{"id":"https://openalex.org/W3135445855","doi":"https://doi.org/10.34067/kid.0006912020","title":"The Potential Role of the Gut Microbiota in Kidney Transplantation","display_name":"The Potential Role of the Gut Microbiota in Kidney Transplantation","publication_year":2021,"publication_date":"2021-03-05","ids":{"openalex":"https://openalex.org/W3135445855","doi":"https://doi.org/10.34067/kid.0006912020","mag":"3135445855","pmid":"https://pubmed.ncbi.nlm.nih.gov/35373069","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/8791346"},"language":"en","primary_location":{"id":"doi:10.34067/kid.0006912020","doi":"https://doi.org/10.34067/kid.0006912020","is_oa":true,"landing_page_url":"https://doi.org/10.34067/kid.0006912020","pdf_url":null,"source":{"id":"https://openalex.org/S4210217782","display_name":"Kidney360","issn_l":"2641-7650","issn":["2641-7650"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","oarl","poland-20","russia-white-list-4","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney360","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://doi.org/10.34067/kid.0006912020","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103011103","display_name":"Jennifer Chunyan Huang","orcid":"https://orcid.org/0000-0003-1971-3310","observed_orcids":["https://orcid.org/0000-0003-1971-3310"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Huang","raw_affiliation_strings":["Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, New York","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Thalia Salinas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thalia Salinas","raw_affiliation_strings":["Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, New York","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022980048","display_name":"Lars F. Westblade","orcid":"https://orcid.org/0000-0003-3079-7674","observed_orcids":["https://orcid.org/0000-0003-3079-7674"]},"institutions":[{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lars F. Westblade","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, New York","institution_ids":["https://openalex.org/I4387153466"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101480458","display_name":"John R. Lee","orcid":"https://orcid.org/0000-0002-9612-5742","observed_orcids":["https://orcid.org/0000-0002-9612-5742"]},"institutions":[{"id":"https://openalex.org/I1340179700","display_name":"NewYork\u2013Presbyterian Hospital","ror":"https://ror.org/03gzbrs57","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1340179700"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"id":"https://openalex.org/I4405272987","display_name":"Weill Cornell Medical Center","ror":"https://ror.org/052v90092","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466","https://openalex.org/I4405272987"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John R. Lee","raw_affiliation_strings":["Department of Transplantation Medicine, New York Presbyterian Hospital Weill Cornell Medical Center, New York, New York","Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, New York"],"raw_orcid":"https://orcid.org/0000-0002-9612-5742","affiliations":[{"raw_affiliation_string":"Department of Transplantation Medicine, New York Presbyterian Hospital Weill Cornell Medical Center, New York, New York","institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I4405272987"]},{"raw_affiliation_string":"Division of Nephrology and Hypertension, Department of Medicine, Weill Cornell Medicine, New York, New York","institution_ids":["https://openalex.org/I4387153466"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5101480458"],"corresponding_institution_ids":["https://openalex.org/I1340179700","https://openalex.org/I4387153466","https://openalex.org/I4405272987"],"apc_list":null,"apc_paid":null,"fwci":0.4702,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.53935948,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"2","issue":"5","first_page":"890","last_page":"893"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10373","display_name":"Renal Transplantation Outcomes and Treatments","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2747","display_name":"Transplantation"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.9879999756813049},{"id":"https://openalex.org/keywords/kidney-transplantation","display_name":"kidney transplantation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/infectious-complications","display_name":"infectious complications","score":0.38499999046325684},{"id":"https://openalex.org/keywords/pathobionts","display_name":"pathobionts","score":0.6740000247955322},{"id":"https://openalex.org/keywords/commensal-bacteria","display_name":"commensal bacteria","score":0.8610000014305115},{"id":"https://openalex.org/keywords/microbial-diversity","display_name":"microbial diversity","score":0.6919999718666077},{"id":"https://openalex.org/keywords/end-stage-renal-disease","display_name":"end-stage renal disease","score":0.7269999980926514},{"id":"https://openalex.org/keywords/blautia-producta","display_name":"Blautia producta","score":0.6660000085830688},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.5550000071525574},{"id":"https://openalex.org/keywords/gut-brain-axis","display_name":"gut-brain axis","score":0.39100000262260437},{"id":"https://openalex.org/keywords/gut-liver-axis","display_name":"gut-liver axis","score":0.42800000309944153},{"id":"https://openalex.org/keywords/allograft-rejection","display_name":"allograft rejection","score":0.5960000157356262},{"id":"https://openalex.org/keywords/host-immunity","display_name":"host immunity","score":0.36800000071525574},{"id":"https://openalex.org/keywords/endotoxin","display_name":"endotoxin","score":0.38199999928474426},{"id":"https://openalex.org/keywords/bile-acids","display_name":"bile acids","score":0.46700000762939453}],"concepts":[{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.6201823353767395},{"id":"https://openalex.org/C137923570","wikidata":"https://www.wikidata.org/wiki/Q2121103","display_name":"Fecal bacteriotherapy","level":4,"score":0.5143533945083618},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.4891231656074524},{"id":"https://openalex.org/C2780303639","wikidata":"https://www.wikidata.org/wiki/Q740909","display_name":"Kidney transplantation","level":3,"score":0.4690200388431549},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4682978689670563},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.39972034096717834},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.3638358414173126},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2825573682785034},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.24436551332473755},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1736203134059906},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.059395283460617065},{"id":"https://openalex.org/C2994496256","wikidata":"https://www.wikidata.org/wiki/Q27031090","display_name":"Clostridium difficile","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000069196","descriptor_name":"Gastrointestinal Microbiome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016030","descriptor_name":"Kidney Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064806","descriptor_name":"Dysbiosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.34067/kid.0006912020","doi":"https://doi.org/10.34067/kid.0006912020","is_oa":true,"landing_page_url":"https://doi.org/10.34067/kid.0006912020","pdf_url":null,"source":{"id":"https://openalex.org/S4210217782","display_name":"Kidney360","issn_l":"2641-7650","issn":["2641-7650"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","oarl","poland-20","russia-white-list-4","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney360","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8791346","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8791346","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney360","raw_type":"Text"},{"id":"pmid:35373069","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35373069","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney360","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.34067/kid.0006912020","doi":"https://doi.org/10.34067/kid.0006912020","is_oa":true,"landing_page_url":"https://doi.org/10.34067/kid.0006912020","pdf_url":null,"source":{"id":"https://openalex.org/S4210217782","display_name":"Kidney360","issn_l":"2641-7650","issn":["2641-7650"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","oarl","poland-20","russia-white-list-4","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Kidney360","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6499999761581421}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4519811819","display_name":"Gut Microbiome, Acute Rejection, and Tacrolimus Dosing in Kidney Transplantation","funder_award_id":"K23AI124464","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1715508959","https://openalex.org/W1993830991","https://openalex.org/W2055601570","https://openalex.org/W2073075095","https://openalex.org/W2128769815","https://openalex.org/W2139284253","https://openalex.org/W2141502494","https://openalex.org/W2147212604","https://openalex.org/W2605334862","https://openalex.org/W2613064135","https://openalex.org/W2737487802","https://openalex.org/W2802205848","https://openalex.org/W2885831009","https://openalex.org/W2904430902","https://openalex.org/W2948160364","https://openalex.org/W2951407024","https://openalex.org/W2952018421","https://openalex.org/W2964374228","https://openalex.org/W2969673299","https://openalex.org/W2977037744","https://openalex.org/W2991800219","https://openalex.org/W3000837182","https://openalex.org/W3004123393","https://openalex.org/W3031965887","https://openalex.org/W3081544587","https://openalex.org/W3094664080"],"related_works":["https://openalex.org/W2524151471","https://openalex.org/W2771404430","https://openalex.org/W3205451819","https://openalex.org/W4379537631","https://openalex.org/W2601732801","https://openalex.org/W4313824353","https://openalex.org/W2936852445","https://openalex.org/W4401978369","https://openalex.org/W4317621287","https://openalex.org/W4404375559"],"abstract_inverted_index":{"Introduction":[0],"Through":[1],"use":[2],"of":[3,14,45,76,111,162,203,220,243,264,319,326,334,373,378,434,463,476,542,582,612,630,648,659,661,675,688,690,698,728,773,797,815,817,829,855,886,893,901,916,935,943,950,1011,1040,1046,1055,1067,1072,1080,1110,1119,1152,1158,1213,1219,1228,1230,1237,1253,1277,1301,1306,1368,1376,1378,1397,1428,1502,1532,1540,1553,1558,1567,1573,1580,1591,1610,1630,1653,1659,1684,1716,1736,1758,1795,1803,1810,1870,1883,1918,1977],"high-throughput":[4],"sequencing":[5,647,930,949,1414],"technologies,":[6],"numerous":[7],"studies":[8,266,304,362,448,520,571,713,1270,1362,1728,1776],"have":[9,363,449,521,572,791,994,1033,1363,1817,1964],"revealed":[10,961,1087],"the":[11,15,74,77,109,118,124,146,163,175,200,217,229,256,268,303,316,371,402,419,426,461,503,515,580,585,610,618,649,706,721,726,736,741,762,765,768,771,779,795,827,849,853,884,887,891,902,962,967,973,978,1038,1044,1053,1058,1076,1081,1125,1139,1150,1207,1226,1231,1251,1275,1307,1326,1366,1369,1374,1379,1407,1530,1556,1571,1578,1583,1598,1639,1648,1656,1667,1682,1697,1734,1737,1801,1808,1843,1846,1854,1867,1915,1974],"multifaceted":[12],"role":[13,453,525,793,885,1276,1367,1683,1766],"gut":[16,36,78,119,147,176,188,201,230,257,283,317,345,517,619,686,722,769,787,813,850,888,933,952,979,984,998,1009,1062,1092,1112,1159,1278,1308,1327,1342,1355,1370,1408,1426,1470,1498,1589,1599,1620,1649,1738,1749,1847],"microbiota":[17,79,110,120,148,177,231,284,318,788,851,873,889,1309,1328,1371,1600,1621,1750,1848],"in":[18,24,48,80,96,152,181,192,216,232,255,296,315,418,459,502,514,531,564,584,592,601,617,720,754,767,794,840,858,876,890,957,966,977,980,1075,1124,1138,1149,1265,1285,1324,1359,1372,1385,1459,1517,1542,1555,1570,1582,1587,1638,1673,1767,1836,1887],"host":[19,41],"immunity":[20,42],"and":[21,31,60,90,116,157,186,246,311,332,347,398,428,480,497,589,615,653,701,809,837,874,931,953,1013,1028,1099,1183,1192,1196,1222,1243,1247,1299,1344,1352,1390,1420,1431,1465,1511,1534,1547,1601,1623,1723,1745,1824,1849,1864,1872,1910,1941,1946,1958,1979],"infection,":[22],"resulting":[23],"wide-ranging":[25],"implications":[26],"for":[27,57,358,454,526,669,708,826,989,1007,1022,1168,1202,1250,1281,1292,1807,1832,1860],"patients":[28,297,632,677,756,806,859,958,1239,1560,1614],"with":[29,84,101,241,259,298,324,351,665,695,718,822,940,959,1018,1052,1116,1132,1261,1504,1563,1709,1761,1914],"cancer":[30],"autoimmune":[32],"diseases":[33],"(1).":[34],"The":[35,104,422,786,991,1304,1440,1526,1595,1628,1702,1748],"microbiota\u2019s":[37,1739],"potential":[38,353,1089,1346,1855],"to":[39,63,272,288,484,511,550,560,725,750,778,845,972,1015,1036,1225,1273,1311,1348,1497,1696,1731,1779,1789,1856,1966],"influence":[40],"may":[43,578,789,866,993,1064,1643,1799,1825],"be":[44,868,1016,1065,1515,1645],"particular":[46],"importance":[47],"solid":[49],"organ":[50],"transplant":[51,82,134,155,184,234,270,289,321,420,606,878,908,919,1084,1185,1287,1387,1400,1523,1545,1575,1613,1641,1763,1838,1862],"recipients,":[52,83,135,290,920,1401,1863],"given":[53],"this":[54,66,193,282,681,752,1443],"population\u2019s":[55],"risk":[56,668,707,825,854,1021,1291],"allograft":[58],"rejection":[59],"increased":[61,215,1008],"susceptibility":[62],"infections.":[64,799,834,1296,1811],"In":[65,627,913,1177,1234,1393,1812],"perspective":[67],"article,":[68],"we":[69],"present":[70],"recent":[71,862,1608],"work":[72,337,863,1333,1676,1970],"on":[73,87,624,1741,1842],"effect":[75,623,1740],"kidney":[81,133,154,183,233,269,320,877,907,918,1083,1184,1286,1386,1399,1522,1544,1574,1640,1762,1837,1861],"a":[85,159,205,250,273,386,431,438,452,524,565,621,628,656,666,685,792,812,823,869,914,987,1003,1019,1088,1181,1235,1262,1394,1422,1450,1476,1493,1607,1756,1787],"focus":[86],"infectious":[88,359,625,856,1170,1283,1791],"complications":[89,857,1171,1284,1759,1869],"immunosuppressive":[91,1383,1483,1636,1829,1850,1858],"drug":[92,1330,1357,1637,1851],"metabolism.":[93,1331],"Gut":[94,330,587,835,1297],"Microbiota":[95,331,588,836,1298],"Kidney":[97,841],"Transplant":[98,597,842],"Recipients":[99,103,598,843],"Compared":[100],"Nontransplant":[102],"Human":[105],"Microbiome":[106],"Project":[107],"characterized":[108],"242":[112],"healthy":[113,244,260,327],"human":[114,516,1341],"volunteers":[115],"found":[117,187,654,683,932,1353,1458,1489,1548],"was":[121,663,693,820,937,969,1002,1049,1114,1209,1259,1445,1971],"dominated":[122],"by":[123,138,190,366,680,745,1334,1453,1647,1677,1973],"phylum":[125,164,206],"Bacteroidetes":[126],"(2).":[127],"This":[128,1969],"is":[129,279,286,294,899,1320,1480,1492,1593,1603,1751],"distinctly":[130],"different":[131],"from":[132,740,781,1101,1134,1521,1820,1899,1929,1951],"as":[136,212,300,986,1163,1720,1754,1786],"evidenced":[137],"several":[139,236,981],"studies.":[140],"Fricke":[141],"et":[142,171,196,225,382,467,536,636,747,801,881,1136,1336,1403,1455,1679],"al.":[143,172,197,226,383,468,537,637,748,802,882,1137,1337,1404,1456,1680],"(3)":[144],"evaluated":[145,174,1339,1406],"using":[149,178,393,643,926,1410],"rectal":[150],"swabs":[151],"61":[153],"recipients":[156,185,235,322,608,909,1085,1288,1524,1546,1576],"reported":[158,399,429,539,1421,1704],"high":[160,1290],"proportion":[161],"Firmicutes":[165,191],"rather":[166],"than":[167,478,1173,1467,1484],"Bacteroidetes.":[168],"Similarly,":[169],"Lee":[170,195,1402,1877],"(4)":[173],"fecal":[179,657,924,1164,1518],"specimens":[180,642,925,955,1519],"26":[182],"dominance":[189],"cohort.":[194],"further":[198,424,489,1528,1775],"noticed":[199],"abundance":[202,475,658,687,814,934,1045,1054,1108,1427],"Proteobacteria,":[204],"that":[207,242,325,354,389,400,413,430,442,470,491,540,655,684,702,715,811,847,906,1060,1094,1462,1479,1490,1586,1689,1705],"includes":[208],"Gram-negative":[209,464,500,691,699,709],"bacteria":[210,346,369,501,692,819,985,1048,1063,1093,1113,1343,1471,1708],"such":[211,1162,1719],"Escherichia":[213,936,944],"coli,":[214],"first":[218,1126],"couple":[219],"weeks":[221],"after":[222,238,911,1129,1418,1438,1537],"transplantation.":[223,912,1439],"Swarte":[224],"(5)":[227],"studied":[228,385],"years":[237,1128],"transplantation":[239,1166,1419],"compared":[240,258,267,323],"controls":[245,479],"observed":[247,469],"they":[248,731,921],"had":[249,473,1187,1244],"significantly":[251],"lower":[252,312,830],"microbial":[253,313,1165,1797],"diversity":[254,314,1622],"controls.":[261,328],"However,":[262,1449],"none":[263],"these":[265,570,1047,1796],"cohort":[271],"nontransplant,":[274],"ESKD":[275,299],"cohort,":[276],"so":[277],"it":[278,293],"unclear":[280],"whether":[281,735],"signature":[285],"unique":[287,1496],"or":[291],"if":[292],"pervasive":[295],"well.":[301],"Nevertheless,":[302],"do":[305],"find":[306],"an":[307,340,394,411,507,1097,1617,1687,1821,1895,1905],"altered":[308],"species":[309],"composition":[310],"Commensal":[329],"Inhibition":[333],"Pathobionts":[335],"Recent":[336,519,599,1332,1361,1675],"has":[338,620,1315,1662,1669,1770,1853],"shown":[339,1035],"intricate":[341],"relationship":[342,870,1596],"between":[343,871,1091,1424,1597,1619,1845],"commensal":[344,368,576,613,872,1469,1783],"pathobionts,":[348],"resident":[349],"microbes":[350],"pathogenic":[352],"are":[355,1143,1271,1729,1777],"often":[356],"responsible":[357],"complications.":[360,1792],"Several":[361],"elucidated":[364,1365],"mechanisms":[365],"which":[367,545,898,1032,1155],"inhibit":[370,494,579,1037],"growth":[372,445,462,581,1039,1074],"common":[374,499,904],"pathobionts":[375,583,616,719],"via":[376,554,1070],"secretion":[377],"specific":[379,432],"metabolites.":[380],"Caballero":[381],"(6)":[384],"four-bacteria":[387],"consortium":[388,403],"included":[390],"Blautia":[391,435],"producta":[392,436],"antibiotic-treated":[395],"mouse":[396,566],"model":[397],"administering":[401],"provided":[404],"colonization":[405],"resistance":[406,559],"against":[407],"vancomycin-resistant":[408],"Enterococcus":[409,662,1194,1220],"(VRE),":[410],"organism":[412],"commonly":[414,1381,1634],"causes":[415],"nosocomial":[416],"infections":[417,875,905,1104,1123,1769],"population.":[421,1141],"group":[423,682,763,992,1527,1703],"investigated":[425,804,883,1529,1681],"mechanism":[427,1441,1668],"strain":[433,965,976],"produces":[437],"lantibiotic":[439],"antimicrobial":[440],"peptide":[441],"inhibits":[443],"VRE":[444,670],"(7).":[446],"Other":[447],"also":[450,522,790,867,995,1086,1218,1488,1615,1644,1826],"established":[451,523,574],"short-chain":[455],"fatty":[456],"acids":[457,549,553],"(SCFAs)":[458],"inhibiting":[460,532],"bacteria.":[465],"Sorbara":[466],"ampicillin-treated":[471],"mice":[472],"less":[474,1482],"SCFAs":[477,492],"were":[481,775,1241],"more":[482,1466],"susceptible":[483],"carbapenem-resistant":[485],"Klebsiella":[486],"pneumoniae.":[487],"They":[488,1487],"showed":[490,1616],"directly":[493,1472,1827],"K.":[495],"pneumoniae":[496],"other":[498,1172,1912],"Enterobacteriaceae":[504,1023,1041,1068,1073],"family":[505],"at":[506,1289,1415,1435],"acidic":[508],"pH,":[509],"similar":[510,777,971],"physiologic":[512],"concentrations":[513],"(8).":[518,1042],"secondary":[527,551],"bile":[528,548,552],"acid":[529,1694,1700],"formation":[530],"Clostridioides":[533],"difficile.":[534],"Buffie":[535],"(9)":[538],"introduction":[541],"Clostridium":[543],"scindens,":[544],"converts":[546],"primary":[547],"7":[555],"alpha-dehydroxylase,":[556],"provides":[557],"enhanced":[558],"C.":[561,1174,1189,1204,1214,1255],"difficile":[562,1175,1190,1205,1215,1256,1294],"infection":[563,896,1191,1216,1822,1871],"model.":[567],"Taken":[568],"together,":[569],"elegantly":[573],"how":[575,1325,1782],"organisms":[577,614,1784],"gut.":[586,742,1077],"Infectious":[590,838,1980],"Complications":[591,839],"Allogeneic":[593],"Hematopoietic":[594],"Stem":[595],"Cell":[596],"investigations":[600],"allogeneic":[602],"hematopoietic":[603],"stem":[604],"cell":[605],"(HSCT)":[607],"show":[609],"balance":[611],"significant":[622,1263],"outcomes.":[626],"study":[629,674,744,915,1236,1396,1452,1609],"94":[631],"receiving":[633,678,757,807,860,1891,1926,1948],"HSCT,":[634,808,861],"Taur":[635],"(10)":[638],"profiled":[639,923],"serial":[640],"stool":[641,1572],"16S":[644,927,1411],"rRNA":[645,928,1412],"gene":[646,929,1413],"V4\u2013V5":[650],"hypervariable":[651],"region":[652],">30%":[660,689],"associated":[664,694,821,939,1017,1115,1260,1760],"future":[667,696,941],"bacteremia.":[671],"A":[672,743,1106],"follow-up":[673,1451],"696":[676],"HSCT":[679,1140],"development":[697,727,772,796,828,892,942,1118,1802],"bacteremia,":[700],"fluoroquinolone":[703],"prophylaxis":[704],"decreased":[705,824,1020,1117],"bacteremia":[710,774,1195,1221],"(11).":[711],"These":[712],"suggest":[714,1156],"intestinal":[716],"domination":[717],"can":[723,1514,1690],"lead":[724],"sepsis;":[729],"however,":[730],"did":[732,1507],"not":[733,1211,1446,1508,1670],"evaluate":[734,751],"bloodstream":[737],"isolates":[738,780],"came":[739],"Tamburini":[746],"sought":[749],"concept":[753,1059],"32":[755],"HSCT.":[758],"Using":[759],"strain-level":[760],"analysis,":[761],"determined":[764],"strains":[766],"before":[770],"most":[776,903,970,1380],"subsequent":[782],"blood":[783,1557,1584],"cultures":[784],"(12).":[785],"viral":[798,833,1103,1122],"Haak":[800,1135],"(13)":[803],"360":[805],"noted":[810],">1%":[816,1109],"butyrate-producing":[818,1111],"respiratory":[831,1102,1120],"tract":[832,895,1121],"Similar":[844],"reports":[846,1890,1903,1911,1925,1947],"demonstrate":[848],"modulate":[852],"suggests":[864,1585],"there":[865,1001],"recipients.":[879,1764,1839],"Magruder":[880],"urinary":[894],"(UTI),":[897],"one":[900,1178],"encounter":[910],"168":[917,1082],"serially":[922],"independently":[938],"UTI":[945,960,1024,1266],"(14).":[946],"Detailed":[947],"metagenomic":[948],"paired":[951],"urine":[954,968],"collected":[956],"E.":[963,974],"coli":[964,975],"patients,":[982],"supporting":[983,1057],"source":[988],"UTIs.":[990],"identified":[996],"protective":[997,1066,1818],"bacteria;":[999],"specifically,":[1000],"trend":[1004],"toward":[1005],"significance":[1006],"abundances":[1010],"Faecalibacterium":[1012,1027,1429],"Romboutsia":[1014],"(15).":[1025],"Interestingly,":[1026],"Rombousia":[1029],"produce":[1030,1095,1509],"SCFAs,":[1031],"been":[1034,1316,1663,1671,1771],"Furthermore,":[1043],"negatively":[1050],"correlated":[1051],"Enterobacteriaceae,":[1056],"SCFA-producing":[1061],"UTIs":[1069,1197,1246],"inhibition":[1071],"Further":[1078,1269,1727,1793,1840],"analysis":[1079],"association":[1090,1444,1618],"butyrate,":[1096],"SCFA,":[1098],"protection":[1100],"(16).":[1105],"relative":[1107],"2":[1127],"transplantation,":[1130],"consistent":[1131],"data":[1133],"There":[1142,1319],"now":[1144,1321],"limited":[1145],"data,":[1146],"albeit":[1147],"mostly":[1148],"form":[1151,1658],"case":[1153,1232],"reports,":[1154],"efficacy":[1157],"microbiota\u2013based":[1160,1279],"therapies,":[1161],"(FMT),":[1167],"preventing":[1169,1282],"infection.":[1176],"patient":[1179,1208],"study,":[1180],"heart":[1182,1612],"recipient":[1186],"recurrent":[1188,1193,1203,1245,1254,1295],"(17).":[1198],"After":[1199],"undergoing":[1200],"FMT":[1201,1249,1258],"infections,":[1206,1257],"free":[1210],"only":[1212],"but":[1217,1550,1666,1774],"UTIs,":[1223],"up":[1224],"time":[1227],"publication":[1229],"report.":[1233],"eight":[1238],"who":[1240],"nontransplant":[1242],"received":[1248],"indication":[1252],"decrease":[1264],"recurrence":[1267],"(18).":[1268],"needed":[1272,1730,1778],"investigate":[1274],"therapies":[1280,1859],"non-C.":[1293],"Metabolism":[1300],"Immunosuppressive":[1302],"Medications":[1303],"alteration":[1305],"due":[1310],"medications,":[1312],"including":[1313],"antibiotics,":[1314],"extensively":[1317],"described.":[1318],"growing":[1322],"interest":[1323],"affects":[1329],"Zimmermann":[1335],"(19)":[1338],"76":[1340],"their":[1345,1564],"ability":[1347],"metabolize":[1349,1473,1828],"271":[1350],"drugs,":[1351],"considerable":[1354],"microbiota\u2013mediated":[1356],"metabolism":[1358,1375,1590,1629,1744,1852],"vitro.":[1360],"specifically":[1364],"influencing":[1373,1755],"two":[1377],"used":[1382,1635],"medications":[1384,1830],"recipients:":[1388],"tacrolimus":[1389,1433,1474,1503,1536,1541,1592,1602,1624],"mycophenolate":[1391,1631,1717,1742],"mofetil.":[1392],"pilot":[1395],"19":[1398],"(20)":[1405],"microbiome":[1409],"1":[1416,1436],"week":[1417],"correlation":[1423],"higher":[1425,1432],"prausnitzii":[1430,1464],"dosage":[1434],"month":[1437],"behind":[1442],"initially":[1447],"understood.":[1448],"Guo":[1454],"(21)":[1457],"vitro":[1460],"evidence":[1461],"F.":[1463],"20":[1468],"into":[1475],"metabolite,":[1477],"M1,":[1478,1510],"15-fold":[1481],"parent":[1485,1535],"tacrolimus.":[1486],"M1":[1491,1512,1533,1554,1568,1581],"bacterial":[1494,1685,1815],"metabolite":[1495],"bacteria,":[1499],"because":[1500,1606],"incubation":[1501],"hepatic":[1505],"microsomes":[1506],"production":[1513,1569],"detected":[1516],"obtained":[1520],"(21).":[1525],"pharmacokinetics":[1531],"oral":[1538],"administration":[1539],"ten":[1543],"detectable":[1549],"variable":[1551],"levels":[1552],"all":[1559],"(22).":[1561],"Along":[1562],"previous":[1565],"finding":[1566],"(21),":[1577],"detection":[1579],"vivo":[1588],"present.":[1594],"likely":[1604],"generalizable,":[1605],"24":[1611],"dosing":[1625],"requirements":[1626],"(23).":[1627],"mofetil,":[1632,1661,1718],"another":[1633],"population,":[1642],"influenced":[1646],"microbiota.":[1650],"Enterohepatic":[1651],"recirculation":[1652],"mycophenolic":[1654,1660,1693,1699],"acid,":[1655],"active":[1657,1698],"described":[1664],"(24)":[1665],"explored":[1672],"detail.":[1674],"Taylor":[1678],"beta-glucuronidase,":[1686],"enzyme":[1688],"convert":[1691],"glucuronidated":[1692],"back":[1695],"(25).":[1701],"vancomycin":[1706],"eliminated":[1707],"beta-glucuronidase":[1710],"activity,":[1711],"thereby":[1712,1865],"decreasing":[1713],"side":[1714],"effects":[1715],"weight":[1721],"loss":[1722],"colonic":[1724],"inflammation":[1725],"(26).":[1726],"better":[1732,1780],"understand":[1733,1781],"extent":[1735],"mofetil\u2019s":[1743],"toxicity.":[1746],"Conclusions":[1747],"increasingly":[1752],"recognized":[1753],"variety":[1757],"Its":[1765],"post-transplant":[1768,1868],"recently":[1772],"suggested,":[1773],"function":[1785,1835],"community":[1788],"combat":[1790],"characterization":[1794],"consortia":[1798],"allow":[1800],"defined":[1804],"microbiota-based":[1805],"treatments":[1806],"prevention":[1809],"addition,":[1813],"some":[1814],"subsets":[1816],"properties":[1819],"standpoint":[1823],"essential":[1831],"preserving":[1833],"graft":[1834,1873],"research":[1841,1892,1897,1927],"dynamics":[1844],"personalize":[1857],"reduce":[1866],"loss.":[1874],"Disclosures":[1875],"J.R.":[1876,1987],"holds":[1878],"US-2020-0048713-A1":[1879],"patent":[1880],"titled":[1881],"\u201cMethods":[1882],"Detecting":[1884],"Cell-Free":[1885],"DNA":[1886],"Biological":[1888],"Samples;\u201d":[1889],"support":[1893,1928],"under":[1894],"investigator-initiated":[1896],"grant":[1898,1985],"BioFire":[1900,1936],"Diagnostics,":[1901,1931,1937,1940],"LLC;":[1902],"being":[1904],"Academic":[1906],"Editor,":[1907],"PLOS":[1908],"ONE;":[1909],"interests/relationships":[1913],"American":[1916],"Society":[1917],"Nephrology":[1919],"Career":[1920],"Advancement":[1921],"Committee.":[1922],"L.":[1923],"Westblade":[1924],"Accelerate":[1930],"Inc.,":[1932,1945,1955],"Affinity":[1933],"Biosensors,":[1934],"LLC,":[1935,1938],"Hardy":[1939],"Roche":[1942,1952],"Molecular":[1943,1953],"Systems,":[1944,1954],"consulting":[1949],"fees":[1950],"Shionogi,":[1956],"Inc,":[1957],"Talis":[1959],"Biomedical.":[1960],"All":[1961],"remaining":[1962],"authors":[1963],"nothing":[1965],"disclose.":[1967],"Funding":[1968],"supported":[1972],"National":[1975],"Institute":[1976],"Allergy":[1978],"Diseases":[1981],"K23":[1982],"AI":[1983],"124464":[1984],"(to":[1986],"Lee).":[1988]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2021-03-15T00:00:00"}
