{"id":"https://openalex.org/W3136067366","doi":"https://doi.org/10.5772/intechopen.97271","title":"A Potential Innovative Therapy for Parkinson\u2019s Disease: Selective Destruction of the Pathological Assemblies of Alpha-Synuclein","display_name":"A Potential Innovative Therapy for Parkinson\u2019s Disease: Selective Destruction of the Pathological Assemblies of Alpha-Synuclein","publication_year":2021,"publication_date":"2021-03-25","ids":{"openalex":"https://openalex.org/W3136067366","doi":"https://doi.org/10.5772/intechopen.97271","mag":"3136067366"},"language":"en","primary_location":{"id":"doi:10.5772/intechopen.97271","doi":"https://doi.org/10.5772/intechopen.97271","is_oa":true,"landing_page_url":"https://doi.org/10.5772/intechopen.97271","pdf_url":null,"source":{"id":"https://openalex.org/S4306463448","display_name":"IntechOpen eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310322558","host_organization_name":"IntechOpen","host_organization_lineage":["https://openalex.org/P4310322558"],"host_organization_lineage_names":["IntechOpen"],"type":"ebook platform"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dementia in Parkinson\u2019s Disease - Everything you Need to Know","raw_type":"book-chapter"},"volume":{"id":"https://openalex.org/W4252112510","display_name":"Dementia in Parkinson\u2019s Disease - Everything you Need to Know"},"type":"book-chapter","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.5772/intechopen.97271","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090070043","display_name":"Judit Ol\u00e1h","orcid":"https://orcid.org/0000-0002-2470-8631","observed_orcids":["https://orcid.org/0000-0002-2470-8631"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Judit Ol\u00e1h","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023912155","display_name":"Attila Lehotzky","orcid":"https://orcid.org/0000-0001-5235-1812","observed_orcids":["https://orcid.org/0000-0001-5235-1812"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Attila Lehotzky","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000859100","display_name":"Tibor Sz\u00e9n\u00e1si","orcid":"https://orcid.org/0000-0002-8405-0798","observed_orcids":["https://orcid.org/0000-0002-8405-0798"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tibor Sz\u00e9n\u00e1si","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5078455552","display_name":"Judit Ov\u00e1di","orcid":"https://orcid.org/0000-0002-3420-682X","observed_orcids":["https://orcid.org/0000-0002-3420-682X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Judit Ov\u00e1di","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.9501,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.86819172,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":93},"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/alpha-synuclein","display_name":"alpha-synuclein","score":0.9959999918937683},{"id":"https://openalex.org/keywords/synucleinopathies","display_name":"synucleinopathies","score":0.8939999938011169},{"id":"https://openalex.org/keywords/antiparkinsonian-drugs","display_name":"antiparkinsonian drugs","score":0.6850000023841858},{"id":"https://openalex.org/keywords/oligodendrocytes","display_name":"oligodendrocytes","score":0.8429999947547913},{"id":"https://openalex.org/keywords/microtubule-dynamics","display_name":"microtubule dynamics","score":0.7680000066757202},{"id":"https://openalex.org/keywords/multiple-system-atrophy","display_name":"multiple system atrophy","score":0.8799999952316284},{"id":"https://openalex.org/keywords/protein-aggregation","display_name":"protein aggregation","score":0.33500000834465027}],"concepts":[{"id":"https://openalex.org/C2777440831","wikidata":"https://www.wikidata.org/wiki/Q2376264","display_name":"Synucleinopathies","level":5,"score":0.825921893119812},{"id":"https://openalex.org/C2781449126","wikidata":"https://www.wikidata.org/wiki/Q288591","display_name":"Alpha-synuclein","level":4,"score":0.8067137598991394},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.6199074983596802},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6009325385093689},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.5084263682365417},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4331769645214081},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4289546310901642},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38798218965530396},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.383732408285141},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2353707253932953},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.11699730157852173},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11231178045272827}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.5772/intechopen.97271","doi":"https://doi.org/10.5772/intechopen.97271","is_oa":true,"landing_page_url":"https://doi.org/10.5772/intechopen.97271","pdf_url":null,"source":{"id":"https://openalex.org/S4306463448","display_name":"IntechOpen eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310322558","host_organization_name":"IntechOpen","host_organization_lineage":["https://openalex.org/P4310322558"],"host_organization_lineage_names":["IntechOpen"],"type":"ebook platform"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dementia in Parkinson\u2019s Disease - Everything you Need to Know","raw_type":"book-chapter"},{"id":"pmh:oai:real.mtak.hu:129529","doi":null,"is_oa":false,"landing_page_url":"http://real.mtak.hu/129529/1/Bookchapter_2021_A-potential-innovative-therapy-for-parkinson---s-disease--selective-destruction-of-the-pathological-assemblies-of-alpha-synuclein-1.pdf","pdf_url":"http://real.mtak.hu/129529/1/Bookchapter_2021_A-potential-innovative-therapy-for-parkinson---s-disease--selective-destruction-of-the-pathological-assemblies-of-alpha-synuclein-1.pdf","source":{"id":"https://openalex.org/S4306400081","display_name":"Repository of the Academy's Library (Library of the Hungarian Academy of Sciences)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210140733","host_organization_name":"Library and Information Centre of the Hungarian Academy of Sciences","host_organization_lineage":["https://openalex.org/I4210140733"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/bookPart"},{"id":"pmh:oai:intechopen.com:74933","doi":null,"is_oa":true,"landing_page_url":"http://www.intechopen.com/articles/show/title/a-potential-innovative-therapy-for-parkinson-s-disease-selective-destruction-of-the-pathological-ass","pdf_url":null,"source":{"id":"https://openalex.org/S4306401291","display_name":"Contact-less Assessment of In-vivo Body Signals Using Microwave Doppler Radar (InTech)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210154139","host_organization_name":"Intech (Slovakia)","host_organization_lineage":["https://openalex.org/I4210154139"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.intechopen.com/chapter/pdf-download/74933","raw_type":"10"}],"best_oa_location":{"id":"doi:10.5772/intechopen.97271","doi":"https://doi.org/10.5772/intechopen.97271","is_oa":true,"landing_page_url":"https://doi.org/10.5772/intechopen.97271","pdf_url":null,"source":{"id":"https://openalex.org/S4306463448","display_name":"IntechOpen eBooks","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4310322558","host_organization_name":"IntechOpen","host_organization_lineage":["https://openalex.org/P4310322558"],"host_organization_lineage_names":["IntechOpen"],"type":"ebook platform"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Dementia in Parkinson\u2019s Disease - Everything you Need to Know","raw_type":"book-chapter"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":111,"referenced_works":["https://openalex.org/W14391843","https://openalex.org/W1496790952","https://openalex.org/W1527671059","https://openalex.org/W1598865329","https://openalex.org/W1965647575","https://openalex.org/W1967603366","https://openalex.org/W1967965714","https://openalex.org/W1974279922","https://openalex.org/W1979591162","https://openalex.org/W1983074102","https://openalex.org/W1983806861","https://openalex.org/W1984394891","https://openalex.org/W1985683279","https://openalex.org/W1991453099","https://openalex.org/W2010623074","https://openalex.org/W2014177596","https://openalex.org/W2015752112","https://openalex.org/W2016473759","https://openalex.org/W2018432142","https://openalex.org/W2019110823","https://openalex.org/W2020261376","https://openalex.org/W2024404623","https://openalex.org/W2027096397","https://openalex.org/W2028502345","https://openalex.org/W2040006951","https://openalex.org/W2041134571","https://openalex.org/W2044627978","https://openalex.org/W2048403302","https://openalex.org/W2050232580","https://openalex.org/W2050265691","https://openalex.org/W2053187409","https://openalex.org/W2053722474","https://openalex.org/W2058629097","https://openalex.org/W2058674503","https://openalex.org/W2060038717","https://openalex.org/W2064746087","https://openalex.org/W2065504621","https://openalex.org/W2068288454","https://openalex.org/W2074180389","https://openalex.org/W2075906033","https://openalex.org/W2081930234","https://openalex.org/W2083314428","https://openalex.org/W2086746882","https://openalex.org/W2091456854","https://openalex.org/W2099679212","https://openalex.org/W2112703333","https://openalex.org/W2117626437","https://openalex.org/W2120127860","https://openalex.org/W2120180072","https://openalex.org/W2128591660","https://openalex.org/W2128938270","https://openalex.org/W2130792966","https://openalex.org/W2143516878","https://openalex.org/W2155477793","https://openalex.org/W2157102136","https://openalex.org/W2157535220","https://openalex.org/W2161334375","https://openalex.org/W2162353774","https://openalex.org/W2178916357","https://openalex.org/W2196826730","https://openalex.org/W2253997490","https://openalex.org/W2299774019","https://openalex.org/W2340875712","https://openalex.org/W2341840009","https://openalex.org/W2412369285","https://openalex.org/W2510112960","https://openalex.org/W2516348886","https://openalex.org/W2520733374","https://openalex.org/W2522389230","https://openalex.org/W2532011813","https://openalex.org/W2550398707","https://openalex.org/W2594806523","https://openalex.org/W2603640757","https://openalex.org/W2740690576","https://openalex.org/W2756388520","https://openalex.org/W2758343154","https://openalex.org/W2770574196","https://openalex.org/W2782141318","https://openalex.org/W2782233266","https://openalex.org/W2793672511","https://openalex.org/W2811150554","https://openalex.org/W2903644235","https://openalex.org/W2939305641","https://openalex.org/W2942383121","https://openalex.org/W2947395266","https://openalex.org/W2947473752","https://openalex.org/W2948242406","https://openalex.org/W2964183846","https://openalex.org/W2964896323","https://openalex.org/W2965427641","https://openalex.org/W2972554696","https://openalex.org/W2972585421","https://openalex.org/W2982558023","https://openalex.org/W3005252823","https://openalex.org/W3005266233","https://openalex.org/W3005285024","https://openalex.org/W3009957334","https://openalex.org/W3012369122","https://openalex.org/W3016844413","https://openalex.org/W3043133492","https://openalex.org/W3046447740","https://openalex.org/W3082291901","https://openalex.org/W3083299978","https://openalex.org/W3092217721","https://openalex.org/W3097129652","https://openalex.org/W3100501784","https://openalex.org/W3102378442","https://openalex.org/W3114631395","https://openalex.org/W4211123396","https://openalex.org/W4244987100","https://openalex.org/W6907665845"],"related_works":["https://openalex.org/W7014743259","https://openalex.org/W3159777696","https://openalex.org/W4244958357","https://openalex.org/W2947395266","https://openalex.org/W2522389230","https://openalex.org/W4391823028","https://openalex.org/W7027334988","https://openalex.org/W2992485745","https://openalex.org/W2168432448","https://openalex.org/W2126708096"],"abstract_inverted_index":{"With":[0],"the":[1,4,21,24,35,56,59,107,125,129,152,174,177,183],"aging":[2],"of":[3,23,28,58,109,119,135,155,176,185],"population,":[5],"Parkinson\u2019s":[6,29,110],"disease":[7,30,111],"poses":[8],"a":[9,162],"serious":[10],"socio-economic":[11],"problem;":[12],"there":[13],"is":[14,62,69],"no":[15],"effective":[16],"therapy":[17],"that":[18],"can":[19],"arrest/revert":[20],"progression":[22],"disease.":[25],"The":[26,117],"hallmarks":[27],"and":[31,38,50,61,75,84,90,97,112,133,144],"other":[32],"synucleinopathies":[33],"are":[34,95,122,128,147],"disordered":[36],"alpha-synuclein":[37,68,83],"TPPP/p25.":[39],"These":[40,137],"proteins":[41,138],"have":[42],"neomorphic":[43],"moonlighting":[44],"characteristics":[45],"by":[46],"displaying":[47],"both":[48,100],"physiological":[49],"pathological":[51],"functions.":[52],"Physiologically":[53],"TPPP/p25":[54,85],"regulates":[55],"dynamics/stability":[57],"microtubules":[60],"crucial":[63],"for":[64],"oligodendrocyte":[65],"differentiation;":[66],"while":[67],"involved":[70],"in":[71,88,99,103,106],"neuronal":[72],"plasticity":[73,143],"modulation":[74],"synaptic":[76],"vesicle":[77],"pool":[78],"maintenance.":[79],"In":[80],"healthy":[81],"brain,":[82],"occur":[86],"predominantly":[87],"neurons":[89],"oligodendrocytes,":[91],"respectively;":[92],"however,":[93],"they":[94],"co-enriched":[96],"co-localized":[98],"cell":[101],"types":[102],"brain":[104],"inclusions":[105],"cases":[108],"multiple":[113],"system":[114],"atrophy,":[115],"respectively.":[116],"pathomechanisms":[118],"these":[120],"diseases":[121],"largely":[123],"unknown;":[124],"fatal":[126],"species":[127],"small,":[130],"soluble":[131],"homo-":[132],"hetero-associations":[134],"alpha-synuclein.":[136],"with":[139,169,188],"their":[140],"high":[141],"conformational":[142],"chameleon":[145],"feature":[146],"challenging":[148],"drug":[149,164],"targets.":[150],"Nevertheless,":[151],"contact":[153],"surface":[154],"TPPP/p25-alpha-synuclein":[156,178],"assemblies":[157],"has":[158],"been":[159],"validated":[160],"as":[161],"specific":[163],"target.":[165],"This":[166],"new":[167],"strategy":[168],"innovative":[170],"impact,":[171],"namely":[172],"targeting":[173],"interface":[175],"complex,":[179],"could":[180],"contribute":[181],"to":[182],"development":[184],"anti-Parkinson":[186],"drugs":[187],"unique":[189],"specificity.":[190]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1}],"updated_date":"2026-10-10T09:11:00.788812","created_date":"2021-03-29T00:00:00"}