{"id":"https://openalex.org/W3135214901","doi":"https://doi.org/10.3389/fonc.2021.638223","title":"Circulating Genetically Abnormal Cells Add Non-Invasive Diagnosis Value to Discriminate Lung Cancer in Patients With Pulmonary Nodules \u226410 mm","display_name":"Circulating Genetically Abnormal Cells Add Non-Invasive Diagnosis Value to Discriminate Lung Cancer in Patients With Pulmonary Nodules \u226410 mm","publication_year":2021,"publication_date":"2021-03-11","ids":{"openalex":"https://openalex.org/W3135214901","doi":"https://doi.org/10.3389/fonc.2021.638223","mag":"3135214901","pmid":"https://pubmed.ncbi.nlm.nih.gov/33777797","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7991838"},"language":"en","primary_location":{"id":"doi:10.3389/fonc.2021.638223","doi":"https://doi.org/10.3389/fonc.2021.638223","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2021.638223","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2021.638223/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fonc.2021.638223/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064607629","display_name":"Maosong Ye","orcid":"https://orcid.org/0000-0002-9821-2575","observed_orcids":["https://orcid.org/0000-0002-9821-2575"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Maosong Ye","raw_affiliation_strings":["Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112596325","display_name":"Xiaoxuan Zheng","orcid":"https://orcid.org/0009-0006-5986-0365","observed_orcids":["https://orcid.org/0009-0006-5986-0365"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2802608112","display_name":"Shanghai Chest Hospital","ror":"https://ror.org/03fjc3817","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802608112"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoxuan Zheng","raw_affiliation_strings":["Department of Respiratory Endoscopy, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China","Department of Respiratory and Critical Care Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Endoscopy, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2802608112"]},{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2802608112"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100348109","display_name":"Xin Ye","orcid":"https://orcid.org/0000-0002-4906-7746","observed_orcids":["https://orcid.org/0000-0002-4906-7746","https://orcid.org/0000-0002-1239-345X"]},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Ye","raw_affiliation_strings":["Joint Research Center of Liquid Biopsy in Guangdong, Hong Kong, and Macao, Zhuhai, China","School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China","Zhuhai Sanmed Biotech Ltd., Zhuhai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Research Center of Liquid Biopsy in Guangdong, Hong Kong, and Macao, Zhuhai, China","institution_ids":[]},{"raw_affiliation_string":"School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China","institution_ids":["https://openalex.org/I90610280"]},{"raw_affiliation_string":"Zhuhai Sanmed Biotech Ltd., Zhuhai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061115598","display_name":"Juncheng Zhang","orcid":"https://orcid.org/0000-0002-1479-1793","observed_orcids":["https://orcid.org/0000-0002-1479-1793","https://orcid.org/0009-0003-1045-5711","https://orcid.org/0009-0004-7858-4226"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Juncheng Zhang","raw_affiliation_strings":["Joint Research Center of Liquid Biopsy in Guangdong, Hong Kong, and Macao, Zhuhai, China","Zhuhai Sanmed Biotech Ltd., Zhuhai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Research Center of Liquid Biopsy in Guangdong, Hong Kong, and Macao, Zhuhai, China","institution_ids":[]},{"raw_affiliation_string":"Zhuhai Sanmed Biotech Ltd., Zhuhai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035127721","display_name":"Chuoji Huang","orcid":"https://orcid.org/0000-0002-3370-5002","observed_orcids":["https://orcid.org/0000-0002-3370-5002"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chuoji Huang","raw_affiliation_strings":["Joint Research Center of Liquid Biopsy in Guangdong, Hong Kong, and Macao, Zhuhai, China","Zhuhai Sanmed Biotech Ltd., Zhuhai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Research Center of Liquid Biopsy in Guangdong, Hong Kong, and Macao, Zhuhai, China","institution_ids":[]},{"raw_affiliation_string":"Zhuhai Sanmed Biotech Ltd., Zhuhai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100629534","display_name":"Zilong Liu","orcid":"https://orcid.org/0000-0003-3637-1586","observed_orcids":["https://orcid.org/0000-0003-3637-1586","https://orcid.org/0009-0009-5054-7593"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zilong Liu","raw_affiliation_strings":["Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102735608","display_name":"Meng Huang","orcid":"https://orcid.org/0009-0008-5251-3058","observed_orcids":["https://orcid.org/0009-0008-5251-3058","https://orcid.org/0000-0003-1666-2853"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Meng Huang","raw_affiliation_strings":["Joint Research Center of Liquid Biopsy in Guangdong, Hong Kong, and Macao, Zhuhai, China","Zhuhai Sanmed Biotech Ltd., Zhuhai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Research Center of Liquid Biopsy in Guangdong, Hong Kong, and Macao, Zhuhai, China","institution_ids":[]},{"raw_affiliation_string":"Zhuhai Sanmed Biotech Ltd., Zhuhai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015084255","display_name":"Xianjun Fan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xianjun Fan","raw_affiliation_strings":["Joint Research Center of Liquid Biopsy in Guangdong, Hong Kong, and Macao, Zhuhai, China","Zhuhai Sanmed Biotech Ltd., Zhuhai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Research Center of Liquid Biopsy in Guangdong, Hong Kong, and Macao, Zhuhai, China","institution_ids":[]},{"raw_affiliation_string":"Zhuhai Sanmed Biotech Ltd., Zhuhai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020781676","display_name":"Yanci Chen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yanci Chen","raw_affiliation_strings":["Joint Research Center of Liquid Biopsy in Guangdong, Hong Kong, and Macao, Zhuhai, China","Zhuhai Sanmed Biotech Ltd., Zhuhai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Joint Research Center of Liquid Biopsy in Guangdong, Hong Kong, and Macao, Zhuhai, China","institution_ids":[]},{"raw_affiliation_string":"Zhuhai Sanmed Biotech Ltd., Zhuhai, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029887247","display_name":"Botao Xiao","orcid":"https://orcid.org/0000-0002-0785-1006","observed_orcids":["https://orcid.org/0000-0002-0785-1006"]},"institutions":[{"id":"https://openalex.org/I90610280","display_name":"South China University of Technology","ror":"https://ror.org/0530pts50","country_code":"CN","type":"education","lineage":["https://openalex.org/I90610280"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Botao Xiao","raw_affiliation_strings":["School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biology and Biological Engineering, South China University of Technology, Guangzhou, China","institution_ids":["https://openalex.org/I90610280"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082268791","display_name":"Jiayuan Sun","orcid":"https://orcid.org/0000-0003-3158-3256","observed_orcids":["https://orcid.org/0000-0003-3158-3256"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2802608112","display_name":"Shanghai Chest Hospital","ror":"https://ror.org/03fjc3817","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802608112"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jiayuan Sun","raw_affiliation_strings":["Department of Respiratory Endoscopy, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China","Department of Respiratory and Critical Care Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Respiratory Endoscopy, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2802608112"]},{"raw_affiliation_string":"Department of Respiratory and Critical Care Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2802608112"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024974078","display_name":"Chunxue Bai","orcid":"https://orcid.org/0000-0001-5798-3130","observed_orcids":["https://orcid.org/0000-0001-5798-3130"]},"institutions":[{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chunxue Bai","raw_affiliation_strings":["Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China","institution_ids":["https://openalex.org/I24943067","https://openalex.org/I4210127074"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5024974078","https://openalex.org/A5082268791"],"corresponding_institution_ids":["https://openalex.org/I183067930","https://openalex.org/I24943067","https://openalex.org/I2802608112","https://openalex.org/I4210127074"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":4.0447,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.94914039,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"11","issue":null,"first_page":"638223","last_page":"638223"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-cancer","display_name":"lung cancer","score":0.5630000233650208},{"id":"https://openalex.org/keywords/non-invasive-diagnosis","display_name":"non-invasive diagnosis","score":0.8379999995231628},{"id":"https://openalex.org/keywords/low-dose-computed-tomography","display_name":"low-dose CT","score":0.8489999771118164},{"id":"https://openalex.org/keywords/fluorescence-in-situ-hybridization","display_name":"fluorescence in situ hybridization","score":0.8360000252723694},{"id":"https://openalex.org/keywords/benign-lung-disease","display_name":"benign lung disease","score":0.5040000081062317},{"id":"https://openalex.org/keywords/diagnostic-accuracy","display_name":"diagnostic accuracy","score":0.6320000290870667},{"id":"https://openalex.org/keywords/nodule-characteristics","display_name":"nodule characteristics","score":0.48899999260902405},{"id":"https://openalex.org/keywords/lung-cancer-screening","display_name":"lung cancer screening","score":0.5410000085830688}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8726679086685181},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.8173577785491943},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.5764546394348145},{"id":"https://openalex.org/C2776731575","wikidata":"https://www.wikidata.org/wiki/Q2916245","display_name":"Nodule (geology)","level":2,"score":0.5593060255050659},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.5298418998718262},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.48695099353790283},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4730229377746582},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.47096091508865356},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.45156410336494446},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.4221653938293457},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.4202854335308075},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3644229769706726},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.353858083486557},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3389/fonc.2021.638223","doi":"https://doi.org/10.3389/fonc.2021.638223","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2021.638223","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2021.638223/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},{"id":"pmid:33777797","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33777797","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in oncology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7991838","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC7991838/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Front Oncol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:10e13817ffa74410b2537c329f896668","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/10e13817ffa74410b2537c329f896668","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Oncology, Vol 11 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fonc.2021.638223","doi":"https://doi.org/10.3389/fonc.2021.638223","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2021.638223","pdf_url":"https://www.frontiersin.org/articles/10.3389/fonc.2021.638223/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3135214901.pdf","grobid_xml":"https://content.openalex.org/works/W3135214901.grobid-xml"},"referenced_works_count":26,"referenced_works":["https://openalex.org/W72324499","https://openalex.org/W130099911","https://openalex.org/W1921769911","https://openalex.org/W1967518090","https://openalex.org/W1975359074","https://openalex.org/W1992099473","https://openalex.org/W2012772431","https://openalex.org/W2014556369","https://openalex.org/W2050105240","https://openalex.org/W2067225660","https://openalex.org/W2101500128","https://openalex.org/W2114374668","https://openalex.org/W2121535138","https://openalex.org/W2133153294","https://openalex.org/W2141140178","https://openalex.org/W2141490694","https://openalex.org/W2185440705","https://openalex.org/W2288157239","https://openalex.org/W2328176404","https://openalex.org/W2337016604","https://openalex.org/W2614322702","https://openalex.org/W2784114724","https://openalex.org/W2889630644","https://openalex.org/W2953320980","https://openalex.org/W2992931937","https://openalex.org/W3016692621"],"related_works":["https://openalex.org/W3029733777","https://openalex.org/W4223423331","https://openalex.org/W2981895970","https://openalex.org/W4376224244","https://openalex.org/W3156785895","https://openalex.org/W3126502243","https://openalex.org/W4399651604","https://openalex.org/W3009308132","https://openalex.org/W4379383821","https://openalex.org/W2953904460"],"abstract_inverted_index":{"Background":[0],"Lung":[1],"cancer":[2,37,52,101,121,142,166,287],"screening":[3],"using":[4,91,122],"low-dose":[5],"computed":[6],"tomography":[7],"(LDCT)":[8],"often":[9],"leads":[10],"to":[11,34,83,115,134,246,260],"unnecessary":[12],"biopsy":[13],"because":[14],"of":[15,47,119,138,156],"the":[16,44,117,136,153,160,209,217,227,247,261],"low":[17],"specificity":[18,163],"among":[19],"patients":[20,54,66,96,147,289],"with":[21,55,67,263,290],"pulmonary":[22,57,68,291],"nodules":[23,58,69,292],"\u226410":[24,59,70,293],"mm.":[25,60,294],"Circulating":[26],"genetically":[27],"abnormal":[28],"cells":[29],"(CACs)":[30],"can":[31],"be":[32],"used":[33,133],"discriminate":[35],"lung":[36,40,51,100,120,141,165,286],"from":[38,80],"benign":[39,103],"disease.":[41],"To":[42],"examine":[43],"diagnostic":[45,282],"value":[46,155,283],"CACs":[48,88,123,139,157,200,229,253,265,278],"in":[49,78,190,216,284],"detecting":[50,285],"for":[53,140,164,214,288],"malignant":[56],"Methods":[61],"In":[62],"this":[63],"prospective":[64],"study,":[65],"mm":[71],"who":[72],"were":[73,86,89,97,113,148,167],"detected":[74,90],"at":[75],"four":[76],"hospitals":[77],"China":[79],"January":[81,84],"2019":[82],"2020":[85],"included.":[87],"fluorescence":[92],"in-situ":[93],"hybridization.":[94],"All":[95],"confirmed":[98],"as":[99],"or":[102,254],"disease":[104],"by":[105],"further":[106],"histopathological":[107],"examination.":[108],"Multivariable":[109],"logistic":[110,222],"regression":[111,223],"models":[112,248],"established":[114],"detect":[116],"presence":[118],"and":[124,150,162,169,199,233,258,266],"other":[125,234,255,267],"associated":[126],"characteristics.":[127],"Receiver":[128],"operating":[129],"characteristic":[130],"analysis":[131],"was":[132,158,244],"evaluate":[135],"performance":[137],"diagnosis.":[143],"Results":[144],"Overall,":[145],"125":[146],"included":[149,226],"analyzed.":[151],"When":[152],"cutoff":[154],">2,":[159],"sensitivity":[161],"70.5":[168],"86.4%.":[170],"Male":[171],"(OR":[172,181,193,202],"=":[173,176,182,185,194,197,203,238,242,271,275],"0.330,":[174],"P":[175,184,196,205,210],"0.005),":[177],"maximum":[178,187],"solid":[179],"nodule":[180,188],"2.362,":[183],"0.089),":[186],"located":[189],"upper":[191],"lobe":[192],"3.867,":[195],"0.001),":[198],">2":[201],"18.525,":[204],"<":[206,211],"0.001)":[207],"met":[208],"0.10":[212],"criterion":[213],"inclusion":[215],"multivariable":[218,221],"models.":[219],"The":[220],"model":[224,262],"that":[225,249],"dichotomized":[228,252],"(>2":[230],"vs.":[231],"\u22642)":[232],"clinical":[235,256,268],"factors":[236,257,269],"(AUC":[237,270],"0.907,":[239],"95%":[240,273],"CI":[241,274],"0.842\u20130.951)":[243],"superior":[245],"only":[250],"considered":[251],"similar":[259],"numerical":[264],"0.913,":[272],"0.850\u20130.956).":[276],"Conclusion":[277],"presented":[279],"a":[280],"significant":[281]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":6}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2021-03-15T00:00:00"}