{"id":"https://openalex.org/W3135915225","doi":null,"title":"Production of [89Zr]Oxinate4 and cell labeling for human use","display_name":"Production of [89Zr]Oxinate4 and cell labeling for human use","publication_year":2020,"publication_date":"2020-05-01","ids":{"openalex":"https://openalex.org/W3135915225","mag":"3135915225"},"language":"en","primary_location":{"id":"mag:3135915225","doi":null,"is_oa":false,"landing_page_url":"http://jnm.snmjournals.org/content/61/supplement_1/468.short","pdf_url":null,"source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Nuclear Medicine","raw_type":null},"volume":null,"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003986132","display_name":"Adriana V. F. Massicano","orcid":"https://orcid.org/0000-0002-6666-1317","observed_orcids":["https://orcid.org/0000-0002-6666-1317"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adriana V. F. Massicano","raw_affiliation_strings":["University of Alabama at Birmingham Birmingham, Al, United States"],"raw_orcid":"https://orcid.org/0000-0002-6666-1317","affiliations":[{"raw_affiliation_string":"University of Alabama at Birmingham Birmingham, Al, United States","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037859908","display_name":"Charlotte Denise Jeffers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Charlotte Denise Jeffers","raw_affiliation_strings":["University of Alabama at Birmingham Birmingham, Al, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Alabama at Birmingham Birmingham, Al, United States","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102787343","display_name":"Jennifer L. Bartels","orcid":"https://orcid.org/0000-0002-0137-2397","observed_orcids":["https://orcid.org/0000-0002-0137-2397"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer L. Bartels","raw_affiliation_strings":["Radiology University of Alabama- Birmingham- Medical Center Birmingham AL United States"],"raw_orcid":"https://orcid.org/0000-0002-0137-2397","affiliations":[{"raw_affiliation_string":"Radiology University of Alabama- Birmingham- Medical Center Birmingham AL United States","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067294261","display_name":"Hailey A. Houson","orcid":"https://orcid.org/0000-0001-8566-2369","observed_orcids":["https://orcid.org/0000-0001-8566-2369"]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hailey Houson","raw_affiliation_strings":["UAB Radiology Birmingham AL United States"],"raw_orcid":"https://orcid.org/0000-0001-8566-2369","affiliations":[{"raw_affiliation_string":"UAB Radiology Birmingham AL United States","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5075304112","display_name":"Suzanne E. Lapi","orcid":"https://orcid.org/0000-0003-0090-0191","observed_orcids":["https://orcid.org/0000-0003-0090-0191"]},"institutions":[{"id":"https://openalex.org/I17301866","display_name":"University of Alabama","ror":"https://ror.org/03xrrjk67","country_code":"US","type":"education","lineage":["https://openalex.org/I17301866"]},{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suzanne E. Lapi","raw_affiliation_strings":["University of Alabama At Bimingham Birmingham AL United States"],"raw_orcid":"https://orcid.org/0000-0003-0090-0191","affiliations":[{"raw_affiliation_string":"University of Alabama At Bimingham Birmingham AL United States","institution_ids":["https://openalex.org/I17301866","https://openalex.org/I32389192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.22564605,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"61","issue":null,"first_page":"468","last_page":"468"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13561","display_name":"Chemical Reactions and Isotopes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/zirconium-89","display_name":"zirconium-89","score":0.9229999780654907},{"id":"https://openalex.org/keywords/pet-radiopharmaceuticals","display_name":"PET radiopharmaceuticals","score":0.8299999833106995},{"id":"https://openalex.org/keywords/oxine","display_name":"oxine","score":0.6439999938011169},{"id":"https://openalex.org/keywords/radiopharmaceutical-production","display_name":"radiopharmaceutical production","score":0.7379999756813049},{"id":"https://openalex.org/keywords/scale-up","display_name":"scale-up","score":0.4779999852180481},{"id":"https://openalex.org/keywords/radiochemical-purity","display_name":"radiochemical purity","score":0.5809999704360962},{"id":"https://openalex.org/keywords/radiopharmaceutical-quality-control","display_name":"radiopharmaceutical quality control","score":0.6119999885559082},{"id":"https://openalex.org/keywords/sterile-filtration","display_name":"sterile filtration","score":0.3529999852180481},{"id":"https://openalex.org/keywords/inflammation-imaging","display_name":"inflammation imaging","score":0.39399999380111694},{"id":"https://openalex.org/keywords/infection-imaging","display_name":"infection imaging","score":0.6439999938011169},{"id":"https://openalex.org/keywords/radiolabeled-leukocytes","display_name":"radiolabeled leukocytes","score":0.38499999046325684}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6501278281211853},{"id":"https://openalex.org/C3017724952","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Pet imaging","level":3,"score":0.635525107383728},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.49636751413345337},{"id":"https://openalex.org/C2776351790","wikidata":"https://www.wikidata.org/wiki/Q417351","display_name":"Oxalate","level":2,"score":0.4314464032649994},{"id":"https://openalex.org/C177322064","wikidata":"https://www.wikidata.org/wiki/Q750955","display_name":"Radiochemistry","level":1,"score":0.41644757986068726},{"id":"https://openalex.org/C81426234","wikidata":"https://www.wikidata.org/wiki/Q1408763","display_name":"Solid phase extraction","level":3,"score":0.41228219866752625},{"id":"https://openalex.org/C4725764","wikidata":"https://www.wikidata.org/wiki/Q844704","display_name":"Extraction (chemistry)","level":2,"score":0.3602721095085144},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.16135919094085693},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.12734198570251465},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:3135915225","doi":null,"is_oa":false,"landing_page_url":"http://jnm.snmjournals.org/content/61/supplement_1/468.short","pdf_url":null,"source":{"id":"https://openalex.org/S4210180780","display_name":"Journal of Nuclear Medicine","issn_l":"0161-5505","issn":["0161-5505","1535-5667","2159-662X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315767","host_organization_name":"Society of Nuclear Medicine and Molecular Imaging","host_organization_lineage":["https://openalex.org/P4310315767"],"host_organization_lineage_names":["Society of Nuclear Medicine and Molecular Imaging"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Journal of Nuclear Medicine","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3111497228","https://openalex.org/W3087801316","https://openalex.org/W277426269","https://openalex.org/W3185314008","https://openalex.org/W2013331637","https://openalex.org/W2117723209","https://openalex.org/W4226128057","https://openalex.org/W2144126123","https://openalex.org/W4296347602","https://openalex.org/W1978195179"],"abstract_inverted_index":{"468":[0],"Introduction:":[2],"Imaging":[4],"of":[5,17,45,81,163,174,191,220,229,234,239,258,271,303,354,383,412,419,435,468,501],"radiolabeled":[6],"White":[7],"Blood":[8],"Cell":[9],"(WBC)":[10],"is":[11,60,448,456],"an":[12],"important":[13],"tool":[14],"for":[15,27,38,47,63,68,83,103,109,202,273,313,359,437,450],"investigation":[16],"several":[18,121,164,478],"conditions":[19,152],"such":[20,123],"as":[21,124,362,487],"infectious/inflammatory":[22],"disease.":[23],"The":[24,150,195,208,223,339,395,466],"radiopharmaceuticals":[25],"available":[26],"clinical":[28],"WBC":[29,110,252,360,376,444],"labeling":[30,88,361,372,410,454],"are":[31,35],"gamma-emitter":[32],"and":[33,49,57,86,132,143,181,215,264,288,308,323,337,416,440,455,482,509],"so":[34],"suitable":[36,65,102,449],"only":[37],"SPECT.":[39],"PET":[40,66,100],"technology":[41],"opens":[42],"a":[43,61,64,99,246,387,409,488],"range":[44],"options":[46],"better":[48],"more":[50],"sensitive":[51],"imaging":[52],"techniques":[53],"compared":[54],"to":[55,91,127,137,145,155,350],"SPECT":[56],"thus":[58],"there":[59],"need":[62],"tracer":[67],"cell":[69,87,371,389,420,453],"labeling.":[70,111,445],"In":[71],"this":[72,469],"work,":[73],"we":[74,115],"describe":[75],"our":[76],"experience":[77],"in":[78,178,183,188,217,236,369,408,460],"the":[79,117,139,147,157,167,282,284,289,352,399,432,484,499],"production":[80,169,433],"[89Zr]Oxinate4":[82,272,297,436],"human":[84,104,314,438,472],"use":[85,105,353,439,473],"from":[89,255,261,380,505],"benchtop":[90,118],"bedside.\n":[92],"Methods:":[94],"We":[97,497],"developed":[98],"radiopharmaceutical":[101,447],"based":[106],"on":[107,443],"oxine":[108,175],"To":[112],"do":[113],"so,":[114],"optimized":[116,151,168],"chemistry":[119],"varying":[120],"aspects":[122],"buffer":[125],"used":[126,154,459],"neutralize":[128],"[89Zr]Oxalate,":[129],"incubation":[130],"time":[131],"temperature,":[133],"organic":[134,209],"solvent,":[135],"glassware":[136],"perform":[138],"labeling,":[140],"quality":[141],"control,":[142],"filters":[144],"sterilize":[146],"final":[148,224,290,340],"product.":[149],"were":[153,253,286,378],"scale-up":[156],"production,":[158],"which":[159,316,406],"required":[160],"another":[161],"modification":[162],"parameters.":[165],"Briefly,":[166],"condition":[170],"was:":[171],"5":[172,189],"mg":[173,233],"was":[176,197,211,243,298,343,401,492],"diluted":[177,187],"dichloromethane":[179],"(DCM)":[180],"mixed":[182],"neutralized":[184],"[89Zr]Oxalate":[185],"already":[186,457],"mL":[190,219,238,257,358],"trace":[192],"metal":[193],"water.":[194],"mixture":[196],"incubated":[198],"at":[199,278],"room":[200,279],"temperature":[201],"30":[203,276],"minutes":[204,277],"under":[205],"vigorous":[206],"agitation.":[207],"phase":[210],"separated,":[212],"completely":[213],"evaporated":[214],"suspended":[216],"45":[218],"dimethylsulfoxide":[221],"(DMSO).":[222],"formulation":[225],"containing":[226],"200":[227],"\u00b5g":[228],"polysorbate":[230],"80,":[231],"12":[232],"HEPES":[235],"2":[237],"0.9%":[240],"sodium":[241],"chloride,":[242],"filtered":[244],"into":[245,398,471,477],"sterile":[247],"borosilicate":[248],"type":[249],"I":[250],"vial.":[251],"isolated":[254,379],"120":[256,381],"whole":[259,384],"blood":[260,385],"healthy":[262],"donors":[263],"labeled":[265],"with":[266,301,386],"640":[267],"-":[268,275],"1500":[269],"\u00b5Ci":[270,405],"20":[274],"temperature.":[280],"After":[281],"incubation,":[283],"cells":[285,377,400],"washed,":[287],"activity":[291],"recorded.\n":[292],"Results:":[294],"successful":[299],"produced":[300],"yield":[302],"67":[304],"\u00b1":[305,334,345,393,403,414,423],"14.54%":[306],"(N=5)":[307],"met":[309],"all":[310,502],"acceptance":[311],"criteria":[312],"use,":[315],"include":[317],"non-residual":[318],"solvents":[319],"(DCM":[320],"<600":[321],"ppm":[322],"DMSO":[324],"<5000":[325],"ppm),":[326],"adequate":[327],"pH":[328],"(7.0),":[329],"high":[330,348,388],"radiochemical":[331],"purity":[332],"(99.67":[333],"0.74%),":[335],"endotoxin-free":[336],"sterility.":[338],"radioactivity":[341,396],"concentration":[342],"1.93":[344],"0.55":[346],"mCi/mL":[347],"enough":[349],"allow":[351],"less":[355],"than":[356],"1":[357],"previous":[363],"studies":[364],"showed":[365],"lower":[366],"volumes":[367],"resulted":[368,407],"higher":[370],"yields.":[373],"Over":[374],"2.0x10^8":[375],"ml":[382],"viability":[390,421],"rate":[391],"(81.0":[392],"3.24%).":[394],"incorporated":[397],"327.86":[402],"116.87":[404],"efficiency":[411],"30.87":[413],"9.58%":[415],"satisfactory":[417],"preservation":[418],"(75.5":[422],"12.85%).\n":[424],"Conclusions:":[426],"This":[429,446,490],"study":[430],"demonstrated":[431],"results":[434],"its":[441],"application":[442],"theoretically":[451],"any":[452],"being":[458],"different":[461],"preclinical":[462],"projects":[463],"across":[464],"UAB.":[465],"translation":[467],"technique":[470],"will":[474],"provide":[475],"insight":[476],"disease":[479],"mechanisms,":[480],"advancing":[481],"benefiting":[483],"scientific":[485],"community":[486],"whole.\nAcknowledgments:":[489],"project":[491],"supported":[493],"by":[494],"UAB":[495,510],"Radiology.":[496],"acknowledge":[498],"support":[500],"team":[503],"members":[504],"Dr.":[506],"Younger\u2019s":[507],"group,":[508],"Cyclotron":[511],"Facility.":[512]},"counts_by_year":[],"updated_date":"2026-10-27T15:51:10.671819","created_date":"2021-03-29T00:00:00"}