{"id":"https://openalex.org/W3136061237","doi":"https://doi.org/10.14309/ctg.0000000000000327","title":"A Multicenter, Open-Label, Single-Arm Study to Evaluate the Efficacy and Safety of Saroglitazar in Patients With Primary Biliary Cholangitis","display_name":"A Multicenter, Open-Label, Single-Arm Study to Evaluate the Efficacy and Safety of Saroglitazar in Patients With Primary Biliary Cholangitis","publication_year":2021,"publication_date":"2021-03-26","ids":{"openalex":"https://openalex.org/W3136061237","doi":"https://doi.org/10.14309/ctg.0000000000000327","mag":"3136061237","pmid":"https://pubmed.ncbi.nlm.nih.gov/33769355","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7997082"},"language":"en","primary_location":{"id":"doi:10.14309/ctg.0000000000000327","doi":"https://doi.org/10.14309/ctg.0000000000000327","is_oa":true,"landing_page_url":"https://doi.org/10.14309/ctg.0000000000000327","pdf_url":null,"source":{"id":"https://openalex.org/S2764670792","display_name":"Clinical and Translational Gastroenterology","issn_l":"2155-384X","issn":["2155-384X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.14309/ctg.0000000000000327","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5037649284","display_name":"Raj Vuppalanchi","orcid":"https://orcid.org/0000-0003-0637-1577","observed_orcids":["https://orcid.org/0000-0003-0637-1577"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Raj Vuppalanchi","raw_affiliation_strings":["Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, Indiana, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, Indiana, USA;","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010475164","display_name":"M.S. Gonz\u00e1lez-Huezo","orcid":"https://orcid.org/0000-0001-6221-4088","observed_orcids":["https://orcid.org/0000-0001-6221-4088"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ma Sara\u00ed Gonz\u00e1lez-Huezo","raw_affiliation_strings":["Consultorio de la Dra. Sarai Gonzalez, Metepec, Estado de M\u00e9xico, Mexico;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Consultorio de la Dra. Sarai Gonzalez, Metepec, Estado de M\u00e9xico, Mexico;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035159453","display_name":"Ramon Payan-Olivas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ramon Payan-Olivas","raw_affiliation_strings":["Investigaci\u00f3n y Biomedicina de Chihuahua, Chihuahua, Mexico;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Investigaci\u00f3n y Biomedicina de Chihuahua, Chihuahua, Mexico;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013743804","display_name":"Linda Elsa Mu\u00f1oz-Espinosa","orcid":"https://orcid.org/0000-0002-0455-9325","observed_orcids":["https://orcid.org/0000-0002-0455-9325"]},"institutions":[{"id":"https://openalex.org/I169046204","display_name":"Universidad Aut\u00f3noma de Nuevo Le\u00f3n","ror":"https://ror.org/01fh86n78","country_code":"MX","type":"education","lineage":["https://openalex.org/I169046204"]}],"countries":["MX"],"is_corresponding":false,"raw_author_name":"Linda E. Mu\u00f1oz-Espinosa","raw_affiliation_strings":["Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo Le\u00f3n, Mexico;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universidad Autonoma de Nuevo Leon, Monterrey, Nuevo Le\u00f3n, Mexico;","institution_ids":["https://openalex.org/I169046204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109424045","display_name":"Farheen Shaikh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Farheen Shaikh","raw_affiliation_strings":["Zydus Discovery DMCC, Dubai, UAE;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zydus Discovery DMCC, Dubai, UAE;","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058011381","display_name":"Jose L. Pio Cruz-Lopez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jose L. Pio Cruz-Lopez","raw_affiliation_strings":["Avant Sante Research Center SA de CV. Monterrey, Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Avant Sante Research Center SA de CV. Monterrey, Mexico","institution_ids":[]}]},{"author_position":"last","author":{"id":null,"display_name":"Deven Parmar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Deven Parmar","raw_affiliation_strings":["Zydus Discovery DMCC, Dubai, UAE;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Zydus Discovery DMCC, Dubai, UAE;","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5037649284"],"corresponding_institution_ids":["https://openalex.org/I4394709130"],"apc_list":{"value":2800,"currency":"USD","value_usd":2800},"apc_paid":{"value":2800,"currency":"USD","value_usd":2800},"fwci":1.7609,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.84352448,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"12","issue":"4","first_page":"e00327","last_page":"e00327"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/saroglitazar","display_name":"saroglitazar","score":0.9909999966621399},{"id":"https://openalex.org/keywords/primary-biliary-cholangitis","display_name":"primary biliary cirrhosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ursodeoxycholic-acid","display_name":"ursodeoxycholic acid","score":0.9710000157356262},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.9229999780654907},{"id":"https://openalex.org/keywords/liver-enzymes","display_name":"liver enzymes","score":0.4620000123977661},{"id":"https://openalex.org/keywords/drug-efficacy-and-safety","display_name":"drug safety and efficacy","score":0.5690000057220459},{"id":"https://openalex.org/keywords/fibrates","display_name":"fibrates","score":0.531000018119812}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8147850036621094},{"id":"https://openalex.org/C203092338","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Clinical endpoint","level":3,"score":0.6555343866348267},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6314542293548584},{"id":"https://openalex.org/C2780965833","wikidata":"https://www.wikidata.org/wiki/Q241374","display_name":"Ursodeoxycholic acid","level":2,"score":0.6079818606376648},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.5796753168106079},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5120394825935364},{"id":"https://openalex.org/C2986274086","wikidata":"https://www.wikidata.org/wiki/Q199678","display_name":"Ascorbic acid","level":2,"score":0.5054290294647217},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.42009350657463074},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.17408806085586548},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.07534328103065491},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.07358819246292114},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000410","descriptor_name":"Alanine Transaminase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000469","descriptor_name":"Alkaline Phosphatase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001219","descriptor_name":"Aspartate Aminotransferases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008105","descriptor_name":"Liver Cirrhosis, Biliary","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008105","descriptor_name":"Liver Cirrhosis, Biliary","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010666","descriptor_name":"Phenylpropionates","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D010666","descriptor_name":"Phenylpropionates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D011758","descriptor_name":"Pyrroles","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D047492","descriptor_name":"Peroxisome Proliferator-Activated Receptors","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":true},{"descriptor_ui":"D057194","descriptor_name":"Intention to Treat Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.14309/ctg.0000000000000327","doi":"https://doi.org/10.14309/ctg.0000000000000327","is_oa":true,"landing_page_url":"https://doi.org/10.14309/ctg.0000000000000327","pdf_url":null,"source":{"id":"https://openalex.org/S2764670792","display_name":"Clinical and Translational Gastroenterology","issn_l":"2155-384X","issn":["2155-384X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Gastroenterology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7997082","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7997082/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7997082/pdf/","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clin Transl Gastroenterol","raw_type":"Text"},{"id":"pmid:33769355","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33769355","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and translational gastroenterology","raw_type":"Journal Article"},{"id":"pmh:oai:scholarworks.iupui.edu:1805/29544","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1805/29544","pdf_url":null,"source":{"id":"https://openalex.org/S4306402593","display_name":"Purdue University Indianapolis (Indiana University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I592451","host_organization_name":"Indiana University","host_organization_lineage":["https://openalex.org/I592451"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PMC","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.14309/ctg.0000000000000327","doi":"https://doi.org/10.14309/ctg.0000000000000327","is_oa":true,"landing_page_url":"https://doi.org/10.14309/ctg.0000000000000327","pdf_url":null,"source":{"id":"https://openalex.org/S2764670792","display_name":"Clinical and Translational Gastroenterology","issn_l":"2155-384X","issn":["2155-384X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","russia-white-list-2"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical and Translational Gastroenterology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3136061237.pdf","grobid_xml":"https://content.openalex.org/works/W3136061237.grobid-xml"},"referenced_works_count":13,"referenced_works":["https://openalex.org/W1556802048","https://openalex.org/W1987523828","https://openalex.org/W1996715170","https://openalex.org/W2153174384","https://openalex.org/W2552097960","https://openalex.org/W2605729742","https://openalex.org/W2768977224","https://openalex.org/W2886703787","https://openalex.org/W2900610594","https://openalex.org/W2915002008","https://openalex.org/W2950722971","https://openalex.org/W3002361265","https://openalex.org/W3047618859"],"related_works":["https://openalex.org/W3196850442","https://openalex.org/W4416904345","https://openalex.org/W4411100245","https://openalex.org/W3125174675","https://openalex.org/W7163913872","https://openalex.org/W4409267713","https://openalex.org/W7114803324","https://openalex.org/W4221099883","https://openalex.org/W2749610744","https://openalex.org/W4413955205"],"abstract_inverted_index":{"INTRODUCTION:":[0],"Patients":[1],"with":[2,30,63,103,166,240,309,316],"primary":[3,106,203],"biliary":[4],"cholangitis":[5],"(PBC)":[6],"without":[7],"biochemical":[8],"response":[9],"to":[10,81,99,122,232],"ursodeoxycholic":[11],"acid":[12],"(UDCA)":[13],"are":[14],"at":[15,117,159,214,254,275,278],"increased":[16],"risk":[17],"of":[18,53,90,127,140,171,179,235,251,274,292,294],"liver-related":[19],"mortality.":[20],"Saroglitazar":[21],"is":[22,37,49],"a":[23,38,50,167,233,246],"novel":[24],"peroxisome":[25],"proliferator-activated":[26],"receptor":[27],"(PPAR)":[28],"agonist":[29],"dual":[31],"PPAR":[32],"agonistic":[33],"properties":[34],"(\u03b1/\u03b3).":[35],"There":[36],"strong":[39],"mechanistic":[40],"rationale":[41],"for":[42,94,298],"studying":[43],"saroglitazar":[44,91,241,296],"in":[45,58,61,97,112,183,188,211,245,302,307,314],"PBC":[46],"because":[47,291],"PPAR\u03b1":[48],"molecular":[51],"target":[52],"fibrates":[54],"that":[55],"showed":[56],"improvements":[57,306],"liver":[59],"tests":[60],"patients":[62,74,86,137,155,265,315],"PBC.":[64,317],"METHODS:":[65],"In":[66],"this":[67],"16-week,":[68],"open-label,":[69],"phase":[70],"3":[71,78],"study,":[72],"37":[73],"were":[75,138],"screened":[76],"across":[77],"clinical":[79],"centers":[80],"enroll":[82],"7":[83],"patients.":[84],"All":[85],"received":[87],"daily":[88,169,177,297],"dose":[89],"4":[92,184,242,256,280],"mg":[93,182,187,243],"16":[95,119,216,299],"weeks":[96,300],"addition":[98],"their":[100],"ongoing":[101],"treatment":[102],"UDCA.":[104],"The":[105,192,202],"efficacy":[107,204],"endpoint":[108],"was":[109,131,148,197,223,289],"the":[110,128,164,176,219,268,287],"reduction":[111,234,273],"alkaline":[113],"phosphatase":[114],"(ALP)":[115],"level":[116,196],"week":[118,215,255,279],"as":[120],"compared":[121],"baseline.":[123],"RESULTS:":[124],"Mean":[125],"age":[126],"study":[129,165,269,288],"population":[130,222],"51.1":[132],"\u00b1":[133,199,225,237,258],"10.0":[134],"years,":[135],"all":[136,282],"female":[139],"Mexican":[141],"descent,":[142],"and":[143,161,185,248,281,304],"mean":[144,168,193,206,271],"body":[145],"mass":[146],"index":[147],"25.5\u00b1":[149],"=":[150,229,262],"4.8":[151],"kg/m2.":[152],"Six":[153,264],"(85.7%)":[154],"reported":[156],"taking":[157],"ursodiol":[158],"baseline":[160,194,210],"continued":[162],"throughout":[163],"dosage":[170,178],"417":[172],"mg.":[173],"Among":[174],"these,":[175],"UDCA":[180],"500":[181],"250":[186],"2":[189],"subjects,":[190],"respectively.":[191],"ALP":[195,212,252,272,308],"230":[198],"103":[200],"U/L.":[201],"endpoint,":[205],"change":[207],"(reduction)":[208],"from":[209],"concentration":[213],"based":[217],"on":[218],"modified":[220],"intent-to-treat":[221],"-94":[224],"53":[226],"U/L":[227],"(P":[228],"0.003),":[230],"corresponding":[231],"48":[236],"23%.":[238],"Treatment":[239],"resulted":[244,301],"rapid":[247,303],"sustained":[249,305],"decrease":[250],"levels":[253],"(-84":[257],"47":[259],"U/L,":[260],"P":[261],"0.003).":[263],"who":[266],"completed":[267],"achieved":[270],"least":[276],"40%":[277],"subsequent":[283],"visits.":[284],"DISCUSSION:":[285],"Although":[286],"terminated":[290],"lack":[293],"enrollment,":[295],"an":[310],"acceptable":[311],"safety":[312],"profile":[313]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2021-03-29T00:00:00"}
