{"id":"https://openalex.org/W3136323948","doi":"https://doi.org/10.1016/j.jtho.2021.01.684","title":"P33.15 TMB in the First-Line Setting of NSCLC: A Systematic Review with Indirect Comparisons Between PD-1 and PD-L1 Inhibitors","display_name":"P33.15 TMB in the First-Line Setting of NSCLC: A Systematic Review with Indirect Comparisons Between PD-1 and PD-L1 Inhibitors","publication_year":2021,"publication_date":"2021-03-01","ids":{"openalex":"https://openalex.org/W3136323948","doi":"https://doi.org/10.1016/j.jtho.2021.01.684","mag":"3136323948"},"language":"en","primary_location":{"id":"doi:10.1016/j.jtho.2021.01.684","doi":"https://doi.org/10.1016/j.jtho.2021.01.684","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jtho.2021.01.684","pdf_url":"http://www.jto.org/article/S1556086421007267/pdf","source":{"id":"https://openalex.org/S90745127","display_name":"Journal of Thoracic Oncology","issn_l":"1556-0864","issn":["1556-0864","1556-1380"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thoracic Oncology","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jto.org/article/S1556086421007267/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011928740","display_name":"Valerio Gristina","orcid":"https://orcid.org/0000-0002-2392-0470","observed_orcids":["https://orcid.org/0000-0002-2392-0470"]},"institutions":[{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"V. Gristina","raw_affiliation_strings":["Aoup Paolo Giaccone, Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo/IT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aoup Paolo Giaccone, Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo/IT","institution_ids":["https://openalex.org/I900890020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072264918","display_name":"Antonio Galvano","orcid":"https://orcid.org/0000-0003-4365-5683","observed_orcids":["https://orcid.org/0000-0003-4365-5683","https://orcid.org/0000-0003-2163-9164"]},"institutions":[{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A. Galvano","raw_affiliation_strings":["Aoup Paolo Giaccone, Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo/IT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aoup Paolo Giaccone, Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo/IT","institution_ids":["https://openalex.org/I900890020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026050980","display_name":"Marta Castiglia","orcid":"https://orcid.org/0000-0002-6299-7235","observed_orcids":["https://orcid.org/0000-0002-6299-7235"]},"institutions":[{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M. Castiglia","raw_affiliation_strings":["Aoup Paolo Giaccone, Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo/IT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aoup Paolo Giaccone, Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo/IT","institution_ids":["https://openalex.org/I900890020"]}]},{"author_position":"middle","author":{"id":null,"display_name":"A. Perez","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A. Perez","raw_affiliation_strings":["Aoup Paolo Giaccone, Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo/IT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aoup Paolo Giaccone, Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo/IT","institution_ids":["https://openalex.org/I900890020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041428894","display_name":"Nadia Barraco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"N. Barraco","raw_affiliation_strings":["Aoup Paolo Giaccone, Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo/IT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aoup Paolo Giaccone, Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo/IT","institution_ids":["https://openalex.org/I900890020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057258444","display_name":"Luisa Castellana","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L. Castellana","raw_affiliation_strings":["Aoup Paolo Giaccone, Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo/IT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aoup Paolo Giaccone, Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo/IT","institution_ids":["https://openalex.org/I900890020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035754604","display_name":"Lavinia Insalaco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"L. Insalaco","raw_affiliation_strings":["Aoup Paolo Giaccone, Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo/IT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aoup Paolo Giaccone, Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo/IT","institution_ids":["https://openalex.org/I900890020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014834143","display_name":"Marta Peri","orcid":"https://orcid.org/0000-0002-2786-0292","observed_orcids":["https://orcid.org/0000-0002-2786-0292"]},"institutions":[{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M. Peri","raw_affiliation_strings":["Aoup Paolo Giaccone, Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo/IT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aoup Paolo Giaccone, Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo/IT","institution_ids":["https://openalex.org/I900890020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001933671","display_name":"Francesco Lo Iacono","orcid":"https://orcid.org/0000-0003-1035-8017","observed_orcids":["https://orcid.org/0000-0003-1035-8017"]},"institutions":[{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"F. Iacono","raw_affiliation_strings":["Aoup Paolo Giaccone, Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo/IT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aoup Paolo Giaccone, Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo/IT","institution_ids":["https://openalex.org/I900890020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044328241","display_name":"Alessandra Cucinella","orcid":"https://orcid.org/0000-0003-1277-3986","observed_orcids":["https://orcid.org/0000-0003-1277-3986"]},"institutions":[{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A. Cucinella","raw_affiliation_strings":["Aoup Paolo Giaccone, Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo/IT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aoup Paolo Giaccone, Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo/IT","institution_ids":["https://openalex.org/I900890020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002757210","display_name":"Marco Bono","orcid":"https://orcid.org/0000-0001-7169-3463","observed_orcids":["https://orcid.org/0000-0001-7169-3463"]},"institutions":[{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"M. Bono","raw_affiliation_strings":["Aoup Paolo Giaccone, Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo/IT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aoup Paolo Giaccone, Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo/IT","institution_ids":["https://openalex.org/I900890020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039656410","display_name":"Stefania Cusenza","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S. Cusenza","raw_affiliation_strings":["Aoup Paolo Giaccone, Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo/IT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aoup Paolo Giaccone, Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo/IT","institution_ids":["https://openalex.org/I900890020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032193786","display_name":"S. Rizzo","orcid":"https://orcid.org/0000-0002-5462-8229","observed_orcids":["https://orcid.org/0000-0002-5462-8229"]},"institutions":[{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"S. Rizzo","raw_affiliation_strings":["Aoup Paolo Giaccone, Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo/IT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aoup Paolo Giaccone, Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo/IT","institution_ids":["https://openalex.org/I900890020"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033609878","display_name":"Viviana Bazan","orcid":"https://orcid.org/0000-0003-0939-255X","observed_orcids":["https://orcid.org/0000-0003-0939-255X"]},"institutions":[{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"V. Bazan","raw_affiliation_strings":["Aoup Paolo Giaccone, Department of Experimental Biomedicine and Clinical Neurosciences, School of Medicine, University of Palermo, Palermo/IT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aoup Paolo Giaccone, Department of Experimental Biomedicine and Clinical Neurosciences, School of Medicine, University of Palermo, Palermo/IT","institution_ids":["https://openalex.org/I900890020"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052878762","display_name":"Anna Russo","orcid":"https://orcid.org/0000-0002-8353-4205","observed_orcids":["https://orcid.org/0000-0002-8353-4205"]},"institutions":[{"id":"https://openalex.org/I900890020","display_name":"University of Palermo","ror":"https://ror.org/044k9ta02","country_code":"IT","type":"education","lineage":["https://openalex.org/I900890020"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"A. Russo","raw_affiliation_strings":["Aoup Paolo Giaccone, Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo/IT"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Aoup Paolo Giaccone, Department of Surgical, Oncological and Oral Sciences, University of Palermo, Palermo/IT","institution_ids":["https://openalex.org/I900890020"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I900890020"],"apc_list":{"value":2800,"currency":"USD","value_usd":2800},"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"3","first_page":"S411","last_page":"S412"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-mutational-burden","display_name":"tumor mutational burden","score":1.0},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9890000224113464},{"id":"https://openalex.org/keywords/first-line-treatment","display_name":"first-line therapy","score":0.8069999814033508},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.8849999904632568},{"id":"https://openalex.org/keywords/pd-1-inhibitors","display_name":"PD-1 inhibitors","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pd-l1-inhibitors","display_name":"PD-L1 inhibitors","score":0.9990000128746033},{"id":"https://openalex.org/keywords/predictive-biomarkers","display_name":"predictive biomarkers","score":0.8920000195503235},{"id":"https://openalex.org/keywords/indirect-comparison","display_name":"indirect comparison","score":0.6309999823570251}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.951464056968689},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6382640600204468},{"id":"https://openalex.org/C2781053074","wikidata":"https://www.wikidata.org/wiki/Q21100639","display_name":"PD-L1","level":4,"score":0.5960472226142883},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.5955479145050049},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5857885479927063},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5000696182250977},{"id":"https://openalex.org/C3019258254","wikidata":"https://www.wikidata.org/wiki/Q1423317","display_name":"Second line","level":3,"score":0.48193931579589844},{"id":"https://openalex.org/C2993493390","wikidata":"https://www.wikidata.org/wiki/Q5453208","display_name":"First line","level":2,"score":0.43616464734077454},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.3897082507610321},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3519424796104431},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.29952701926231384},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.jtho.2021.01.684","doi":"https://doi.org/10.1016/j.jtho.2021.01.684","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jtho.2021.01.684","pdf_url":"http://www.jto.org/article/S1556086421007267/pdf","source":{"id":"https://openalex.org/S90745127","display_name":"Journal of Thoracic Oncology","issn_l":"1556-0864","issn":["1556-0864","1556-1380"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thoracic Oncology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.jtho.2021.01.684","doi":"https://doi.org/10.1016/j.jtho.2021.01.684","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.jtho.2021.01.684","pdf_url":"http://www.jto.org/article/S1556086421007267/pdf","source":{"id":"https://openalex.org/S90745127","display_name":"Journal of Thoracic Oncology","issn_l":"1556-0864","issn":["1556-0864","1556-1380"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Thoracic Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3088838264","https://openalex.org/W3216645156","https://openalex.org/W4405165509","https://openalex.org/W3137960754","https://openalex.org/W4413365768","https://openalex.org/W3182921423","https://openalex.org/W2898416788","https://openalex.org/W3202323126","https://openalex.org/W3118366712","https://openalex.org/W4388045450"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2021-03-29T00:00:00"}
