{"id":"https://openalex.org/W3135009631","doi":"https://doi.org/10.31925/farmacia.2021.1.9","title":"PHENOLIC CONTENT, ANTIOXIDANT AND IN VITRO ANTIDIABETIC EFFECTS OF THIRTEEN MARINE ORGANISMS FROM MEDITERRANEAN SEA","display_name":"PHENOLIC CONTENT, ANTIOXIDANT AND IN VITRO ANTIDIABETIC EFFECTS OF THIRTEEN MARINE ORGANISMS FROM MEDITERRANEAN SEA","publication_year":2021,"publication_date":"2021-02-27","ids":{"openalex":"https://openalex.org/W3135009631","doi":"https://doi.org/10.31925/farmacia.2021.1.9","mag":"3135009631"},"language":"en","primary_location":{"id":"doi:10.31925/farmacia.2021.1.9","doi":"https://doi.org/10.31925/farmacia.2021.1.9","is_oa":true,"landing_page_url":"https://doi.org/10.31925/farmacia.2021.1.9","pdf_url":"https://farmaciajournal.com/wp-content/uploads/art-09-Orhan_Konuklugil_68-74.pdf","source":{"id":"https://openalex.org/S77753237","display_name":"FARMACIA","issn_l":"0014-8237","issn":["0014-8237","2065-0019"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-70","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FARMACIA","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"diamond","oa_url":"https://farmaciajournal.com/wp-content/uploads/art-09-Orhan_Konuklugil_68-74.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101532681","display_name":"Didem Deliorman Orhan","orcid":"https://orcid.org/0000-0003-3916-4048","observed_orcids":["https://orcid.org/0000-0003-3916-4048"]},"institutions":[{"id":"https://openalex.org/I95634034","display_name":"Gazi University","ror":"https://ror.org/054xkpr46","country_code":"TR","type":"education","lineage":["https://openalex.org/I95634034"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"DIDEM DELIORMAN ORHAN","raw_affiliation_strings":["Gazi University, Faculty of Pharmacy, Department of Pharmacognosy, 06330, Etiler Ankara, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gazi University, Faculty of Pharmacy, Department of Pharmacognosy, 06330, Etiler Ankara, Turkey","institution_ids":["https://openalex.org/I95634034"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5101532681"],"corresponding_institution_ids":["https://openalex.org/I95634034"],"apc_list":null,"apc_paid":null,"fwci":1.1291,"has_fulltext":true,"cited_by_count":11,"citation_normalized_percentile":{"value":0.7,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"69","issue":"1","first_page":"68","last_page":"74"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11340","display_name":"Marine Sponges and Natural Products","score":0.9359999895095825,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11340","display_name":"Marine Sponges and Natural Products","score":0.9359999895095825,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11140","display_name":"Natural Antidiabetic Agents Studies","score":0.06030000001192093,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11390","display_name":"Seaweed-derived Bioactive Compounds","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1104","display_name":"Aquatic Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/marine-sponges","display_name":"marine sponges","score":0.8569999933242798},{"id":"https://openalex.org/keywords/soft-coral","display_name":"soft coral","score":0.7279999852180481},{"id":"https://openalex.org/keywords/total-phenolic-content","display_name":"total phenolic content","score":0.8149999976158142},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.9369999766349792},{"id":"https://openalex.org/keywords/antidiabetic-activity","display_name":"antidiabetic activity","score":0.8330000042915344},{"id":"https://openalex.org/keywords/alpha-glucosidase-inhibition","display_name":"\u03b1-glucosidase inhibition","score":0.9789999723434448},{"id":"https://openalex.org/keywords/alpha-amylase-inhibition","display_name":"\u03b1-amylase inhibition","score":0.8220000267028809},{"id":"https://openalex.org/keywords/dysidea-avara","display_name":"Dysidea avara","score":0.8880000114440918},{"id":"https://openalex.org/keywords/avarol","display_name":"avarol","score":0.8610000014305115},{"id":"https://openalex.org/keywords/eunicella-singularis","display_name":"Eunicella singularis","score":0.8600000143051147},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.6890000104904175},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.5960000157356262},{"id":"https://openalex.org/keywords/metal-chelation","display_name":"metal chelation","score":0.753000020980835},{"id":"https://openalex.org/keywords/free-radical-scavenging-activity","display_name":"free radical scavenging","score":0.9660000205039978}],"concepts":[{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.7650434970855713},{"id":"https://openalex.org/C4646841","wikidata":"https://www.wikidata.org/wiki/Q13996","display_name":"Mediterranean climate","level":2,"score":0.607274055480957},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5969511270523071},{"id":"https://openalex.org/C2779043415","wikidata":"https://www.wikidata.org/wiki/Q986177","display_name":"Mediterranean sea","level":3,"score":0.5108065605163574},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.40145543217658997},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.3782520890235901},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.3608947992324829},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3202337622642517},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1994819939136505},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.1586942970752716},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.08206263184547424}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.31925/farmacia.2021.1.9","doi":"https://doi.org/10.31925/farmacia.2021.1.9","is_oa":true,"landing_page_url":"https://doi.org/10.31925/farmacia.2021.1.9","pdf_url":"https://farmaciajournal.com/wp-content/uploads/art-09-Orhan_Konuklugil_68-74.pdf","source":{"id":"https://openalex.org/S77753237","display_name":"FARMACIA","issn_l":"0014-8237","issn":["0014-8237","2065-0019"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-70","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FARMACIA","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.31925/farmacia.2021.1.9","doi":"https://doi.org/10.31925/farmacia.2021.1.9","is_oa":true,"landing_page_url":"https://doi.org/10.31925/farmacia.2021.1.9","pdf_url":"https://farmaciajournal.com/wp-content/uploads/art-09-Orhan_Konuklugil_68-74.pdf","source":{"id":"https://openalex.org/S77753237","display_name":"FARMACIA","issn_l":"0014-8237","issn":["0014-8237","2065-0019"],"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":["poland-70","russia-white-list-3"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"FARMACIA","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"},{"display_name":"Life below water","score":0.5769000053405762,"id":"https://metadata.un.org/sdg/14"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3135009631.pdf","grobid_xml":"https://content.openalex.org/works/W3135009631.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W82711744","https://openalex.org/W1963883961","https://openalex.org/W1969136629","https://openalex.org/W1987473963","https://openalex.org/W2019624034","https://openalex.org/W2037982223","https://openalex.org/W2077013120","https://openalex.org/W2086551847","https://openalex.org/W2090762264","https://openalex.org/W2106463494","https://openalex.org/W2117426925","https://openalex.org/W2119953219","https://openalex.org/W2164124814","https://openalex.org/W2169660540","https://openalex.org/W2181794880","https://openalex.org/W2183151691","https://openalex.org/W2329240342","https://openalex.org/W2559825829","https://openalex.org/W2566614266","https://openalex.org/W2611705988"],"related_works":["https://openalex.org/W4300861835","https://openalex.org/W7065046266","https://openalex.org/W4317241271","https://openalex.org/W2987792500","https://openalex.org/W3160104617","https://openalex.org/W4410900878","https://openalex.org/W2072697428","https://openalex.org/W4399659892","https://openalex.org/W7128740626","https://openalex.org/W2615392378"],"abstract_inverted_index":{"The":[0],"aim":[1],"of":[2,18,26,104,147],"the":[3,8,88,132,145],"study":[4,129],"was":[5,84,111],"to":[6,86,115],"evaluate":[7],"total":[9,67,70],"phenolic":[10,68],"content,":[11,69],"in":[12,144],"vitro":[13],"antidiabetic":[14,159],"and":[15,32,79,109,113,120],"antioxidant":[16,71,75,163],"potential":[17],"marine":[19,166],"organisms":[20],"collected":[21],"from":[22],"Mediterranean":[23],"coast.Methanol":[24],"extracts":[25],"one":[27],"soft":[28],"coral":[29,176],"(Eunicella":[30,177],"singularis)":[31,178],"twelve":[33],"sponge":[34,133],"species":[35],"(Agelas":[36,184],"oroides,":[37,185],"Aplysina":[38,186],"aerophoba,":[39,187],"Axinella":[40,188],"cannabina,":[41,189],"A.":[42,190],"polypoides,":[43,191],"Cliona":[44,192],"viridis,":[45,193],"Dictyonella":[46,194],"incisa,":[47,51,195,199],"Dysidea":[48,134,196,279],"avara,":[49,197],"Ircinia":[50,198],"I.":[52,54,200,202],"oros,":[53,201],"variabilis,":[55,203],"Petrosia":[56,204],"ficiformis,":[57,205],"Sarcotragus":[58,206],"spinulosa)":[59,207],"were":[60],"investigated":[61],"for":[62,97],"their":[63],"enzyme":[64,94],"inhibitory":[65,102],"activities,":[66],"capacity,":[72],"ferric":[73],"reducing":[74],"power,":[76],"metal":[77],"chelating":[78],"radical":[80],"scavenging":[81],"activities.Dysidea":[82],"avara":[83,135,230,280],"found":[85,114],"be":[87,116,137],"most":[89],"active":[90],"extract":[91],"on":[92],"\u03b1-glucosidase":[93,101],"(94.66":[95],"-4.87%":[96],"3000":[98,247],"-100":[99,248],"\u00b5g/mL).Therefore,":[100],"activity":[103],"its":[105],"major":[106],"compounds":[107],"avarol":[108,255],"avarone":[110],"tested":[112],"86.18":[117],"\u00b1":[118,122,264,269],"1.76%":[119],"78.94":[121],"1.38%":[123],"respectively,":[124],"at":[125],"10":[126,274],"\u00b5M.The":[127],"present":[128],"indicated":[130],"that":[131],"can":[136],"evaluated":[138],"as":[139],"a":[140,152,233,253,260,276],"new":[141],"natural":[142],"source":[143],"treatment":[146],"diabetes":[148],"mellitus.":[149],"RezumatScopul":[150],"studiului":[151],"fost":[153,209],"evaluarea":[154],"con\u021binutului":[155],"fenolic":[156,217],"total,":[157,218],"poten\u021bialul":[158],"in-vitro":[160],"\u0219i":[161,179,226,256],"cel":[162,235],"al":[164],"organismelor":[165],"colectate":[167],"de":[168,175,182,228,262,273],"pe":[169],"coasta":[170],"mediteranean\u0103.Extractele":[171],"metanolice":[172],"dintr-o":[173],"specie":[174],"dou\u0103sprezece":[180],"specii":[181],"burete":[183],"au":[208],"investigate":[210],"privind":[211],"activit\u0103\u021bile":[212],"lor":[213],"inhibitoare":[214],"enzimatice,":[215],"con\u021binutul":[216],"capacitatea":[219],"antioxidant\u0103":[220],"total\u0103,":[221],"poten\u021ba":[222],"reduc\u0103toare,":[223],"chelarea":[224],"metalelor":[225],"activitatea":[227],"scavenger.Dysidea":[229],"s-a":[231,258],"dovedit":[232,259],"fi":[234,261,283],"mai":[236],"activ":[237],"extract,":[238],"cu":[239],"ac\u021biune":[240],"asupra":[241,251],"enzimei":[242],"\u03b1-glucozidaz\u0103":[243],"(94,66":[244],"-4,87%":[245],"pentru":[246],"\u00b5g/mL).Activitatea":[249],"inhibitorie":[250],"\u03b1-glucozidazei":[252],"compu\u0219ilor":[254],"avaron\u0103":[257],"86,18":[263],"1,76%":[265],"\u0219i,":[266],"respectiv":[267],"78,94":[268],"1,38%":[270],"la":[271],"concentra\u021bia":[272],"\u00b5M.Studiul":[275],"ar\u0103tat":[277],"c\u0103":[278],"ar":[281],"putea":[282],"evaluat":[284],"ca":[285],"o":[286],"surs\u0103":[287],"natural\u0103":[288],"\u00een":[289],"tratamentul":[290],"diabetului":[291],"zaharat.":[292]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2021-03-15T00:00:00"}