{"id":"https://openalex.org/W3136505229","doi":"https://doi.org/10.1016/s2213-2600(20)30567-1","title":"REPLACE and the role of riociguat in pulmonary arterial hypertension therapy","display_name":"REPLACE and the role of riociguat in pulmonary arterial hypertension therapy","publication_year":2021,"publication_date":"2021-03-24","ids":{"openalex":"https://openalex.org/W3136505229","doi":"https://doi.org/10.1016/s2213-2600(20)30567-1","mag":"3136505229","pmid":"https://pubmed.ncbi.nlm.nih.gov/33773119"},"language":"en","primary_location":{"id":"doi:10.1016/s2213-2600(20)30567-1","doi":"https://doi.org/10.1016/s2213-2600(20)30567-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s2213-2600(20)30567-1","pdf_url":null,"source":{"id":"https://openalex.org/S4210192742","display_name":"The Lancet Respiratory Medicine","issn_l":"2213-2600","issn":["2213-2600","2213-2619"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet Respiratory Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5078732560","display_name":"Robert P. Frantz","orcid":"https://orcid.org/0000-0003-4128-3978","observed_orcids":["https://orcid.org/0000-0003-4128-3978"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robert P Frantz","raw_affiliation_strings":["Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55902, USA. Electronic address: frantz.robert@mayo.edu","Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55902, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55902, USA. Electronic address: frantz.robert@mayo.edu","institution_ids":["https://openalex.org/I1330342723"]},{"raw_affiliation_string":"Department of Cardiovascular Medicine, Mayo Clinic, Rochester, MN 55902, USA","institution_ids":["https://openalex.org/I1330342723"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5078732560"],"corresponding_institution_ids":["https://openalex.org/I1330342723"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.9728,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.74179175,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"9","issue":"6","first_page":"546","last_page":"547"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12199","display_name":"Vascular Anomalies and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/riociguat","display_name":"riociguat","score":1.0},{"id":"https://openalex.org/keywords/pulmonary-arterial-hypertension","display_name":"pulmonary arterial hypertension","score":0.9739999771118164},{"id":"https://openalex.org/keywords/phosphodiesterase-5-inhibitors","display_name":"phosphodiesterase-5 inhibitors","score":0.9010000228881836},{"id":"https://openalex.org/keywords/sildenafil","display_name":"sildenafil","score":0.9629999995231628},{"id":"https://openalex.org/keywords/tadalafil","display_name":"tadalafil","score":0.9950000047683716},{"id":"https://openalex.org/keywords/treatment-switching","display_name":"treatment switching","score":0.6679999828338623},{"id":"https://openalex.org/keywords/soluble-guanylate-cyclase-stimulator","display_name":"soluble guanylate cyclase stimulator","score":0.8410000205039978},{"id":"https://openalex.org/keywords/nitric-oxide-pathway","display_name":"nitric oxide pathway","score":0.8820000290870667},{"id":"https://openalex.org/keywords/treatment-escalation","display_name":"treatment escalation","score":0.5699999928474426},{"id":"https://openalex.org/keywords/chronic-thromboembolic-pulmonary-hypertension","display_name":"chronic thromboembolic pulmonary hypertension","score":0.7760000228881836}],"concepts":[{"id":"https://openalex.org/C2776304953","wikidata":"https://www.wikidata.org/wiki/Q2154494","display_name":"Riociguat","level":4,"score":0.997246503829956},{"id":"https://openalex.org/C2776768464","wikidata":"https://www.wikidata.org/wiki/Q191521","display_name":"Sildenafil","level":2,"score":0.870903730392456},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8632107973098755},{"id":"https://openalex.org/C2777428986","wikidata":"https://www.wikidata.org/wiki/Q1958249","display_name":"Chronic thromboembolic pulmonary hypertension","level":3,"score":0.8195209503173828},{"id":"https://openalex.org/C2780816001","wikidata":"https://www.wikidata.org/wiki/Q424156","display_name":"Tadalafil","level":3,"score":0.7312454581260681},{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.655407726764679},{"id":"https://openalex.org/C74534348","wikidata":"https://www.wikidata.org/wiki/Q410798","display_name":"cGMP-specific phosphodiesterase type 5","level":3,"score":0.6123331785202026},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.45472896099090576},{"id":"https://openalex.org/C144980905","wikidata":"https://www.wikidata.org/wiki/Q24721308","display_name":"Endothelin receptor","level":3,"score":0.45219549536705017},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.43392664194107056},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41953903436660767},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0786481499671936}],"mesh":[{"descriptor_ui":"D000081029","descriptor_name":"Pulmonary Arterial Hypertension","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011720","descriptor_name":"Pyrazoles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054706","descriptor_name":"Cyclic Nucleotide Phosphodiesterases, Type 5","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058986","descriptor_name":"Phosphodiesterase 5 Inhibitors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s2213-2600(20)30567-1","doi":"https://doi.org/10.1016/s2213-2600(20)30567-1","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s2213-2600(20)30567-1","pdf_url":null,"source":{"id":"https://openalex.org/S4210192742","display_name":"The Lancet Respiratory Medicine","issn_l":"2213-2600","issn":["2213-2600","2213-2619"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet Respiratory Medicine","raw_type":"journal-article"},{"id":"pmid:33773119","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33773119","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Lancet. Respiratory medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.7599999904632568}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W2107011819","https://openalex.org/W2108559440","https://openalex.org/W2751121827","https://openalex.org/W2911671206","https://openalex.org/W3082697358","https://openalex.org/W3138574248"],"related_works":["https://openalex.org/W3138574248","https://openalex.org/W3112115861","https://openalex.org/W2780294174","https://openalex.org/W2321228285","https://openalex.org/W2896846362","https://openalex.org/W3109865249","https://openalex.org/W2949714132","https://openalex.org/W3206108338","https://openalex.org/W3007277423","https://openalex.org/W1978930078"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-03-29T00:00:00"}
