{"id":"https://openalex.org/W3135070800","doi":"https://doi.org/10.1186/s13578-021-00563-y","title":"ApoE4 (\u0394272\u2013299) induces mitochondrial\u2010associated membrane formation and mitochondrial impairment by enhancing GRP75-modulated mitochondrial calcium overload in neuron","display_name":"ApoE4 (\u0394272\u2013299) induces mitochondrial\u2010associated membrane formation and mitochondrial impairment by enhancing GRP75-modulated mitochondrial calcium overload in neuron","publication_year":2021,"publication_date":"2021-03-06","ids":{"openalex":"https://openalex.org/W3135070800","doi":"https://doi.org/10.1186/s13578-021-00563-y","mag":"3135070800","pmid":"https://pubmed.ncbi.nlm.nih.gov/33676568","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/7937300"},"language":"en","primary_location":{"id":"doi:10.1186/s13578-021-00563-y","doi":"https://doi.org/10.1186/s13578-021-00563-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13578-021-00563-y","pdf_url":"https://cellandbioscience.biomedcentral.com/counter/pdf/10.1186/s13578-021-00563-y","source":{"id":"https://openalex.org/S14303005","display_name":"Cell & Bioscience","issn_l":"2045-3701","issn":["2045-3701"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell & Bioscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://cellandbioscience.biomedcentral.com/counter/pdf/10.1186/s13578-021-00563-y","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101606206","display_name":"Tao Liang","orcid":"https://orcid.org/0000-0002-5980-5503","observed_orcids":["https://orcid.org/0000-0002-5980-5503"]},"institutions":[{"id":"https://openalex.org/I4210129222","display_name":"Wuhan Union Hospital","ror":"https://ror.org/0371fqr87","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129222"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tao Liang","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China","Department of Clinical laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China","institution_ids":["https://openalex.org/I47720641"]},{"raw_affiliation_string":"Department of Clinical laboratory, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430022, Wuhan, China","institution_ids":["https://openalex.org/I4210129222","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049736084","display_name":"Weijian Hang","orcid":"https://orcid.org/0000-0002-7277-2929","observed_orcids":["https://orcid.org/0000-0002-7277-2929"]},"institutions":[{"id":"https://openalex.org/I4210160344","display_name":"Tongji Hospital","ror":"https://ror.org/04xy45965","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210160344"]},{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weijian Hang","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China","Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China","institution_ids":["https://openalex.org/I47720641"]},{"raw_affiliation_string":"Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China","institution_ids":["https://openalex.org/I4210160344","https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054988112","display_name":"Jiehui Chen","orcid":"https://orcid.org/0000-0002-0550-2195","observed_orcids":["https://orcid.org/0000-0002-0550-2195"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiehui Chen","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China","Department of Biochemistry and Molecular Biology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China. chenjuanlinda69@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China","institution_ids":["https://openalex.org/I47720641"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China. chenjuanlinda69@163.com","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100512037","display_name":"Yue Wu","orcid":"https://orcid.org/0009-0005-8031-5292","observed_orcids":["https://orcid.org/0009-0005-8031-5292"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Wu","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100831222","display_name":"Bin Wen","orcid":"https://orcid.org/0000-0002-7870-1953","observed_orcids":["https://orcid.org/0000-0002-7870-1953"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bin Wen","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101863844","display_name":"Kai Xu","orcid":"https://orcid.org/0009-0004-2385-4778","observed_orcids":["https://orcid.org/0009-0004-2385-4778"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai Xu","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Bingbing Ding","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bingbing Ding","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China","institution_ids":["https://openalex.org/I47720641"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100359186","display_name":"Juan Chen","orcid":"https://orcid.org/0000-0001-5639-7615","observed_orcids":["https://orcid.org/0000-0001-5639-7615"]},"institutions":[{"id":"https://openalex.org/I47720641","display_name":"Huazhong University of Science and Technology","ror":"https://ror.org/00p991c53","country_code":"CN","type":"education","lineage":["https://openalex.org/I47720641"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Juan Chen","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China","Department of Biochemistry and Molecular Biology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China. chenjuanlinda69@163.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China","institution_ids":["https://openalex.org/I47720641"]},{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, School of Basic Medicine and the Collaborative Innovation Center for Brain Science, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China. chenjuanlinda69@163.com","institution_ids":["https://openalex.org/I47720641"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100359186"],"corresponding_institution_ids":["https://openalex.org/I47720641"],"apc_list":{"value":2390,"currency":"USD","value_usd":2390},"apc_paid":{"value":2390,"currency":"USD","value_usd":2390},"fwci":2.1022,"has_fulltext":true,"cited_by_count":55,"citation_normalized_percentile":{"value":0.89381057,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"11","issue":"1","first_page":"50","last_page":"50"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.8125,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.8125,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.10840000212192535,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11150","display_name":"Endoplasmic Reticulum Stress and Disease","score":0.05139999836683273,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apoe-epsilon4","display_name":"APOE \u03b54","score":0.9369999766349792},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.7680000066757202},{"id":"https://openalex.org/keywords/mitochondrial-dysfunction","display_name":"mitochondrial dysfunction","score":0.6990000009536743},{"id":"https://openalex.org/keywords/mitochondria-associated-membranes","display_name":"mitochondria-associated membranes","score":0.8330000042915344},{"id":"https://openalex.org/keywords/grp75","display_name":"GRP75","score":0.8460000157356262},{"id":"https://openalex.org/keywords/endoplasmic-reticulum-stress","display_name":"endoplasmic reticulum stress","score":0.7580000162124634},{"id":"https://openalex.org/keywords/mitochondrial-calcium-overload","display_name":"mitochondrial calcium overload","score":0.9940000176429749},{"id":"https://openalex.org/keywords/pba","display_name":"PBA","score":0.6880000233650208},{"id":"https://openalex.org/keywords/mitochondrial-calcium-transport","display_name":"mitochondrial calcium transport","score":0.5559999942779541}],"concepts":[{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.6973072290420532},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.6256433725357056},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.577854573726654},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5398465991020203},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3266937732696533},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.17649993300437927},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.16848281025886536},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1186/s13578-021-00563-y","doi":"https://doi.org/10.1186/s13578-021-00563-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13578-021-00563-y","pdf_url":"https://cellandbioscience.biomedcentral.com/counter/pdf/10.1186/s13578-021-00563-y","source":{"id":"https://openalex.org/S14303005","display_name":"Cell & Bioscience","issn_l":"2045-3701","issn":["2045-3701"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell & Bioscience","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7937300","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7937300","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell Biosci","raw_type":"Text"},{"id":"pmid:33676568","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33676568","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell & bioscience","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:5abbfd524d1a48f994366c345c2ccff1","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5abbfd524d1a48f994366c345c2ccff1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cell & Bioscience, Vol 11, Iss 1, Pp 1-14 (2021)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/s13578-021-00563-y","doi":"https://doi.org/10.1186/s13578-021-00563-y","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13578-021-00563-y","pdf_url":"https://cellandbioscience.biomedcentral.com/counter/pdf/10.1186/s13578-021-00563-y","source":{"id":"https://openalex.org/S14303005","display_name":"Cell & Bioscience","issn_l":"2045-3701","issn":["2045-3701"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cell & Bioscience","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9940000176429749,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G7681105147","display_name":null,"funder_award_id":"81873725","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7785193008","display_name":null,"funder_award_id":"31670778","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3135070800.pdf","grobid_xml":"https://content.openalex.org/works/W3135070800.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W281419550","https://openalex.org/W1559324825","https://openalex.org/W1622243645","https://openalex.org/W1633483419","https://openalex.org/W1669771493","https://openalex.org/W1693486396","https://openalex.org/W1892274889","https://openalex.org/W1971034264","https://openalex.org/W1976943917","https://openalex.org/W1982259828","https://openalex.org/W2000983899","https://openalex.org/W2002439304","https://openalex.org/W2019079031","https://openalex.org/W2021346090","https://openalex.org/W2027783468","https://openalex.org/W2036362108","https://openalex.org/W2044911918","https://openalex.org/W2059543535","https://openalex.org/W2063505049","https://openalex.org/W2073268517","https://openalex.org/W2075843588","https://openalex.org/W2076386951","https://openalex.org/W2096579721","https://openalex.org/W2102921784","https://openalex.org/W2115709331","https://openalex.org/W2130893307","https://openalex.org/W2132314273","https://openalex.org/W2142815459","https://openalex.org/W2156998090","https://openalex.org/W2169391157","https://openalex.org/W2170218376","https://openalex.org/W2344943776","https://openalex.org/W2395746382","https://openalex.org/W2399232837","https://openalex.org/W2546671354","https://openalex.org/W2587964013","https://openalex.org/W2592032683","https://openalex.org/W2737181235","https://openalex.org/W2756852269","https://openalex.org/W2767266537","https://openalex.org/W2789816844","https://openalex.org/W2883974615","https://openalex.org/W2896387873","https://openalex.org/W2896917224","https://openalex.org/W2912941375","https://openalex.org/W2921231677","https://openalex.org/W2922380492","https://openalex.org/W2943862192","https://openalex.org/W2969029965","https://openalex.org/W2970633802","https://openalex.org/W2995254660","https://openalex.org/W3022539327"],"related_works":["https://openalex.org/W2922380492","https://openalex.org/W2021346090","https://openalex.org/W4313471793","https://openalex.org/W2115709331","https://openalex.org/W2083075684","https://openalex.org/W4319789741","https://openalex.org/W4319302769","https://openalex.org/W2012870681","https://openalex.org/W2169391157","https://openalex.org/W2022943683"],"abstract_inverted_index":{"BACKGROUND:":[0],"Apolipoprotein":[1],"E4":[2],"(apoE4)":[3],"is":[4],"a":[5],"major":[6],"genetic":[7],"risk":[8],"factor":[9],"of":[10,31,43,71,136,179,193],"Alzheimer's":[11,194],"disease.":[12,195],"Its":[13],"C-terminal-truncated":[14],"apoE4":[15,32,45,79,89,110,180],"(\u0394272-299)":[16,33,46,90,111,149,181],"has":[17],"neurotoxicity":[18,178],"by":[19,95,130,155],"affecting":[20],"mitochondrial":[21,35,59,81,93,116,153,167,183],"respiratory":[22],"function.":[23],"However,":[24],"the":[25,29,69,78,122,177,191],"molecular":[26],"mechanism(s)":[27],"underlying":[28],"action":[30],"in":[34,63,66,77,83,104,107,124],"function":[36,154,184],"remain":[37],"poorly":[38],"understood.":[39],"METHODS:":[40],"The":[41],"impact":[42],"neuronal":[44],"expression":[47,91,112,161],"on":[48],"ER":[49,72,97,137,157],"stress,":[50,158],"mitochondrial-associated":[51,100],"membrane":[52,101],"(MAM)":[53,102],"formation,":[54,165],"GRP75,":[55],"calcium":[56,119,168],"transport":[57,120],"and":[58,65,99,106,118,166,185],"impairment":[60,94],"was":[61,85],"determined":[62],"vivo":[64,105],"vitro.":[67,108],"Furthermore,":[68,109],"importance":[70],"stress":[73,98],"or":[74,144],"GRP75":[75,114,142,145,160],"activity":[76],"(\u0394272-299)-promoted":[80],"dysfunction":[82,117],"neuron":[84,152],"investigated.":[86],"RESULTS:":[87],"Neuronal":[88],"induced":[92],"inducing":[96],"formation":[103],"promoted":[113],"expression,":[115],"into":[121,176],"mitochondria":[123],"neuron,":[125],"which":[126],"were":[127],"significantly":[128,150],"mitigated":[129],"treatment":[131],"with":[132],"PBA":[133],"(an":[134],"inhibitor":[135],"stress),":[138],"MKT077":[139],"(a":[140],"specific":[141],"inhibitor)":[143],"silencing.":[146],"CONCLUSIONS:":[147],"ApoE4":[148],"impaired":[151],"triggering":[156],"up-regulating":[159],"to":[162],"increase":[163],"MAM":[164],"overload.":[169],"Our":[170],"findings":[171],"may":[172],"provide":[173],"new":[174,187],"insights":[175],"against":[182],"uncover":[186],"therapeutic":[188],"targets":[189],"for":[190],"intervention":[192]},"counts_by_year":[{"year":2026,"cited_by_count":14},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2021-03-15T00:00:00"}