin","level":3,"score":0.5410624146461487},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5297502279281616},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5149474740028381},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.49167877435684204},{"id":"https://openalex.org/C2780692422","wikidata":"https://www.wikidata.org/wiki/Q18031995","display_name":"TIMP1","level":4,"score":0.486944317817688},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4585632085800171},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3498426675796509},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.34387385845184326},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2294289767742157},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.0778006911277771},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001761","descriptor_name":"Bleomycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054990","descriptor_name":"Idiopathic Pulmonary Fibrosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054990","descriptor_name":"Idiopathic Pulmonary Fibrosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.3390/ijms22073331","doi":"https://doi.org/10.3390/ijms22073331","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms22073331","pdf_url":"https://www.mdpi.com/1422-0067/22/7/3331/pdf?version=1616595103","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8078165","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8078165","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:33805152","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33805152","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:d502c9a183744b308a2b02b98bdb97fa","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d502c9a183744b308a2b02b98bdb97fa","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 22, Iss 3331, p 3331 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijms22073331","doi":"https://doi.org/10.3390/ijms22073331","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms22073331","pdf_url":"https://www.mdpi.com/1422-0067/22/7/3331/pdf?version=1616595103","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3136626802.pdf","grobid_xml":"https://content.openalex.org/works/W3136626802.grobid-xml"},"referenced_works_count":53,"referenced_works":["https://openalex.org/W1894287559","https://openalex.org/W1963740134","https://openalex.org/W1969080012","https://openalex.org/W1976363248","https://openalex.org/W1986014993","https://openalex.org/W2009466546","https://openalex.org/W2018131877","https://openalex.org/W2050076172","https://openalex.org/W2077455531","https://openalex.org/W2081415617","https://openalex.org/W2088561726","https://openalex.org/W2089402488","https://openalex.org/W2089756110","https://openalex.org/W2090897026","https://openalex.org/W2095562829","https://openalex.org/W2095947403","https://openalex.org/W2097593914","https://openalex.org/W2134658682","https://openalex.org/W2138153375","https://openalex.org/W2142197498","https://openalex.org/W2145026142","https://openalex.org/W2158217645","https://openalex.org/W2159864284","https://openalex.org/W2164134225","https://openalex.org/W2174542233","https://openalex.org/W2462113069","https://openalex.org/W2482748595","https://openalex.org/W2485589748","https://openalex.org/W2620123585","https://openalex.org/W2655242042","https://openalex.org/W2734568032","https://openalex.org/W2754468979","https://openalex.org/W2781934183","https://openalex.org/W2792157500","https://openalex.org/W2799897205","https://openalex.org/W2805771055","https://openalex.org/W2888765075","https://openalex.org/W2902949106","https://openalex.org/W2904478560","https://openalex.org/W2904920374","https://openalex.org/W2904924400","https://openalex.org/W2946173685","https://openalex.org/W2950209105","https://openalex.org/W2950944645","https://openalex.org/W2952481429","https://openalex.org/W2979790944","https://openalex.org/W2995721821","https://openalex.org/W3044493739","https://openalex.org/W3046269947","https://openalex.org/W3080193412","https://openalex.org/W3103111545","https://openalex.org/W3110182161","https://openalex.org/W7096050474"],"related_works":["https://openalex.org/W3095310361","https://openalex.org/W2792157500","https://openalex.org/W2120791222","https://openalex.org/W1936060851","https://openalex.org/W2987049246","https://openalex.org/W2147322791","https://openalex.org/W2991063759","https://openalex.org/W4321598411","https://openalex.org/W4321019514","https://openalex.org/W2345930404"],"abstract_inverted_index":{"Idiopathic":[0],"pulmonary":[1],"fibrosis":[2],"(IPF)":[3],"is":[4,34],"a":[5,177],"progressive":[6],"lung":[7,75],"disease":[8],"with":[9,116,132],"poor":[10],"prognosis.":[11],"The":[12],"IPF-conditioned":[13],"matrix":[14,178],"(IPF-CM)":[15],"system":[16],"enables":[17],"the":[18,32,39,44,53,88,165,172,192],"study":[19],"of":[20,124],"matrix\u2013fibroblast":[21],"interplay.":[22],"While":[23],"effective":[24],"at":[25],"slowing":[26],"fibrosis,":[27],"nintedanib":[28,50,111],"has":[29],"limitations":[30],"and":[31,48,64,69,82,97,112,138,167],"mechanism":[33],"not":[35],"fully":[36],"elucidated.":[37],"In":[38],"current":[40],"work,":[41],"we":[42],"explored":[43],"underlying":[45],"signaling":[46,126],"pathways":[47],"characterized":[49],"involvement":[51],"in":[52,107,113,148,156,164,185],"IPF-CM":[54,121,166],"fibrotic":[55],"process.":[56],"Results":[57],"were":[58,78,99,103],"validated":[59],"using":[60,85],"IPF":[61,140],"patient":[62,114,141],"samples":[63,115,142],"bleomycin-treated":[65,108],"animals":[66],"with/without":[67,110],"oral":[68],"inhaled":[70],"nintedanib.":[71,200],"IPF-derived":[72],"primary":[73],"human":[74],"fibroblasts":[76],"(HLFs)":[77],"cultured":[79,119],"on":[80,120,134],"Matrigel":[81],"then":[83],"cleared":[84],"NH4OH,":[86],"creating":[87,176],"IPF-CM.":[89],"Normal":[90],"HLF-CM":[91],"served":[92],"as":[93],"control.":[94],"RNA-sequencing,":[95],"PCR":[96],"western-blots":[98],"performed.":[100],"HIF1\u03b1":[101,145,162,193],"targets":[102],"evaluated":[104],"by":[105,199],"immunohistochemistry":[106],"rats":[109],"IPF.":[117],"HLFs":[118],"showed":[122,143],"over-expression":[123],"\u2018HIF1\u03b1":[125],"pathway\u2019":[127],"(KEGG,":[128],"p":[129],"<":[130],"0.0001),":[131],"emphasis":[133],"SERPINE1":[135],"(PAI-1),":[136],"VEGFA":[137],"TIMP1.":[139],"high":[144],"staining,":[146],"especially":[147],"established":[149],"fibrous":[150],"tissue.":[151],"PAI-1":[152],"was":[153],"overexpressed,":[154],"mainly":[155],"alveolar":[157],"macrophages.":[158],"Nintedanib":[159],"completely":[160],"reduced":[161],"upregulation":[163],"rat-bleomycin":[168],"models.":[169],"IPF-HLFs":[170],"alter":[171],"extracellular":[173],"matrix,":[174],"thus":[175],"that":[179],"further":[180],"propagates":[181],"an":[182],"IPF-like":[183],"phenotype":[184],"normal":[186],"HLFs.":[187],"This":[188],"pro-fibrotic":[189],"loop":[190],"includes":[191],"pathway,":[194],"which":[195],"can":[196],"be":[197],"blocked":[198]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":11},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-03-29T00:00:00"}