{"id":"https://openalex.org/W3135953469","doi":"https://doi.org/10.3390/biomedicines9030327","title":"Long-Term Treatment of Azathioprine in Rats Induces Vessel Mineralization","display_name":"Long-Term Treatment of Azathioprine in Rats Induces Vessel Mineralization","publication_year":2021,"publication_date":"2021-03-23","ids":{"openalex":"https://openalex.org/W3135953469","doi":"https://doi.org/10.3390/biomedicines9030327","mag":"3135953469","pmid":"https://pubmed.ncbi.nlm.nih.gov/33806932","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8004774"},"language":"en","primary_location":{"id":"doi:10.3390/biomedicines9030327","doi":"https://doi.org/10.3390/biomedicines9030327","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines9030327","pdf_url":"https://www.mdpi.com/2227-9059/9/3/327/pdf?version=1616498388","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2227-9059/9/3/327/pdf?version=1616498388","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023220329","display_name":"Mirjam Schuchardt","orcid":"https://orcid.org/0000-0001-7388-9611","observed_orcids":["https://orcid.org/0000-0001-7388-9611"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Mirjam Schuchardt","raw_affiliation_strings":["Department of Nephrology and Medical Intensive Care, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, 12203 Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0001-7388-9611","affiliations":[{"raw_affiliation_string":"Department of Nephrology and Medical Intensive Care, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, 12203 Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064113998","display_name":"Jaqueline Herrmann","orcid":"https://orcid.org/0000-0003-1043-3945","observed_orcids":["https://orcid.org/0000-0003-1043-3945"]},"institutions":[{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]},{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jaqueline Herrmann","raw_affiliation_strings":["Department of Biochemistry, Chemistry and Pharmacy, Freie Universit\u00e4t Berlin, 14195 Berlin, Germany","Department of Nephrology and Medical Intensive Care, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, 12203 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Chemistry and Pharmacy, Freie Universit\u00e4t Berlin, 14195 Berlin, Germany","institution_ids":["https://openalex.org/I75951250"]},{"raw_affiliation_string":"Department of Nephrology and Medical Intensive Care, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, 12203 Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043730250","display_name":"Cornelia Henkel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Cornelia Henkel","raw_affiliation_strings":["Department of Nephrology and Medical Intensive Care, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, 12203 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology and Medical Intensive Care, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, 12203 Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071500167","display_name":"Milen Babic","orcid":"https://orcid.org/0000-0001-6248-0570","observed_orcids":["https://orcid.org/0000-0001-6248-0570"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Milen Babic","raw_affiliation_strings":["Department of Nephrology and Medical Intensive Care, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, 12203 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology and Medical Intensive Care, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, 12203 Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015274001","display_name":"Markus van der Giet","orcid":"https://orcid.org/0000-0003-3590-5451","observed_orcids":["https://orcid.org/0000-0003-3590-5451"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Markus van der Giet","raw_affiliation_strings":["Department of Nephrology and Medical Intensive Care, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, 12203 Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Nephrology and Medical Intensive Care, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, 12203 Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038753946","display_name":"Markus T\u00f6lle","orcid":"https://orcid.org/0000-0001-9843-2132","observed_orcids":["https://orcid.org/0000-0001-9843-2132"]},"institutions":[{"id":"https://openalex.org/I7877124","display_name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","ror":"https://ror.org/001w7jn25","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I7877124"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus T\u00f6lle","raw_affiliation_strings":["Department of Nephrology and Medical Intensive Care, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, 12203 Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0001-9843-2132","affiliations":[{"raw_affiliation_string":"Department of Nephrology and Medical Intensive Care, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, 12203 Berlin, Germany","institution_ids":["https://openalex.org/I7877124"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5015274001"],"corresponding_institution_ids":["https://openalex.org/I7877124"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2160},"apc_paid":{"value":1555,"currency":"EUR","value_usd":1677},"fwci":0.8381,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.69970816,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"9","issue":"3","first_page":"327","last_page":"327"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.7285000085830688,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10516","display_name":"Parathyroid Disorders and Treatments","score":0.7285000085830688,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12924","display_name":"Dermatological and Skeletal Disorders","score":0.12880000472068787,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.05040000006556511,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/azathioprine","display_name":"azathioprine","score":0.996999979019165},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.8410000205039978},{"id":"https://openalex.org/keywords/immunosuppressive-drugs","display_name":"immunosuppressants","score":0.9229999780654907},{"id":"https://openalex.org/keywords/xanthine-oxidase","display_name":"xanthine oxidase","score":0.9940000176429749},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9950000047683716},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8600000143051147},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.9990000128746033},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.9440000057220459},{"id":"https://openalex.org/keywords/osteopontin","display_name":"osteopontin","score":0.8379999995231628},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.9629999995231628},{"id":"https://openalex.org/keywords/aortic-calcification","display_name":"aortic calcification","score":0.796999990940094},{"id":"https://openalex.org/keywords/vascular-stiffness","display_name":"vascular stiffness","score":0.5649999976158142},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.890999972820282},{"id":"https://openalex.org/keywords/cardiovascular-disease","display_name":"cardiovascular disease","score":0.5239999890327454}],"concepts":[{"id":"https://openalex.org/C2780804394","wikidata":"https://www.wikidata.org/wiki/Q411994","display_name":"Osteopontin","level":2,"score":0.6372971534729004},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.5665200352668762},{"id":"https://openalex.org/C2778102346","wikidata":"https://www.wikidata.org/wiki/Q412509","display_name":"Xanthine oxidase","level":3,"score":0.5578335523605347},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.549855649471283},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5360555648803711},{"id":"https://openalex.org/C2780309369","wikidata":"https://www.wikidata.org/wiki/Q933382","display_name":"Calcification","level":2,"score":0.5276219844818115},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5146878361701965},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.5114697217941284},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.5013368129730225},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.36891311407089233},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.3335195481777191},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.28256916999816895},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.15138360857963562},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3390/biomedicines9030327","doi":"https://doi.org/10.3390/biomedicines9030327","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines9030327","pdf_url":"https://www.mdpi.com/2227-9059/9/3/327/pdf?version=1616498388","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},{"id":"pmid:33806932","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33806932","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8004774","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8004774/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"Text"},{"id":"pmh:oai:refubium.fu-berlin.de:fub188/31798","doi":null,"is_oa":true,"landing_page_url":"https://refubium.fu-berlin.de/handle/fub188/31798","pdf_url":"https://refubium.fu-berlin.de/handle/fub188/31798","source":{"id":"https://openalex.org/S4306402444","display_name":"Refubium (Universit\u00e4tsbibliothek der Freien Universit\u00e4t Berlin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I75951250","host_organization_name":"Freie Universit\u00e4t Berlin","host_organization_lineage":["https://openalex.org/I75951250"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"doc-type:article"},{"id":"pmh:oai:doaj.org/article:75eace354428404cb1176044b6c74505","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/75eace354428404cb1176044b6c74505","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Biomedicines, Vol 9, Iss 3, p 327 (2021)","raw_type":"article"},{"id":"doi:10.17169/refubium-31530","doi":"https://doi.org/10.17169/refubium-31530","is_oa":true,"landing_page_url":"https://doi.org/10.17169/refubium-31530","pdf_url":null,"source":{"id":"https://openalex.org/S7407052913","display_name":"Universit\u00e4tsbibliothek der FU Berlin Hochschulschriftenstelle u. Dokumentenserver","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.3390/biomedicines9030327","doi":"https://doi.org/10.3390/biomedicines9030327","is_oa":true,"landing_page_url":"https://doi.org/10.3390/biomedicines9030327","pdf_url":"https://www.mdpi.com/2227-9059/9/3/327/pdf?version=1616498388","source":{"id":"https://openalex.org/S2737005842","display_name":"Biomedicines","issn_l":"2227-9059","issn":["2227-9059"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biomedicines","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311802","display_name":"Sonnenfeld Stiftung","ror":"https://ror.org/04z2zsa77"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3135953469.pdf","grobid_xml":"https://content.openalex.org/works/W3135953469.grobid-xml"},"referenced_works_count":55,"referenced_works":["https://openalex.org/W1482286587","https://openalex.org/W1552427008","https://openalex.org/W1935527472","https://openalex.org/W1936105291","https://openalex.org/W1964844224","https://openalex.org/W1971008448","https://openalex.org/W1971278669","https://openalex.org/W1973948354","https://openalex.org/W1974289426","https://openalex.org/W1974426737","https://openalex.org/W1983820182","https://openalex.org/W1991619620","https://openalex.org/W1998091440","https://openalex.org/W2009626075","https://openalex.org/W2010964474","https://openalex.org/W2012665720","https://openalex.org/W2016131977","https://openalex.org/W2027334114","https://openalex.org/W2042487456","https://openalex.org/W2054435322","https://openalex.org/W2058001691","https://openalex.org/W2058294087","https://openalex.org/W2074081767","https://openalex.org/W2080703364","https://openalex.org/W2092134373","https://openalex.org/W2104741338","https://openalex.org/W2108152450","https://openalex.org/W2116381107","https://openalex.org/W2121860616","https://openalex.org/W2123077388","https://openalex.org/W2127755451","https://openalex.org/W2135804517","https://openalex.org/W2140930678","https://openalex.org/W2148660920","https://openalex.org/W2149841987","https://openalex.org/W2162381113","https://openalex.org/W2182043493","https://openalex.org/W2294532682","https://openalex.org/W2517631128","https://openalex.org/W2582222761","https://openalex.org/W2585304543","https://openalex.org/W2585418260","https://openalex.org/W2789761943","https://openalex.org/W2790056846","https://openalex.org/W2805352006","https://openalex.org/W2918628142","https://openalex.org/W2918652202","https://openalex.org/W2922795099","https://openalex.org/W2938431949","https://openalex.org/W2965015935","https://openalex.org/W2999495572","https://openalex.org/W3008314468","https://openalex.org/W3010473336","https://openalex.org/W3012801491","https://openalex.org/W3015858898"],"related_works":["https://openalex.org/W2016131977","https://openalex.org/W7096850239","https://openalex.org/W6887619670","https://openalex.org/W6887537420","https://openalex.org/W2223167867","https://openalex.org/W2883451963","https://openalex.org/W2787665040","https://openalex.org/W3212419813","https://openalex.org/W2089358094","https://openalex.org/W4410431630"],"abstract_inverted_index":{"Medial":[0],"vascular":[1,53,188],"calcification":[2,199],"(mVC)":[3],"is":[4,29,50],"closely":[5],"related":[6],"to":[7,100,180],"cardiovascular":[8,24],"disease,":[9],"especially":[10],"in":[11,38,46,52,67,71,73,87,127,152,156,168],"patients":[12],"suffering":[13],"from":[14],"chronic":[15],"kidney":[16,22],"disease":[17],"(CKD).":[18],"Even":[19],"after":[20],"successful":[21],"transplantation,":[23],"mortality":[25],"remains":[26],"increased.":[27],"There":[28],"evidence":[30,194],"that":[31,48],"immunosuppressive":[32],"drugs":[33],"might":[34,164],"influence":[35],"pathophysiological":[36],"mechanisms":[37,96],"the":[39,68,88,128,146,161,172,182],"vessel":[40,207],"wall.":[41],"Previously,":[42],"we":[43],"have":[44],"shown":[45],"vitro":[47],"mVC":[49],"induced":[51],"smooth":[54],"muscle":[55],"cells":[56],"(VSMCs)":[57],"upon":[58,91,121],"treatment":[59,202],"with":[60,78,106],"azathioprine":[61],"(AZA).":[62],"This":[63],"effect":[64,148],"was":[65],"confirmed":[66],"current":[69],"study":[70],"an":[72,134,157],"vivo":[74,159],"rat":[75],"model":[76],"treated":[77],"AZA":[79,92,98,122,147,186,201],"for":[80],"24":[81],"weeks.":[82],"The":[83,94],"calcium":[84],"content":[85],"increased":[86,135],"aortic":[89,129,154],"tissue":[90],"treatment.":[93],"pathophysiologic":[95],"involve":[97],"catabolism":[99],"6-thiouracil":[101],"via":[102],"xanthine":[103],"oxidase":[104],"(XO)":[105],"subsequent":[107],"induction":[108,196],"of":[109,137,185,195,197],"oxidative":[110],"stress.":[111],"Proinflammatory":[112],"cytokines,":[113],"such":[114],"as":[115],"interleukin":[116],"(IL)-1\u00df":[117],"and":[118,126,143,203],"IL-6,":[119],"increase":[120],"treatment,":[123],"both":[124],"systemically":[125],"tissue.":[130],"Further,":[131],"VSMCs":[132],"show":[133],"expression":[136],"core-binding":[138],"factor":[139],"\u03b1-1,":[140],"alkaline":[141],"phosphatase":[142],"osteopontin.":[144],"As":[145],"could":[149],"be":[150],"decreased":[151],"NLRP3\u2212/\u2212":[153],"rings":[155],"ex":[158],"experiment,":[160],"signaling":[162],"pathway":[163],"be,":[165],"at":[166],"least":[167],"part,":[169],"dependent":[170],"on":[171,187,206],"NLRP3":[173],"inflammasome.":[174],"Although":[175],"human":[176],"studies":[177],"are":[178],"necessary":[179],"confirm":[181],"harmful":[183],"effects":[184,205],"stiffening,":[189],"these":[190],"results":[191],"provide":[192],"further":[193],"VSMC":[198],"under":[200],"its":[204],"structure.":[208]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-03-29T00:00:00"}
