{"id":"https://openalex.org/W3135072829","doi":"https://doi.org/10.3389/fcell.2021.635189","title":"The Dynamic Interface Between the Bone Marrow Vascular Niche and Hematopoietic Stem Cells in Myeloid Malignancy","display_name":"The Dynamic Interface Between the Bone Marrow Vascular Niche and Hematopoietic Stem Cells in Myeloid Malignancy","publication_year":2021,"publication_date":"2021-03-11","ids":{"openalex":"https://openalex.org/W3135072829","doi":"https://doi.org/10.3389/fcell.2021.635189","mag":"3135072829","pmid":"https://pubmed.ncbi.nlm.nih.gov/33777944"},"language":"en","primary_location":{"id":"doi:10.3389/fcell.2021.635189","doi":"https://doi.org/10.3389/fcell.2021.635189","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2021.635189","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcell.2021.635189/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/articles/10.3389/fcell.2021.635189/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023274542","display_name":"Laura Mosteo","orcid":"https://orcid.org/0000-0002-4410-2370","observed_orcids":["https://orcid.org/0000-0002-4410-2370"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4210158732","display_name":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto","ror":"https://ror.org/04wjk1035","country_code":"PT","type":"facility","lineage":["https://openalex.org/I182534213","https://openalex.org/I4210158732"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Laura Mosteo","raw_affiliation_strings":["Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), University of Porto, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), University of Porto, Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210158732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047796308","display_name":"Joanna A Storer","orcid":"https://orcid.org/0000-0002-6614-9735","observed_orcids":["https://orcid.org/0000-0002-6614-9735"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Joanna Storer","raw_affiliation_strings":["Epigenetics of Haematopoiesis Group, Division of Cancer Sciences, The University of Manchester, Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epigenetics of Haematopoiesis Group, Division of Cancer Sciences, The University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035317323","display_name":"Kiran Batta","orcid":"https://orcid.org/0000-0002-3494-0979","observed_orcids":["https://orcid.org/0000-0002-3494-0979"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Kiran Batta","raw_affiliation_strings":["Epigenetics of Haematopoiesis Group, Division of Cancer Sciences, The University of Manchester, Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Epigenetics of Haematopoiesis Group, Division of Cancer Sciences, The University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032366727","display_name":"Emma J Searle","orcid":"https://orcid.org/0000-0002-3942-3081","observed_orcids":["https://orcid.org/0000-0002-3942-3081"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I4210131968","display_name":"The Christie Hospital","ror":"https://ror.org/03nd63441","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]},{"id":"https://openalex.org/I4210133995","display_name":"The Christie NHS Foundation Trust","ror":"https://ror.org/03v9efr22","country_code":"GB","type":"funder","lineage":["https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Emma J. Searle","raw_affiliation_strings":["Department of Haematology, The Christie NHS Foundation Trust, Manchester, United Kingdom","Epigenetics of Haematopoiesis Group, Division of Cancer Sciences, The University of Manchester, Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, The Christie NHS Foundation Trust, Manchester, United Kingdom","institution_ids":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]},{"raw_affiliation_string":"Epigenetics of Haematopoiesis Group, Division of Cancer Sciences, The University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I28407311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045027226","display_name":"Delfim Duarte","orcid":"https://orcid.org/0000-0003-3476-0211","observed_orcids":["https://orcid.org/0000-0003-3476-0211"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I4210111164","display_name":"IPO Porto","ror":"https://ror.org/027ras364","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210111164"]},{"id":"https://openalex.org/I4210158732","display_name":"i3S - Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade, Universidade do Porto","ror":"https://ror.org/04wjk1035","country_code":"PT","type":"facility","lineage":["https://openalex.org/I182534213","https://openalex.org/I4210158732"]}],"countries":["PT"],"is_corresponding":true,"raw_author_name":"Delfim Duarte","raw_affiliation_strings":["Department of Biomedicine, Faculdade de Medicina da Universidade do Porto (FMUP), Porto, Portugal","Department of Onco-Hematology, Instituto Portugu\u00eas de Oncologia (IPO)-Porto, Porto, Portugal","Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), University of Porto, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedicine, Faculdade de Medicina da Universidade do Porto (FMUP), Porto, Portugal","institution_ids":["https://openalex.org/I182534213"]},{"raw_affiliation_string":"Department of Onco-Hematology, Instituto Portugu\u00eas de Oncologia (IPO)-Porto, Porto, Portugal","institution_ids":["https://openalex.org/I4210111164"]},{"raw_affiliation_string":"Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade (i3S), University of Porto, Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4210158732"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019235395","display_name":"Daniel H. Wiseman","orcid":"https://orcid.org/0000-0003-0715-1402","observed_orcids":["https://orcid.org/0000-0003-0715-1402"]},"institutions":[{"id":"https://openalex.org/I28407311","display_name":"University of Manchester","ror":"https://ror.org/027m9bs27","country_code":"GB","type":"education","lineage":["https://openalex.org/I28407311"]},{"id":"https://openalex.org/I4210131968","display_name":"The Christie Hospital","ror":"https://ror.org/03nd63441","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]},{"id":"https://openalex.org/I4210133995","display_name":"The Christie NHS Foundation Trust","ror":"https://ror.org/03v9efr22","country_code":"GB","type":"funder","lineage":["https://openalex.org/I4210133995"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Daniel H. Wiseman","raw_affiliation_strings":["Department of Haematology, The Christie NHS Foundation Trust, Manchester, United Kingdom","Epigenetics of Haematopoiesis Group, Division of Cancer Sciences, The University of Manchester, Manchester, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Haematology, The Christie NHS Foundation Trust, Manchester, United Kingdom","institution_ids":["https://openalex.org/I4210131968","https://openalex.org/I4210133995"]},{"raw_affiliation_string":"Epigenetics of Haematopoiesis Group, Division of Cancer Sciences, The University of Manchester, Manchester, United Kingdom","institution_ids":["https://openalex.org/I28407311"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5019235395","https://openalex.org/A5045027226"],"corresponding_institution_ids":["https://openalex.org/I182534213","https://openalex.org/I28407311","https://openalex.org/I4210111164","https://openalex.org/I4210131968","https://openalex.org/I4210133995","https://openalex.org/I4210158732"],"apc_list":{"value":2950,"currency":"USD","value_usd":2950},"apc_paid":{"value":2950,"currency":"USD","value_usd":2950},"fwci":2.7765,"has_fulltext":true,"cited_by_count":36,"citation_normalized_percentile":{"value":0.90981595,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"9","issue":null,"first_page":"635189","last_page":"635189"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.8964999914169312,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":0.8964999914169312,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":0.07819999754428864,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.012000000104308128,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bone-marrow-vascular-niche","display_name":"bone marrow vascular niche","score":0.8740000128746033},{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.9919999837875366},{"id":"https://openalex.org/keywords/bone-marrow-endothelial-cells","display_name":"bone marrow endothelial cells","score":0.8209999799728394},{"id":"https://openalex.org/keywords/vascular-niche","display_name":"vascular niche","score":0.49399998784065247},{"id":"https://openalex.org/keywords/myeloid-neoplasms","display_name":"myeloid neoplasms","score":0.8259999752044678},{"id":"https://openalex.org/keywords/acute-myeloid-leukemia","display_name":"acute myeloid leukemia","score":0.949999988079071},{"id":"https://openalex.org/keywords/myelodysplastic-syndrome","display_name":"myelodysplastic syndrome","score":1.0},{"id":"https://openalex.org/keywords/inflammaging","display_name":"inflammaging","score":0.8100000023841858},{"id":"https://openalex.org/keywords/clonal-hematopoiesis","display_name":"clonal hematopoiesis","score":0.9919999837875366},{"id":"https://openalex.org/keywords/endothelial-cell-heterogeneity","display_name":"endothelial heterogeneity","score":0.7739999890327454}],"concepts":[{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.7725459337234497},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.7694820761680603},{"id":"https://openalex.org/C95862172","wikidata":"https://www.wikidata.org/wiki/Q9032597","display_name":"Myelopoiesis","level":4,"score":0.674111008644104},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5756737589836121},{"id":"https://openalex.org/C2779282312","wikidata":"https://www.wikidata.org/wiki/Q1956561","display_name":"Myeloid","level":2,"score":0.5585893988609314},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5377082824707031},{"id":"https://openalex.org/C2778086970","wikidata":"https://www.wikidata.org/wiki/Q514525","display_name":"Hematopoietic stem cell","level":4,"score":0.507216215133667},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.47811359167099},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4733597934246063},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.4482561945915222},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.41075974702835083},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.2696320116519928},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.09027749300003052}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.3389/fcell.2021.635189","doi":"https://doi.org/10.3389/fcell.2021.635189","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2021.635189","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcell.2021.635189/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},{"id":"pmid:33777944","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33777944","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in cell and developmental biology","raw_type":"Journal Article"},{"id":"pmh:oai:pure.atira.dk:openaire/21a499b8-9788-47bf-8066-58ddb0c9d982","doi":null,"is_oa":true,"landing_page_url":"https://research.manchester.ac.uk/en/publications/21a499b8-9788-47bf-8066-58ddb0c9d982","pdf_url":null,"source":{"id":"https://openalex.org/S4306400662","display_name":"Research Explorer (The University of Manchester)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28407311","host_organization_name":"University of Manchester","host_organization_lineage":["https://openalex.org/I28407311"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mosteo, L, Storer, J, Batta, K, Searle, E, Duarte, D & Wiseman, D 2021, 'The Dynamic Interface Between the Bone Marrow Vascular Niche and Hematopoietic Stem Cells in Myeloid Malignancy', Frontiers in cell and developmental biology, vol. 9, 635189. https://doi.org/10.3389/fcell.2021.635189","raw_type":"info:eu-repo/semantics/review"},{"id":"pmh:oai:pubmedcentral.nih.gov:7991089","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7991089","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Front Cell Dev Biol","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:a17adb3b88eb49d38a801e90a5148d33","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a17adb3b88eb49d38a801e90a5148d33","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cell and Developmental Biology, Vol 9 (2021)","raw_type":"article"},{"id":"pmh:oai:repositorio-aberto.up.pt:10216/152517","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/10216/152517","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"journal article"}],"best_oa_location":{"id":"doi:10.3389/fcell.2021.635189","doi":"https://doi.org/10.3389/fcell.2021.635189","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2021.635189","pdf_url":"https://www.frontiersin.org/articles/10.3389/fcell.2021.635189/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9537000060081482,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.7599999904632568,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1157527330","display_name":null,"funder_award_id":"S_3797","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G2121573167","display_name":null,"funder_award_id":"TRTH156","funder_id":"https://openalex.org/F4320310646","funder_display_name":"European Hematology Association"},{"id":"https://openalex.org/G445302239","display_name":null,"funder_award_id":"SGL020\\1043","funder_id":"https://openalex.org/F4320320241","funder_display_name":"Academy of Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320310646","display_name":"European Hematology Association","ror":"https://ror.org/05hk0hn26"},{"id":"https://openalex.org/F4320317246","display_name":"Funda\u00e7\u00e3o Am\u00e9lia de Mello","ror":"https://ror.org/03hhrgn91"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320320241","display_name":"Academy of Medical Sciences","ror":"https://ror.org/00c489v88"},{"id":"https://openalex.org/F4320324760","display_name":"Bloodwise","ror":"https://ror.org/0055acf80"},{"id":"https://openalex.org/F4320329013","display_name":"Blood Cancer UK","ror":null},{"id":"https://openalex.org/F4320332905","display_name":"National Blood Foundation","ror":"https://ror.org/036bpjh12"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3135072829.pdf","grobid_xml":"https://content.openalex.org/works/W3135072829.grobid-xml"},"referenced_works_count":260,"referenced_works":["https://openalex.org/W11516097","https://openalex.org/W69990049","https://openalex.org/W135651168","https://openalex.org/W182715940","https://openalex.org/W182858095","https://openalex.org/W269389925","https://openalex.org/W331857686","https://openalex.org/W1528621722","https://openalex.org/W1549257184","https://openalex.org/W1561399318","https://openalex.org/W1567732942","https://openalex.org/W1603300429","https://openalex.org/W1904303816","https://openalex.org/W1917059837","https://openalex.org/W1966952910","https://openalex.org/W1967784191","https://openalex.org/W1968276167","https://openalex.org/W1968628080","https://openalex.org/W1975025595","https://openalex.org/W1975208402","https://openalex.org/W1975558291","https://openalex.org/W1975612301","https://openalex.org/W1977789828","https://openalex.org/W1978373692","https://openalex.org/W1979421565","https://openalex.org/W1979935756","https://openalex.org/W1980267743","https://openalex.org/W1980725734","https://openalex.org/W1985753831","https://openalex.org/W1985801522","https://openalex.org/W1985823023","https://openalex.org/W1987633400","https://openalex.org/W1990070364","https://openalex.org/W1991950992","https://openalex.org/W1996093680","https://openalex.org/W2000675829","https://openalex.org/W2002889467","https://openalex.org/W2005605006","https://openalex.org/W2005718040","https://openalex.org/W2006702697","https://openalex.org/W2007901065","https://openalex.org/W2009069027","https://openalex.org/W2011413594","https://openalex.org/W2012056552","https://openalex.org/W2012857468","https://openalex.org/W2012902583","https://openalex.org/W2014634026","https://openalex.org/W2016034318","https://openalex.org/W2016675217","https://openalex.org/W2017509374","https://openalex.org/W2017748853","https://openalex.org/W2017907565","https://openalex.org/W2017965105","https://openalex.org/W2018420076","https://openalex.org/W2018566131","https://openalex.org/W2019676650","https://openalex.org/W2019703078","https://openalex.org/W2021157669","https://openalex.org/W2021276131","https://openalex.org/W2022734786","https://openalex.org/W2025016054","https://openalex.org/W2025371271","https://openalex.org/W2027066896","https://openalex.org/W2028034052","https://openalex.org/W2028160054","https://openalex.org/W2028574594","https://openalex.org/W2030956730","https://openalex.org/W2032683917","https://openalex.org/W2035673396","https://openalex.org/W2036108191","https://openalex.org/W2036459016","https://openalex.org/W2037157001","https://openalex.org/W2037775640","https://openalex.org/W2038448524","https://openalex.org/W2038608871","https://openalex.org/W2038824910","https://openalex.org/W2041357218","https://openalex.org/W2043083650","https://openalex.org/W2043488365","https://openalex.org/W2043658681","https://openalex.org/W2044022462","https://openalex.org/W2045024858","https://openalex.org/W2045032252","https://openalex.org/W2045755019","https://openalex.org/W2045993548","https://openalex.org/W2046578266","https://openalex.org/W2047708963","https://openalex.org/W2048348395","https://openalex.org/W2049231184","https://openalex.org/W2051628747","https://openalex.org/W2053737668","https://openalex.org/W2054719244","https://openalex.org/W2054821489","https://openalex.org/W2056265113","https://openalex.org/W2056415390","https://openalex.org/W2057106552","https://openalex.org/W2060610551","https://openalex.org/W2060621193","https://openalex.org/W2060930865","https://openalex.org/W2067298584","https://openalex.org/W2069943416","https://openalex.org/W2070154483","https://openalex.org/W2070554668","https://openalex.org/W2070793750","https://openalex.org/W2072172632","https://openalex.org/W2073440691","https://openalex.org/W2075990374","https://openalex.org/W2076165474","https://openalex.org/W2076188533","https://openalex.org/W2077330278","https://openalex.org/W2078719918","https://openalex.org/W2079458041","https://openalex.org/W2079521785","https://openalex.org/W2080039717","https://openalex.org/W2080274993","https://openalex.org/W2080287792","https://openalex.org/W2082641686","https://openalex.org/W2084944550","https://openalex.org/W2086243699","https://openalex.org/W2087363756","https://openalex.org/W2088022688","https://openalex.org/W2089254126","https://openalex.org/W2091525085","https://openalex.org/W2092123763","https://openalex.org/W2093570808","https://openalex.org/W2093818708","https://openalex.org/W2094022450","https://openalex.org/W2096354265","https://openalex.org/W2096637671","https://openalex.org/W2100140007","https://openalex.org/W2101808949","https://openalex.org/W2101886636","https://openalex.org/W2109525494","https://openalex.org/W2110564887","https://openalex.org/W2110630778","https://openalex.org/W2111141291","https://openalex.org/W2113874362","https://openalex.org/W2114409684","https://openalex.org/W2114514472","https://openalex.org/W2114805956","https://openalex.org/W2118781121","https://openalex.org/W2120372000","https://openalex.org/W2124562153","https://openalex.org/W2126816979","https://openalex.org/W2127447993","https://openalex.org/W2129663763","https://openalex.org/W2130356372","https://openalex.org/W2131263031","https://openalex.org/W2132016263","https://openalex.org/W2132211636","https://openalex.org/W2135901973","https://openalex.org/W2139481826","https://openalex.org/W2143193295","https://openalex.org/W2144470337","https://openalex.org/W2149032069","https://openalex.org/W2149858388","https://openalex.org/W2150763257","https://openalex.org/W2157155777","https://openalex.org/W2157479632","https://openalex.org/W2158822788","https://openalex.org/W2161232450","https://openalex.org/W2163714061","https://openalex.org/W2163751866","https://openalex.org/W2163841494","https://openalex.org/W2164886552","https://openalex.org/W2166825418","https://openalex.org/W2169181389","https://openalex.org/W2170097602","https://openalex.org/W2171523933","https://openalex.org/W2178039206","https://openalex.org/W2184334224","https://openalex.org/W2193032347","https://openalex.org/W2204697639","https://openalex.org/W2230641108","https://openalex.org/W2233797537","https://openalex.org/W2261428502","https://openalex.org/W2318982124","https://openalex.org/W2331141044","https://openalex.org/W2331467208","https://openalex.org/W2332364317","https://openalex.org/W2336488824","https://openalex.org/W2337668972","https://openalex.org/W2339406441","https://openalex.org/W2339658711","https://openalex.org/W2344093195","https://openalex.org/W2509630779","https://openalex.org/W2515013664","https://openalex.org/W2522868325","https://openalex.org/W2553708507","https://openalex.org/W2560485180","https://openalex.org/W2562412556","https://openalex.org/W2577917182","https://openalex.org/W2585283489","https://openalex.org/W2589859055","https://openalex.org/W2590746129","https://openalex.org/W2592412315","https://openalex.org/W2595342131","https://openalex.org/W2599067920","https://openalex.org/W2603284695","https://openalex.org/W2605621434","https://openalex.org/W2620130373","https://openalex.org/W2628145035","https://openalex.org/W2735853786","https://openalex.org/W2750755858","https://openalex.org/W2751980430","https://openalex.org/W2755024874","https://openalex.org/W2761220236","https://openalex.org/W2770587365","https://openalex.org/W2775836849","https://openalex.org/W2778032060","https://openalex.org/W2789257778","https://openalex.org/W2795808866","https://openalex.org/W2796018590","https://openalex.org/W2800364130","https://openalex.org/W2802571930","https://openalex.org/W2806760348","https://openalex.org/W2808016383","https://openalex.org/W2809282001","https://openalex.org/W2883082490","https://openalex.org/W2896164571","https://openalex.org/W2902259832","https://openalex.org/W2913883264","https://openalex.org/W2914523197","https://openalex.org/W2936664461","https://openalex.org/W2937674030","https://openalex.org/W2938719760","https://openalex.org/W2939542860","https://openalex.org/W2940857160","https://openalex.org/W2946721812","https://openalex.org/W2946900271","https://openalex.org/W2955097599","https://openalex.org/W2956029799","https://openalex.org/W2957271680","https://openalex.org/W2959362600","https://openalex.org/W2963903719","https://openalex.org/W2969664559","https://openalex.org/W2973536301","https://openalex.org/W2980906575","https://openalex.org/W2990370974","https://openalex.org/W2991288381","https://openalex.org/W2992842952","https://openalex.org/W2998369348","https://openalex.org/W3001274125","https://openalex.org/W3004951630","https://openalex.org/W3009414066","https://openalex.org/W3015011311","https://openalex.org/W3015478246","https://openalex.org/W3015889007","https://openalex.org/W3018664449","https://openalex.org/W3026493820","https://openalex.org/W3037229000","https://openalex.org/W3044618203","https://openalex.org/W3048219096","https://openalex.org/W3081065285","https://openalex.org/W3081594107","https://openalex.org/W4235722921","https://openalex.org/W4241894380","https://openalex.org/W6674374959","https://openalex.org/W6684620952","https://openalex.org/W6752280486"],"related_works":["https://openalex.org/W4238220025","https://openalex.org/W2611046857","https://openalex.org/W4252868850","https://openalex.org/W2958299423","https://openalex.org/W2007729411","https://openalex.org/W2006359661","https://openalex.org/W4245859490","https://openalex.org/W3207386056","https://openalex.org/W2413629122","https://openalex.org/W4387357349"],"abstract_inverted_index":{"Hematopoietic":[0],"stem":[1],"cells":[2,93],"interact":[3],"with":[4,91],"bone":[5,23,51],"marrow":[6,24,52,60],"niches,":[7],"including":[8],"highly":[9],"specialized":[10],"blood":[11],"vessels.":[12],"Recent":[13],"studies":[14],"have":[15],"revealed":[16],"the":[17,30,33,50,59,70,74,84],"phenotypic":[18],"and":[19,39,79,82,89,98],"functional":[20],"heterogeneity":[21],"of":[22,32,49,58,73,104,112],"endothelial":[25,85],"cells.":[26],"This":[27],"has":[28],"facilitated":[29],"analysis":[31],"vascular":[34,61,75],"microenvironment":[35,86],"in":[36,64,77,94,122],"steady":[37],"state":[38],"malignant":[40,105],"hematopoiesis.":[41],"In":[42],"this":[43],"review,":[44],"we":[45,108],"provide":[46,109],"an":[47,110],"overview":[48,111],"microenvironment,":[53],"focusing":[54],"on":[55],"refined":[56],"analyses":[57],"compartment":[62],"performed":[63],"mouse":[65],"studies.":[66],"We":[67],"also":[68],"discuss":[69],"emerging":[71],"role":[72],"niche":[76],"\"inflamm-aging\"":[78],"clonal":[80],"hematopoiesis,":[81],"how":[83],"influences,":[87],"supports":[88],"interacts":[90],"hematopoietic":[92],"acute":[95],"myeloid":[96,123],"leukemia":[97],"myelodysplastic":[99],"syndromes,":[100],"as":[101],"exemplar":[102],"states":[103],"myelopoiesis.":[106],"Finally,":[107],"strategies":[113],"for":[114],"modulating":[115],"these":[116],"bidirectional":[117],"interactions":[118],"to":[119],"therapeutic":[120],"effect":[121],"malignancies.":[124]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":2}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}