{"id":"https://openalex.org/W3136328103","doi":"https://doi.org/10.1097/md.0000000000025015","title":"Potentially inappropriate prescriptions to Brazilian older people with Alzheimer disease: A cross-sectional study","display_name":"Potentially inappropriate prescriptions to Brazilian older people with Alzheimer disease: A cross-sectional study","publication_year":2021,"publication_date":"2021-03-23","ids":{"openalex":"https://openalex.org/W3136328103","doi":"https://doi.org/10.1097/md.0000000000025015","mag":"3136328103","pmid":"https://pubmed.ncbi.nlm.nih.gov/33761656","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/9282042"},"language":"en","primary_location":{"id":"doi:10.1097/md.0000000000025015","doi":"https://doi.org/10.1097/md.0000000000025015","is_oa":true,"landing_page_url":"https://doi.org/10.1097/md.0000000000025015","pdf_url":null,"source":{"id":"https://openalex.org/S28966261","display_name":"Medicine","issn_l":"0025-7974","issn":["0025-7974","1536-5964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1097/md.0000000000025015","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5089342139","display_name":"T\u00e2nia Regina Ferreira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210119971","display_name":"Universidade de Sorocaba","ror":"https://ror.org/02hnvfm11","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210119971"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"T\u00e2nia Regina Ferreira","raw_affiliation_strings":["Postgraduate Program in Pharmaceutical Sciences, University of Sorocaba, Sorocaba, State of S\u00e3o Paulo, Brazil","100:12(e25015)","Abbreviations: AD = Alzheimer disease, ATC Code = Anatomical Therapeutic Chemical Code, DRS-XVI = Regional Health Department-XVI, ICD-10 = International Classification of Diseases code 10, MEDEX = Drugs of Exceptional Distribution, PIM = potentially inappropriate medication, PIP = potentially inappropriate prescribing","Consent for publication: Not applicable","Ethical approval: This study was approved by the Ethics Committee on Research of the University of Sorocaba (protocol number: 1860724). All subjects enrolled in the study received explanations regarding the aims of the studies and signed a form attesting that their participation was voluntary","How to cite this article: Ferreira TR, Lopes LC, Motter FR, de C\u00e1ssia Bergamaschi C. Potentially inappropriate prescriptions to Brazilian older people with Alzheimer disease: A cross-sectional study. Medicine. 2021","Informed consent: Each participant signed and provided written informed consent","The authors report no conflicts of interest","This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Postgraduate Program in Pharmaceutical Sciences, University of Sorocaba, Sorocaba, State of S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I4210119971"]},{"raw_affiliation_string":"100:12(e25015)","institution_ids":[]},{"raw_affiliation_string":"Abbreviations: AD = Alzheimer disease, ATC Code = Anatomical Therapeutic Chemical Code, DRS-XVI = Regional Health Department-XVI, ICD-10 = International Classification of Diseases code 10, MEDEX = Drugs of Exceptional Distribution, PIM = potentially inappropriate medication, PIP = potentially inappropriate prescribing","institution_ids":[]},{"raw_affiliation_string":"Consent for publication: Not applicable","institution_ids":[]},{"raw_affiliation_string":"Ethical approval: This study was approved by the Ethics Committee on Research of the University of Sorocaba (protocol number: 1860724). All subjects enrolled in the study received explanations regarding the aims of the studies and signed a form attesting that their participation was voluntary","institution_ids":["https://openalex.org/I4210119971"]},{"raw_affiliation_string":"How to cite this article: Ferreira TR, Lopes LC, Motter FR, de C\u00e1ssia Bergamaschi C. Potentially inappropriate prescriptions to Brazilian older people with Alzheimer disease: A cross-sectional study. Medicine. 2021","institution_ids":[]},{"raw_affiliation_string":"Informed consent: Each participant signed and provided written informed consent","institution_ids":[]},{"raw_affiliation_string":"The authors report no conflicts of interest","institution_ids":[]},{"raw_affiliation_string":"This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026942372","display_name":"Luciane Cruz Lopes","orcid":"https://orcid.org/0000-0002-3684-3275","observed_orcids":["https://orcid.org/0000-0002-3684-3275"]},"institutions":[{"id":"https://openalex.org/I4210119971","display_name":"Universidade de Sorocaba","ror":"https://ror.org/02hnvfm11","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210119971"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Luciane Cruz Lopes","raw_affiliation_strings":["Postgraduate Program in Pharmaceutical Sciences, University of Sorocaba, Sorocaba, State of S\u00e3o Paulo, Brazil","100:12(e25015)","Abbreviations: AD = Alzheimer disease, ATC Code = Anatomical Therapeutic Chemical Code, DRS-XVI = Regional Health Department-XVI, ICD-10 = International Classification of Diseases code 10, MEDEX = Drugs of Exceptional Distribution, PIM = potentially inappropriate medication, PIP = potentially inappropriate prescribing","Consent for publication: Not applicable","Ethical approval: This study was approved by the Ethics Committee on Research of the University of Sorocaba (protocol number: 1860724). All subjects enrolled in the study received explanations regarding the aims of the studies and signed a form attesting that their participation was voluntary","How to cite this article: Ferreira TR, Lopes LC, Motter FR, de C\u00e1ssia Bergamaschi C. Potentially inappropriate prescriptions to Brazilian older people with Alzheimer disease: A cross-sectional study. Medicine. 2021","Informed consent: Each participant signed and provided written informed consent","The authors report no conflicts of interest","This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Postgraduate Program in Pharmaceutical Sciences, University of Sorocaba, Sorocaba, State of S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I4210119971"]},{"raw_affiliation_string":"100:12(e25015)","institution_ids":[]},{"raw_affiliation_string":"Abbreviations: AD = Alzheimer disease, ATC Code = Anatomical Therapeutic Chemical Code, DRS-XVI = Regional Health Department-XVI, ICD-10 = International Classification of Diseases code 10, MEDEX = Drugs of Exceptional Distribution, PIM = potentially inappropriate medication, PIP = potentially inappropriate prescribing","institution_ids":[]},{"raw_affiliation_string":"Consent for publication: Not applicable","institution_ids":[]},{"raw_affiliation_string":"Ethical approval: This study was approved by the Ethics Committee on Research of the University of Sorocaba (protocol number: 1860724). All subjects enrolled in the study received explanations regarding the aims of the studies and signed a form attesting that their participation was voluntary","institution_ids":["https://openalex.org/I4210119971"]},{"raw_affiliation_string":"How to cite this article: Ferreira TR, Lopes LC, Motter FR, de C\u00e1ssia Bergamaschi C. Potentially inappropriate prescriptions to Brazilian older people with Alzheimer disease: A cross-sectional study. Medicine. 2021","institution_ids":[]},{"raw_affiliation_string":"Informed consent: Each participant signed and provided written informed consent","institution_ids":[]},{"raw_affiliation_string":"The authors report no conflicts of interest","institution_ids":[]},{"raw_affiliation_string":"This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014551696","display_name":"Fabiane Raquel Motter","orcid":"https://orcid.org/0000-0003-0796-1130","observed_orcids":["https://orcid.org/0000-0003-0796-1130"]},"institutions":[{"id":"https://openalex.org/I4210119971","display_name":"Universidade de Sorocaba","ror":"https://ror.org/02hnvfm11","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210119971"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Fabiane Raquel Motter","raw_affiliation_strings":["Postgraduate Program in Pharmaceutical Sciences, University of Sorocaba, Sorocaba, State of S\u00e3o Paulo, Brazil","100:12(e25015)","Abbreviations: AD = Alzheimer disease, ATC Code = Anatomical Therapeutic Chemical Code, DRS-XVI = Regional Health Department-XVI, ICD-10 = International Classification of Diseases code 10, MEDEX = Drugs of Exceptional Distribution, PIM = potentially inappropriate medication, PIP = potentially inappropriate prescribing","Consent for publication: Not applicable","Ethical approval: This study was approved by the Ethics Committee on Research of the University of Sorocaba (protocol number: 1860724). All subjects enrolled in the study received explanations regarding the aims of the studies and signed a form attesting that their participation was voluntary","How to cite this article: Ferreira TR, Lopes LC, Motter FR, de C\u00e1ssia Bergamaschi C. Potentially inappropriate prescriptions to Brazilian older people with Alzheimer disease: A cross-sectional study. Medicine. 2021","Informed consent: Each participant signed and provided written informed consent","The authors report no conflicts of interest","This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Postgraduate Program in Pharmaceutical Sciences, University of Sorocaba, Sorocaba, State of S\u00e3o Paulo, Brazil","institution_ids":["https://openalex.org/I4210119971"]},{"raw_affiliation_string":"100:12(e25015)","institution_ids":[]},{"raw_affiliation_string":"Abbreviations: AD = Alzheimer disease, ATC Code = Anatomical Therapeutic Chemical Code, DRS-XVI = Regional Health Department-XVI, ICD-10 = International Classification of Diseases code 10, MEDEX = Drugs of Exceptional Distribution, PIM = potentially inappropriate medication, PIP = potentially inappropriate prescribing","institution_ids":[]},{"raw_affiliation_string":"Consent for publication: Not applicable","institution_ids":[]},{"raw_affiliation_string":"Ethical approval: This study was approved by the Ethics Committee on Research of the University of Sorocaba (protocol number: 1860724). All subjects enrolled in the study received explanations regarding the aims of the studies and signed a form attesting that their participation was voluntary","institution_ids":["https://openalex.org/I4210119971"]},{"raw_affiliation_string":"How to cite this article: Ferreira TR, Lopes LC, Motter FR, de C\u00e1ssia Bergamaschi C. Potentially inappropriate prescriptions to Brazilian older people with Alzheimer disease: A cross-sectional study. Medicine. 2021","institution_ids":[]},{"raw_affiliation_string":"Informed consent: Each participant signed and provided written informed consent","institution_ids":[]},{"raw_affiliation_string":"The authors report no conflicts of interest","institution_ids":[]},{"raw_affiliation_string":"This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC), where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc/4.0","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5004053821","display_name":"Cristiane de C\u00e1ssia Bergamaschi","orcid":"https://orcid.org/0000-0002-6608-1806","observed_orcids":["https://orcid.org/0000-0002-6608-1806"]},"institutions":[{"id":"https://openalex.org/I4210119971","display_name":"Universidade de Sorocaba","ror":"https://ror.org/02hnvfm11","country_code":"BR","type":"education","lineage":["https://openalex.org/I4210119971"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Cristiane de C\u00e1ssia Bergamaschi","raw_affiliation_strings":["Correspondence: Cristiane de C\u00e1ssia Bergamaschi, Universidade de Sorocaba\u2014UNISO, Rodovia Raposo Tavares, Km 92.5, 18023-000, Sorocaba, SP, Brasil (e-mail: [email\u00a0protected])"],"raw_orcid":"https://orcid.org/0000-0002-6608-1806","affiliations":[{"raw_affiliation_string":"Correspondence: Cristiane de C\u00e1ssia Bergamaschi, Universidade de Sorocaba\u2014UNISO, Rodovia Raposo Tavares, Km 92.5, 18023-000, Sorocaba, SP, Brasil (e-mail: [email\u00a0protected])","institution_ids":["https://openalex.org/I4210119971"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5004053821"],"corresponding_institution_ids":["https://openalex.org/I4210119971"],"apc_list":{"value":1950,"currency":"USD","value_usd":1950},"apc_paid":{"value":1950,"currency":"USD","value_usd":1950},"fwci":2.1742,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.85744519,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"100","issue":"12","first_page":"e25015","last_page":"e25015"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10496","display_name":"Pharmaceutical Practices and Patient Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2717","display_name":"Geriatrics and Gerontology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13970","display_name":"Pharmacy and Medical Practices","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3611","display_name":"Pharmacy"},"field":{"id":"https://openalex.org/fields/36","display_name":"Health Professions"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/potentially-inappropriate-prescribing","display_name":"potentially inappropriate prescribing","score":0.9160000085830688},{"id":"https://openalex.org/keywords/potentially-inappropriate-medications","display_name":"potentially inappropriate medications","score":0.9940000176429749},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9679999947547913},{"id":"https://openalex.org/keywords/older-adults","display_name":"older adults","score":0.9950000047683716},{"id":"https://openalex.org/keywords/beers-criteria","display_name":"Beers criteria","score":0.8309999704360962},{"id":"https://openalex.org/keywords/drug-safety","display_name":"drug safety","score":0.6650000214576721},{"id":"https://openalex.org/keywords/quetiapine","display_name":"quetiapine","score":0.8100000023841858},{"id":"https://openalex.org/keywords/aspirin","display_name":"aspirin","score":0.9610000252723694},{"id":"https://openalex.org/keywords/sertraline","display_name":"sertraline","score":0.9359999895095825},{"id":"https://openalex.org/keywords/clonazepam","display_name":"clonazepam","score":0.996999979019165},{"id":"https://openalex.org/keywords/depression","display_name":"depression","score":0.8870000243186951},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.9359999895095825},{"id":"https://openalex.org/keywords/polypharmacy","display_name":"polypharmacy","score":0.5709999799728394}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9417338967323303},{"id":"https://openalex.org/C53875530","wikidata":"https://www.wikidata.org/wiki/Q814106","display_name":"Beers Criteria","level":3,"score":0.6767398715019226},{"id":"https://openalex.org/C73269764","wikidata":"https://www.wikidata.org/wiki/Q954529","display_name":"Poisson regression","level":3,"score":0.612156867980957},{"id":"https://openalex.org/C36434225","wikidata":"https://www.wikidata.org/wiki/Q1895998","display_name":"Polypharmacy","level":2,"score":0.5476098656654358},{"id":"https://openalex.org/C2426938","wikidata":"https://www.wikidata.org/wiki/Q3355478","display_name":"Medical prescription","level":2,"score":0.544080913066864},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4843622148036957},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4734113812446594},{"id":"https://openalex.org/C104863432","wikidata":"https://www.wikidata.org/wiki/Q614304","display_name":"Pharmacy","level":2,"score":0.4704750180244446},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.4509456157684326},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.4457484185695648},{"id":"https://openalex.org/C142052008","wikidata":"https://www.wikidata.org/wiki/Q954027","display_name":"Cross-sectional study","level":2,"score":0.44365057349205017},{"id":"https://openalex.org/C20387591","wikidata":"https://www.wikidata.org/wiki/Q930752","display_name":"Specialty","level":2,"score":0.43115752935409546},{"id":"https://openalex.org/C54183767","wikidata":"https://www.wikidata.org/wiki/Q10384","display_name":"Geriatrics","level":2,"score":0.356219619512558},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.3343977630138397},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.32188764214515686},{"id":"https://openalex.org/C512399662","wikidata":"https://www.wikidata.org/wiki/Q3505712","display_name":"Family medicine","level":1,"score":0.3192310333251953},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.16204309463500977},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1259903907775879},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000069348","descriptor_name":"Quetiapine Fumarate","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000069348","descriptor_name":"Quetiapine Fumarate","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D001241","descriptor_name":"Aspirin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001938","descriptor_name":"Brazil","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002317","descriptor_name":"Cardiovascular Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002317","descriptor_name":"Cardiovascular Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002491","descriptor_name":"Central Nervous System Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002491","descriptor_name":"Central Nervous System Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002998","descriptor_name":"Clonazepam","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D002998","descriptor_name":"Clonazepam","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019338","descriptor_name":"Polypharmacy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020280","descriptor_name":"Sertraline","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D020280","descriptor_name":"Sertraline","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D057970","descriptor_name":"Inappropriate Prescribing","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1097/md.0000000000025015","doi":"https://doi.org/10.1097/md.0000000000025015","is_oa":true,"landing_page_url":"https://doi.org/10.1097/md.0000000000025015","pdf_url":null,"source":{"id":"https://openalex.org/S28966261","display_name":"Medicine","issn_l":"0025-7974","issn":["0025-7974","1536-5964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9282042","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9282042/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC9282042/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine (Baltimore)","raw_type":"Text"},{"id":"pmid:33761656","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33761656","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1097/md.0000000000025015","doi":"https://doi.org/10.1097/md.0000000000025015","is_oa":true,"landing_page_url":"https://doi.org/10.1097/md.0000000000025015","pdf_url":null,"source":{"id":"https://openalex.org/S28966261","display_name":"Medicine","issn_l":"0025-7974","issn":["0025-7974","1536-5964"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310318547","host_organization_name":"Wolters Kluwer","host_organization_lineage":["https://openalex.org/P4310318547"],"host_organization_lineage_names":["Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3136328103.pdf","grobid_xml":"https://content.openalex.org/works/W3136328103.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W333819909","https://openalex.org/W1524993883","https://openalex.org/W1983392865","https://openalex.org/W2039251076","https://openalex.org/W2066578763","https://openalex.org/W2075394440","https://openalex.org/W2084392662","https://openalex.org/W2098891980","https://openalex.org/W2125308079","https://openalex.org/W2139867940","https://openalex.org/W2158087005","https://openalex.org/W2165057233","https://openalex.org/W2257575319","https://openalex.org/W2344518133","https://openalex.org/W2526516097","https://openalex.org/W2554739972","https://openalex.org/W2559732081","https://openalex.org/W2564453682","https://openalex.org/W2572486841","https://openalex.org/W2582124757","https://openalex.org/W2763630594","https://openalex.org/W2763920048","https://openalex.org/W2777458837","https://openalex.org/W2791127185","https://openalex.org/W2898578237","https://openalex.org/W2903517662","https://openalex.org/W2908039570","https://openalex.org/W2952409761","https://openalex.org/W2998398112","https://openalex.org/W3014251530","https://openalex.org/W3040586852","https://openalex.org/W4211139529","https://openalex.org/W4231537243","https://openalex.org/W4238488672","https://openalex.org/W4241984066","https://openalex.org/W4246430038","https://openalex.org/W6748771988","https://openalex.org/W6820250935","https://openalex.org/W7101084658"],"related_works":["https://openalex.org/W2116720822","https://openalex.org/W4399756161","https://openalex.org/W3166869890","https://openalex.org/W2973530548","https://openalex.org/W2896928924","https://openalex.org/W2490046341","https://openalex.org/W4396213177","https://openalex.org/W3030958779","https://openalex.org/W2023330025","https://openalex.org/W2048034459"],"abstract_inverted_index":{"ABSTRACT:":[0],"Older":[1],"adults":[2],"are":[3],"the":[4,55,73,78,90,118,152,165,182,199,204,212,251],"leading":[5],"users":[6],"of":[7,18,24,57,80,143,181,206,214,223,231,253],"medications,":[8],"where":[9],"this":[10,238],"can":[11,243],"be":[12,185],"associated":[13,202],"with":[14,44,65,95,103,139,162,203,258],"a":[15,220,228],"high":[16,221],"number":[17,213,222,230],"potentially":[19,25,38],"inappropriate":[20,26,39,161],"medications":[21,154,254],"(PIMs)":[22],"and":[23,29,53,59,97,109,126,174,193,211],"prescribing":[27,40],"(PIP)":[28],"consequent":[30],"harm":[31],"to":[32,117,247],"health.":[33],"No":[34],"Brazilian":[35],"study":[36,51,68,134],"evaluating":[37],"in":[41,77,92,187,237,250],"older":[42,63,93,137,188,226],"patients":[43,104,138,257],"Alzheimer's":[45],"disease":[46],"(AD)":[47],"was":[48,69,129,146,219],"found.":[49],"This":[50],"determined":[52],"analyzed":[54,130],"prevalence":[56,142],"PIP":[58,144],"PIM":[60],"prescribed":[61,145],"for":[62,255],"people":[64,94],"AD.A":[66],"cross-sectional":[67],"carried":[70],"out":[71],"at":[72],"Specialty":[74],"Drugs":[75],"Pharmacy":[76],"city":[79],"Sorocaba,":[81],"S\u00e3o":[82],"Paulo":[83],"State,":[84],"Brazil.":[85],"The":[86,112,122,141],"MEDEX":[87],"system":[88,168],"provided":[89],"register":[91],"AD":[96],"data":[98],"were":[99,114,160,201],"collected":[100],"during":[101],"interviews":[102],"and/or":[105],"caregivers":[106],"between":[107,124],"June":[108],"September":[110],"2017.":[111],"PIMs":[113,125,183,200,224],"identified":[115],"according":[116],"2019":[119],"Beers":[120],"Criteria.":[121],"association":[123],"independent":[127],"variables":[128],"by":[131],"Poisson":[132],"regression.This":[133],"included":[135],"234":[136],"AD.":[140,259],"66.7%":[147],"(n":[148,157],"=":[149,158,209,217],"156).":[150],"Of":[151],"1073":[153],"prescribed,":[155],"30.5%":[156],"327)":[159],"most":[163],"affecting":[164],"central":[166],"nervous":[167],"or":[169],"cardiovascular,":[170],"particularly":[171],"quetiapine":[172],"(12.8%)":[173],"acetylsalicylic":[175],"acid":[176],"(11.6%),":[177],"respectively.":[178],"Around":[179],"45.2%":[180],"should":[184,233],"avoided":[186,236],"people,":[189,227],"especially":[190],"sertraline":[191],"(14.2%)":[192],"clonazepam":[194],"(7.4%).":[195],"After":[196],"adjusted":[197],"analysis,":[198],"diagnosis":[205],"depression":[207],"(P":[208,216],"0.010)":[210],"comorbidities":[215],"0.005).There":[218],"among":[225],"substantial":[229],"which":[232],"have":[234],"been":[235],"population.":[239],"Health":[240],"care":[241],"professionals":[242],"apply":[244],"these":[245],"findings":[246],"improve":[248],"safety":[249],"use":[252],"treating":[256]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2021-03-29T00:00:00"}