{"id":"https://openalex.org/W3135210880","doi":"https://doi.org/10.3390/ijms22052716","title":"Perlecan in Pericellular Mechanosensory Cell-Matrix Communication, Extracellular Matrix Stabilisation and Mechanoregulation of Load-Bearing Connective Tissues","display_name":"Perlecan in Pericellular Mechanosensory Cell-Matrix Communication, Extracellular Matrix Stabilisation and Mechanoregulation of Load-Bearing Connective Tissues","publication_year":2021,"publication_date":"2021-03-08","ids":{"openalex":"https://openalex.org/W3135210880","doi":"https://doi.org/10.3390/ijms22052716","mag":"3135210880","pmid":"https://pubmed.ncbi.nlm.nih.gov/33800241","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7962540"},"language":"en","primary_location":{"id":"doi:10.3390/ijms22052716","doi":"https://doi.org/10.3390/ijms22052716","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms22052716","pdf_url":"https://www.mdpi.com/1422-0067/22/5/2716/pdf?version=1615201029","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/1422-0067/22/5/2716/pdf?version=1615201029","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090627153","display_name":"Farshid Guilak","orcid":"https://orcid.org/0000-0001-7380-0330","observed_orcids":["https://orcid.org/0000-0001-7380-0330"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I4210158667","display_name":"Shriners Hospitals for Children - St. Louis","ror":"https://ror.org/049mpkx27","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210144267","https://openalex.org/I4210158667"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Farshid Guilak","raw_affiliation_strings":["Department of Orthopaedic Surgery, Washington University, St. Louis, MO 63110, USA","Shriners Hospitals for Children\u2014St. Louis, St. Louis, MO 63110, USA"],"raw_orcid":"https://orcid.org/0000-0001-7380-0330","affiliations":[{"raw_affiliation_string":"Department of Orthopaedic Surgery, Washington University, St. Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Shriners Hospitals for Children\u2014St. Louis, St. Louis, MO 63110, USA","institution_ids":["https://openalex.org/I4210158667"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061677318","display_name":"Anthony J. Hayes","orcid":"https://orcid.org/0000-0002-2918-3723","observed_orcids":["https://orcid.org/0000-0002-2918-3723"]},"institutions":[{"id":"https://openalex.org/I79510175","display_name":"Cardiff University","ror":"https://ror.org/03kk7td41","country_code":"GB","type":"education","lineage":["https://openalex.org/I79510175"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anthony J. Hayes","raw_affiliation_strings":["Bioimaging Research Hub, Cardiff School of Biosciences, Cardiff University, Cardiff, Wales CF10 3AX, UK"],"raw_orcid":"https://orcid.org/0000-0002-2918-3723","affiliations":[{"raw_affiliation_string":"Bioimaging Research Hub, Cardiff School of Biosciences, Cardiff University, Cardiff, Wales CF10 3AX, UK","institution_ids":["https://openalex.org/I79510175"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076112559","display_name":"James Melrose","orcid":"https://orcid.org/0000-0001-9237-0524","observed_orcids":["https://orcid.org/0000-0001-9237-0524"]},"institutions":[{"id":"https://openalex.org/I129604602","display_name":"The University of Sydney","ror":"https://ror.org/0384j8v12","country_code":"AU","type":"education","lineage":["https://openalex.org/I129604602"]},{"id":"https://openalex.org/I2800079252","display_name":"Royal North Shore Hospital","ror":"https://ror.org/02gs2e959","country_code":"AU","type":"healthcare","lineage":["https://openalex.org/I2800079252"]},{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]},{"id":"https://openalex.org/I4210119033","display_name":"Northern Sydney Local Health District","ror":"https://ror.org/02hmf0879","country_code":"AU","type":"government","lineage":["https://openalex.org/I1311436738","https://openalex.org/I2801351115","https://openalex.org/I4210119033"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"James Melrose","raw_affiliation_strings":["Graduate School of Biomedical Engineering, University of New South Wales, Sydney, NSW 2052, Australia","Raymond Purves Laboratory, Institute of Bone and Joint Research, Kolling Institute, Northern Sydney Local Health District, Royal North Shore Hospital, St. Leonards, NSW 2065, Australia","Sydney Medical School, Northern, University of Sydney at Royal North Shore Hospital, St. Leonards, NSW 2065, Australia"],"raw_orcid":"https://orcid.org/0000-0001-9237-0524","affiliations":[{"raw_affiliation_string":"Graduate School of Biomedical Engineering, University of New South Wales, Sydney, NSW 2052, Australia","institution_ids":["https://openalex.org/I31746571"]},{"raw_affiliation_string":"Raymond Purves Laboratory, Institute of Bone and Joint Research, Kolling Institute, Northern Sydney Local Health District, Royal North Shore Hospital, St. Leonards, NSW 2065, Australia","institution_ids":["https://openalex.org/I2800079252","https://openalex.org/I4210119033"]},{"raw_affiliation_string":"Sydney Medical School, Northern, University of Sydney at Royal North Shore Hospital, St. Leonards, NSW 2065, Australia","institution_ids":["https://openalex.org/I129604602","https://openalex.org/I2800079252"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5076112559"],"corresponding_institution_ids":["https://openalex.org/I129604602","https://openalex.org/I2800079252","https://openalex.org/I31746571","https://openalex.org/I4210119033"],"apc_list":{"value":2000,"currency":"CHF","value_usd":2160},"apc_paid":{"value":2000,"currency":"CHF","value_usd":2160},"fwci":1.5097,"has_fulltext":true,"cited_by_count":70,"citation_normalized_percentile":{"value":0.82180685,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"22","issue":"5","first_page":"2716","last_page":"2716"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11131","display_name":"Proteoglycans and glycosaminoglycans research","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/perlecan","display_name":"perlecan","score":1.0},{"id":"https://openalex.org/keywords/mechanoregulation","display_name":"mechanoregulation","score":0.8799999952316284},{"id":"https://openalex.org/keywords/tropoelastin","display_name":"tropoelastin","score":0.7990000247955322},{"id":"https://openalex.org/keywords/fibrillin","display_name":"fibrillin","score":0.9139999747276306},{"id":"https://openalex.org/keywords/collagen-vi","display_name":"collagen VI","score":0.9039999842643738},{"id":"https://openalex.org/keywords/collagen-xi","display_name":"collagen XI","score":0.9980000257492065},{"id":"https://openalex.org/keywords/chondrogenic-differentiation","display_name":"chondrogenic differentiation","score":0.8619999885559082},{"id":"https://openalex.org/keywords/chondrocyte-metabolism","display_name":"chondrocyte metabolism","score":0.9179999828338623},{"id":"https://openalex.org/keywords/wnt-signaling","display_name":"Wnt signaling","score":0.6359999775886536},{"id":"https://openalex.org/keywords/hedgehog-signaling","display_name":"Hedgehog signaling","score":0.9929999709129333},{"id":"https://openalex.org/keywords/morphogen-gradients","display_name":"morphogen gradients","score":0.9369999766349792},{"id":"https://openalex.org/keywords/osteocytes","display_name":"osteocytes","score":0.6940000057220459},{"id":"https://openalex.org/keywords/endothelial-cells","display_name":"endothelial cells","score":0.6079999804496765},{"id":"https://openalex.org/keywords/vascular-tone","display_name":"vascular tone","score":0.7089999914169312},{"id":"https://openalex.org/keywords/bone-metabolism","display_name":"bone metabolism","score":0.8989999890327454}],"concepts":[{"id":"https://openalex.org/C22731427","wikidata":"https://www.wikidata.org/wiki/Q2071346","display_name":"Perlecan","level":4,"score":0.9760696291923523},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.8054995536804199},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.7605940103530884},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4654774069786072},{"id":"https://openalex.org/C106487976","wikidata":"https://www.wikidata.org/wiki/Q685816","display_name":"Matrix (chemical analysis)","level":2,"score":0.4452223479747772},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40827447175979614},{"id":"https://openalex.org/C2779335624","wikidata":"https://www.wikidata.org/wiki/Q407976","display_name":"Proteoglycan","level":3,"score":0.3246542811393738},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003238","descriptor_name":"Connective Tissue","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005109","descriptor_name":"Extracellular Matrix","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016474","descriptor_name":"Weight-Bearing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019812","descriptor_name":"Heparan Sulfate Proteoglycans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.3390/ijms22052716","doi":"https://doi.org/10.3390/ijms22052716","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms22052716","pdf_url":"https://www.mdpi.com/1422-0067/22/5/2716/pdf?version=1615201029","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7962540","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7962540","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Int J Mol Sci","raw_type":"Text"},{"id":"pmid:33800241","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33800241","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of molecular sciences","raw_type":"Journal Article"},{"id":"pmh:oai:https://orca.cardiff.ac.uk:139875","doi":null,"is_oa":false,"landing_page_url":"https://orca.cardiff.ac.uk/id/eprint/139875/1/ijms-22-02716.pdf","pdf_url":"https://orca.cardiff.ac.uk/id/eprint/139875/1/ijms-22-02716.pdf","source":{"id":"https://openalex.org/S4306401195","display_name":"ORCA Online Research @Cardiff (Cardiff University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79510175","host_organization_name":"Cardiff University","host_organization_lineage":["https://openalex.org/I79510175"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:digitalcommons.wustl.edu:open_access_pubs-11200","doi":null,"is_oa":false,"landing_page_url":"https://digitalcommons.wustl.edu/open_access_pubs/10209","pdf_url":null,"source":{"id":"https://openalex.org/S4306400764","display_name":"Digital Commons@Becker (Washington University School of Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204465549","host_organization_name":"Washington University in St. Louis","host_organization_lineage":["https://openalex.org/I204465549"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Publications","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:d640d1b6887c468aa0c1ecb9089cb81e","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d640d1b6887c468aa0c1ecb9089cb81e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"International Journal of Molecular Sciences, Vol 22, Iss 2716, p 2716 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/ijms22052716","doi":"https://doi.org/10.3390/ijms22052716","is_oa":true,"landing_page_url":"https://doi.org/10.3390/ijms22052716","pdf_url":"https://www.mdpi.com/1422-0067/22/5/2716/pdf?version=1615201029","source":{"id":"https://openalex.org/S10623703","display_name":"International Journal of Molecular Sciences","issn_l":"1422-0067","issn":["1422-0067","1661-6596"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","medline","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Molecular Sciences","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.504800021648407}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2126390962","display_name":null,"funder_award_id":"AG46027","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6331636482","display_name":"Elastic components in tensional tissues","funder_award_id":"512167","funder_id":"https://openalex.org/F4320334705","funder_display_name":"National Health and Medical Research Council"},{"id":"https://openalex.org/G638817986","display_name":"Deconstructing Cartilage Mechanotransduction by Piezo Channels","funder_award_id":"R01AR072999","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"},{"id":"https://openalex.org/G6454837097","display_name":"Viscoelastic Properties of Normal and OA Chondrons","funder_award_id":"R01AG015768","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320334705","display_name":"National Health and Medical Research Council","ror":"https://ror.org/011kf5r70"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"},{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3135210880.pdf","grobid_xml":"https://content.openalex.org/works/W3135210880.grobid-xml"},"referenced_works_count":127,"referenced_works":["https://openalex.org/W165193783","https://openalex.org/W197462632","https://openalex.org/W296514445","https://openalex.org/W643329104","https://openalex.org/W1492952392","https://openalex.org/W1501588760","https://openalex.org/W1515445354","https://openalex.org/W1580307320","https://openalex.org/W1581938358","https://openalex.org/W1902204700","https://openalex.org/W1913891964","https://openalex.org/W1967814530","https://openalex.org/W1967976331","https://openalex.org/W1974861507","https://openalex.org/W1975310085","https://openalex.org/W1978353860","https://openalex.org/W1981376081","https://openalex.org/W1987534533","https://openalex.org/W1991457267","https://openalex.org/W1994247424","https://openalex.org/W1994874248","https://openalex.org/W1995681816","https://openalex.org/W1998566831","https://openalex.org/W2003331951","https://openalex.org/W2006056916","https://openalex.org/W2014618196","https://openalex.org/W2014957559","https://openalex.org/W2015724236","https://openalex.org/W2018972666","https://openalex.org/W2019993348","https://openalex.org/W2024810189","https://openalex.org/W2025733563","https://openalex.org/W2026433343","https://openalex.org/W2027880075","https://openalex.org/W2028981706","https://openalex.org/W2034432297","https://openalex.org/W2035815992","https://openalex.org/W2036395758","https://openalex.org/W2044474278","https://openalex.org/W2046268974","https://openalex.org/W2048247334","https://openalex.org/W2049612999","https://openalex.org/W2050380787","https://openalex.org/W2052291791","https://openalex.org/W2053392590","https://openalex.org/W2054228700","https://openalex.org/W2054388804","https://openalex.org/W2059934579","https://openalex.org/W2066310776","https://openalex.org/W2068125835","https://openalex.org/W2072406795","https://openalex.org/W2073298576","https://openalex.org/W2075547308","https://openalex.org/W2081148596","https://openalex.org/W2081652520","https://openalex.org/W2081790518","https://openalex.org/W2082342652","https://openalex.org/W2084068131","https://openalex.org/W2086898489","https://openalex.org/W2088405783","https://openalex.org/W2090183574","https://openalex.org/W2092323785","https://openalex.org/W2092868973","https://openalex.org/W2092914777","https://openalex.org/W2093402961","https://openalex.org/W2096380189","https://openalex.org/W2108490633","https://openalex.org/W2121360069","https://openalex.org/W2130093537","https://openalex.org/W2131244812","https://openalex.org/W2137284441","https://openalex.org/W2137987395","https://openalex.org/W2151448988","https://openalex.org/W2154902077","https://openalex.org/W2158266845","https://openalex.org/W2159601540","https://openalex.org/W2163753450","https://openalex.org/W2165014861","https://openalex.org/W2231999542","https://openalex.org/W2252208090","https://openalex.org/W2257224317","https://openalex.org/W2269206242","https://openalex.org/W2333054128","https://openalex.org/W2402883613","https://openalex.org/W2404395320","https://openalex.org/W2404918471","https://openalex.org/W2427509428","https://openalex.org/W2466000789","https://openalex.org/W2537670537","https://openalex.org/W2734492229","https://openalex.org/W2737467192","https://openalex.org/W2744908358","https://openalex.org/W2746362054","https://openalex.org/W2765586411","https://openalex.org/W2786604007","https://openalex.org/W2792570925","https://openalex.org/W2802771215","https://openalex.org/W2804160472","https://openalex.org/W2804412795","https://openalex.org/W2804418842","https://openalex.org/W2809997034","https://openalex.org/W2883970303","https://openalex.org/W2884060324","https://openalex.org/W2887365703","https://openalex.org/W2911396749","https://openalex.org/W2911572729","https://openalex.org/W2912049655","https://openalex.org/W2921775396","https://openalex.org/W2938344879","https://openalex.org/W2951374056","https://openalex.org/W2951565158","https://openalex.org/W2951918153","https://openalex.org/W2967398248","https://openalex.org/W2977074046","https://openalex.org/W2982017672","https://openalex.org/W2995939890","https://openalex.org/W3014328688","https://openalex.org/W3014662150","https://openalex.org/W3014963960","https://openalex.org/W3015952096","https://openalex.org/W3017376602","https://openalex.org/W3037717181","https://openalex.org/W3100583014","https://openalex.org/W3108963123","https://openalex.org/W3123153087","https://openalex.org/W4211100021","https://openalex.org/W6717666865"],"related_works":["https://openalex.org/W2068125835","https://openalex.org/W4401152731","https://openalex.org/W2518355022","https://openalex.org/W2777776752","https://openalex.org/W2305151418","https://openalex.org/W2084068131","https://openalex.org/W2137544603","https://openalex.org/W2077952390","https://openalex.org/W2466000789","https://openalex.org/W2047721737"],"abstract_inverted_index":{"In":[0],"this":[1,55,83],"study,":[2],"we":[3],"review":[4],"mechanoregulatory":[5],"roles":[6,190],"for":[7],"perlecan":[8,44,105,148],"in":[9,24,111,115,159,191],"load-bearing":[10,192],"connective":[11,193],"tissues.":[12,194],"Perlecan":[13,118],"facilitates":[14],"the":[15,34,38,68,77,88,131,137,162,180],"co-acervation":[16],"of":[17,21,37,139,182],"tropoelastin":[18],"and":[19,31,49,53,70,94,114,161,176,179],"assembly":[20],"elastic":[22],"microfibrils":[23],"translamellar":[25],"cross-bridges":[26],"which,":[27],"together":[28],"with":[29,46],"fibrillin":[30],"elastin":[32],"stabilise":[33],"extracellular":[35,73,78],"matrix":[36,56,79,85],"intervertebral":[39],"disc":[40],"annulus":[41],"fibrosus.":[42],"Pericellular":[43],"interacts":[45],"collagen":[47],"VI":[48],"XI":[50],"to":[51,87,92,96,100,169],"define":[52],"stabilize":[54],"compartment":[57],"which":[58],"has":[59],"a":[60,107,121,156],"strategic":[61],"position":[62],"facilitating":[63,136],"two-way":[64],"cell-matrix":[65],"communication":[66],"between":[67],"cell":[69],"its":[71],"wider":[72],"matrix.":[74],"Cues":[75],"from":[76],"are":[80],"fed":[81],"through":[82],"pericellular":[84],"back":[86],"chondrocyte,":[89],"allowing":[90],"it":[91],"perceive":[93],"respond":[95],"subtle":[97],"microenvironmental":[98],"changes":[99],"regulate":[101],"tissue":[102,144],"homeostasis.":[103],"Thus":[104],"plays":[106],"key":[108],"regulatory":[109],"role":[110],"chondrocyte":[112,116],"metabolism,":[113],"differentiation.":[117],"acts":[119,154],"as":[120,130,155],"transport":[122],"proteoglycan":[123],"carrying":[124],"poorly":[125],"soluble,":[126],"lipid-modified":[127],"proteins":[128],"such":[129],"Wnt":[132],"or":[133,152],"Hedgehog":[134],"families":[135],"establishment":[138],"morphogen":[140],"gradients":[141],"that":[142],"drive":[143],"morphogenesis.":[145],"Cell":[146],"surface":[147],"on":[149],"endothelial":[150],"cells":[151,172],"osteocytes":[153,186],"flow":[157],"sensor":[158],"blood":[160,177],"lacunar":[163],"canalicular":[164],"fluid":[165],"providing":[166],"feedback":[167],"cues":[168],"smooth":[170],"muscle":[171],"regulating":[173],"vascular":[174],"tone":[175],"pressure,":[178],"regulation":[181],"bone":[183],"metabolism":[184],"by":[185],"highlighting":[187],"perlecan's":[188],"multifaceted":[189]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":14},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":22},{"year":2021,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-03-15T00:00:00"}