{"id":"https://openalex.org/W3136529336","doi":"https://doi.org/10.1097/md.0000000000025173","title":"Role of tocilizumab for concomitant systemic fungal infection in severe COVID-19 patient","display_name":"Role of tocilizumab for concomitant systemic fungal infection in severe COVID-19 patient","publication_year":2021,"publication_date":"2021-03-23","ids":{"openalex":"https://openalex.org/W3136529336","doi":"https://doi.org/10.1097/md.0000000000025173","mag":"3136529336","pmid":"https://pubmed.ncbi.nlm.nih.gov/33761696","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9282040"},"language":"en","primary_location":{"id":"doi:10.1097/md.0000000000025173","doi":"https://doi.org/10.1097/md.0000000000025173","is_oa":true,"landing_page_url":"https://doi.org/10.1097/md.0000000000025173","pdf_url":null,"source":{"id":"https://openalex.org/S28966261","display_name":"Medicine","issn_l":"0025-7974","issn":["0025-7974","1536-5964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1097/md.0000000000025173","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5049389415","display_name":"Anggraini Permata Sari","orcid":"https://orcid.org/0000-0001-6005-0104","observed_orcids":["https://orcid.org/0000-0001-6005-0104"]},"institutions":[{"id":"https://openalex.org/I4210164273","display_name":"Fatmawati Hospital","ror":"https://ror.org/05hdpwb59","country_code":"ID","type":"healthcare","lineage":["https://openalex.org/I4210164273"]}],"countries":["ID"],"is_corresponding":true,"raw_author_name":"Anggraini Permata Sari","raw_affiliation_strings":["Department of Internal Medicine, Fatmawati General Hospital, South Jakarta, DKI Jakarta, Indonesia"],"raw_orcid":"https://orcid.org/0000-0001-6005-0104","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Fatmawati General Hospital, South Jakarta, DKI Jakarta, Indonesia","institution_ids":["https://openalex.org/I4210164273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051073021","display_name":"Nikko Darnindro","orcid":"https://orcid.org/0000-0001-9361-0948","observed_orcids":["https://orcid.org/0000-0001-9361-0948"]},"institutions":[{"id":"https://openalex.org/I4210164273","display_name":"Fatmawati Hospital","ror":"https://ror.org/05hdpwb59","country_code":"ID","type":"healthcare","lineage":["https://openalex.org/I4210164273"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Nikko Darnindro","raw_affiliation_strings":["Data sharing not applicable to this article as no datasets were generated or analyzed during the current study","Department of Internal Medicine, Fatmawati General Hospital, South Jakarta, DKI Jakarta, Indonesia","How to cite this article: Sari AP, Darnindro N, Yohanes A, Mokoagow MI. Role of tocilizumab for concomitant systemic fungal infection in severe COVID-19 patient: case report. Medicine. 2021;100:12(e25173)","Written informed consent was obtained from the patient for publication of the case details and accompanying images","100:12(e25173)","How to cite this article: Sari AP, Darnindro N, Yohanes A, Mokoagow MI. Role of tocilizumab for concomitant systemic fungal infection in severe COVID-19 patient: case report. Medicine. 2021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Data sharing not applicable to this article as no datasets were generated or analyzed during the current study","institution_ids":[]},{"raw_affiliation_string":"Department of Internal Medicine, Fatmawati General Hospital, South Jakarta, DKI Jakarta, Indonesia","institution_ids":["https://openalex.org/I4210164273"]},{"raw_affiliation_string":"How to cite this article: Sari AP, Darnindro N, Yohanes A, Mokoagow MI. Role of tocilizumab for concomitant systemic fungal infection in severe COVID-19 patient: case report. Medicine. 2021;100:12(e25173)","institution_ids":[]},{"raw_affiliation_string":"Written informed consent was obtained from the patient for publication of the case details and accompanying images","institution_ids":[]},{"raw_affiliation_string":"100:12(e25173)","institution_ids":[]},{"raw_affiliation_string":"How to cite this article: Sari AP, Darnindro N, Yohanes A, Mokoagow MI. Role of tocilizumab for concomitant systemic fungal infection in severe COVID-19 patient: case report. Medicine. 2021","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024737756","display_name":"Aryan Yohanes Djojo","orcid":"https://orcid.org/0000-0001-7282-4920","observed_orcids":["https://orcid.org/0000-0001-7282-4920"]},"institutions":[{"id":"https://openalex.org/I4210164273","display_name":"Fatmawati Hospital","ror":"https://ror.org/05hdpwb59","country_code":"ID","type":"healthcare","lineage":["https://openalex.org/I4210164273"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Aryan Yohanes","raw_affiliation_strings":["Data sharing not applicable to this article as no datasets were generated or analyzed during the current study","Department of Internal Medicine, Fatmawati General Hospital, South Jakarta, DKI Jakarta, Indonesia","How to cite this article: Sari AP, Darnindro N, Yohanes A, Mokoagow MI. Role of tocilizumab for concomitant systemic fungal infection in severe COVID-19 patient: case report. Medicine. 2021;100:12(e25173)","Written informed consent was obtained from the patient for publication of the case details and accompanying images","100:12(e25173)","How to cite this article: Sari AP, Darnindro N, Yohanes A, Mokoagow MI. Role of tocilizumab for concomitant systemic fungal infection in severe COVID-19 patient: case report. Medicine. 2021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Data sharing not applicable to this article as no datasets were generated or analyzed during the current study","institution_ids":[]},{"raw_affiliation_string":"Department of Internal Medicine, Fatmawati General Hospital, South Jakarta, DKI Jakarta, Indonesia","institution_ids":["https://openalex.org/I4210164273"]},{"raw_affiliation_string":"How to cite this article: Sari AP, Darnindro N, Yohanes A, Mokoagow MI. Role of tocilizumab for concomitant systemic fungal infection in severe COVID-19 patient: case report. Medicine. 2021;100:12(e25173)","institution_ids":[]},{"raw_affiliation_string":"Written informed consent was obtained from the patient for publication of the case details and accompanying images","institution_ids":[]},{"raw_affiliation_string":"100:12(e25173)","institution_ids":[]},{"raw_affiliation_string":"How to cite this article: Sari AP, Darnindro N, Yohanes A, Mokoagow MI. Role of tocilizumab for concomitant systemic fungal infection in severe COVID-19 patient: case report. Medicine. 2021","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5089289974","display_name":"Md Ikhsan Mokoagow","orcid":"https://orcid.org/0000-0001-8141-0324","observed_orcids":["https://orcid.org/0000-0001-8141-0324"]},"institutions":[{"id":"https://openalex.org/I4210164273","display_name":"Fatmawati Hospital","ror":"https://ror.org/05hdpwb59","country_code":"ID","type":"healthcare","lineage":["https://openalex.org/I4210164273"]}],"countries":["ID"],"is_corresponding":false,"raw_author_name":"Muhammad Ikhsan Mokoagow","raw_affiliation_strings":["Data sharing not applicable to this article as no datasets were generated or analyzed during the current study","Department of Internal Medicine, Fatmawati General Hospital, South Jakarta, DKI Jakarta, Indonesia","How to cite this article: Sari AP, Darnindro N, Yohanes A, Mokoagow MI. Role of tocilizumab for concomitant systemic fungal infection in severe COVID-19 patient: case report. Medicine. 2021;100:12(e25173)","Written informed consent was obtained from the patient for publication of the case details and accompanying images","100:12(e25173)","How to cite this article: Sari AP, Darnindro N, Yohanes A, Mokoagow MI. Role of tocilizumab for concomitant systemic fungal infection in severe COVID-19 patient: case report. Medicine. 2021"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Data sharing not applicable to this article as no datasets were generated or analyzed during the current study","institution_ids":[]},{"raw_affiliation_string":"Department of Internal Medicine, Fatmawati General Hospital, South Jakarta, DKI Jakarta, Indonesia","institution_ids":["https://openalex.org/I4210164273"]},{"raw_affiliation_string":"How to cite this article: Sari AP, Darnindro N, Yohanes A, Mokoagow MI. Role of tocilizumab for concomitant systemic fungal infection in severe COVID-19 patient: case report. Medicine. 2021;100:12(e25173)","institution_ids":[]},{"raw_affiliation_string":"Written informed consent was obtained from the patient for publication of the case details and accompanying images","institution_ids":[]},{"raw_affiliation_string":"100:12(e25173)","institution_ids":[]},{"raw_affiliation_string":"How to cite this article: Sari AP, Darnindro N, Yohanes A, Mokoagow MI. Role of tocilizumab for concomitant systemic fungal infection in severe COVID-19 patient: case report. Medicine. 2021","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5049389415"],"corresponding_institution_ids":["https://openalex.org/I4210164273"],"apc_list":{"value":1950,"currency":"USD","value_usd":1950},"apc_paid":{"value":1950,"currency":"USD","value_usd":1950},"fwci":3.062,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.93395203,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"100","issue":"12","first_page":"e25173","last_page":"e25173"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10041","display_name":"COVID-19 Clinical Research Studies","score":0.9761000275611877,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.02070000022649765,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tocilizumab","display_name":"tocilizumab","score":1.0},{"id":"https://openalex.org/keywords/covid-19","display_name":"COVID-19 pandemic","score":0.9179999828338623},{"id":"https://openalex.org/keywords/candidemia","display_name":"candidemia","score":0.9539999961853027},{"id":"https://openalex.org/keywords/candida-tropicalis","display_name":"Candida tropicalis","score":0.9240000247955322},{"id":"https://openalex.org/keywords/fungal-coinfection","display_name":"fungal co-infection","score":0.6079999804496765},{"id":"https://openalex.org/keywords/acute-respiratory-distress-syndrome","display_name":"acute respiratory distress syndrome","score":0.7590000033378601},{"id":"https://openalex.org/keywords/il-6-inhibition","display_name":"IL-6 inhibition","score":0.9200000166893005},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.6949999928474426},{"id":"https://openalex.org/keywords/severe-covid-19","display_name":"severe COVID-19","score":0.7720000147819519}],"concepts":[{"id":"https://openalex.org/C2777178219","wikidata":"https://www.wikidata.org/wiki/Q425154","display_name":"Tocilizumab","level":3,"score":0.9766780138015747},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9642220735549927},{"id":"https://openalex.org/C2776348555","wikidata":"https://www.wikidata.org/wiki/Q344873","display_name":"ARDS","level":3,"score":0.8170217275619507},{"id":"https://openalex.org/C2779384505","wikidata":"https://www.wikidata.org/wiki/Q17007513","display_name":"Concomitant","level":2,"score":0.6045961380004883},{"id":"https://openalex.org/C2780850621","wikidata":"https://www.wikidata.org/wiki/Q3961647","display_name":"Cytokine release syndrome","level":5,"score":0.4504099190235138},{"id":"https://openalex.org/C141983124","wikidata":"https://www.wikidata.org/wiki/Q188008","display_name":"Respiratory distress","level":2,"score":0.4434173107147217},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43923309445381165},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.3843424320220947},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3620700240135193},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.26215285062789917},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.2527826428413391},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.1829533874988556},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.10170352458953857}],"mesh":[{"descriptor_ui":"D000077551","descriptor_name":"Micafungin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000093242","descriptor_name":"Interleukin-6 Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000935","descriptor_name":"Antifungal Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041022","descriptor_name":"Candida tropicalis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058387","descriptor_name":"Candidemia","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D058387","descriptor_name":"Candidemia","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D060085","descriptor_name":"Coinfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1097/md.0000000000025173","doi":"https://doi.org/10.1097/md.0000000000025173","is_oa":true,"landing_page_url":"https://doi.org/10.1097/md.0000000000025173","pdf_url":null,"source":{"id":"https://openalex.org/S28966261","display_name":"Medicine","issn_l":"0025-7974","issn":["0025-7974","1536-5964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9282040","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9282040/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9282040/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine (Baltimore)","raw_type":"Text"},{"id":"pmid:33761696","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33761696","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"Case Reports"}],"best_oa_location":{"id":"doi:10.1097/md.0000000000025173","doi":"https://doi.org/10.1097/md.0000000000025173","is_oa":true,"landing_page_url":"https://doi.org/10.1097/md.0000000000025173","pdf_url":null,"source":{"id":"https://openalex.org/S28966261","display_name":"Medicine","issn_l":"0025-7974","issn":["0025-7974","1536-5964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Case Report","id":"https://openalex.org/study-designs/case-report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3136529336.pdf","grobid_xml":"https://content.openalex.org/works/W3136529336.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W2022022413","https://openalex.org/W2111240123","https://openalex.org/W2117771953","https://openalex.org/W2134827411","https://openalex.org/W2286228001","https://openalex.org/W2464357651","https://openalex.org/W2912679257","https://openalex.org/W3011610993","https://openalex.org/W3012421327","https://openalex.org/W3012655019","https://openalex.org/W3014663601","https://openalex.org/W3015369767","https://openalex.org/W3015522797","https://openalex.org/W3015607499","https://openalex.org/W3022381041","https://openalex.org/W3022523387","https://openalex.org/W3031365196","https://openalex.org/W3042184234","https://openalex.org/W3045525085","https://openalex.org/W6776208904"],"related_works":["https://openalex.org/W3157405852","https://openalex.org/W4200369726","https://openalex.org/W4385872761","https://openalex.org/W4416971977","https://openalex.org/W3124557989","https://openalex.org/W3026301261","https://openalex.org/W3022523387","https://openalex.org/W4224990467","https://openalex.org/W3158291988","https://openalex.org/W4312409719"],"abstract_inverted_index":{"RATIONALE:":[0],"Bacterial":[1],"and":[2,14,58,62,89,114,148],"fungal":[3],"infections":[4],"in":[5,25,76,121,162,168],"Coronavirus":[6],"Disease-19":[7],"(COVID-19)":[8],"patients":[9],"have":[10],"been":[11],"inadequately":[12],"investigated":[13],"reported":[15],"thus":[16],"far.":[17],"The":[18],"safety":[19,157],"profile":[20,158],"of":[21,43,53,87,91,124,141,159],"tocilizumab":[22],"(TCZ)":[23],"administration":[24],"candidemia":[26,163],"patient":[27],"still":[28],"debatable.":[29],"PATIENT":[30],"CONCERNS:":[31],"A":[32],"54":[33],"year-old":[34],"woman":[35],"presenting":[36],"with":[37,48,118,132],"weakness":[38],"on":[39,82],"the":[40,115,122,143,156],"left":[41],"side":[42],"her":[44,55,103],"body":[45],"was":[46,63,79,99,112,149],"diagnosed":[47],"COVID-19.":[49],"After":[50,138],"7":[51],"days":[52,140],"admission,":[54],"condition":[56,146],"worsened":[57],"developed":[59],"respiratory":[60,65,72],"distress":[61,66,73],"having":[64],"despite":[67],"standard":[68],"treatment.":[69],"DIAGNOSES:":[70],"Acute":[71],"syndrome":[74],"(ARDS)":[75],"COVID":[77],"19":[78],"diagnoses":[80],"based":[81],"real":[83],"time-PCR":[84],"swab,":[85],"deterioration":[86],"PaO2/FiO2":[88],"increased":[90],"acute":[92],"phase":[93],"reactants.":[94],"INTERVENTIONS:":[95],"Anti":[96],"Interleukin-6":[97],"(IL-6)":[98],"considered":[100],"to":[101,107],"tackle":[102],"inflammatory":[104],"condition.":[105],"Prior":[106],"TCZ":[108,136,161],"administration,":[109],"blood":[110],"culture":[111],"performed":[113],"result":[116],"came":[117],"Candida":[119],"tropicalis":[120],"absence":[123],"bacterial":[125],"growth.":[126],"OUTCOMES:":[127],"No":[128],"major":[129],"complications":[130],"associated":[131],"intravenous":[133],"antifungal":[134],"or":[135],"occurred.":[137],"40":[139],"hospitalization,":[142],"patient's":[144],"clinical":[145],"improved":[147],"finally":[150],"discharged.":[151],"LESSONS:":[152],"This":[153],"case":[154],"underscores":[155],"giving":[160],"as":[164],"a":[165],"secondary":[166],"infection":[167],"severe":[169],"COVID-19":[170],"patient.":[171]},"counts_by_year":[{"year":2022,"cited_by_count":32},{"year":2021,"cited_by_count":4}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2021-03-29T00:00:00"}