{"id":"https://openalex.org/W3136565550","doi":null,"title":"Cellular and Developmental Insights into the Early Evolution of Muscle","display_name":"Cellular and Developmental Insights into the Early Evolution of Muscle","publication_year":2020,"publication_date":"2020-01-01","ids":{"openalex":"https://openalex.org/W3136565550","mag":"3136565550"},"language":"en","primary_location":{"id":"pmh:oai:digitalcommons.du.edu:etd-2737","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.du.edu/etd/1733","pdf_url":null,"source":{"id":"https://openalex.org/S4377196520","display_name":"Digital Commons - DU (University of Denver)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I131651094","host_organization_name":"University of Denver","host_organization_lineage":["https://openalex.org/I131651094"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Theses and Dissertations","raw_type":"text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073693220","display_name":"Jeffrey J. Colgren","orcid":"https://orcid.org/0000-0003-3912-0926","observed_orcids":["https://orcid.org/0000-0003-3912-0926"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jeffrey Colgren","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-3912-0926","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5073693220"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12142","display_name":"Marine Invertebrate Physiology and Ecology","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12142","display_name":"Marine Invertebrate Physiology and Ecology","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ephydatia-muelleri","display_name":"Ephydatia muelleri","score":0.9340000152587891},{"id":"https://openalex.org/keywords/sponges","display_name":"sponges","score":0.8510000109672546},{"id":"https://openalex.org/keywords/contractile-tissue","display_name":"contractile tissue","score":0.8700000047683716},{"id":"https://openalex.org/keywords/actin-bundles","display_name":"actin bundles","score":0.8159999847412109},{"id":"https://openalex.org/keywords/myosin-heavy-chain","display_name":"myosin heavy chain","score":0.7950000166893005},{"id":"https://openalex.org/keywords/myosin-regulatory-light-chain","display_name":"myosin regulatory light chain","score":0.777999997138977},{"id":"https://openalex.org/keywords/myosin-light-chain-kinase","display_name":"myosin light chain kinase","score":0.9750000238418579},{"id":"https://openalex.org/keywords/intracellular-calcium-stores","display_name":"intracellular calcium stores","score":0.6209999918937683},{"id":"https://openalex.org/keywords/mrtf","display_name":"MRTF","score":0.8519999980926514},{"id":"https://openalex.org/keywords/myogenesis","display_name":"myogenesis","score":0.6840000152587891},{"id":"https://openalex.org/keywords/nematostella-vectensis","display_name":"Nematostella vectensis","score":0.8519999980926514},{"id":"https://openalex.org/keywords/homology","display_name":"homology","score":0.5180000066757202}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3557853698730469}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:digitalcommons.du.edu:etd-2737","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.du.edu/etd/1733","pdf_url":null,"source":{"id":"https://openalex.org/S4377196520","display_name":"Digital Commons - DU (University of Denver)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I131651094","host_organization_name":"University of Denver","host_organization_lineage":["https://openalex.org/I131651094"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Electronic Theses and Dissertations","raw_type":"text"},{"id":"mag:3136565550","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.du.edu/etd/1733/","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3155856767","https://openalex.org/W4285492553","https://openalex.org/W4387026462","https://openalex.org/W7170169907","https://openalex.org/W4253332515","https://openalex.org/W3047528415","https://openalex.org/W2024218798","https://openalex.org/W2153450752","https://openalex.org/W1995750883","https://openalex.org/W2150822864"],"abstract_inverted_index":{"Whereas":[0,66],"a":[1,100,122,159,200],"great":[2],"deal":[3],"has":[4],"been":[5,71],"learned":[6],"about":[7,20],"the":[8,21,30,34,67,73,90,95,126,142,224,228,246,271],"molecular":[9],"underpinnings":[10],"of":[11,23,52,76,84,94,125,129,162,181,189,204,227,235,249,254,258,273],"morphological":[12],"evolution":[13,272],"in":[14,32,120,218,264,270],"animals,":[15,121],"much":[16],"less":[17],"is":[18,87,108,114,132,144,168],"known":[19],"origin":[22],"novel":[24],"cell":[25,41],"and":[26,42,103,184,261],"tissue":[27,43,93,128,148,248,275],"types.":[28],"During":[29],"time":[31],"which":[33,154],"earliest":[35],"animal":[36,54],"lineages":[37,55],"were":[38],"diversifying,":[39],"fundamental":[40],"types,":[44],"such":[45],"as":[46],"muscles,":[47,58],"arose.":[48],"Sponges":[49],"are":[50,78,185],"one":[51],"two":[53],"that":[56,113],"lack":[57],"yet":[59],"they":[60],"undergo":[61],"coordinated":[62],"full":[63,123],"body":[64],"contractions.":[65,157],"signaling":[68],"processes":[69],"have":[70],"studied,":[72],"physical":[74],"mechanisms":[75],"contraction":[77],"completely":[79],"uncharacterized.":[80],"The":[81],"main":[82],"purpose":[83],"this":[85,274],"work":[86],"to":[88,134,176],"understand":[89],"primary":[91],"contractile":[92,127,205,247],"sponge":[96],"Ephydatia":[97],"muelleri,":[98],"from":[99],"structural,":[101],"functional,":[102],"developmental":[104,201,237],"standpoint.":[105],"As":[106],"there":[107],"no":[109],"single":[110],"unique":[111],"feature":[112],"shared":[115],"by":[116,179,187,194,239],"all":[117],"muscle":[118],"types":[119],"picture":[124],"E.":[130,250],"muelleri":[131,251],"needed":[133],"assess":[135],"its":[136],"homology":[137,255],"with":[138,256],"these":[139,172,243],"tissues.":[140],"Here":[141],"focus":[143],"on":[145,208,223],"an":[146,214],"endothelial-like":[147],"containing":[149],"tissue-level":[150],"organized":[151],"actin":[152],"bundles,":[153],"shorten":[155],"during":[156],"Additionally,":[158],"muscle-specific":[160],"paralog":[161],"type":[163],"II-Myosin":[164],"heavy":[165],"chain":[166,193,197],"(stMyHC)":[167],"found":[169,233],"exclusively":[170],"at":[171],"structures.":[173],"Contractions":[174],"appear":[175],"be":[177],"initiated":[178],"release":[180],"internal":[182],"Ca2+stores":[183],"regulated":[186],"phosphorylation":[188],"myosin":[190,195],"regulatory":[191],"light":[192,196],"kinase.":[198],"From":[199],"perspective,":[202],"formation":[203],"bundles":[206],"depends":[207],"myocardin":[209],"related":[210],"transcription":[211],"factor":[212,217],"(MRTF),":[213],"important":[215],"myogenic":[216],"many":[219],"animals.":[220],"Comparative":[221],"studies":[222],"myoepithelial":[225],"muscles":[226,257],"cnidarian":[229],"model":[230],"Nematostella":[231],"vectensis,":[232],"evidence":[234],"conserved":[236],"regulation":[238],"MRTF.":[240],"Taken":[241],"together,":[242],"finding":[244],"suggest":[245],"shares":[252],"elements":[253],"other":[259],"animals":[260],"can":[262],"aid":[263],"understanding":[265],"key":[266],"cellular":[267],"innovations":[268],"involved":[269],"type.":[276]},"counts_by_year":[{"year":2024,"cited_by_count":1}],"updated_date":"2026-09-22T06:50:58.402377","created_date":"2021-03-29T00:00:00"}