{"id":"https://openalex.org/W3135073795","doi":"https://doi.org/10.3390/cancers13051049","title":"Clinical Significance of PDCD4 in Melanoma by Subcellular Expression and in Tumor-Associated Immune Cells","display_name":"Clinical Significance of PDCD4 in Melanoma by Subcellular Expression and in Tumor-Associated Immune Cells","publication_year":2021,"publication_date":"2021-03-02","ids":{"openalex":"https://openalex.org/W3135073795","doi":"https://doi.org/10.3390/cancers13051049","mag":"3135073795","pmid":"https://pubmed.ncbi.nlm.nih.gov/33801444"},"language":"en","primary_location":{"id":"doi:10.3390/cancers13051049","doi":"https://doi.org/10.3390/cancers13051049","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers13051049","pdf_url":"https://www.mdpi.com/2072-6694/13/5/1049/pdf","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.mdpi.com/2072-6694/13/5/1049/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5005783017","display_name":"Thuy Thanh Thi Tran","orcid":"https://orcid.org/0000-0002-6244-7575","observed_orcids":["https://orcid.org/0000-0002-6244-7575"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thuy T. Tran","raw_affiliation_strings":["Department of Medicine (Medical Oncology), Yale University School of Medicine, New Haven, CT 06510, USA"],"raw_orcid":"https://orcid.org/0000-0002-6244-7575","affiliations":[{"raw_affiliation_string":"Department of Medicine (Medical Oncology), Yale University School of Medicine, New Haven, CT 06510, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078404596","display_name":"Chetan K. Rane","orcid":"https://orcid.org/0000-0003-2344-7502","observed_orcids":["https://orcid.org/0000-0003-2344-7502"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chetan K. Rane","raw_affiliation_strings":["Department of Medicine (Medical Oncology), Yale University School of Medicine, New Haven, CT 06510, USA"],"raw_orcid":"https://orcid.org/0000-0003-2344-7502","affiliations":[{"raw_affiliation_string":"Department of Medicine (Medical Oncology), Yale University School of Medicine, New Haven, CT 06510, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013767340","display_name":"Christopher R. Zito","orcid":"https://orcid.org/0009-0006-6070-3287","observed_orcids":["https://orcid.org/0009-0006-6070-3287"]},"institutions":[{"id":"https://openalex.org/I192633058","display_name":"University of Saint Joseph","ror":"https://ror.org/05m5j6s60","country_code":"US","type":"education","lineage":["https://openalex.org/I192633058"]},{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher R. Zito","raw_affiliation_strings":["Department of Biology, School of Arts, Sciences, Business, and Education, University of Saint Joseph, West Hartford, CT 06117, USA","Department of Medicine (Medical Oncology), Yale University School of Medicine, New Haven, CT 06510, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, School of Arts, Sciences, Business, and Education, University of Saint Joseph, West Hartford, CT 06117, USA","institution_ids":["https://openalex.org/I192633058"]},{"raw_affiliation_string":"Department of Medicine (Medical Oncology), Yale University School of Medicine, New Haven, CT 06510, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066292518","display_name":"Sarah Ann Weiss","orcid":"https://orcid.org/0000-0002-1106-7089","observed_orcids":["https://orcid.org/0000-0002-1106-7089"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sarah A. Weiss","raw_affiliation_strings":["Department of Medicine (Medical Oncology), Yale University School of Medicine, New Haven, CT 06510, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine (Medical Oncology), Yale University School of Medicine, New Haven, CT 06510, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062890564","display_name":"Shlomit Jessel","orcid":"https://orcid.org/0000-0001-8489-0351","observed_orcids":["https://orcid.org/0000-0001-8489-0351"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Shlomit Jessel","raw_affiliation_strings":["Department of Medicine (Medical Oncology), Yale University School of Medicine, New Haven, CT 06510, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine (Medical Oncology), Yale University School of Medicine, New Haven, CT 06510, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076852874","display_name":"Liliana E. Lucca","orcid":"https://orcid.org/0000-0002-5109-0128","observed_orcids":["https://orcid.org/0000-0002-5109-0128"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liliana Lucca","raw_affiliation_strings":["Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046828105","display_name":"Benjamin Y. Lu","orcid":"https://orcid.org/0000-0001-8764-8384","observed_orcids":["https://orcid.org/0000-0001-8764-8384"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benjamin Y. Lu","raw_affiliation_strings":["Department of Medicine (Medical Oncology), Yale University School of Medicine, New Haven, CT 06510, USA","Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA"],"raw_orcid":"https://orcid.org/0000-0001-8764-8384","affiliations":[{"raw_affiliation_string":"Department of Medicine (Medical Oncology), Yale University School of Medicine, New Haven, CT 06510, USA","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062757747","display_name":"Victor Oginga Oria","orcid":"https://orcid.org/0000-0001-7187-7916","observed_orcids":["https://orcid.org/0000-0001-7187-7916"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Victor O. Oria","raw_affiliation_strings":["Department of Medicine (Medical Oncology), Yale University School of Medicine, New Haven, CT 06510, USA"],"raw_orcid":"https://orcid.org/0000-0001-7187-7916","affiliations":[{"raw_affiliation_string":"Department of Medicine (Medical Oncology), Yale University School of Medicine, New Haven, CT 06510, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001635790","display_name":"Adebowale Adeniran","orcid":"https://orcid.org/0000-0001-9820-632X","observed_orcids":["https://orcid.org/0000-0001-9820-632X"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Adebowale Adeniran","raw_affiliation_strings":["Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Yale University School of Medicine, New Haven, CT 06510, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058373918","display_name":"Veronica Chiang","orcid":"https://orcid.org/0000-0003-1882-3876","observed_orcids":["https://orcid.org/0000-0003-1882-3876"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Veronica L. Chiang","raw_affiliation_strings":["Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06510, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06510, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034081033","display_name":"Sacit Bulent Omay","orcid":"https://orcid.org/0000-0002-3606-9267","observed_orcids":["https://orcid.org/0000-0002-3606-9267"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sacit Bulent Omay","raw_affiliation_strings":["Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06510, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurosurgery, Yale University School of Medicine, New Haven, CT 06510, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004216670","display_name":"David A. Hafler","orcid":"https://orcid.org/0000-0003-4664-535X","observed_orcids":["https://orcid.org/0000-0003-4664-535X"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Hafler","raw_affiliation_strings":["Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Yale University School of Medicine, New Haven, CT 06510, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001175430","display_name":"Harriet M. Kluger","orcid":"https://orcid.org/0000-0002-4932-9873","observed_orcids":["https://orcid.org/0000-0002-4932-9873"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harriet M. Kluger","raw_affiliation_strings":["Department of Medicine (Medical Oncology), Yale University School of Medicine, New Haven, CT 06510, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine (Medical Oncology), Yale University School of Medicine, New Haven, CT 06510, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5067591137","display_name":"Lucia B. Jilaveanu","orcid":"https://orcid.org/0000-0001-8900-5083","observed_orcids":["https://orcid.org/0000-0001-8900-5083"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Lucia B. Jilaveanu","raw_affiliation_strings":["Department of Medicine (Medical Oncology), Yale University School of Medicine, New Haven, CT 06510, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine (Medical Oncology), Yale University School of Medicine, New Haven, CT 06510, USA","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5067591137"],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":{"value":2200,"currency":"CHF","value_usd":2376},"apc_paid":{"value":2200,"currency":"CHF","value_usd":2376},"fwci":0.8142,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.73971667,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":97},"biblio":{"volume":"13","issue":"5","first_page":"1049","last_page":"1049"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.5590999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.5590999722480774,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10392","display_name":"Cutaneous Melanoma Detection and Management","score":0.30300000309944153,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11533","display_name":"Melanoma and MAPK Pathways","score":0.07169999927282333,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pdcd4","display_name":"PDCD4","score":0.9959999918937683},{"id":"https://openalex.org/keywords/melanoma","display_name":"melanoma","score":0.9909999966621399},{"id":"https://openalex.org/keywords/melanoma-brain-metastases","display_name":"melanoma brain metastases","score":0.9620000123977661},{"id":"https://openalex.org/keywords/subcellular-localization","display_name":"subcellular localization","score":0.9350000023841858},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.9380000233650208},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.8489999771118164},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.996999979019165},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.9890000224113464},{"id":"https://openalex.org/keywords/mast-cells","display_name":"mast cells","score":1.0},{"id":"https://openalex.org/keywords/immune-infiltration","display_name":"immune cell infiltration","score":0.9300000071525574},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.41999998688697815},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7369999885559082},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.6710000038146973}],"concepts":[{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.6936736106872559},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.6859767436981201},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6571629047393799},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6167933940887451},{"id":"https://openalex.org/C193270364","wikidata":"https://www.wikidata.org/wiki/Q17141925","display_name":"Tissue microarray","level":3,"score":0.581909716129303},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.5534418821334839},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5085541009902954},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.4936717450618744},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.468982994556427},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.45799949765205383},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.4262658655643463},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2836062014102936},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.25561976432800293},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.21797394752502441},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.202775239944458},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.3390/cancers13051049","doi":"https://doi.org/10.3390/cancers13051049","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers13051049","pdf_url":"https://www.mdpi.com/2072-6694/13/5/1049/pdf","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},{"id":"pmid:33801444","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33801444","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7958624","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7958624","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancers (Basel)","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:b52fe8e973dd414d9aae12faeaa4e03e","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/b52fe8e973dd414d9aae12faeaa4e03e","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancers, Vol 13, Iss 1049, p 1049 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3390/cancers13051049","doi":"https://doi.org/10.3390/cancers13051049","is_oa":true,"landing_page_url":"https://doi.org/10.3390/cancers13051049","pdf_url":"https://www.mdpi.com/2072-6694/13/5/1049/pdf","source":{"id":"https://openalex.org/S168415115","display_name":"Cancers","issn_l":"2072-6694","issn":["2072-6694"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancers","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7799999713897705,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[{"id":"https://openalex.org/G1358700859","display_name":null,"funder_award_id":"P50 CA121974","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1507628419","display_name":null,"funder_award_id":"K12CA215119","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3208209428","display_name":"Inherent tropism and/or immune modulation in melanoma brain metastasis","funder_award_id":"130157-RSG-16-216-01-TBG","funder_id":"https://openalex.org/F4320306095","funder_display_name":"American Cancer Society"},{"id":"https://openalex.org/G3222097784","display_name":null,"funder_award_id":"R01 CA204002","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G3968055098","display_name":null,"funder_award_id":"K12CA215110","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G633865952","display_name":null,"funder_award_id":"R01 CA227472","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000090109","display_name":null,"funder_award_id":"R01 CA216846","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000888329","display_name":"Yale SPORE in Lung Cancer (YSILC): The Biology and Personalized Treatment of Lung Cancer","funder_award_id":"2p50ca196530-11","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000905448","display_name":"Yale Clinical and Translational Science Award","funder_award_id":"5ul1tr001863-10","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000907031","display_name":"Yale Cancer Center Advanced Training Program for Physician-Scientists (YCC-ATPP)","funder_award_id":"5t32ca233414-07","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306095","display_name":"American Cancer Society","ror":"https://ror.org/02e463172"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3135073795.pdf","grobid_xml":"https://content.openalex.org/works/W3135073795.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W1885174764","https://openalex.org/W1908062513","https://openalex.org/W1922885614","https://openalex.org/W1965370740","https://openalex.org/W1966417898","https://openalex.org/W1969082125","https://openalex.org/W1970111367","https://openalex.org/W1973921593","https://openalex.org/W1974499786","https://openalex.org/W1984101390","https://openalex.org/W1989790390","https://openalex.org/W1999018351","https://openalex.org/W2027696262","https://openalex.org/W2042812307","https://openalex.org/W2045424472","https://openalex.org/W2055050962","https://openalex.org/W2065272192","https://openalex.org/W2079876796","https://openalex.org/W2085578966","https://openalex.org/W2094146259","https://openalex.org/W2102899135","https://openalex.org/W2102978104","https://openalex.org/W2103277177","https://openalex.org/W2112572789","https://openalex.org/W2121886536","https://openalex.org/W2121948013","https://openalex.org/W2140293999","https://openalex.org/W2151886488","https://openalex.org/W2154307972","https://openalex.org/W2155073814","https://openalex.org/W2157026647","https://openalex.org/W2164626076","https://openalex.org/W2169301624","https://openalex.org/W2240499496","https://openalex.org/W2257484201","https://openalex.org/W2509811343","https://openalex.org/W2525304626","https://openalex.org/W2555909205","https://openalex.org/W2618369933","https://openalex.org/W2679259315","https://openalex.org/W2794627893","https://openalex.org/W2805897039","https://openalex.org/W2809401532","https://openalex.org/W2884299577","https://openalex.org/W2899566169","https://openalex.org/W2900126305","https://openalex.org/W2901777868","https://openalex.org/W2902656536","https://openalex.org/W2921256344","https://openalex.org/W2925325226","https://openalex.org/W2944085962","https://openalex.org/W2945802148","https://openalex.org/W2955753801","https://openalex.org/W2965989125","https://openalex.org/W2971738094","https://openalex.org/W2977288834","https://openalex.org/W2989656234","https://openalex.org/W2990161293","https://openalex.org/W2991037706","https://openalex.org/W2996248278","https://openalex.org/W3089088060","https://openalex.org/W6639869718","https://openalex.org/W6762978640","https://openalex.org/W6770535015"],"related_works":["https://openalex.org/W2897072461","https://openalex.org/W3032348021","https://openalex.org/W2944910448","https://openalex.org/W2063062622","https://openalex.org/W2294221646","https://openalex.org/W4312201105","https://openalex.org/W2985479685","https://openalex.org/W4361826906","https://openalex.org/W2286673285","https://openalex.org/W4213197580"],"abstract_inverted_index":{"Little":[0],"is":[1,135,149,164],"known":[2],"about":[3],"the":[4,49,58,131,161,177,186],"subcellular":[5,50],"localization":[6],"and":[7,56,64,82,109,120,141,155,181,183],"function":[8],"of":[9,52,133,179,188],"programmed":[10],"cell":[11,95,169],"death":[12],"4":[13],"(PDCD4)":[14],"in":[15,54,57,100,117,121,126,160,195],"melanoma.":[16],"Our":[17],"past":[18],"studies":[19,172],"suggest":[20],"PDCD4":[21,39,53,101,111,134,158,180],"interacts":[22],"with":[23,75,106,114,166],"Pleckstrin":[24],"Homology":[25],"Domain":[26],"Containing":[27],"A5":[28],"(PLEKHA5)":[29],"to":[30,42,47,91,175,184],"influence":[31],"melanoma":[32,55,196],"brain":[33,88,197],"metastasis":[34,89],"outcomes,":[35],"as":[36,191],"high":[37,107],"intracranial":[38,122],"expression":[40,102,132,159],"leads":[41],"improved":[43,115],"survival.":[44],"We":[45,70,97],"aimed":[46],"define":[48,176],"distribution":[51],"tumor":[59,108,162],"microenvironment":[60,163],"during":[61,103],"neoplastic":[62,104],"progression":[63],"its":[65],"impact":[66],"on":[67,86,137,152],"clinical":[68],"outcomes.":[69],"analyzed":[71],"multiple":[72],"tissue":[73],"microarrays":[74],"well-annotated":[76],"clinicopathological":[77],"variables":[78],"using":[79],"quantitative":[80],"immunofluorescence":[81],"evaluated":[83],"single-cell":[84],"RNA-sequencing":[85],"a":[87,192],"sample":[90],"characterize":[92],"PDCD4+":[93],"immune":[94,168],"subsets.":[96],"demonstrate":[98],"differences":[99],"progression,":[105],"stromal":[110],"levels":[112],"associated":[113,165],"survival":[116],"primary":[118],"melanomas":[119],"metastases,":[123],"but":[124],"not":[125],"extracranial":[127],"metastatic":[128],"disease.":[129],"While":[130],"well-documented":[136],"CD8+":[138],"T":[139],"cells":[140,154],"natural":[142],"killer":[143],"cells,":[144],"we":[145],"show":[146],"that":[147],"it":[148],"also":[150],"found":[151],"B":[153],"mast":[156],"cells.":[157],"increased":[167],"infiltration.":[170],"Further":[171],"are":[173],"needed":[174],"interaction":[178],"PLEKHA5":[182],"evaluate":[185],"utility":[187],"this":[189],"pathway":[190],"therapeutic":[193],"target":[194],"metastasis.":[198]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":2}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2025-10-10T00:00:00"}