{"id":"https://openalex.org/W3136511896","doi":"https://doi.org/10.3390/children8030224","title":"The Effect of NUDT15, TPMT, APEX1, and ITPA Genetic Variations on Mercaptopurine Treatment of Pediatric Acute Lymphoblastic Leukemia","display_name":"The Effect of NUDT15, TPMT, APEX1, and ITPA Genetic Variations on Mercaptopurine Treatment of Pediatric Acute Lymphoblastic Leukemia","publication_year":2021,"publication_date":"2021-03-15","ids":{"openalex":"https://openalex.org/W3136511896","doi":"https://doi.org/10.3390/children8030224","mag":"3136511896","pmid":"https://pubmed.ncbi.nlm.nih.gov/33804051","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7998516"},"language":"en","primary_location":{"id":"doi:10.3390/children8030224","doi":"https://doi.org/10.3390/children8030224","is_oa":true,"landing_page_url":"https://doi.org/10.3390/children8030224","pdf_url":"https://www.mdpi.com/2227-9067/8/3/224/pdf?version=1616398341","source":{"id":"https://openalex.org/S2736895435","display_name":"Children","issn_l":"2227-9067","issn":["2227-9067"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Children","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2227-9067/8/3/224/pdf?version=1616398341","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100381272","display_name":"Jae Min Lee","orcid":"https://orcid.org/0000-0001-6822-1051","observed_orcids":["https://orcid.org/0000-0001-6822-1051"]},"institutions":[{"id":"https://openalex.org/I4400573303","display_name":"Yeungnam University College","ror":"https://ror.org/05e6g0130","country_code":"KR","type":"education","lineage":["https://openalex.org/I4400573303"]},{"id":"https://openalex.org/I55240360","display_name":"Yeungnam University","ror":"https://ror.org/05yc6p159","country_code":"KR","type":"education","lineage":["https://openalex.org/I55240360"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jae Min Lee","raw_affiliation_strings":["Department of Pediatrics, Yeungnam University College of Medicine, Daegu 42415, Korea"],"raw_orcid":"https://orcid.org/0000-0001-6822-1051","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Yeungnam University College of Medicine, Daegu 42415, Korea","institution_ids":["https://openalex.org/I4400573303","https://openalex.org/I55240360"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063838307","display_name":"Ye Jee Shim","orcid":"https://orcid.org/0000-0002-5047-3493","observed_orcids":["https://orcid.org/0000-0002-5047-3493"]},"institutions":[{"id":"https://openalex.org/I52010207","display_name":"Keimyung University","ror":"https://ror.org/00tjv0s33","country_code":"KR","type":"education","lineage":["https://openalex.org/I52010207"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Ye Jee Shim","raw_affiliation_strings":["Department of Pediatrics, Keimyung University School of Medicine, Daegu 42601, Korea"],"raw_orcid":"https://orcid.org/0000-0002-5047-3493","affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Keimyung University School of Medicine, Daegu 42601, Korea","institution_ids":["https://openalex.org/I52010207"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100686012","display_name":"Do\u2010Hoon Kim","orcid":"https://orcid.org/0000-0002-9854-7850","observed_orcids":["https://orcid.org/0000-0002-9854-7850"]},"institutions":[{"id":"https://openalex.org/I52010207","display_name":"Keimyung University","ror":"https://ror.org/00tjv0s33","country_code":"KR","type":"education","lineage":["https://openalex.org/I52010207"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Do-Hoon Kim","raw_affiliation_strings":["Department of Laboratory Medicine, Keimyung University School of Medicine, Daegu 42601, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Keimyung University School of Medicine, Daegu 42601, Korea","institution_ids":["https://openalex.org/I52010207"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050643971","display_name":"Nani Jung","orcid":"https://orcid.org/0000-0003-3941-7498","observed_orcids":["https://orcid.org/0000-0003-3941-7498"]},"institutions":[{"id":"https://openalex.org/I52010207","display_name":"Keimyung University","ror":"https://ror.org/00tjv0s33","country_code":"KR","type":"education","lineage":["https://openalex.org/I52010207"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Nani Jung","raw_affiliation_strings":["Department of Pediatrics, Keimyung University School of Medicine, Daegu 42601, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Keimyung University School of Medicine, Daegu 42601, Korea","institution_ids":["https://openalex.org/I52010207"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5091621636","display_name":"Jung\u2010Sook Ha","orcid":"https://orcid.org/0000-0002-6475-4886","observed_orcids":["https://orcid.org/0000-0002-6475-4886"]},"institutions":[{"id":"https://openalex.org/I52010207","display_name":"Keimyung University","ror":"https://ror.org/00tjv0s33","country_code":"KR","type":"education","lineage":["https://openalex.org/I52010207"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jung-Sook Ha","raw_affiliation_strings":["Department of Laboratory Medicine, Keimyung University School of Medicine, Daegu 42601, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine, Keimyung University School of Medicine, Daegu 42601, Korea","institution_ids":["https://openalex.org/I52010207"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5091621636"],"corresponding_institution_ids":["https://openalex.org/I52010207"],"apc_list":{"value":1600,"currency":"CHF","value_usd":1728},"apc_paid":{"value":1600,"currency":"CHF","value_usd":1728},"fwci":1.0329,"has_fulltext":true,"cited_by_count":13,"citation_normalized_percentile":{"value":0.68946618,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"8","issue":"3","first_page":"224","last_page":"224"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.6654999852180481,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.6654999852180481,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10950","display_name":"Acute Lymphoblastic Leukemia research","score":0.301800012588501,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/6-mercaptopurine","display_name":"6-mercaptopurine","score":0.9319999814033508},{"id":"https://openalex.org/keywords/childhood-acute-lymphoblastic-leukemia","display_name":"childhood acute lymphoblastic leukemia","score":0.9760000109672546},{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"pharmacogenetics","score":0.8169999718666077},{"id":"https://openalex.org/keywords/nudt15","display_name":"NUDT15","score":0.8840000033378601},{"id":"https://openalex.org/keywords/thiopurine-methyltransferase","display_name":"thiopurine S-methyltransferase","score":0.9819999933242798},{"id":"https://openalex.org/keywords/apex1","display_name":"APEX1","score":0.8999999761581421},{"id":"https://openalex.org/keywords/itpa","display_name":"ITPA","score":0.9990000128746033},{"id":"https://openalex.org/keywords/maintenance-therapy","display_name":"maintenance therapy","score":0.5479999780654907},{"id":"https://openalex.org/keywords/febrile-neutropenia","display_name":"febrile neutropenia","score":0.8889999985694885},{"id":"https://openalex.org/keywords/dose-intensity","display_name":"dose intensity","score":0.5289999842643738},{"id":"https://openalex.org/keywords/genetic-variants","display_name":"genetic variants","score":0.5230000019073486},{"id":"https://openalex.org/keywords/drug-toxicity","display_name":"drug toxicity","score":0.45500001311302185},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.5899999737739563},{"id":"https://openalex.org/keywords/liver-enzymes","display_name":"liver enzymes","score":0.4059999883174896},{"id":"https://openalex.org/keywords/thiopurine-metabolism","display_name":"thiopurine metabolism","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C70917649","wikidata":"https://www.wikidata.org/wiki/Q94307","display_name":"Thiopurine methyltransferase","level":4,"score":0.9026170372962952},{"id":"https://openalex.org/C2779300928","wikidata":"https://www.wikidata.org/wiki/Q18028065","display_name":"ITPA","level":5,"score":0.8771229386329651},{"id":"https://openalex.org/C2777173762","wikidata":"https://www.wikidata.org/wiki/Q418529","display_name":"Mercaptopurine","level":2,"score":0.7979505658149719},{"id":"https://openalex.org/C2777063308","wikidata":"https://www.wikidata.org/wiki/Q1435822","display_name":"Neutropenia","level":3,"score":0.7184861898422241},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7016064524650574},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5898367762565613},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.516035795211792},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.31959256529808044},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.2534950375556946},{"id":"https://openalex.org/C2776760755","wikidata":"https://www.wikidata.org/wiki/Q18939","display_name":"Azathioprine","level":3,"score":0.1411687731742859},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C2780040827","wikidata":"https://www.wikidata.org/wiki/Q421862","display_name":"Ribavirin","level":4,"score":0.0},{"id":"https://openalex.org/C2776408679","wikidata":"https://www.wikidata.org/wiki/Q708693","display_name":"Hepatitis C virus","level":3,"score":0.0},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/children8030224","doi":"https://doi.org/10.3390/children8030224","is_oa":true,"landing_page_url":"https://doi.org/10.3390/children8030224","pdf_url":"https://www.mdpi.com/2227-9067/8/3/224/pdf?version=1616398341","source":{"id":"https://openalex.org/S2736895435","display_name":"Children","issn_l":"2227-9067","issn":["2227-9067"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Children","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7998516","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7998516","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Children (Basel)","raw_type":"Text"},{"id":"pmid:33804051","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33804051","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Children (Basel, Switzerland)","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:becc9e485e17485c865bb07274d6fb98","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/becc9e485e17485c865bb07274d6fb98","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Children, Vol 8, Iss 3, p 224 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/children8030224","doi":"https://doi.org/10.3390/children8030224","is_oa":true,"landing_page_url":"https://doi.org/10.3390/children8030224","pdf_url":"https://www.mdpi.com/2227-9067/8/3/224/pdf?version=1616398341","source":{"id":"https://openalex.org/S2736895435","display_name":"Children","issn_l":"2227-9067","issn":["2227-9067"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Children","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3136511896.pdf","grobid_xml":"https://content.openalex.org/works/W3136511896.grobid-xml"},"referenced_works_count":40,"referenced_works":["https://openalex.org/W39184900","https://openalex.org/W568926096","https://openalex.org/W1872688600","https://openalex.org/W1977840951","https://openalex.org/W1980507180","https://openalex.org/W2023648193","https://openalex.org/W2023728971","https://openalex.org/W2044141667","https://openalex.org/W2045595216","https://openalex.org/W2064737168","https://openalex.org/W2064928200","https://openalex.org/W2079345935","https://openalex.org/W2092925278","https://openalex.org/W2108562530","https://openalex.org/W2109000403","https://openalex.org/W2119685895","https://openalex.org/W2146829486","https://openalex.org/W2157249349","https://openalex.org/W2168127783","https://openalex.org/W2168795023","https://openalex.org/W2225153305","https://openalex.org/W2271765448","https://openalex.org/W2275947820","https://openalex.org/W2480796907","https://openalex.org/W2512386861","https://openalex.org/W2592485629","https://openalex.org/W2731117318","https://openalex.org/W2751953081","https://openalex.org/W2755495069","https://openalex.org/W2769243422","https://openalex.org/W2786984596","https://openalex.org/W2791017116","https://openalex.org/W2805416018","https://openalex.org/W2809534736","https://openalex.org/W2963843897","https://openalex.org/W2980318480","https://openalex.org/W2982272005","https://openalex.org/W6615936028","https://openalex.org/W6743802039","https://openalex.org/W6744898512"],"related_works":["https://openalex.org/W3201946015","https://openalex.org/W2805416018","https://openalex.org/W4380238893","https://openalex.org/W4212939323","https://openalex.org/W2963843897","https://openalex.org/W6920623288","https://openalex.org/W4396229659","https://openalex.org/W7222860752","https://openalex.org/W2908504589","https://openalex.org/W2980318480"],"abstract_inverted_index":{"Mercaptopurine":[0],"(MP)":[1],"is":[2,55],"a":[3,17,312],"commonly":[4],"used":[5],"maintenance":[6,162,182,202],"regimen":[7],"for":[8,220],"childhood":[9],"acute":[10,73],"lymphoblastic":[11,74],"leukemia":[12,75],"(ALL).":[13],"However,":[14,218],"6-MP":[15,47,67,123,155,158,177,194,283,302],"has":[16],"narrow":[18],"therapeutic":[19],"index,":[20],"which":[21,42],"causes":[22],"dose-limiting":[23],"toxicities":[24,70,121,304],"in":[25,71,208,288,320],"hematopoietic":[26],"tissues.":[27],"Recent":[28],"studies":[29],"reported":[30],"several":[31,130],"candidate":[32],"pharmacogenetic":[33],"markers":[34],"such":[35],"as":[36,239,241],"TPMT,":[37],"NUDT15,":[38],"ITPA,":[39],"and":[40,69,89,108,153,157,164,200,215,228,255,268,305,324],"APEX1,":[41],"predict":[43,282],"the":[44,58,180,186,198,235,247,250,264,277,306],"possibility":[45],"of":[46,52,60,63,80,119,134,141,148,223,237,249,252,298,309],"related":[48],"toxicities.":[49],"The":[50,92,169,193,273],"aim":[51],"this":[53],"study":[54,290,316],"to":[56,281],"evaluate":[57],"effect":[59,248],"major":[61],"variants":[62,110,287,300],"these":[64],"genes":[65],"on":[66],"intolerances":[68],"pediatric":[72,82],"(ALL)":[76],"patients.":[77],"A":[78],"total":[79],"83":[81],"ALL":[83],"patients":[84],"were":[85,111,167,204,231,261],"included":[86],"(56":[87],"males":[88],"27":[90],"females).":[91],"NUDT15":[93,96,170,209,253,265,274],"c.415C>T":[94,171,210,238,254,266,275],"(rs116855232),":[95],"c.55_56insGAGTCG":[97],"(rs746071566),":[98],"ITPA":[99,102,256],"c.94C>A":[100],"(rs1127354),":[101],"c.IVS2+21A>C":[103],"(rs7270101),":[104],"APEX":[105],"c.190A>G":[106],"(rs2307486),":[107],"TPMT":[109],"analyzed":[112,243,286],"by":[113],"sanger":[114],"sequencing.":[115],"Correlations":[116],"between":[117,263],"indexes":[118,219],"6-MP-related":[120],"or":[122],"intolerance":[124,284],"(absolute":[125],"neutrophil":[126],"count":[127],"[ANC]":[128],"at":[129,179,197],"time":[131],"point,":[132],"days":[133,140,222],"ANC":[135,142],"<":[136,143],"1":[137],"\u00d7":[138,145],"103/mm3,":[139,146],"0.5":[144],"frequency":[147],"febrile":[149,224],"neutropenia,":[150,221,225],"maximum":[151,226],"AST":[152],"ALT,":[154],"dose":[156,159,195],"intensity":[160],"during":[161],"therapy)":[163],"genetic":[165],"variations":[166],"analyzed.":[168],"allele":[172],"carrier":[173,189,267,269],"showed":[174],"significantly":[175,206],"low":[176,207],"doses":[178],"final":[181,201],"therapy":[183],"period":[184,203],"than":[185],"wild":[187],"type":[188],"(p":[190,212],"=":[191,213],"0.007).":[192],"intensities":[196],"sixth":[199],"also":[205],"carriers":[211],"0.003":[214],"0.008,":[216],"respectively).":[217],"AST,":[227],"ALT":[229],"levels":[230],"not":[232,295],"associated":[233],"with":[234,270,301],"presence":[236],"well":[240],"other":[242],"variants.":[244],"When":[245],"analyzing":[246],"coexistence":[251],"c.94C>A,":[257],"no":[258],"significant":[259],"differences":[260],"found":[262],"both":[271],"variations.":[272],"was":[276],"most":[278],"useful":[279],"marker":[280],"among":[285],"our":[289],"population.":[291],"Although":[292],"we":[293],"could":[294],"find":[296],"association":[297],"those":[299,310],"induced":[303],"synergistic":[307],"effects":[308],"variants,":[311],"well-planed":[313],"larger":[314],"scale":[315],"would":[317],"be":[318],"helpful":[319],"clarifying":[321],"new":[322],"candidates":[323],"their":[325],"clinical":[326],"effects.":[327]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":4},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-03-29T00:00:00"}