{"id":"https://openalex.org/W3135596733","doi":"https://doi.org/10.1186/s13019-021-01402-4","title":"Is there a renoprotective value to leukodepletion during heart valve surgery? A randomized controlled trial (ROLO)","display_name":"Is there a renoprotective value to leukodepletion during heart valve surgery? A randomized controlled trial (ROLO)","publication_year":2021,"publication_date":"2021-03-26","ids":{"openalex":"https://openalex.org/W3135596733","doi":"https://doi.org/10.1186/s13019-021-01402-4","mag":"3135596733","pmid":"https://pubmed.ncbi.nlm.nih.gov/33771192","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8004389"},"language":"en","primary_location":{"id":"doi:10.1186/s13019-021-01402-4","doi":"https://doi.org/10.1186/s13019-021-01402-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13019-021-01402-4","pdf_url":"https://cardiothoracicsurgery.biomedcentral.com/counter/pdf/10.1186/s13019-021-01402-4","source":{"id":"https://openalex.org/S172459203","display_name":"Journal of Cardiothoracic Surgery","issn_l":"1749-8090","issn":["1749-8090"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiothoracic Surgery","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://cardiothoracicsurgery.biomedcentral.com/counter/pdf/10.1186/s13019-021-01402-4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023794618","display_name":"Espeed Khoshbin","orcid":"https://orcid.org/0000-0001-8714-934X","observed_orcids":["https://orcid.org/0000-0001-8714-934X"]},"institutions":[{"id":"https://openalex.org/I2801924861","display_name":"Freeman Hospital","ror":"https://ror.org/00cdwy346","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801663869","https://openalex.org/I2801924861"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Espeed Khoshbin","raw_affiliation_strings":["Department of Cardiothoracic Surgery, Freeman Hospital, High Heaton, Newcastle upon Tyne, NE7 7DN, UK. Espeed.Khoshbin1@nhs.net","Department of Cardiothoracic Surgery, Freeman Hospital, Newcastle upon Tyne, UK"],"raw_orcid":"https://orcid.org/0000-0001-8714-934X","affiliations":[{"raw_affiliation_string":"Department of Cardiothoracic Surgery, Freeman Hospital, High Heaton, Newcastle upon Tyne, NE7 7DN, UK. Espeed.Khoshbin1@nhs.net","institution_ids":["https://openalex.org/I2801924861"]},{"raw_affiliation_string":"Department of Cardiothoracic Surgery, Freeman Hospital, Newcastle upon Tyne, UK","institution_ids":["https://openalex.org/I2801924861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007202398","display_name":"Sally Spencer","orcid":"https://orcid.org/0000-0001-6330-7200","observed_orcids":["https://orcid.org/0000-0001-6330-7200"]},"institutions":[{"id":"https://openalex.org/I67415387","display_name":"Lancaster University","ror":"https://ror.org/04f2nsd36","country_code":"GB","type":"education","lineage":["https://openalex.org/I67415387"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sally Spencer","raw_affiliation_strings":["School of Health and Medicine, Lancaster University, Bailing, Upper Market Street, Lancaster, Lancashire, LA1 4YW, UK","School of Health and Medicine, Lancaster University, Lancaster, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Health and Medicine, Lancaster University, Bailing, Upper Market Street, Lancaster, Lancashire, LA1 4YW, UK","institution_ids":["https://openalex.org/I67415387"]},{"raw_affiliation_string":"School of Health and Medicine, Lancaster University, Lancaster, UK","institution_ids":["https://openalex.org/I67415387"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112800911","display_name":"Laurence Solomon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1293129422","display_name":"Lancashire Teaching Hospitals NHS Foundation Trust","ror":"https://ror.org/02j7n9748","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I1293129422"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Laurence Solomon","raw_affiliation_strings":["Renal Unit, Lancashire Teaching Hospitals NHS Foundation Trust, Sharoe Green Lane, Fulwood, Preston, Lancashire, PR2 9HT, UK","Renal Unit, Lancashire Teaching Hospitals NHS Foundation Trust, Sharoe Green Lane, Preston, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Renal Unit, Lancashire Teaching Hospitals NHS Foundation Trust, Sharoe Green Lane, Fulwood, Preston, Lancashire, PR2 9HT, UK","institution_ids":["https://openalex.org/I1293129422"]},{"raw_affiliation_string":"Renal Unit, Lancashire Teaching Hospitals NHS Foundation Trust, Sharoe Green Lane, Preston, UK","institution_ids":["https://openalex.org/I1293129422"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108500504","display_name":"Augustine T.M. Tang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801018919","display_name":"Blackpool Victoria Hospital","ror":"https://ror.org/01r9ea713","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801018919","https://openalex.org/I4210127133"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Augustine Tang","raw_affiliation_strings":["Department of Cardiothoracic Surgery, Blackpool Victoria Hospital, Blackpool, FY3 8NR, UK","Department of Cardiothoracic Surgery, Blackpool Victoria Hospital, Blackpool, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiothoracic Surgery, Blackpool Victoria Hospital, Blackpool, FY3 8NR, UK","institution_ids":["https://openalex.org/I2801018919"]},{"raw_affiliation_string":"Department of Cardiothoracic Surgery, Blackpool Victoria Hospital, Blackpool, UK","institution_ids":["https://openalex.org/I2801018919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057392864","display_name":"Stephen Charles Clark","orcid":"https://orcid.org/0000-0002-2193-4705","observed_orcids":["https://orcid.org/0000-0002-2193-4705"]},"institutions":[{"id":"https://openalex.org/I2801924861","display_name":"Freeman Hospital","ror":"https://ror.org/00cdwy346","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I2801663869","https://openalex.org/I2801924861"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Stephen Clark","raw_affiliation_strings":["Department of Cardiothoracic Surgery, Freeman Hospital, High Heaton, Newcastle upon Tyne, NE7 7DN, UK","Department of Cardiothoracic Surgery, Freeman Hospital, Newcastle upon Tyne, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiothoracic Surgery, Freeman Hospital, High Heaton, Newcastle upon Tyne, NE7 7DN, UK","institution_ids":["https://openalex.org/I2801924861"]},{"raw_affiliation_string":"Department of Cardiothoracic Surgery, Freeman Hospital, Newcastle upon Tyne, UK","institution_ids":["https://openalex.org/I2801924861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012788525","display_name":"Elizabeth A Stokes","orcid":"https://orcid.org/0000-0002-4179-1369","observed_orcids":["https://orcid.org/0000-0002-4179-1369"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Elizabeth Stokes","raw_affiliation_strings":["Department of Public Health, University of Oxford, Rosemary Rue Building, Old Road Campus, Headington, Oxford, OX3 7LF, UK","Department of Public Health, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health, University of Oxford, Rosemary Rue Building, Old Road Campus, Headington, Oxford, OX3 7LF, UK","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Department of Public Health, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056372307","display_name":"Sarah Wordsworth","orcid":"https://orcid.org/0000-0002-2361-3040","observed_orcids":["https://orcid.org/0000-0002-2361-3040"]},"institutions":[{"id":"https://openalex.org/I40120149","display_name":"University of Oxford","ror":"https://ror.org/052gg0110","country_code":"GB","type":"education","lineage":["https://openalex.org/I40120149"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sarah Wordsworth","raw_affiliation_strings":["Department of Public Health, University of Oxford, Rosemary Rue Building, Old Road Campus, Headington, Oxford, OX3 7LF, UK","Department of Public Health, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health, University of Oxford, Rosemary Rue Building, Old Road Campus, Headington, Oxford, OX3 7LF, UK","institution_ids":["https://openalex.org/I40120149"]},{"raw_affiliation_string":"Department of Public Health, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I40120149"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009968504","display_name":"Lucy Dabner","orcid":"https://orcid.org/0000-0001-7269-1945","observed_orcids":["https://orcid.org/0000-0001-7269-1945"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lucy Dabner","raw_affiliation_strings":["Clinical Trials and Evaluation Unit, Bristol Medical School, University of Bristol, Bristol, BS2 8HW, UK","Clinical Trials and Evaluation Unit, Bristol Medical School, University of Bristol, Bristol, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Trials and Evaluation Unit, Bristol Medical School, University of Bristol, Bristol, BS2 8HW, UK","institution_ids":["https://openalex.org/I36234482"]},{"raw_affiliation_string":"Clinical Trials and Evaluation Unit, Bristol Medical School, University of Bristol, Bristol, UK","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045940395","display_name":"Julia M. Edwards","orcid":"https://orcid.org/0000-0001-8337-8962","observed_orcids":["https://orcid.org/0000-0001-8337-8962"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Julia Edwards","raw_affiliation_strings":["Clinical Trials and Evaluation Unit, Bristol Medical School, University of Bristol, Bristol, BS2 8HW, UK","Clinical Trials and Evaluation Unit, Bristol Medical School, University of Bristol, Bristol, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Trials and Evaluation Unit, Bristol Medical School, University of Bristol, Bristol, BS2 8HW, UK","institution_ids":["https://openalex.org/I36234482"]},{"raw_affiliation_string":"Clinical Trials and Evaluation Unit, Bristol Medical School, University of Bristol, Bristol, UK","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049611346","display_name":"Barnaby C Reeves","orcid":"https://orcid.org/0000-0002-5101-9487","observed_orcids":["https://orcid.org/0000-0002-5101-9487"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Barnaby Reeves","raw_affiliation_strings":["Clinical Trials and Evaluation Unit, Bristol Medical School, University of Bristol, Bristol, BS2 8HW, UK","Clinical Trials and Evaluation Unit, Bristol Medical School, University of Bristol, Bristol, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Trials and Evaluation Unit, Bristol Medical School, University of Bristol, Bristol, BS2 8HW, UK","institution_ids":["https://openalex.org/I36234482"]},{"raw_affiliation_string":"Clinical Trials and Evaluation Unit, Bristol Medical School, University of Bristol, Bristol, UK","institution_ids":["https://openalex.org/I36234482"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5007945636","display_name":"Chris A. Rogers","orcid":"https://orcid.org/0000-0002-9624-2615","observed_orcids":["https://orcid.org/0000-0002-9624-2615"]},"institutions":[{"id":"https://openalex.org/I36234482","display_name":"University of Bristol","ror":"https://ror.org/0524sp257","country_code":"GB","type":"education","lineage":["https://openalex.org/I36234482"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Chris Rogers","raw_affiliation_strings":["Clinical Trials and Evaluation Unit, Bristol Medical School, University of Bristol, Bristol, BS2 8HW, UK","Clinical Trials and Evaluation Unit, Bristol Medical School, University of Bristol, Bristol, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Trials and Evaluation Unit, Bristol Medical School, University of Bristol, Bristol, BS2 8HW, UK","institution_ids":["https://openalex.org/I36234482"]},{"raw_affiliation_string":"Clinical Trials and Evaluation Unit, Bristol Medical School, University of Bristol, Bristol, UK","institution_ids":["https://openalex.org/I36234482"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5023794618"],"corresponding_institution_ids":["https://openalex.org/I2801924861"],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":0.3338,"has_fulltext":true,"cited_by_count":8,"citation_normalized_percentile":{"value":0.53035948,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":98},"biblio":{"volume":"16","issue":"1","first_page":"58","last_page":"58"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.8618000149726868,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.8618000149726868,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11055","display_name":"Cardiac and Coronary Surgery Techniques","score":0.12559999525547028,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10693","display_name":"Blood transfusion and management","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leukodepletion","display_name":"leukocyte depletion","score":0.7279999852180481},{"id":"https://openalex.org/keywords/leukocyte-depletion-filter","display_name":"leukocyte depletion filter","score":0.7350000143051147},{"id":"https://openalex.org/keywords/acute-kidney-injury","display_name":"acute kidney injury","score":0.8799999952316284},{"id":"https://openalex.org/keywords/cardiopulmonary-bypass","display_name":"cardiopulmonary bypass","score":0.847000002861023},{"id":"https://openalex.org/keywords/heart-valve-surgery","display_name":"heart valve surgery","score":0.9039999842643738},{"id":"https://openalex.org/keywords/valvular-heart-disease","display_name":"valvular heart disease","score":0.7870000004768372},{"id":"https://openalex.org/keywords/renal-protection","display_name":"renal protection","score":0.4350000023841858},{"id":"https://openalex.org/keywords/cystatin-c","display_name":"cystatin C","score":0.9589999914169312},{"id":"https://openalex.org/keywords/glomerular-injury","display_name":"glomerular injury","score":0.6809999942779541},{"id":"https://openalex.org/keywords/renal-tubular-injury","display_name":"renal tubular injury","score":0.625},{"id":"https://openalex.org/keywords/quality-of-life","display_name":"quality of life","score":0.6510000228881836},{"id":"https://openalex.org/keywords/length-of-hospital-stay","display_name":"length of hospital stay","score":0.8240000009536743},{"id":"https://openalex.org/keywords/postoperative-renal-dysfunction","display_name":"postoperative renal dysfunction","score":0.6470000147819519},{"id":"https://openalex.org/keywords/kdigo-criteria","display_name":"KDIGO criteria","score":0.6909999847412109},{"id":"https://openalex.org/keywords/neutrophil-gelatinase-associated-lipocalin","display_name":"neutrophil gelatinase-associated lipocalin","score":0.8519999980926514}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.856387734413147},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.7401306629180908},{"id":"https://openalex.org/C2778789114","wikidata":"https://www.wikidata.org/wiki/Q235007","display_name":"Cardiac surgery","level":2,"score":0.7300593256950378},{"id":"https://openalex.org/C2779548226","wikidata":"https://www.wikidata.org/wiki/Q413243","display_name":"Cystatin C","level":3,"score":0.7055031061172485},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.638737142086029},{"id":"https://openalex.org/C2778881276","wikidata":"https://www.wikidata.org/wiki/Q552304","display_name":"Cardiopulmonary bypass","level":2,"score":0.572493314743042},{"id":"https://openalex.org/C77411442","wikidata":"https://www.wikidata.org/wiki/Q181100","display_name":"Urinary system","level":2,"score":0.46961647272109985},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.43925613164901733},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.39333224296569824},{"id":"https://openalex.org/C2780306776","wikidata":"https://www.wikidata.org/wiki/Q426660","display_name":"Creatinine","level":2,"score":0.3728353977203369},{"id":"https://openalex.org/C126894567","wikidata":"https://www.wikidata.org/wiki/Q105650","display_name":"Urology","level":1,"score":0.3539937138557434},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3342290222644806}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006348","descriptor_name":"Cardiac Surgical Procedures","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D006349","descriptor_name":"Heart Valve Diseases","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D006351","descriptor_name":"Heart Valves","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007432","descriptor_name":"Intraoperative Period","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007677","descriptor_name":"Kidney Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007902","descriptor_name":"Length of Stay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011788","descriptor_name":"Quality of Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047589","descriptor_name":"Leukocyte Reduction Procedures","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D058186","descriptor_name":"Acute Kidney Injury","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true}],"locations_count":11,"locations":[{"id":"doi:10.1186/s13019-021-01402-4","doi":"https://doi.org/10.1186/s13019-021-01402-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13019-021-01402-4","pdf_url":"https://cardiothoracicsurgery.biomedcentral.com/counter/pdf/10.1186/s13019-021-01402-4","source":{"id":"https://openalex.org/S172459203","display_name":"Journal of Cardiothoracic Surgery","issn_l":"1749-8090","issn":["1749-8090"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiothoracic Surgery","raw_type":"journal-article"},{"id":"doi:10.21203/rs.3.rs-42300/v1","doi":"https://doi.org/10.21203/rs.3.rs-42300/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-42300/v1","pdf_url":"https://www.researchsquare.com/article/rs-42300/v1.pdf?c=1595014649000","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},{"id":"pmid:33771192","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33771192","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cardiothoracic surgery","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8004389","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC8004389/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cardiothorac Surg","raw_type":"Text"},{"id":"pmh:oai:research-information.bris.ac.uk:openaire_cris_publications/423d68db-d219-4f28-b2ee-e4f6deee5c3a","doi":null,"is_oa":true,"landing_page_url":"https://research-information.bris.ac.uk/en/publications/423d68db-d219-4f28-b2ee-e4f6deee5c3a","pdf_url":null,"source":{"id":"https://openalex.org/S7407055359","display_name":"Explore Bristol Research","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Khoshbin, E, Spencer, S, Solomon, L, Tang, A, Clark, S, Stokes, E, Wordsworth, S, Dabner, L, Edwards, J, Reeves, B & Rogers, C 2021, 'Is There A Renoprotective Value to Leukodepletion During Heart Valve Surgery? A Randomized Controlled Trial (ROLO)', Journal of Cardiothoracic Surgery, vol. 16, no. 1, 58. https://doi.org/10.1186/s13019-021-01402-4","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:nrl.northumbria.ac.uk:45996","doi":null,"is_oa":false,"landing_page_url":"http://nrl.northumbria.ac.uk/id/eprint/45996/1/s13019-021-01402-4.pdf","pdf_url":"http://nrl.northumbria.ac.uk/id/eprint/45996/1/s13019-021-01402-4.pdf","source":{"id":"https://openalex.org/S4306401884","display_name":"Northumbria Research Link (Northumbria University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32394136","host_organization_name":"Northumbria University","host_organization_lineage":["https://openalex.org/I32394136"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:research-information.bris.ac.uk:openaire/423d68db-d219-4f28-b2ee-e4f6deee5c3a","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/1983/423d68db-d219-4f28-b2ee-e4f6deee5c3a","pdf_url":"https://research-information.bris.ac.uk/files/274133056/s13019_021_01402_4.pdf","source":{"id":"https://openalex.org/S4306400895","display_name":"Bristol Research (University of Bristol)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I36234482","host_organization_name":"University of Bristol","host_organization_lineage":["https://openalex.org/I36234482"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Khoshbin, E, Spencer, S, Solomon, L, Tang, A, Clark, S, Stokes, E, Wordsworth, S, Dabner, L, Edwards, J, Reeves, B & Rogers, C 2021, 'Is There A Renoprotective Value to Leukodepletion During Heart Valve Surgery? A Randomized Controlled Trial (ROLO)', Journal of Cardiothoracic Surgery, vol. 16, no. 1, 58. https://doi.org/10.1186/s13019-021-01402-4","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:ora.ox.ac.uk:uuid:28b4d9dc-5323-4c1b-b36d-2da53ae3a036","doi":null,"is_oa":true,"landing_page_url":"https://ora.ox.ac.uk/objects/uuid:28b4d9dc-5323-4c1b-b36d-2da53ae3a036","pdf_url":"https://ora.ox.ac.uk/objects/uuid:28b4d9dc-5323-4c1b-b36d-2da53ae3a036/files/sth83kz94m","source":{"id":"https://openalex.org/S4306402636","display_name":"Oxford University Research Archive (ORA) (University of Oxford)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I40120149","host_organization_name":"University of Oxford","host_organization_lineage":["https://openalex.org/I40120149"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Symplectic Elements","raw_type":"Journal article"},{"id":"pmh:oai:pure.atira.dk:openaire/74cd67d5-e477-4030-9541-9afe2d788604","doi":null,"is_oa":true,"landing_page_url":"https://research.edgehill.ac.uk/files/37971407/ROLO_trial_JCTS_2021.pdf","pdf_url":"https://research.edgehill.ac.uk/ws/files/37971407/ROLO_trial_JCTS_2021.pdf","source":{"id":"https://openalex.org/S4306402462","display_name":"Edge Hill University Research Information Repository (Edge Hill University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I165525304","host_organization_name":"Edge Hill University","host_organization_lineage":["https://openalex.org/I165525304"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Khoshbin, E, SPENCER, SALLY, Solomon, L, Tang, A, Clark, S, Stokes, E, Wordsworth, S, Dabner, L, Edwards, J, Reeves, B & Rogers, C 2021, 'Is there a renoprotective value to leukodepletion during heart valve surgery? A randomized controlled trial (ROLO)', Journal of Cardiothoracic Surgery, vol. 16, no. 1, 58, pp. 58. https://doi.org/10.1186/s13019-021-01402-4","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:6e11cd54bdcd453085b4d39bdb6f969f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/6e11cd54bdcd453085b4d39bdb6f969f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Cardiothoracic Surgery, Vol 16, Iss 1, Pp 1-10 (2021)","raw_type":"article"},{"id":"pmh:oai:eprints.lancs.ac.uk:153863","doi":null,"is_oa":false,"landing_page_url":"https://eprints.lancs.ac.uk/id/eprint/153863/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401916","display_name":"Lancaster EPrints (Lancaster University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I67415387","host_organization_name":"Lancaster University","host_organization_lineage":["https://openalex.org/I67415387"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1186/s13019-021-01402-4","doi":"https://doi.org/10.1186/s13019-021-01402-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13019-021-01402-4","pdf_url":"https://cardiothoracicsurgery.biomedcentral.com/counter/pdf/10.1186/s13019-021-01402-4","source":{"id":"https://openalex.org/S172459203","display_name":"Journal of Cardiothoracic Surgery","issn_l":"1749-8090","issn":["1749-8090"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cardiothoracic Surgery","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[{"display_name":"Randomized Controlled Trial","id":"https://openalex.org/study-designs/randomized-controlled-trial"},{"display_name":"Clinical Trial","id":"https://openalex.org/study-designs/clinical-trial"}],"awards":[{"id":"https://openalex.org/G1000035702","display_name":"The Renoprotective value of Leukodepletion in Heart Valve surgery: an external feasibility randomised controlled trial (ROLO Trial)","funder_award_id":"PB-PG-0711-25090","funder_id":"https://openalex.org/F4320319990","funder_display_name":"National Institute for Health and Care Research"},{"id":"https://openalex.org/G4396653070","display_name":null,"funder_award_id":"PB-PG-0711-25090","funder_id":"https://openalex.org/F4320335361","funder_display_name":"Research for Patient Benefit Programme"}],"funders":[{"id":"https://openalex.org/F4320319990","display_name":"National Institute for Health and Care Research","ror":"https://ror.org/0187kwz08"},{"id":"https://openalex.org/F4320335361","display_name":"Research for Patient Benefit Programme","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3135596733.pdf","grobid_xml":"https://content.openalex.org/works/W3135596733.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W1594077015","https://openalex.org/W1752304426","https://openalex.org/W1995935151","https://openalex.org/W2007193748","https://openalex.org/W2011482108","https://openalex.org/W2013873227","https://openalex.org/W2031602401","https://openalex.org/W2041014406","https://openalex.org/W2043473335","https://openalex.org/W2051908709","https://openalex.org/W2057571412","https://openalex.org/W2066362593","https://openalex.org/W2071686284","https://openalex.org/W2074773055","https://openalex.org/W2084368529","https://openalex.org/W2085798593","https://openalex.org/W2089226005","https://openalex.org/W2098810075","https://openalex.org/W2104305817","https://openalex.org/W2107030820","https://openalex.org/W2108386246","https://openalex.org/W2111943085","https://openalex.org/W2125178621","https://openalex.org/W2136049487","https://openalex.org/W2136134525","https://openalex.org/W2141413316","https://openalex.org/W2154329627","https://openalex.org/W2159791285","https://openalex.org/W2163972304","https://openalex.org/W2410078976","https://openalex.org/W2417225377","https://openalex.org/W2473786944","https://openalex.org/W2548351969","https://openalex.org/W2682583422","https://openalex.org/W2885131865","https://openalex.org/W4245240996","https://openalex.org/W4321258623"],"related_works":["https://openalex.org/W2098810075","https://openalex.org/W1908569252","https://openalex.org/W137340004","https://openalex.org/W2049185835","https://openalex.org/W2364725916","https://openalex.org/W2463460404","https://openalex.org/W2034189468","https://openalex.org/W1549597182","https://openalex.org/W1975999173","https://openalex.org/W2003948839"],"abstract_inverted_index":{"BACKGROUND:":[0],"Acute":[1],"Kidney":[2,112],"Injury":[3,113],"(AKI)":[4],"adversely":[5],"affects":[6],"outcomes":[7],"after":[8,280,290],"cardiac":[9,47,291],"surgery.":[10,48,265,283],"A":[11],"major":[12],"mediator":[13],"of":[14,19,32,61,92,103,136,141,157,168,240,244,252,264,278,341],"AKI":[15,41,93,169,241,279],"is":[16,51],"the":[17,24,30,59,90,96,134,173,226,236,276,304,316,325,338],"activation":[18],"leukocytes":[20,45],"through":[21,144],"exposure":[22],"to":[23,37,95,187,220,255,286,294],"cardiopulmonary":[25,270],"bypass":[26,36,271],"circuit.":[27],"We":[28],"evaluate":[29],"use":[31,60],"leukodepletion":[33,62,174],"filters":[34],"throughout":[35,68],"protect":[38],"against":[39],"post-operative":[40],"by":[42,194,198,208,303,324,337],"removing":[43],"activated":[44],"during":[46,269],"METHODS:":[49],"This":[50,189,332],"a":[52,64,155,199,209],"single-centre,":[53],"double-blind,":[54],"randomized":[55,151],"controlled":[56],"trial":[57,150,300,321,333],"comparing":[58],"versus":[63,178],"standard":[65],"arterial":[66],"filter":[67,175],"bypass.":[69],"Elective":[70],"adult":[71],"patients":[72],"undergoing":[73],"heart":[74,282],"valve":[75],"surgery":[76,292],"with":[77,154],"or":[78,238],"without":[79],"concomitant":[80],"procedures":[81],"were":[82],"investigated.":[83,296],"The":[84,148,166,299,320],"primary":[85],"clinical":[86,190],"outcome":[87],"measured":[88],"was":[89,170,192,230,301,322,334],"development":[91],"according":[94],"KDIGO":[97],"criteria.":[98],"Secondary":[99],"measures":[100,143],"included":[101],"biomarkers":[102],"renal":[104,288],"tubular":[105],"damage":[106],"(urinary":[107,118],"Retinol":[108],"Binding":[109],"Protein":[110],"and":[111,121,125,139,242,329],"Molecule-1),":[114],"glomerular":[115,202],"kidney":[116],"injury":[117],"Micro":[119],"Albumin":[120],"serum":[122,211],"Cystatin":[123,212],"C)":[124],"urinary":[126],"Neutrophil":[127],"Gelatinase":[128],"Associated":[129],"Lipocalin,":[130],"as":[131,133],"well":[132],"length":[135,243],"hospital":[137,245],"stay":[138],"quality":[140,251],"life":[142,253],"EQ-5D-5L":[145],"questionnaires.":[146],"RESULTS:":[147],"ROLO":[149],"64":[152],"participants":[153],"rate":[156],"recruitment":[158],"higher":[159],"than":[160],"anticipated":[161],"(57%":[162],"achieved,":[163],"40%":[164],"anticipated).":[165],"incidence":[167,237,277],"greater":[171],"in":[172,225,258],"group":[176],"(44%":[177],"23%,":[179],"risk":[180],"difference":[181,215],"21,":[182],"95%":[183,217],"CI":[184,218],"-":[185],"2":[186],"44%).":[188],"finding":[191],"supported":[193,336],"biomarker":[195],"levels":[196,257],"especially":[197],"tendency":[200],"toward":[201],"insult":[203],"at":[204],"48":[205],"h,":[206],"demonstrated":[207],"raised":[210],"C":[213],"(mean":[214],"0.11,":[216],"0.00":[219],"0.23,":[221],"p":[222],"=":[223],"0.068)":[224],"leukodepleted":[227],"group.":[228],"There":[229],"however":[231],"no":[232],"clear":[233],"association":[234],"between":[235],"severity":[239],"stay.":[246],"On":[247],"average,":[248],"health":[249],"related":[250],"returned":[254],"pre-operative":[256],"both":[259],"groups":[260],"within":[261],"3":[262],"months":[263],"CONCLUSIONS:":[266],"Leukocyte":[267],"depletion":[268],"does":[272],"not":[273],"significantly":[274],"reduce":[275],"valvular":[281],"Other":[284],"methods":[285],"ameliorate":[287],"dysfunction":[289],"need":[293],"be":[295],"TRIAL":[297],"REGISTRATION:":[298],"registered":[302],"International":[305],"Standard":[306],"Randomized":[307],"Controlled":[308],"Trial":[309],"Number":[310],"Registry":[311],"ISRCTN42121335":[312],".":[313],"Registered":[314],"on":[315],"18":[317],"February":[318],"2014.":[319],"run":[323],"Bristol":[326],"Clinical":[327],"Trials":[328],"Evaluation":[330],"Unit.":[331],"financially":[335],"National":[339],"Institute":[340],"Health":[342],"Research":[343],"(Research":[344],"for":[345],"Patient":[346],"Benefit),":[347],"award":[348],"ID:":[349],"PB-PG-0711-25,090.":[350]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2021-03-15T00:00:00"}